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12954816 2 N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.BDB J Pharmacol Exp Ther 307: 322-30 (2003) Novartis Pharma AG 2D 3D TSV
12954796 58 In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.BDB J Pharmacol Exp Ther 307: 138-45 (2003) National Institute on Drug Abuse 2D 3D TSV
12954329 8 The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.BDB Chem Biol 10: 705-12 (2003) Merck Research Laboratories 2D 3D TSV
12954072 46 New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.EBI J Med Chem 46: 4196-204 (2003) Georgetown University Medical Center 2D 3D TSV
12954071 109 A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.EBI J Med Chem 46: 4188-95 (2003) Alcon Research, Ltd. 2D 3D TSV
12954070 24 Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.EBI J Med Chem 46: 4182-7 (2003) University of Innsbruck 2D 3D TSV
12954066 63 In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues.EBI J Med Chem 46: 4141-8 (2003) Medical University of South Carolina 2D 3D TSV
12954065 8 Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity.EBI J Med Chem 46: 4136-40 (2003) University Center for Pharmacy 2D 3D TSV
12954062 140 5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.EBI J Med Chem 46: 4104-12 (2003) Ligand Pharmaceuticals Inc. 2D 3D TSV
12954061 153 Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.EBI J Med Chem 46: 4087-103 (2003) Ligand Pharmaceuticals, Inc. 2D 3D TSV
12954060 4 CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.EBI J Med Chem 46: 4070-86 (2003) GlaxoSmithKline 2D 3D TSV
12954059 55 Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.EBI J Med Chem 46: 4063-9 (2003) Moscow State University 2D 3D TSV
12954058 193 Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.BDB J Med Chem 46: 4050-62 (2003) Pharmacia Corporation 2D 3D TSV
12954057 113 Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.EBI J Med Chem 46: 4043-9 (2003) Pharmacia Corporation 2D 3D TSV
12954056 14 Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.EBI J Med Chem 46: 4032-42 (2003) Università di Pisa 2D 3D TSV
12954055 47 Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.EBI J Med Chem 46: 4021-31 (2003) Johnson and Johnson Pharmaceutical Research and Development 2D 3D TSV
12954053 39 Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.EBI J Med Chem 46: 4002-8 (2003) University of Maryland 2D 3D TSV
12954052 25 Synthesis and SAR of thrombin inhibitors incorporating a novel 4-amino-morpholinone sscaffold: analysis of X-ray crystal structure of enzyme inhibitor complex.EBI J Med Chem 46: 3985-4001 (2003) Link£ping University 2D 3D TSV
12954051 10 Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.EBI J Med Chem 46: 3975-84 (2003) Dr Reddy's Laboratories Ltd. 2D 3D TSV
12954050 2 Receptor-mediated targeting of a photosensitizer by its conjugation to gonadotropin-releasing hormone analogues.EBI J Med Chem 46: 3965-74 (2003) Institute of Science 2D 3D TSV
12954048 36 The first potent and selective non-imidazole human histamine H4 receptor antagonists.EBI J Med Chem 46: 3957-60 (2003) Johnson& Johnson Pharmaceutical Research and Development 2D 3D TSV
12954047 80 Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.EBI J Med Chem 46: 3953-6 (2003) The Lilly Research Laboratories 2D 3D TSV
12951129 30 Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.EBI Bioorg Med Chem Lett 13: 3375-9 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12951128 51 Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists.EBI Bioorg Med Chem Lett 13: 3371-4 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12951127 32 Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists.EBI Bioorg Med Chem Lett 13: 3367-70 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12951126 39 Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).EBI Bioorg Med Chem Lett 13: 3361-5 (2003) Berlex Biosciences 2D 3D TSV
12951125 18 N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates.EBI Bioorg Med Chem Lett 13: 3355-9 (2003) Virginia Commonwealth University 2D 3D TSV
12951124 2 Stereoselective synthesis of phosphoramidate alpha(2-6)sialyltransferase transition-state analogue inhibitors.EBI Bioorg Med Chem Lett 13: 3351-4 (2003) Universitaet Konstanz 2D 3D TSV
12951122 20 Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.EBI Bioorg Med Chem Lett 13: 3341-4 (2003) Shire BioChem Inc. 2D 3D TSV
12951120 32 Alpha-keto amides as inhibitors of histone deacetylase.EBI Bioorg Med Chem Lett 13: 3331-5 (2003) Cancer Research, Abbott Laboratories, Department R47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. carol.wada@abbott.com 2D 3D TSV
12951118 24 HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.BDB Bioorg Med Chem Lett 13: 3323-6 (2003) Merck Research Laboratories 2D 3D TSV
12951117 31 Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.EBI Bioorg Med Chem Lett 13: 3317-22 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12951116 30 Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.EBI Bioorg Med Chem Lett 13: 3311-5 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12951114 18 Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.EBI Bioorg Med Chem Lett 13: 3301-3 (2003) University of California 2D 3D TSV
12951113 11 Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.EBI Bioorg Med Chem Lett 13: 3297-300 (2003) McGill University/Royal Victoria Hospital 2D 3D TSV
12951112 150 Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid.EBI Bioorg Med Chem Lett 13: 3293-6 (2003) Friedrich Alexander University 2D 3D TSV
12951108 63 Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.EBI Bioorg Med Chem Lett 13: 3277-80 (2003) Lilly Research Centre 2D 3D TSV
12951107 8 Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives.EBI Bioorg Med Chem Lett 13: 3273-6 (2003) Senju Pharmaceutical Co., Ltd. 2D 3D TSV
12951102 46 Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.EBI Bioorg Med Chem Lett 13: 3247-52 (2003) Purdue Pharma L.P. 2D 3D TSV
12951101 79 Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.EBI Bioorg Med Chem Lett 13: 3243-6 (2003) Pfizer Global Research and Development 2D 3D TSV
12951100 6 Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.EBI Bioorg Med Chem Lett 13: 3237-42 (2003) Lilly Research Laboratories 2D 3D TSV
12951099 28 Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.EBI Bioorg Med Chem Lett 13: 3231-5 (2003) Universidad de Buenos Aires 2D 3D TSV
12951093 12 Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.EBI Bioorg Med Chem Lett 13: 3203-5 (2003) NIH 2D 3D TSV
12951091 36 Design and synthesis of fluorinated RXR modulators.EBI Bioorg Med Chem Lett 13: 3191-5 (2003) Lilly Research Laboratories 2D 3D TSV
12951090 57 O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.EBI Bioorg Med Chem Lett 13: 3185-90 (2003) Merck Research Laboratories 2D 3D TSV
12951089 13 Regulation of gene expression by synthetic dimerizers with novel specificity.EBI Bioorg Med Chem Lett 13: 3181-4 (2003) ARIAD Gene Therapeutics, Inc. 2D 3D TSV
12951088 22 Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.EBI Bioorg Med Chem Lett 13: 3177-80 (2003) Universidad Complutense 2D 3D TSV
12951087 23 Selective 3-amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic partially saturated heterobicyclic P1-arginine mimetics.EBI Bioorg Med Chem Lett 13: 3171-6 (2003) University of Ljubljana 2D 3D TSV
12951085 10 Reversed hydroxamate-bearing thermolysin inhibitors mimic a high-energy intermediate along the enzyme-catalyzed proteolytic reaction pathway.EBI Bioorg Med Chem Lett 13: 3161-6 (2003) Pohang University of Science and Technology 2D 3D TSV
12951084 8 1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.EBI Bioorg Med Chem Lett 13: 3155-9 (2003) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12951083 12 Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.EBI Bioorg Med Chem Lett 13: 3151-3 (2003) Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan. 2D 3D TSV
12951082 10 Analysis of the critical structural determinant(s) of species-selective peroxisome proliferator-activated receptor alpha (PPAR alpha)-activation by phenylpropanoic acid-type PPAR alpha agonists.EBI Bioorg Med Chem Lett 13: 3145-9 (2003) Kyorin Pharmaceutical Co., Ltd. 2D 3D TSV
