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PMIDDataArticle TitleCitationOrganizationSD Files Download
2955541974Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.EBIBioorg Med Chem 26: 1727-1739 (2018)National Center for Advancing Translational Sciences2D 3D TSV
2951094720A combination ofEBIBioorg Med Chem 26: 1929-1938 (2018)The University of Tokyo2D 3D TSV
2968148633Novel naphthyloxy derivatives - Potent histamine HEBIBioorg Med Chem 26: 2573-2585 (2018)Jagiellonian University Medical College2D 3D TSV
296737154Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules.EBIBioorg Med Chem 26: 2610-2620 (2018)Amherst College2D 3D TSV
297842711Boronic acid inhibitors of the class A?-lactamase KPC-2.EBIBioorg Med Chem 26: 2921-2927 (2018)UCL School of Pharmacy2D 3D TSV
2965560964Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-?-lactamases.EBIBioorg Med Chem 26: 2928-2936 (2018)University of Oxford2D 3D TSV
2977683458BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.EBIBioorg Med Chem 26: 2937-2957 (2018)University of Oxford2D 3D TSV
2976475585Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.EBIBioorg Med Chem 26: 2984-2991 (2018)University of Oxford2D 3D TSV
2977966912Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.EBIBioorg Med Chem 26: 2996-3005 (2018)University of Liverpool2D 3D TSV
2960267349Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.EBIBioorg Med Chem 26: 3039-3045 (2018)Imperial College2D 3D TSV
298533414The recent progress of isoxazole in medicinal chemistry.EBIBioorg Med Chem 26: 3065-3075 (2018)China Pharmaceutical University2D 3D TSV
2986648122Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.EBIBioorg Med Chem 26: 3076-3095 (2018)Alzahra University2D 3D TSV
2972998766Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.EBIBioorg Med Chem 26: 3117-3125 (2018)East China University of Science and Technology2D 3D TSV
2970537728Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.EBIBioorg Med Chem 26: 3133-3144 (2018)Seoul National University2D 3D TSV
2985975056Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.EBIBioorg Med Chem 26: 3145-3157 (2018)Shandong University2D 3D TSV
296999112Novel amidrazone derivatives: Design, synthesis and activity evaluation.EBIBioorg Med Chem 26: 3158-3165 (2018)Anhui Medical University2D 3D TSV
2970652513Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid? aggregation.EBIBioorg Med Chem 26: 3202-3209 (2018)University of Tsukuba2D 3D TSV
2973542545Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.EBIBioorg Med Chem 26: 3227-3241 (2018)Boehringer Ingelheim Pharma GmbH & Co. KG2D 3D TSV
2975483373Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.EBIBioorg Med Chem 26: 3261-3286 (2018)Takeda Pharmaceutical Co., Ltd2D 3D TSV
2975356619Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure.EBIBioorg Med Chem 26: 3296-3307 (2018)Universities of Lille2D 3D TSV
2976475617Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors.EBIBioorg Med Chem 26: 3399-3405 (2018)Bienta/Enamine Ltd.2D 3D TSV
2977683225An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated CaEBIBioorg Med Chem 26: 3406-3413 (2018)University of Auckland2D 3D TSV
2980769912Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors.EBIBioorg Med Chem 26: 3429-3437 (2018)China Pharmaceutical University2D 3D TSV
2980335913Drug efficacy of novel 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans; evaluated via DNA gyrase inhibition, bacterial cell wall lesion and antibacterial prospective.EBIBioorg Med Chem 26: 3438-3452 (2018)Bharathiar University2D 3D TSV
298050742Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus.EBIBioorg Med Chem 26: 3453-3460 (2018)University of Delaware2D 3D TSV
2978920716Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair.EBIBioorg Med Chem 26: 3461-3467 (2018)CSIR-National Institute for Interdisciplinary Science and Technology2D 3D TSV
297937514Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.EBIBioorg Med Chem 26: 3474-3490 (2018)National Research Centre2D 3D TSV
2985333831Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells.EBIBioorg Med Chem 26: 3491-3501 (2018)Shihezi University2D 3D TSV
2978427440Chiral analogues of (+)-cyclazosin as potent?EBIBioorg Med Chem 26: 3502-3513 (2018)Universit£ di Camerino2D 3D TSV
2980507528Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy.EBIBioorg Med Chem 26: 3559-3572 (2018)Shanghai Institute of Materia Medica2D 3D TSV
298664796Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists.EBIBioorg Med Chem 26: 3580-3587 (2018)Hospital del Mar Medical Research Institute (IMIM)2D 3D TSV
2985333711Pyrroloquinoline scaffold-based 5-HTEBIBioorg Med Chem 26: 3588-3595 (2018)Jagiellonian University Medical College2D 3D TSV
2985334039Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.EBIBioorg Med Chem 26: 3619-3633 (2018)Xi'an Jiaotong University2D 3D TSV
2988458242Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.EBIBioorg Med Chem 26: 3639-3653 (2018)Asubio Pharma Co., Ltd2D 3D TSV
2985333922Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase.EBIBioorg Med Chem 26: 3654-3663 (2018)Imam Abdulrahman Bin Faisal University2D 3D TSV
2985815763Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors.EBIBioorg Med Chem 26: 3664-3667 (2018)University of Arizona2D 3D TSV
2988608274Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.EBIBioorg Med Chem 26: 3668-3687 (2018)Ludwig-Maximilians-Universit£t M£nchen2D 3D TSV
2988025084Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human AEBIBioorg Med Chem 26: 3688-3695 (2018)Universit£ degli Studi di Firenze2D 3D TSV
2988608322Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors.EBIBioorg Med Chem 26: 3696-3706 (2018)University of Gujrat2D 3D TSV
2988458113Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis.EBIBioorg Med Chem 26: 3707-3715 (2018)Quaid-i-Azam University2D 3D TSV
2988751127Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists.EBIBioorg Med Chem 26: 3716-3726 (2018)Astellas Pharma Inc2D 3D TSV
3001711236Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.EBIBioorg Med Chem 26: 3731-3762 (2018)Abbottabad University of Science and Technology2D 3D TSV
3001711319Synthesis of 1,5-Anhydro-d-fructose derivatives and evaluation of their inflammasome inhibitors.EBIBioorg Med Chem 26: 3763-3772 (2018)The Noguchi Institute2D 3D TSV
2970652922Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone.EBIBioorg Med Chem 26: 3773-3784 (2018)Jagiellonian University Medical College2D 3D TSV
2990341413Synthesis, in vitro and in silico studies of novel potent urease inhibitors: N-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides.EBIBioorg Med Chem 26: 3791-3804 (2018)Kongju National University2D 3D TSV
2996072829Design, synthesis and evaluation of novel bivalent ?-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.EBIBioorg Med Chem 26: 3812-3824 (2018)China Pharmaceutical University2D 3D TSV
299832854Antiplasmodial activity of hydroxyethylamine analogs: Synthesis, biological activity and structure activity relationship of plasmepsin inhibitors.EBIBioorg Med Chem 26: 3837-3844 (2018)University of Delhi2D 3D TSV
299832814Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus.EBIBioorg Med Chem 26: 3845-3851 (2018)Foundation for Research& Technology-Hellas2D 3D TSV