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PMIDDataArticle TitleCitationOrganizationSD Files Download
29631962252Identification and biological evaluation of thiazole-based inverse agonists of ROR?t.EBIBioorg Med Chem Lett 28: 1446-1455 (2018)Phenex Pharmaceuticals AG2D 3D TSV
2962832612Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.EBIBioorg Med Chem Lett 28: 1476-1483 (2018)University of Jinan2D 3D TSV
2962726115Development of novel pyridazinone-based adenosine receptor ligands.EBIBioorg Med Chem Lett 28: 1484-1489 (2018)Universit£ degli Studi di Firenze2D 3D TSV
2961534511Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-?/FFAR1 agonists.EBIBioorg Med Chem Lett 28: 1595-1602 (2018)Suez Canal University2D 3D TSV
2969992347Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model.EBIBioorg Med Chem Lett 28: 1686-1692 (2018)WuXi AppTec (Shanghai) Co. Ltd2D 3D TSV
296814335Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.EBIBioorg Med Chem Lett 28: 1725-1730 (2018)Taisho Pharmaceutical Co., Ltd2D 3D TSV
297064225Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents.EBIBioorg Med Chem Lett 28: 1731-1735 (2018)Nanjing University of Technology2D 3D TSV
2965598013Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.EBIBioorg Med Chem Lett 28: 1849-1852 (2018)Cadila Healthcare Ltd.2D 3D TSV
2965029310Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A.EBIBioorg Med Chem Lett 28: 1864-1869 (2018)Shanghai Institute of Materia Medica2D 3D TSV
2965597925Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.EBIBioorg Med Chem Lett 28: 1887-1891 (2018)Eli Lilly and Company2D 3D TSV
296615337Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.EBIBioorg Med Chem Lett 28: 1903-1910 (2018)University of Iowa2D 3D TSV
2965389442MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.EBIBioorg Med Chem Lett 28: 1954-1957 (2018)Merck & Co.2D 3D TSV
29653895210An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.EBIBioorg Med Chem Lett 28: 1958-1963 (2018)GlaxoSmithKline2D 3D TSV
2965028954Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.EBIBioorg Med Chem Lett 28: 1972-1980 (2018)University of Michigan2D 3D TSV
297521851Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery.EBIBioorg Med Chem Lett 28: 1981-1991 (2018)Eli Lilly and Company2D 3D TSV
2974805026Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors.EBIBioorg Med Chem Lett 28: 2003-2007 (2018)Shanghai Institute of Technology2D 3D TSV
2974805387Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.EBIBioorg Med Chem Lett 28: 2050-2054 (2018)McDaniel College2D 3D TSV
2972458940Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism.EBIBioorg Med Chem Lett 28: 2055-2060 (2018)Mitsubishi Tanabe Pharma Corporation2D 3D TSV
29709253302-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists.EBIBioorg Med Chem Lett 28: 2080-2083 (2018)Sookmyung Women's University2D 3D TSV
297480483Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.EBIBioorg Med Chem Lett 28: 2084-2090 (2018)West China Hospital2D 3D TSV
29709252311,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaEBIBioorg Med Chem Lett 28: 2103-2108 (2018)Amgen Inc2D 3D TSV
2977997655The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.EBIBioorg Med Chem Lett 28: 2124-2130 (2018)Bristol-Myers Squibb Research and Development2D 3D TSV
297735024Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors.EBIBioorg Med Chem Lett 28: 2131-2135 (2018)Chinese Academy of Sciences2D 3D TSV
2977674255Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.EBIBioorg Med Chem Lett 28: 2143-2147 (2018)FORMA Therapeutics2D 3D TSV
2977350413Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib.EBIBioorg Med Chem Lett 28: 2148-2152 (2018)Fudan University2D 3D TSV
2975972650N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.EBIBioorg Med Chem Lett 28: 2153-2158 (2018)Novartis Institutes for BioMedical Research2D 3D TSV