12951078 38 Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.EBI Bioorg Med Chem Lett 13: 3129-32 (2003) Abbott Laboratories 2D 3D TSV
12946343 3 The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors.BDB J Mol Biol 332: 13-21 (2003) Morphochem AG 2D 3D TSV
12941345 42 Potent small molecule inhibitors of spleen tyrosine kinase (Syk).EBI Bioorg Med Chem Lett 13: 3111-4 (2003) Aventis Pharmaceuticals 2D 3D TSV
12941344 18 Mapping the kinase domain of Janus Kinase 3.EBI Bioorg Med Chem Lett 13: 3105-10 (2003) Aventis Pharmaceuticals 2D 3D TSV
12941343 49 The kinetics of binding to p38MAP kinase by analogues of BIRB 796.EBI Bioorg Med Chem Lett 13: 3101-4 (2003) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
12941342 21 Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor.EBI Bioorg Med Chem Lett 13: 3097-100 (2003) Aventis Pharmaceuticals 2D 3D TSV
12941341 23 Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.EBI Bioorg Med Chem Lett 13: 3091-5 (2003) Aventis Pharmaceuticals 2D 3D TSV
12941340 10 Indole-based heterocyclic inhibitors of p38alpha MAP kinase: designing a conformationally restricted analogue.EBI Bioorg Med Chem Lett 13: 3087-90 (2003) Scios Inc. 2D 3D TSV
12941339 23 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).EBI Bioorg Med Chem Lett 13: 3083-6 (2003) University of Newcastle 2D 3D TSV
12941338 18 Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.BDB Bioorg Med Chem Lett 13: 3079-82 (2003) University of Newcastle 2D 3D TSV
12941336 7 Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.EBI Bioorg Med Chem Lett 13: 3071-4 (2003) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
12941335 8 Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.EBI Bioorg Med Chem Lett 13: 3067-70 (2003) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
12941334 22 Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.EBI Bioorg Med Chem Lett 13: 3063-6 (2003) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
12941333 61 6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).BDB Bioorg Med Chem Lett 13: 3059-62 (2003) GlaxoSmithKline 2D 3D TSV
12941332 27 6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).BDB Bioorg Med Chem Lett 13: 3055-7 (2003) GlaxoSmithKline 2D 3D TSV
12941331 96 Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.EBI Bioorg Med Chem Lett 13: 3049-53 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12941330 30 Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.EBI Bioorg Med Chem Lett 13: 3045-8 (2003) Ghent University 2D 3D TSV
12941329 30 Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.EBI Bioorg Med Chem Lett 13: 3041-4 (2003) Abbott Laboratories 2D 3D TSV
12941327 24 Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.EBI Bioorg Med Chem Lett 13: 3031-4 (2003) Wyeth Research 2D 3D TSV
12941326 26 Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.EBI Bioorg Med Chem Lett 13: 3027-30 (2003) Instituto de Química Médica (CSIC) 2D 3D TSV
12941325 18 Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.BDB Bioorg Med Chem Lett 13: 3021-6 (2003) AstraZeneca 2D 3D TSV
12941324 66 Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.EBI Bioorg Med Chem Lett 13: 3015-9 (2003) Kyoto University 2D 3D TSV
12941322 12 Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.EBI Bioorg Med Chem Lett 13: 3005-7 (2003) NIH 2D 3D TSV
12941321 40 Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.EBI Bioorg Med Chem Lett 13: 3001-4 (2003) Kyowa Hakko Kogyo Co., Ltd. 2D 3D TSV
12941319 15 2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.EBI Bioorg Med Chem Lett 13: 2993-6 (2003) Academy of Sciences of the Czech Republic 2D 3D TSV
12941318 46 Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.EBI Bioorg Med Chem Lett 13: 2989-92 (2003) Academy of Sciences of the Czech Republic 2D 3D TSV
12941317 25 Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis.BDB Bioorg Med Chem Lett 13: 2985-8 (2003) GlaxoSmithKline 2D 3D TSV
12941316 9 Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase.EBI Bioorg Med Chem Lett 13: 2981-4 (2003) Pohang University of Science & Technology 2D 3D TSV
12941315 19 Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.EBI Bioorg Med Chem Lett 13: 2977-80 (2003) Wyeth Research 2D 3D TSV
12941314 17 Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors.BDB Bioorg Med Chem Lett 13: 2973-6 (2003) Merck Research Laboratories 2D 3D TSV
12941313 20 Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching.EBI Bioorg Med Chem Lett 13: 2967-71 (2003) Novartis Pharma AG 2D 3D TSV
12941312 58 Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines.BDB Bioorg Med Chem Lett 13: 2961-6 (2003) AstraZeneca 2D 3D TSV
12941311 34 Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines.BDB Bioorg Med Chem Lett 13: 2955-60 (2003) AstraZeneca 2D 3D TSV
12941292 7 Novel bisubstrate analog inhibitors of serotonin N-acetyltransferase: the importance of being neutral.BDB Bioorg Chem 31: 398-411 (2003) Johns Hopkins University School of Medicine 2D 3D TSV
12940739 30 Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin.BDB J Am Chem Soc 125: 10570-9 (2003) University of Groningen 2D 3D TSV
12932138 3 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum.EBI J Nat Prod 66: 1116-7 (2003) MerLion Pharmaceuticals 2D 3D TSV
12930155 20 Pyrazole derivatives as partial agonists for the nicotinic acid receptor.EBI J Med Chem 46: 3945-51 (2003) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
12930154 6 A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.EBI J Med Chem 46: 3938-44 (2003) Johnson& Johnson Pharmaceutical Research& Development 2D 3D TSV
12930153 128 Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.EBI J Med Chem 46: 3930-7 (2003) Virginia Commonwealth University 2D 3D TSV
12930151 1 Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.EBI J Med Chem 46: 3900-13 (2003) INSERM 2D 3D TSV
12930150 155 N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.EBI J Med Chem 46: 3883-99 (2003) Johann Wolfgang Goethe-Universität 2D 3D TSV
12930149 37 Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.EBI J Med Chem 46: 3877-82 (2003) Institute of Research 2D 3D TSV
12930148 41 Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.EBI J Med Chem 46: 3865-76 (2003) Johnson& Johnson Pharmaceutical Research& Development 2D 3D TSV
12930147 96 Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.EBI J Med Chem 46: 3853-64 (2003) Universit£ degli Studi di Siena 2D 3D TSV
12930146 170 Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.EBI J Med Chem 46: 3840-52 (2003) Institut de Recherches Servier 2D 3D TSV
12930145 77 Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.EBI J Med Chem 46: 3822-39 (2003) Universit£ di Siena 2D 3D TSV
12930144 28 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.EBI J Med Chem 46: 3811-21 (2003) Ghent University 2D 3D TSV
12930139 22 Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.EBI J Med Chem 46: 3778-81 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12930138 1 N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.EBI J Med Chem 46: 3775-7 (2003) Ewha Womans University 2D 3D TSV
12930137 2 Structure-based design of a macrocyclic inhibitor for peptide deformylase.EBI J Med Chem 46: 3771-4 (2003) The Ohio State University 2D 3D TSV
12924948 1 Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3.EBI Biochemistry 42: 9989-10000 (2003) Queen's University 2D 3D TSV
12921854 130 Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.BDB Eur J Pharmacol 474: 137-40 (2003) Harvard University 2D 3D TSV
12904082 20 New potential uroselective NO-donor alpha1-antagonists.EBI J Med Chem 46: 3762-5 (2003) Università degli Studi di Torino 2D 3D TSV
12904080 5 Bispyridinium cyclophanes: novel templates for human choline kinase inhibitors.EBI J Med Chem 46: 3754-7 (2003) Universidad de Granada 2D 3D TSV
12904077 75 Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.EBI J Med Chem 46: 3728-33 (2003) University of Arizona 2D 3D TSV
12904076 158 A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.BDB J Med Chem 46: 3709-27 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12904075 32 A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.EBI J Med Chem 46: 3703-8 (2003) Utah State University 2D 3D TSV
