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Compounds Sorted by Binding Data per Compound

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43   44   45   46   47   48   49   50   51   52   53   54   55   56   57   58   59   60   61   62   63   
64   65   66   67   68   69   70   71   72   73   74   75   76   77   78   79   80   81   82   83   84   
85   86   87   88   89   90   91   92   93   94   95   96   97   99   100   101   102   103   104   105   107   
108   109   110   111   112   113   114   115   116   118   119   121   122   123   124   125   126   127   128   130   131   
133   137   138   139   140   141   142   143   144   146   147   148   150   152   153   154   156   157   158   159   160   
162   163   164   165   168   169   171   172   173   174   177   183   185   186   188   190   196   198   199   203   206   
207   208   213   215   216   219   224   225   227   230   233   237   246   249   261   262   263   277   285   297   299   
303   308   311   317   326   330   333   335   336   337   344   359   360   379   389   391   413   442   443   444   445   
446   447   448   450   453   454   456   460   461   462   464   465   467   469   471   482   496   511   516   517   518   
529   531   539   559   571   583   790   804   818   821   824   831   839   841   848   849   851   853   859   869   876   
880   913   922   923   931   938   966   975   990   1015   1016   1018   1027   1058   1096   1125   1196   1381   1438   1490   1608   
Compounds Sorted Alphabetically
Compound Name
(alphabetical)
Enz. Inhib. DataITC DataBinding TargetsAlternate Compound Names
KiIC50KdEC50KoffKonOther
BDBM10330
PNG
111000000
  • Caspase-1
  • Caspase-3
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • (S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
  • 1-[(4-methoxyphenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL200677
  • Pyrrolidine Isatin Analogue 11b
BDBM10334
PNG
111000000
  • Caspase-1
  • Caspase-3
  • Caspase-6
  • Caspase-7
  • Caspase-8
  • (S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
  • 1-[(4-hydroxyphenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL200927
  • Pyrrolidine Isatin Analogue 11f
BDBM10355
PNG
48000000
  • Caspase-1
  • Caspase-3
  • hIL-1beta
  • (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid
  • Ac-YVAD-CHO
  • CHEMBL37630
BDBM103796
PNG
90030000
  • Beta-2 adrenergic receptor and beta-3 adrenergic receptor
  • Muscarinic acetylcholine receptor M3
  • US8551978, 322
  • US8551978, 323
  • US8816088, I-66
  • US8816088, I-67
  • US9394275, I-66
  • US9572802, Compound I-67
  • US9682957, I-67
BDBM104213
PNG
012000000
  • Serine/threonine-protein kinase PIM-3
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • US8575145, 120
  • US8575145, 121
  • US8575145, 150
  • US8575145, 151
  • US8575145, 90
  • US8575145, 91
BDBM10458
PNG
46110000
  • Acetylcholinesterase
  • Carboxylic ester hydrolase
  • Choline transporter
  • Plasminogen
  • Potassium voltage-gated channel subfamily H member 2
  • Pteridine reductase 1
  • Thrombin and coagulation factor X
  • Trypsin
  • Twik-RElated Potassium (K+) channel 1 (TREK1)
  • Voltage-gated potassium channel
  • Voltage-gated potassium channel subfamily A member 1/beta-1
  • 4-AP
  • 4-Aminopyridine 10
  • CHEMBL284348
  • DALFAMPRIDINE
  • pyridin-4-amine
BDBM104963
PNG
010200000
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase kinase kinase 8
  • Serine/threonine-protein kinase B-raf
  • CHEMBL507361
  • US8575391, Q
BDBM106722
PNG
012000000
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Sodium-dependent noradrenaline transporter
  • CHEMBL2036264
  • US8586620, 114
BDBM107486
PNG
012000000
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
  • US8575157, 200
  • US8592410, Comparator 12
  • US8598163, 70
BDBM10840
PNG
012000000
  • 3-phosphoinositide dependent protein kinase-1
  • Casein Kinase I
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Glycogen Synthase Kinase-3, beta
  • Glycogen synthase kinase-3 beta