2977997553Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.EBIBioorg Med Chem Lett 28: 2159-2164 (2018)Janssen Research and Development LLC2D 3D TSV
2977997726Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.EBIBioorg Med Chem Lett 28: 2165-2170 (2018)Emory University2D 3D TSV
2975494869The discovery of VU0486846: steep SAR from a series of MEBIBioorg Med Chem Lett 28: 2175-2179 (2018)Vanderbilt University Medical Center2D 3D TSV
2976474146Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.EBIBioorg Med Chem Lett 28: 2195-2200 (2018)Novartis Institutes for BioMedical Research2D 3D TSV
297647426Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors.EBIBioorg Med Chem Lett 28: 2201-2205 (2018)Shandong University2D 3D TSV
2975218252Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).EBIBioorg Med Chem Lett 28: 2222-2227 (2018)Daiichi Sankyo Co., Ltd2D 3D TSV
298611423Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity.EBIBioorg Med Chem Lett 28: 2229-2233 (2018)Capital Medical University2D 3D TSV
2985333250Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.EBIBioorg Med Chem Lett 28: 2250-2255 (2018)Universit£ de Nantes2D 3D TSV
298599066Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group.EBIBioorg Med Chem Lett 28: 2256-2260 (2018)Showa Pharmaceutical University2D 3D TSV
2979882529Development of autotaxin inhibitors: A series of zinc binding triazoles.EBIBioorg Med Chem Lett 28: 2279-2284 (2018)Novartis Institutes for BioMedical Research2D 3D TSV
297988275Isoxazole-tethered diarylheptanoid analogs: Discovery of a new drug-like PAR2 antagonist.EBIBioorg Med Chem Lett 28: 2285-2288 (2018)Advinus Therapeutics Ltd2D 3D TSV
2980779612New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.EBIBioorg Med Chem Lett 28: 2289-2293 (2018)University of Ferrara2D 3D TSV
2980373168Adamantyl thioureas as soluble epoxide hydrolase inhibitors.EBIBioorg Med Chem Lett 28: 2302-2313 (2018)University of California Davis2D 3D TSV
29853330106Chemical space screening around PheEBIBioorg Med Chem Lett 28: 2320-2323 (2018)Vrije Universiteit Brussel2D 3D TSV
2980199711Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.EBIBioorg Med Chem Lett 28: 2324-2327 (2018)Novartis Institute for Tropical Diseases2D 3D TSV
2980505540Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.EBIBioorg Med Chem Lett 28: 2338-2342 (2018)Shionogi & Co., Ltd2D 3D TSV
2992147625The mimics of NEBIBioorg Med Chem Lett 28: 2375-2378 (2018)School of Pharmacy2D 3D TSV
299342453Design and synthesis of selenazole-substituted ritonavir analogs.EBIBioorg Med Chem Lett 28: 2379-2381 (2018)Chinese Academy of Science2D 3D TSV
2992548026Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.EBIBioorg Med Chem Lett 28: 2403-2407 (2018)Sunchon National University2D 3D TSV
2993424612Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EPEBIBioorg Med Chem Lett 28: 2408-2412 (2018)Asahi Kasei Pharma Corporation2D 3D TSV
299100808Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.EBIBioorg Med Chem Lett 28: 2436-2441 (2018)Yeungnam University2D 3D TSV
299298827An imidazole based H-Phe-Phe-NHEBIBioorg Med Chem Lett 28: 2446-2450 (2018)Uppsala University2D 3D TSV
2988735426A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives.EBIBioorg Med Chem Lett 28: 2481-2484 (2018)Fr£res Mentouri-Constantine University2D 3D TSV
29880399171,2-Diphenoxiethane salts as potent antiplasmodial agents.EBIBioorg Med Chem Lett 28: 2485-2489 (2018)Universidad de Granada2D 3D TSV
29871845125Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.EBIBioorg Med Chem Lett 28: 2513-2517 (2018)Keimyung University2D 3D TSV
2988453421Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists.EBIBioorg Med Chem Lett 28: 2539-2542 (2018)Seoul National University2D 3D TSV