12904068 5 Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.EBI J Med Chem 46: 3644-54 (2003) Prassis Istituto di Ricerche Sigma-Tau 2D 3D TSV
12904065 30 Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.EBI J Med Chem 46: 3612-22 (2003) LG Life Sciences Ltd. 2D 3D TSV
12904063 69 Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.EBI J Med Chem 46: 3581-99 (2003) Kyorin Pharmaceutical Co. Ltd. 2D 3D TSV
12904061 17 Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.EBI J Med Chem 46: 3568-71 (2003) Universit£ degli Studi di Siena 2D 3D TSV
12904059 10 Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.EBI J Med Chem 46: 3563-4 (2003) Institut f£r Molekularbiologie und Biophysik 2D 3D TSV
12904058 2 Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand: synthesis of [(76)Br]MJL-1-109-2.EBI J Med Chem 46: 3559-62 (2003) National Institutes of Health 2D 3D TSV
12897767 18 Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.BDB Nat Struct Biol 10: 764-9 (2003) Merck Research Laboratories 2D 3D TSV
12893846 3 A natural product ligand of the oxysterol receptor, liver X receptor.BDB J Pharmacol Exp Ther 307: 291-6 (2003) Lilly Research Laboratories 2D 3D TSV
12892559 2 Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.BDB Biochem J 375: 255-62 (2003) University of Dundee 2D 3D TSV
12887776 4 [BRCA1 protein expression in sporadic breast and its clinical significance].BDB Zhonghua Wai Ke Za Zhi 41: 186-8 (2003) Anhui Medical University 2D 3D TSV
12887410 15 Binding characteristics of [3H]14-methoxymetopon, a high affinity mu-opioid receptor agonist.BDB Eur J Neurosci 18: 290-5 (2003) University of Innsbruck 2D 3D TSV
12880321 2 Acetophenone derivatives from Acronychia pedunculata.EBI J Nat Prod 66: 990-3 (2003) National Cheng Kung University 2D 3D TSV
12877594 14 Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.EBI J Med Chem 46: 3555-8 (2003) Università di Pisa 2D 3D TSV
12877591 36 Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.EBI J Med Chem 46: 3526-35 (2003) Purdue University 2D 3D TSV
12877590 28 A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.EBI J Med Chem 46: 3514-25 (2003) Pfizer Global Research and Development 2D 3D TSV
12877589 2 Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.EBI J Med Chem 46: 3508-13 (2003) Novartis Pharma AG 2D 3D TSV
12877587 6 Development of a water-soluble matrix metalloproteinase inhibitor as an intra-arterial infusion drug for prevention of restenosis after angioplasty.EBI J Med Chem 46: 3497-501 (2003) National Cardiovascular Center Research Institute 2D 3D TSV
12877586 40 A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.EBI J Med Chem 46: 3483-96 (2003) Organix Inc. 2D 3D TSV
12877584 182 Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.EBI J Med Chem 46: 3463-75 (2003) Domp&egrove; pha.r.ma s.p.a. 2D 3D TSV
12877583 13 Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model.EBI J Med Chem 46: 3455-62 (2003) Uppsala University 2D 3D TSV
12877582 3 Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis.EBI J Med Chem 46: 3452-4 (2003) Johns Hopkins University School of Medicine 2D 3D TSV
12877579 6 Identification of"latent hits" in compound screening collections.EBI J Med Chem 46: 3441-4 (2003) Organon Laboratories Ltd. 2D 3D TSV
12877578 33 Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.EBI J Med Chem 46: 3437-40 (2003) Abbott Laboratories 2D 3D TSV
12873518 81 Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.EBI Bioorg Med Chem Lett 13: 2799-803 (2003) Wyeth Research 2D 3D TSV
12873517 90 5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.EBI Bioorg Med Chem Lett 13: 2795-8 (2003) Merck Research Laboratories 2D 3D TSV
12873514 56 Design and synthesis of potent and selective macrocyclic thrombin inhibitors.EBI Bioorg Med Chem Lett 13: 2781-4 (2003) Merck Research Laboratories 2D 3D TSV
12873513 8 Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship.EBI Bioorg Med Chem Lett 13: 2777-80 (2003) Institute of Chemical Technology 2D 3D TSV
12873512 68 Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.EBI Bioorg Med Chem Lett 13: 2773-5 (2003) Gedeon Richter Ltd 2D 3D TSV
12873509 4 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?EBI Bioorg Med Chem Lett 13: 2759-63 (2003) Università degli Studi di Firenze 2D 3D TSV
12873506 8 Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures.EBI Bioorg Med Chem Lett 13: 2745-8 (2003) MRL Rome 2D 3D TSV
12873505 20 Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.EBI Bioorg Med Chem Lett 13: 2741-4 (2003) Hokkaido Collaboration Center 2D 3D TSV
12873504 36 Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.EBI Bioorg Med Chem Lett 13: 2737-40 (2003) Hokkaido Collaboration Center 2D 3D TSV
12873501 110 Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.EBI Bioorg Med Chem Lett 13: 2719-25 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12873500 37 Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains.EBI Bioorg Med Chem Lett 13: 2715-8 (2003) British Biotech Pharmaceuticals Limited 2D 3D TSV
12873499 25 Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.EBI Bioorg Med Chem Lett 13: 2709-13 (2003) British Biotech Pharmaceuticals Limited 2D 3D TSV
12873495 2 Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([(18)F]FEFE) for the in vivo visualisation and quantification of the beta2-adrenergic receptor status in lung.EBI Bioorg Med Chem Lett 13: 2687-92 (2003) University of Mainz 2D 3D TSV
12873488 11 Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.EBI Bioorg Med Chem Lett 13: 2659-62 (2003) Universit£ de Lille 2 2D 3D TSV
12873487 5 Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.EBI Bioorg Med Chem Lett 13: 2655-8 (2003) The University of Tokyo 2D 3D TSV
12873485 150 Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH(2).EBI Bioorg Med Chem Lett 13: 2647-50 (2003) University of Cincinnati 2D 3D TSV
12873480 30 Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists.EBI Bioorg Med Chem Lett 13: 2625-8 (2003) AstraZeneca R&D Charnwood 2D 3D TSV
12871036 2 GABA(C) receptors as drug targets.BDB Curr Drug Targets CNS Neurol Disord 2: 260-8 (2003) University of Sydney 2D 3D TSV
12857114 102 High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.BDB J Comb Chem 5: 456-64 (2003) Uppsala University 2D 3D TSV
12852973 63 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis.EBI Bioorg Med Chem Lett 13: 2591-4 (2003) Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA. 2D 3D TSV
12852972 79 Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors.EBI Bioorg Med Chem Lett 13: 2587-90 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12852971 8 Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide.EBI Bioorg Med Chem Lett 13: 2583-6 (2003) Kyowa Hakko Kogyo Co., Ltd. 2D 3D TSV
12852970 28 Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.EBI Bioorg Med Chem Lett 13: 2577-81 (2003) National Cancer Institute 2D 3D TSV
12852969 13 The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.BDB Bioorg Med Chem Lett 13: 2573-6 (2003) Merck Research Laboratories 2D 3D TSV
12852968 17 HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.BDB Bioorg Med Chem Lett 13: 2569-72 (2003) Merck Research Laboratories 2D 3D TSV
12852967 15 Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.EBI Bioorg Med Chem Lett 13: 2565-8 (2003) Virginia Commonwealth University 2D 3D TSV
12852966 23 Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.EBI Bioorg Med Chem Lett 13: 2561-3 (2003) Inha University 2D 3D TSV
12852960 48 Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1.EBI Bioorg Med Chem Lett 13: 2535-8 (2003) National Research Institute of Chinese Medicine 2D 3D TSV
12852955 25 Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones.EBI Bioorg Med Chem Lett 13: 2513-8 (2003) Guilford Pharmaceuticals Inc. 2D 3D TSV
12852954 22 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.EBI Bioorg Med Chem Lett 13: 2509-12 (2003) University of California 2D 3D TSV
12852951 21 2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.EBI Bioorg Med Chem Lett 13: 2497-500 (2003) Neurogen Corporation 2D 3D TSV