  • Serine/threonine-protein kinase pim-1
  • cAMP-Dependent Protein Kinase (PKA)
  • cGMP-Dependent Protein Kinase
  • 4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine
  • Meridianin C
BDBM10844
PNG
012000000
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 5 (CDK5)
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Glycogen Synthase Kinase-3, beta
  • Glycogen synthase kinase-3 beta
  • NF-kappa-beta-inducing kinase (NF-kB)
  • cAMP-Dependent Protein Kinase (PKA)
  • cGMP-Dependent Protein Kinase
  • 4-(1H-indol-3-yl)pyrimidin-2-amine
  • Meridianin G
BDBM10854
PNG
13800000
  • Chitinase
  • Chitinase B
  • Chitinase Mutant (A217G)
  • Chitinase Mutant (D175A)
  • Chitinase Mutant (E322A)
  • Chitinase Mutant (M243A)
  • Chitinase Mutant (R301K)
  • Chitinase Mutant (T138A)
  • Chitinase Mutant (Y245F)
  • Endochitinase B1
  • 4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethanimidoyl)amino]propyl}-18-hydroxy-16-(1H-imidazol-4-ylmethyl)-3,9,12,15,20-pentaoxo-2,8,11,14,17-pentaazatricyclo[15.2.1.0^{4,8}]icosan-13-yl]butanoic acid
  • Argadin
  • CHEMBL445236
BDBM11140
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • (1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropan-2-aminium; 2,2,2-trifluoroacetate
  • beta-dimethylamide 4
  • beta-substituted phenylalanine deriv. 22
  • phenylalanine derived inhibitor, 3
BDBM11189
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • (2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium; 2,2,2-trifluoroacetate
  • 3-(S)-fluoropyrrolidide 25
  • beta-substituted phenylalanine deriv. 14
  • phenylalanine derived inhibitor, 4
BDBM11343
PNG
102000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix Metalloproteinase-8 (MMP-8)
  • Matrix metalloproteinase 12
  • (2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide
  • Hydroxamate 24
  • N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate
BDBM11362
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix Metalloproteinase-8 (MMP-8)
  • 2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 43
  • hydroxamate deriv. B4
BDBM11363
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix Metalloproteinase-8 (MMP-8)
  • 2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorobenzene)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 44
  • hydroxamate deriv. B21
BDBM11364
PNG
111000000
  • 72 kDa type IV collagenase
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix Metalloproteinase-8 (MMP-8)
  • 2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfonamido}-N-hydroxypropanamide
  • Hydroxamate 45
  • hydroxamate deriv. B24
BDBM11719
PNG
012000000
  • Dipeptidyl peptidase 2 (DPP II)
  • Dipeptidyl peptidase 4
  • Dipeptidyl peptidase 9
  • Dipeptidyl peptidase VIII
  • Fibroblast Activation Protein (FAP)
  • Fibroblast activation protein alpha
  • (2S)-1-(2-{[4-(2,3-dihydro-1H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
  • (2S)-Cyanopyrrolidine analogue 21d
  • (2S)-cyanopyrrolidine 4
  • 2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole
BDBM11870
PNG
57000000
  • 72 kDa type IV collagenase
  • Collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix Metalloproteinase-8 (MMP-8)
  • Matrix metalloproteinase-14 (MMP14)
  • Stromelysin-1
  • 4-{[4-(4-Chlorophenoxy)phenyl]sulfonyl}-N-hydroxy tetrahydro-2H-pyran-4-carboxamide
  • 4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxyoxane-4-carboxamide
  • alpha-sulfone 21
BDBM119440
PNG
111000000
  • Histone Deacetylase 10 (HDAC10)
  • Histone deacetylase 1
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 6
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • Prostaglandin E2 receptor EP2 subtype
  • BDBM119696
  • US8685986, 15
BDBM123325
PNG
44400000
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Orexin receptor type 1
  • Orexin receptor type 2
  • Potassium voltage-gated channel subfamily H member 2
  • US8742106, 1.4
BDBM12355
PNG
39000000
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • 3-(thiophen-3-yl)pyridine
  • CHEMBL361153