12852950 36 High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.EBI Bioorg Med Chem Lett 13: 2493-6 (2003) McMaster University 2D 3D TSV
12852948 10 Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR.BDB Bioorg Med Chem Lett 13: 2485-8 (2003) Merck Research Laboratories 2D 3D TSV
12852947 36 Development of 3D-QSAR models in cyclic ureidobenzenesulfonamides: human beta3-adrenergic receptor agonist.EBI Bioorg Med Chem Lett 13: 2481-4 (2003) Central Drug Research Institute 2D 3D TSV
12852946 69 Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors.EBI Bioorg Med Chem Lett 13: 2473-9 (2003) Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar 160 062, Punjab, India. akchakraborti@niper.ac.in 2D 3D TSV
12852944 26 3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors.BDB Bioorg Med Chem Lett 13: 2465-8 (2003) Hoffmann-La Roche Inc. 2D 3D TSV
12852938 7 Effect of catechol derivatives on cell growth and lipoxygenase activity.EBI Bioorg Med Chem Lett 13: 2435-9 (2003) Aston University 2D 3D TSV
12852771 26 Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.EBI J Med Chem 46: 3412-23 (2003) Industrial Research Limited 2D 3D TSV
12852770 28 Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors.EBI J Med Chem 46: 3403-11 (2003) Washington University School of Medicine 2D 3D TSV
12852767 51 Tethered dimers as NAD synthetase inhibitors with antibacterial activity.EBI J Med Chem 46: 3371-81 (2003) University of Alabama at Birmingham 2D 3D TSV
12852766 22 Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.EBI J Med Chem 46: 3354-70 (2003) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12852764 20 Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.EBI J Med Chem 46: 3333-41 (2003) Novo Nordisk A/S 2D 3D TSV
12852763 20 Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.EBI J Med Chem 46: 3326-32 (2003) Institute of Biomedical Chemistry of Russian Academy of Medical Sciences 2D 3D TSV
12852762 10 A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.EBI J Med Chem 46: 3314-25 (2003) University of California 2D 3D TSV
12852759 2 A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.EBI J Med Chem 46: 3292-9 (2003) National Cancer Institute-Frederick 2D 3D TSV
12852756 5 Drug rings database with web interface. A tool for identifying alternative chemical rings in lead discovery programs.EBI J Med Chem 46: 3257-74 (2003) GlaxoSmithKline Research and Development 2D 3D TSV
12852755 27 l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.EBI J Med Chem 46: 3245-56 (2003) The University of Georgia 2D 3D TSV
12852753 17 Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.EBI J Med Chem 46: 3221-9 (2003) National Hellenic Research Foundation 2D 3D TSV
12852751 34 Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.EBI J Med Chem 46: 3201-9 (2003) Kobe Gakuin University 2D 3D TSV
12852750 2 (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.EBI J Med Chem 46: 3197-200 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12852749 11 First dual aromatase-steroid sulfatase inhibitors.BDB J Med Chem 46: 3193-6 (2003) University of Bath 2D 3D TSV
12852748 4 Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.EBI J Med Chem 46: 3189-92 (2003) Lilly Research Laboratories 2D 3D TSV
12842269 16 Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.BDB J Chem Neuroanat 25: 233-47 (2003) University of Michigan 2D 3D TSV
12828470 5 Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.EBI J Nat Prod 66: 829-37 (2003) Bayer Health Care 2D 3D TSV
12828454 8 New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.EBI J Nat Prod 66: 739-42 (2003) University of Karachi 2D 3D TSV
12825957 60 Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge.EBI J Med Chem 46: 3174-7 (2003) University of Bath 2D 3D TSV
12825953 12 Structural determinants of selective thyromimetics.EBI J Med Chem 46: 3152-61 (2003) University of California 2D 3D TSV
12825952 31 Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.EBI J Med Chem 46: 3138-51 (2003) Guilford Pharmaceuticals Inc 2D 3D TSV
12825951 54 Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.EBI J Med Chem 46: 3127-37 (2003) Research Triangle Institute 2D 3D TSV
12825950 43 N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.EBI J Med Chem 46: 3116-26 (2003) Seoul National University 2D 3D TSV
12825948 13 Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.EBI J Med Chem 46: 3102-8 (2003) Università degli Studi di Milano 2D 3D TSV
12825944 184 Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.EBI J Med Chem 46: 3060-71 (2003) Lilly Research Laboratories 2D 3D TSV
12825939 7 Histamine-releasing activity and binding to the FcepsilonRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions.EBI J Med Chem 46: 3008-12 (2003) Mount Sinai School of Medicine 2D 3D TSV
12825937 63 Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.EBI J Med Chem 46: 2973-84 (2003) Merck Research Laboratories 2D 3D TSV
12825935 54 Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.BDB J Med Chem 46: 2945-57 (2003) Novartis Pharmaceuticals 2D 3D TSV
12825934 55 A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.EBI J Med Chem 46: 2932-44 (2003) University of Illinois at Urbana-Champaign 2D 3D TSV
12825933 17 Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold.EBI J Med Chem 46: 2917-31 (2003) Institut für molekulare Physiologie 2D 3D TSV
12825932 61 Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.EBI J Med Chem 46: 2908-16 (2003) National Institute on Drug Abuse 2D 3D TSV
12825930 16 New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.EBI J Med Chem 46: 2877-94 (2003) Universit£ di Catania 2D 3D TSV
12825927 84 Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.EBI J Med Chem 46: 2834-45 (2003) Università di Modena e Reggio Emilia 2D 3D TSV
12825924 8 Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.EBI J Med Chem 46: 2816-8 (2003) University of Minnesota 2D 3D TSV
12825922 207 Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).EBI J Med Chem 46: 2795-812 (2003) Virginia Commonwealth University 2D 3D TSV
12824047 99 Novel IKK inhibitors: beta-carbolines.EBI Bioorg Med Chem Lett 13: 2419-22 (2003) Millennium Pharmaceuticals Inc. 2D 3D TSV
12824045 3 Identification of oxidation product of arbutin in mushroom tyrosinase assay system.EBI Bioorg Med Chem Lett 13: 2409-12 (2003) University of California 2D 3D TSV
12824044 41 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.BDB Bioorg Med Chem Lett 13: 1133-6 (2003) Bristol-Myers Squibb Company 2D 3D TSV
12824043 40 Constrained phytoestrogens and analogues as ERbeta selective ligands.EBI Bioorg Med Chem Lett 13: 2399-403 (2003) Wyeth Research 2D 3D TSV
12824042 64 Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.EBI Bioorg Med Chem Lett 13: 2393-7 (2003) Lilly Research Laboratories 2D 3D TSV
12824041 14 Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.EBI Bioorg Med Chem Lett 13: 2389-91 (2003) C.N.R.S. 2D 3D TSV
12824040 5 Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I.EBI Bioorg Med Chem Lett 13: 2385-8 (2003) Kyoto University 2D 3D TSV
12824039 56 Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.EBI Bioorg Med Chem Lett 13: 2381-4 (2003) CombiChem Inc. 2D 3D TSV
12824037 15 Synthesis and biological testing of non-fluorinated analogues of levofloxacin.EBI Bioorg Med Chem Lett 13: 2373-5 (2003) Procter& Gamble Pharmaceuticals, 8700Mason-Montgomery Rd, 45040, Mason, OH, USA. gray.jl.2@pg.com 2D 3D TSV
12824036 77 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists.EBI Bioorg Med Chem Lett 13: 2369-72 (2003) Pharmacia Corporation 2D 3D TSV
12824035 39 Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors.EBI Bioorg Med Chem Lett 13: 2363-7 (2003) Pharmacia Corporation 2D 3D TSV
12824033 30 Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics.EBI Bioorg Med Chem Lett 13: 2355-8 (2003) Pharmacology and Analytical Chemistry Research, 319 Hyundai I Valley, 223-12 Sandaewon-dong, Choongwon-gu, Sungnam-si, 462-120, Kyonggi-do, Republic of Korea. ekim@postech.ac.kr 2D 3D TSV
12824031 26 Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors.EBI Bioorg Med Chem Lett 13: 2347-50 (2003) Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa, 532-8505, Osaka, Japan. t-ukita@tanabe.co.jp 2D 3D TSV
12824030 67 1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.EBI Bioorg Med Chem Lett 13: 2341-5 (2003) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
12824029 21 Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).EBI Bioorg Med Chem Lett 13: 2337-40 (2003) Amgen Inc. 2D 3D TSV
12824028 75 Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.EBI Bioorg Med Chem Lett 13: 2331-6 (2003) Pfizer Inc. 2D 3D TSV
12824026 14 Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.EBI Bioorg Med Chem Lett 13: 2319-25 (2003) Pharmacia Corporation 2D 3D TSV
12824023 6 An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.EBI Bioorg Med Chem Lett 13: 2307-10 (2003) Abbott Laboratories 2D 3D TSV
12824021 39 Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents.EBI Bioorg Med Chem Lett 13: 2297-302 (2003) Boehringer Ingelheim Pharma KG 2D 3D TSV
12824020 31 Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives.EBI Bioorg Med Chem Lett 13: 2291-5 (2003) Boehringer Ingelheim Pharma KG 2D 3D TSV
12824018 6 Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.EBI Bioorg Med Chem Lett 13: 2281-4 (2003) University of Sydney 2D 3D TSV
12824014 284 Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.BDB Bioorg Med Chem Lett 13: 2261-7 (2003) Lilly Research Laboratories 2D 3D TSV
12816539 9 Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).BDB Biochem J 374: 639-46 (2003) University of Padova 2D 3D TSV
12816482 38 Complexation and chiral recognition thermodynamics of gamma-cyclodextrin with N-acetyl- and N-carbobenzyloxy-dipeptides possessing two aromatic rings.BDB J Org Chem 68: 5228-35 (2003) Japan Science and Technology Agency 2D 3D TSV
12815170 15 [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.BDB Mol Pharmacol 64: 143-53 (2003) Abbott Laboratories 2D 3D TSV
12801241 4 Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.EBI J Med Chem 46: 2790-3 (2003) National Cancer Institute at Frederick 2D 3D TSV
12801240 105 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.EBI J Med Chem 46: 2774-89 (2003) Novartis Institute for Biomedical Research 2D 3D TSV
12801237 19 Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.EBI J Med Chem 46: 2740-54 (2003) University of Pittsburgh 2D 3D TSV
12801236 34 Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth.EBI J Med Chem 46: 2731-9 (2003) GLSynthesis Inc. 2D 3D TSV
12801235 5 Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.EBI J Med Chem 46: 2716-30 (2003) University of Vermont 2D 3D TSV
12801232 71 Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.EBI J Med Chem 46: 2683-96 (2003) Ligand Pharmaceuticals, Inc 2D 3D TSV
12801228 18 The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.EBI J Med Chem 46: 2641-55 (2003) Wroclaw University of Technology 2D 3D TSV
12801227 87 Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.EBI J Med Chem 46: 2631-40 (2003) Chinese Academy of Sciences 2D 3D TSV
12801226 6 Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.EBI J Med Chem 46: 2621-30 (2003) National Cancer Institute 2D 3D TSV
12801225 16 Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors.EBI J Med Chem 46: 2606-20 (2003) UMR C8076 (CNRS) 2D 3D TSV
12801224 16 Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors.EBI J Med Chem 46: 2599-605 (2003) Wichita State University 2D 3D TSV
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI J Med Chem 46: 2589-98 (2003) NIDA-IRP 2D 3D TSV
12801222 76 Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones.EBI J Med Chem 46: 2580-8 (2003) Duke University 2D 3D TSV
12801220 16 Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.EBI J Med Chem 46: 2569-71 (2003) Wyeth Research 2D 3D TSV
12798341 1 Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway.EBI Bioorg Med Chem Lett 13: 2235-7 (2003) Boston University 2D 3D TSV
12798340 66 Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.EBI Bioorg Med Chem Lett 13: 2231-4 (2003) Cubist Pharmaceutical Inc. 2D 3D TSV
12798337 6 Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.EBI Bioorg Med Chem Lett 13: 2217-22 (2003) Indiana University School of Medicine 2D 3D TSV
12798336 21 4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK(2)) receptor.EBI Bioorg Med Chem Lett 13: 2211-5 (2003) Pfizer Global Research and Development 2D 3D TSV
12798335 22 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 13: 2205-9 (2003) University of Alberta 2D 3D TSV
12798334 18 High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.EBI Bioorg Med Chem Lett 13: 2199-203 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12798333 56 Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists.EBI Bioorg Med Chem Lett 13: 2195-8 (2003) Wyeth Research 2D 3D TSV
12798332 35 Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists.EBI Bioorg Med Chem Lett 13: 2191-4 (2003) Wyeth Research 2D 3D TSV
12798330 63 N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.EBI Bioorg Med Chem Lett 13: 2179-83 (2003) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
12798329 18 Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.EBI Bioorg Med Chem Lett 13: 2173-7 (2003) National Cancer Institute 2D 3D TSV
12798328 87 Muscarinic M(3) receptor antagonists with (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2.EBI Bioorg Med Chem Lett 13: 2167-72 (2003) Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories 2D 3D TSV
12798324 36 Bivalent biogenic amine reuptake inhibitors.EBI Bioorg Med Chem Lett 13: 2151-4 (2003) Human BioMolecular Research Institute 2D 3D TSV
12798323 72 Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117.EBI Bioorg Med Chem Lett 13: 2145-9 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12798321 26 Nicotinyl aspartyl ketones as inhibitors of caspase-3.BDB Bioorg Med Chem Lett 13: 2137-40 (2003) Merck Frosst Canada & Co. 2D 3D TSV
12798320 64 A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines.EBI Bioorg Med Chem Lett 13: 2131-5 (2003) Abbott Laboratories 2D 3D TSV
12798316 25 2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships.EBI Bioorg Med Chem Lett 13: 2113-8 (2003) GlaxoSmithKline Medicine Research Centre 2D 3D TSV
12798313 19 Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.EBI Bioorg Med Chem Lett 13: 2101-4 (2003) CombiChem Inc. 2D 3D TSV
12798312 22 Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.EBI Bioorg Med Chem Lett 13: 2097-100 (2003) Guilford Pharmaceuticals Inc. 2D 3D TSV
12784105 53 Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.BDB Neuropsychopharmacology 28: 1400-11 (2003) Case Western Reserve University 2D 3D TSV
12781199 64 Urea small molecule agonists on mouse melanocortin receptors.EBI Bioorg Med Chem Lett 13: 2079-82 (2003) University of Florida 2D 3D TSV
12781198 108 Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.EBI Bioorg Med Chem Lett 13: 2075-8 (2003) Ligand Pharmaceuticals 2D 3D TSV
12781197 59 Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.EBI Bioorg Med Chem Lett 13: 2071-4 (2003) Ligand Pharmaceuticals 2D 3D TSV
12781195 49 Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.EBI Bioorg Med Chem Lett 13: 2059-63 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12781194 1 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.EBI Bioorg Med Chem Lett 13: 2055-8 (2003) Pfizer Central Research 2D 3D TSV
12781193 36 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity.EBI Bioorg Med Chem Lett 13: 2051-3 (2003) Ligand Pharmaceuticals 2D 3D TSV
12781191 11 Inhibition of mandelate racemase by alpha-fluorobenzylphosphonates.EBI Bioorg Med Chem Lett 13: 2041-4 (2003) Dalhousie University 2D 3D TSV
12781190 113 Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).EBI Bioorg Med Chem Lett 13: 2035-40 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12781189 6 D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.EBI Bioorg Med Chem Lett 13: 2029-33 (2003) BASF AG 2D 3D TSV
12781187 15 Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).EBI Bioorg Med Chem Lett 13: 2021-4 (2003) Organon K.K. 2D 3D TSV
12781183 12 The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles.EBI Bioorg Med Chem Lett 13: 2003-7 (2003) Abbott Laboratories 2D 3D TSV
12781182 81 Arylaminoethyl amides as inhibitors of the cysteine protease cathepsin K-investigating P1' substituents.EBI Bioorg Med Chem Lett 13: 1997-2001 (2003) Novartis Pharma AG 2D 3D TSV