  • US8609708,11
  • nicotine 3-heteroaromatic analogue 8
BDBM127726
PNG
012000000
  • High affinity nerve growth factor receptor
  • JAK2 (aa 808-1132)
  • Tyrosine-protein kinase JAK2
  • US10251889, Example 100
  • US8791123, 99
  • US9782415, Example 99
  • US9796724, Example 100
BDBM127808
PNG
012000000
  • High affinity nerve growth factor receptor
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US8791123, 181
  • US9782415, Example 181
BDBM136570
PNG
012000000
  • Beta-secretase 1
  • Cathepsin D
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Potassium voltage-gated channel subfamily H member 2
  • US8865706, 9
BDBM13940
PNG
120000000
  • Coagulation factor X
  • Thrombin and coagulation factor X
  • Trypsin
  • Urokinase-type plasminogen activator
  • 2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
  • APC-1801
  • {amino[2-(3-hydroxypyridin-2-yl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium
BDBM13990
PNG
93000000
  • Protein-Tyrosine Phosphatase 1B (PTP1B)
  • Protein-tyrosine phosphatase 1B
  • Tyrosine-protein phosphatase non-receptor type 2
  • 5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-1,2-oxazole-3-carboxylic acid
  • CHEMBL117869
  • Isoxazole carboxylic acid analog 1
BDBM141368
PNG
012000000
  • Androgen Receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estrogen receptor
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
  • US8916600, 2
  • US8916600, 3
  • US9738632, Example 2
BDBM14144
PNG
120000000
  • Coagulation factor X
  • Plasminogen
  • Thrombin and coagulation factor X
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase (uPA) Mutant (S190A)
  • Urokinase-type plasminogen activator
  • 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(cyclopentyloxy)benzen-1-olate
  • APC-10655
  • CA-06
BDBM14333
PNG
120000000
  • Coagulation factor X
  • Plasminogen
  • Thrombin and coagulation factor X
  • Tissue-type plasminogen activator
  • Trypsin
  • Trypsin-1
  • Tryptase
  • Urokinase (uPA) Mutant (S190A)
  • Urokinase-type plasminogen activator
  • 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate
  • CA-09
  • CRA-10818
BDBM143745
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 4
  • US8969352, 4
  • US9611277, Example 4
  • US9845333, 4
BDBM143760
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 21
  • US8969352, 21
  • US9611277, Example 21
  • US9845333, 21
BDBM143770
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 31
  • US8969352, 31
  • US9611277, Example 31
  • US9845333, 31
BDBM143771
PNG
120000000
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 32
  • US8969352, 32
  • US9845333, 32
BDBM143780
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 41
  • US8969352, 41
  • US9611277, Example 41
  • US9845333, 41
BDBM143790
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 51
  • US8969352, 51
  • US9611277, Example 51
  • US9845333, 51
BDBM143791
PNG
120000000
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 52
  • US8969352, 52
  • US9611277, Example 52
  • US9845333, 52
BDBM143793
PNG
120000000
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US8969352, 54
  • US9611277, Example 54
  • US9845333, 54
BDBM145650
PNG
120000000
  • 5-lipoxygenase-activating protein (FLAP)
  • 5-lipoxygenase/FLAP
  • US8952177, 1
  • US8952177, 5
  • US8952177, 6
  • US9089569, 7
  • US9695149, 6
BDBM14771
PNG
012000000
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Mitogen-activated protein kinase 14
  • Phosphodiesterase 8
  • Phosphodiesterase Type 10 (PDE10A)
  • Phosphodiesterase Type 11 (PDE11A)
  • Phosphodiesterase Type 2 (PDE2A)
  • Phosphodiesterase Type 3 (PDE3B)
  • Phosphodiesterase Type 4 (PDE4B)
  • Phosphodiesterase Type 4 (PDE4D)
  • Phosphodiesterase Type 5 (PDE5A)
  • Phosphodiesterase Type 7 (PDE7B)
  • Phosphodiesterase Type 9 (PDE9A)
  • (E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate
  • Filaminast
  • [1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate
BDBM149772
PNG
2100000
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