12781181 8 The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).EBI Bioorg Med Chem Lett 13: 1993-6 (2003) The University of Georgia 2D 3D TSV
12781180 24 Structure-activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres.EBI Bioorg Med Chem Lett 13: 1989-92 (2003) Pfizer Global Research and Development 2D 3D TSV
12781179 4 Unexpected inhibition of S-adenosyl-L-homocysteine hydrolase by a guanosine nucleoside.EBI Bioorg Med Chem Lett 13: 1985-8 (2003) School of Chemistry and Biochemistry 2D 3D TSV
12781178 33 Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.EBI Bioorg Med Chem Lett 13: 1981-4 (2003) Schering AG 2D 3D TSV
12781177 7 Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.EBI Bioorg Med Chem Lett 13: 1977-80 (2003) UMR CNRS 5074 2D 3D TSV
12781174 18 Sphingomyelin analogues as inhibitors of sphingomyelinase.EBI Bioorg Med Chem Lett 13: 1963-6 (2003) Taisho Pharmaceutical Co., Ltd. 2D 3D TSV
12781173 28 Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.EBI Bioorg Med Chem Lett 13: 1959-61 (2003) The Schering-Plough Research Institute 2D 3D TSV
12773058 15 Analysis of 6-(2,2-Dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.EBI J Med Chem 46: 2548-50 (2003) University of Connecticut 2D 3D TSV
12773056 21 Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.EBI J Med Chem 46: 2534-41 (2003) Pharmaceutical Research Institute 2D 3D TSV
12773053 2 Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics.EBI J Med Chem 46: 2494-501 (2003) University of Virginia 2D 3D TSV
12773052 14 Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.BDB J Med Chem 46: 2482-93 (2003) Universita degli Studi di Roma La Sapienza 2D 3D TSV
12773050 26 Discovery and structure-activity relationships of novel piperidine inhibitors of farnesyltransferase.EBI J Med Chem 46: 2467-73 (2003) Pharmaceutical Research Institute 2D 3D TSV
12773048 88 Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives.EBI J Med Chem 46: 2446-55 (2003) Shionogi & Co., Ltd. 2D 3D TSV
12773047 94 Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives.EBI J Med Chem 46: 2436-45 (2003) Shionogi & Co., Ltd. 2D 3D TSV
12773045 27 Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.EBI J Med Chem 46: 2413-26 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12773044 18 Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.EBI J Med Chem 46: 2404-12 (2003) Abbott GmbH & Co. KG 2D 3D TSV
12773042 195 Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.EBI J Med Chem 46: 2376-96 (2003) Wyeth Research 2D 3D TSV
12773041 119 Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.EBI J Med Chem 46: 2361-75 (2003) Wyeth Research 2D 3D TSV
12773040 41 Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.EBI J Med Chem 46: 2352-60 (2003) Università degli Studi di Urbino Carlo Bo 2D 3D TSV
12773039 37 Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.EBI J Med Chem 46: 2345-51 (2003) Accelrys 2D 3D TSV
12773035 56 Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.EBI J Med Chem 46: 2304-12 (2003) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12773033 17 A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.BDB J Med Chem 46: 2283-6 (2003) Pfizer 2D 3D TSV
12773032 4 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.BDB J Med Chem 46: 2279-82 (2003) University of Bologna 2D 3D TSV
12773029 8 Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.EBI J Med Chem 46: 2261-70 (2003) Technische Universit£t Darmstadt 2D 3D TSV
12767917 30 Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.BDB Biochem Biophys Res Commun 305: 909-14 (2003) St. Maryamppound39s Hospital 2D 3D TSV
12761343 23 Developmental expression of heteromeric nicotinic receptor subtypes in chick retina.BDB Mol Pharmacol 63: 1329-37 (2003) University of Milan 2D 3D TSV
12761331 97 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.BDB Mol Pharmacol 63: 1223-9 (2003) Case Western Reserve University 2D 3D TSV
12757844 9 In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand.BDB Life Sci 73: 371-9 (2003) Merck Research Laboratories 2D 3D TSV
12750432 19 The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways.BDB J Pharmacol Exp Ther 306: 954-64 (2003) Institut de Recherches Servier 2D 3D TSV
12749904 34 Synthesis and SAR of cis-1-benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems.EBI Bioorg Med Chem Lett 13: 1943-6 (2003) RHeoGene 2D 3D TSV
12749903 69 Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.BDB Bioorg Med Chem Lett 13: 1939-42 (2003) SUGEN, Inc. 2D 3D TSV
12749902 5 Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.EBI Bioorg Med Chem Lett 13: 1935-7 (2003) GPC Biotech, Inc. 2D 3D TSV
12749901 10 Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.EBI Bioorg Med Chem Lett 13: 1931-4 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12749900 29 6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain.EBI Bioorg Med Chem Lett 13: 1927-30 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12749899 17 Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.EBI Bioorg Med Chem Lett 13: 1923-6 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12749898 11 A novel estrogen receptor ligand template.EBI Bioorg Med Chem Lett 13: 1919-22 (2003) Bayer Corporation 2D 3D TSV
12749896 47 Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.EBI Bioorg Med Chem Lett 13: 1911-4 (2003) Rensselaer Polytechnic Institute 2D 3D TSV
12749895 37 Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).EBI Bioorg Med Chem Lett 13: 1907-10 (2003) Lilly Research Laboratories 2D 3D TSV
12749894 48 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1.EBI Bioorg Med Chem Lett 13: 1903-5 (2003) Lilly Research Laboratories 2D 3D TSV
12749893 37 Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.EBI Bioorg Med Chem Lett 13: 1897-901 (2003) Cancer Research, Abbott Laboratories, Dept. R47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA. yujia.dai@abbott.com 2D 3D TSV
12749892 42 N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.EBI Bioorg Med Chem Lett 13: 1891-5 (2003) Merck Research Laboratories 2D 3D TSV
12749891 37 Potent, selective inhibitors of protein tyrosine phosphatase 1B.BDB Bioorg Med Chem Lett 13: 1887-90 (2003) Abbott Laboratories 2D 3D TSV
12749890 37 Optimization of alpha-acylaminoketone ecdysone agonists for control of gene expression.EBI Bioorg Med Chem Lett 13: 1883-6 (2003) RHeoGene 2D 3D TSV
12749889 2 Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.EBI Bioorg Med Chem Lett 13: 1879-82 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12749888 63 Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective alpha1A-antagonists.EBI Bioorg Med Chem Lett 13: 1873-8 (2003) Roche Bioscience, 3431 Hillview Ave, Palo Alto, CA 94304, USA. francisco.lopez-tapia@roche.com 2D 3D TSV
12749886 7 Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).EBI Bioorg Med Chem Lett 13: 1865-8 (2003) Universit£ di Perugia 2D 3D TSV
12749885 4 Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition.EBI Bioorg Med Chem Lett 13: 1861-4 (2003) Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium. 2D 3D TSV
12749884 126 Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.EBI Bioorg Med Chem Lett 13: 1857-9 (2003) Lilly Research Laboratories 2D 3D TSV
12747796 39 Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).EBI J Med Chem 46: 2246-9 (2003) The Danish University of Pharmaceutical Sciences 2D 3D TSV
12747794 124 Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.EBI J Med Chem 46: 2227-40 (2003) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
12747793 32 C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.EBI J Med Chem 46: 2216-26 (2003) University of North Carolina at Chapel Hill 2D 3D TSV
12747792 12 Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.EBI J Med Chem 46: 2205-15 (2003) Wayne State University 2D 3D TSV
12747791 91 Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.EBI J Med Chem 46: 2197-204 (2003) Universit£ Montpellier II 2D 3D TSV
12747790 171 Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.BDB J Med Chem 46: 2187-96 (2003) University of Agricultural Sciences and Veterinary Medicine 2D 3D TSV
12747789 29 Metal coordination-based inhibitors of adenylyl cyclase: novel potent P-site antagonists.EBI J Med Chem 46: 2177-86 (2003) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12747787 106 Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.EBI J Med Chem 46: 2152-68 (2003) Pharmacia Discovery Research (Pfizer Global Research and Development) 2D 3D TSV
12747784 28 Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites.EBI J Med Chem 46: 2117-24 (2003) Universit£ di Bari 2D 3D TSV
12747783 17 Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.EBI J Med Chem 46: 2110-6 (2003) Bristol-Myers Squibb 2D 3D TSV
12747782 79 Structure-activity relationships of dynorphin a analogues modified in the address sequence.EBI J Med Chem 46: 2104-9 (2003) University of California 2D 3D TSV
12747781 29 Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.BDB J Med Chem 46: 2093-103 (2003) Abbott Laboratories 2D 3D TSV
12747780 56 Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.EBI J Med Chem 46: 2083-92 (2003) Albert-Ludwigs-Universität 2D 3D TSV
12747779 13 Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method.EBI J Med Chem 46: 2074-82 (2003) Johnson& Johnson Pharmaceutical Research and Development 2D 3D TSV
12747775 56 Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.BDB J Med Chem 46: 2027-30 (2003) Lilly Research Laboratories 2D 3D TSV
12747774 17 Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.EBI J Med Chem 46: 2023-6 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12747773 13 Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.EBI J Med Chem 46: 2017-22 (2003) Aventis Pharmaceuticals 2D 3D TSV
12742021 191 Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.BDB J Mol Biol 329: 93-120 (2003) Celera 2D 3D TSV
12739951 91 Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases.BDB J Comb Chem 5: 336-44 (2003) University of Anterwerp 2D 3D TSV
12739759 25 Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.EBI Pharm Res 20: 537-44 (2003) Schering-Plough Research Institute 2D 3D TSV
12731874 10 Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase.BDB Biochemistry 42: 5333-40 (2003) Medical College of Ohio 2D 3D TSV
12729675 32 Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.EBI Bioorg Med Chem Lett 13: 1829-35 (2003) Aventis Pharmaceuticals 2D 3D TSV
12729674 6 Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.EBI Bioorg Med Chem Lett 13: 1825-7 (2003) Instituto Politécnico Nacional 2D 3D TSV
12729673 39 Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.EBI Bioorg Med Chem Lett 13: 1821-4 (2003) Merck Research Laboratories 2D 3D TSV
12729670 49 Non-peptide alphavbeta3 antagonists. Part 6: design and synthesis of alphavbeta3 antagonists containing a pyridone or pyrazinone central scaffold.EBI Bioorg Med Chem Lett 13: 1809-12 (2003) Merck Research Laboratories 2D 3D TSV
12729668 106 5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.EBI Bioorg Med Chem Lett 13: 1801-4 (2003) Merck Research Laboratories 2D 3D TSV
12729667 47 Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library.EBI Bioorg Med Chem Lett 13: 1795-9 (2003) Bristol-Myers Squibb Co. 2D 3D TSV
12729666 2 A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.EBI Bioorg Med Chem Lett 13: 1791-4 (2003) Schering-Plough Research Institute 2D 3D TSV
12729664 14 Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives.EBI Bioorg Med Chem Lett 13: 1783-6 (2003) Université de Reims Champagne-Ardenne 2D 3D TSV
12729661 20 Non-imidazole heterocyclic histamine H3 receptor antagonists.EBI Bioorg Med Chem Lett 13: 1767-70 (2003) Johnson & Johnson Pharmaceutical Research and Development L. L. C. 2D 3D TSV
12729659 29 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.EBI Bioorg Med Chem Lett 13: 1759-62 (2003) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12729655 51 Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.EBI Bioorg Med Chem Lett 13: 1741-4 (2003) Abbott Laboratories 2D 3D TSV
12729652 1 Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics.EBI Bioorg Med Chem Lett 13: 1729-32 (2003) Peking University 2D 3D TSV
12729650 2 Solid-phase synthesis of endothelin receptor antagonists.EBI Bioorg Med Chem Lett 13: 1721-4 (2003) BASF AG 2D 3D TSV
12729649 16 Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine.EBI Bioorg Med Chem Lett 13: 1717-20 (2003) Peking University 2D 3D TSV
12729646 24 New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.EBI Bioorg Med Chem Lett 13: 1705-8 (2003) Institut de Recherches Servier 2D 3D TSV
12729643 31 Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening.EBI Bioorg Med Chem Lett 13: 1691-4 (2003) Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, Herts AL7 3AY, UK. stephen.d.pickett@gsk.com 2D 3D TSV
12729639 20 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.BDB Bioorg Med Chem Lett 13: 1673-7 (2003) Merck Research Laboratories 2D 3D TSV
12729633 3 Inactivation of S-adenosyl-L-homocysteine hydrolase with novel 5'-thioadenosine derivatives. Antiviral effects.EBI Bioorg Med Chem Lett 13: 1649-52 (2003) UMR 6519 2D 3D TSV
12729631 16 Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 13: 1639-43 (2003) Dr. Reddy's Laboratories Ltd. 2D 3D TSV
12729627 4 Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors.EBI Bioorg Med Chem Lett 13: 1623-6 (2003) The University of Birmingham 2D 3D TSV
12729570 8 Synthesis and tyrosinase inhibitory activity of novel N-hydroxybenzyl-N-nitrosohydroxylamines.BDB Bioorg Chem 31: 129-35 (2003) Keio University 2D 3D TSV
12725862 9 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.BDB Chem Biol 10: 341-9 (2003) University of North Carolina at Chapel Hill 2D 3D TSV
12723962 69 Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.EBI J Med Chem 46: 1997-2007 (2003) Georgetown University Medical Center 2D 3D TSV
12723961 15 Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.EBI J Med Chem 46: 1989-96 (2003) Guilford Pharmaceuticals Inc. 2D 3D TSV
12723960 58 Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.EBI J Med Chem 46: 1980-8 (2003) Hokkaido University 2D 3D TSV
12723959 61 Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives.EBI J Med Chem 46: 1962-79 (2003) Université d'Orléans 2D 3D TSV
12723956 22 Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues.EBI J Med Chem 46: 1940-7 (2003) National Cancer Institute-Frederick 2D 3D TSV
12723954 47 Design of selective peptidomimetic agonists for the human orphan receptor BRS-3.EBI J Med Chem 46: 1918-30 (2003) Technische Universität München 2D 3D TSV
12723951 7 Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies.EBI J Med Chem 46: 1878-85 (2003) University of Utah 2D 3D TSV
12723950 2 2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.EBI J Med Chem 46: 1870-7 (2003) Deakin University 2D 3D TSV
12723949 9 Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.EBI J Med Chem 46: 1858-69 (2003) University of Pennsylvania 2D 3D TSV
12723948 30 Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.EBI J Med Chem 46: 1845-57 (2003) Ajinomoto Company Inc. 2D 3D TSV
12723947 10 Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.BDB J Med Chem 46: 1831-44 (2003) University of Pennsylvania 2D 3D TSV
12723945 167 Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.EBI J Med Chem 46: 1811-23 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12723943 29 Benzodiazepines as potent and selective bradykinin B1 antagonists.EBI J Med Chem 46: 1803-6 (2003) Merck Research Laboratories 2D 3D TSV
12723942 38 Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase.EBI J Med Chem 46: 1799-802 (2003) Elan Pharmaceuticals 2D 3D TSV
12723940 145 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.EBI J Med Chem 46: 1775-94 (2003) Research Triangle Institute 2D 3D TSV
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB J Pharmacol Exp Ther 306: 377-86 (2003) Pudue Pharma Discovery Research 2D 3D TSV
12714592 8 Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.BDB J Biol Chem 278: 27652-7 (2003) Schering-Plough Research Institute 2D 3D TSV
12713409 7 Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.EBI J Nat Prod 66: 535-7 (2003) Tom's of Maine 2D 3D TSV
12704428 9 Insights into antifolate resistance from malarial DHFR-TS structures.BDB Nat Struct Biol 10: 257-65 (2003) Mahidol University 2D 3D TSV
12704225 26 Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.BDB J Pharmacol Exp Ther 305: 565-72 (2003) University of Tennessee 2D 3D TSV
12700464 1 Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.EBI AIDS 17: 1092-4 (2003) Tufts University School of Medicine 2D 3D TSV
12699763 6 The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity.EBI Bioorg Med Chem Lett 13: 1597-600 (2003) University of California at Irvine 2D 3D TSV
12699762 27 Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.EBI Bioorg Med Chem Lett 13: 1591-5 (2003) Wayne State University 2D 3D TSV
12699761 85 New scaffolds in the development of mu opioid-receptor ligands.EBI Bioorg Med Chem Lett 13: 1585-9 (2003) AstraZeneca R&D Montreal 2D 3D TSV
12699760 19 5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).BDB Bioorg Med Chem Lett 13: 1581-4 (2003) GlaxoSmithKline 2D 3D TSV
12699759 32 5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).BDB Bioorg Med Chem Lett 13: 1577-80 (2003) GlaxoSmithKline 2D 3D TSV
12699757 72 Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.EBI Bioorg Med Chem Lett 13: 1571-4 (2003) Abbott Laboratories 2D 3D TSV
12699755 4 Nonpeptide RGD antagonists: a novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam.EBI Bioorg Med Chem Lett 13: 1561-4 (2003) Université Montpellier I 2D 3D TSV
12699753 12 Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.EBI Bioorg Med Chem Lett 13: 1553-5 (2003) UFR des Sciences Pharmaceutiques 2D 3D TSV
12699752 40 Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.EBI Bioorg Med Chem Lett 13: 1549-52 (2003) College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong, Yongsan-ku, Seoul 140-742, South Korea. 2D 3D TSV
12699751 18 5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.EBI Bioorg Med Chem Lett 13: 1543-7 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12699746 7 A novel metal-chelating inhibitor of protein farnesyltransferase.EBI Bioorg Med Chem Lett 13: 1523-6 (2003) Kumamoto University 2D 3D TSV
12699745 49 Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.EBI Bioorg Med Chem Lett 13: 1517-21 (2003) GlaxoSmithKline 2D 3D TSV
12699744 15 Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo.EBI Bioorg Med Chem Lett 13: 1513-5 (2003) Genentech 2D 3D TSV
12699396 28 Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.EBI J Med Chem 46: 1769-72 (2003) Neurocrine Biosciences, Inc. 2D 3D TSV
12699395 5 Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.EBI J Med Chem 46: 1764-8 (2003) Kyoto University 2D 3D TSV
12699394 30 Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.EBI J Med Chem 46: 1758-63 (2003) University of Innsbruck 2D 3D TSV
12699390 71 Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.EBI J Med Chem 46: 1726-36 (2003) Harvard Medical School 2D 3D TSV
12699389 152 Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.EBI J Med Chem 46: 1716-25 (2003) F. Hoffmann-LaRoche Ltd. 2D 3D TSV
12699385 25 Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.EBI J Med Chem 46: 1670-82 (2003) Purdue University 2D 3D TSV
12699384 69 Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.EBI J Med Chem 46: 1661-9 (2003) Northwestern University 2D 3D TSV
12699382 4 An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.BDB J Med Chem 45: 1432-8 (2002) Academy of Sciences of the Czech Republic 2D 3D TSV
12699381 31 Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.BDB J Med Chem 46: 1627-35 (2003) GlaxoSmithKline 2D 3D TSV
12699376 20 Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.BDB J Med Chem 46: 1580-8 (2003) Karo Bio AB 2D 3D TSV
12699375 10 Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).EBI J Med Chem 46: 1571-9 (2003) National Cancer Institute at Frederick 2D 3D TSV
12697690 15 Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor?BDB Endocrinology 144: 1842-6 (2003) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
12695538 11 Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.EBI Mol Pharmacol 63: 1094-103 (2003) The Netherlands Cancer Institute 2D 3D TSV
12695537 25 [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.BDB Mol Pharmacol 63: 1082-93 (2003) Johnson and Johnson Pharmaceutical Research and Development, Beerse 2D 3D TSV
12694187 9 Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.BDB Eur J Biochem 270: 1746-58 (2003) Uppsala University 2D 3D TSV
12683677 8 Design, synthesis and in vitro evaluation of novel derivatives as serotonin N-acetyltransferase inhibitors.BDB J Enzyme Inhib Med Chem 17: 409-14 (2002) Université de Lille 2D 3D TSV
12682217 7 SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.BDB J Pharmacol Exp Ther 306: 407-20 (2003) Sanofi-Synthelabo Research 2D 3D TSV
12679137 6 Interactions of human organic anion as well as cation transporters with indoxyl sulfate.EBI Eur J Pharmacol 466: 13-20 (2003) Nagoya University School of Medicine 2D 3D TSV
12672258 99 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.EBI J Med Chem 46: 1563-6 (2003) University of Bath 2D 3D TSV
12672255 18 Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate.EBI J Med Chem 46: 1538-45 (2003) Organix Inc. 2D 3D TSV
12672253 60 Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.EBI J Med Chem 46: 1523-30 (2003) Freie Universit£t Berlin 2D 3D TSV
12672252 104 Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.EBI J Med Chem 46: 1512-22 (2003) Universidad Complutense 2D 3D TSV
12672251 9 1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.EBI J Med Chem 46: 1504-11 (2003) Universit£ degli Studi di Modena e Reggio Emilia 2D 3D TSV
12672250 10 N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.EBI J Med Chem 46: 1492-503 (2003) Leiden University 2D 3D TSV
12672248 50 Kinase inhibitors: not just for kinases anymore.EBI J Med Chem 46: 1478-83 (2003) Northwestern University 2D 3D TSV
12672246 68 Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.EBI J Med Chem 46: 1465-9 (2003) NIDDK 2D 3D TSV
12672245 54 Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.EBI J Med Chem 46: 1456-64 (2003) School of Chemistry and Biochemistry 2D 3D TSV
12672241 37 Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.EBI J Med Chem 46: 1419-28 (2003) Università di Pisa 2D 3D TSV
12672240 18 De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor.EBI J Med Chem 46: 1408-18 (2003) SignalGene Inc. 2D 3D TSV
12672238 3 Mechanism of action of the diazabicyclononanone-type kappa-agonists.EBI J Med Chem 46: 1383-9 (2003) Universität Würzburg 2D 3D TSV
12672235 15 (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.EBI J Med Chem 46: 1350-8 (2003) The Danish University of Pharmaceutical Sciences 2D 3D TSV
12672234 64 Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.EBI J Med Chem 46: 1337-49 (2003) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
12672232 28 Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.EBI J Med Chem 46: 1318-29 (2003) Università di Ferrara 2D 3D TSV
12672231 18 Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.EBI J Med Chem 46: 1306-17 (2003) Novo Nordisk A/S 2D 3D TSV
12672230 22 Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin.EBI J Med Chem 46: 1293-305 (2003) Thrombosis Research Institute 2D 3D TSV
12672227 22 Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.EBI J Med Chem 46: 1283-5 (2003) Shire BioChem Inc. 2D 3D TSV
12672226 9 A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus.EBI J Med Chem 46: 1279-82 (2003) University of Maryland 2D 3D TSV
12670229 8 Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.BDB J Am Chem Soc 125: 4087-96 (2003) Abbott Laboratories 2D 3D TSV
12668020 29 Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.EBI Bioorg Med Chem Lett 13: 1495-8 (2003) 3-Dimensional Pharmaceuticals, Inc. 2D 3D TSV
12668018 138 Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.EBI Bioorg Med Chem Lett 13: 1487-90 (2003) Wyeth-Ayerst Research 2D 3D TSV
12668017 17 Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists.EBI Bioorg Med Chem Lett 13: 1483-6 (2003) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
12668015 6 Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-ones containing a basic side chain.EBI Bioorg Med Chem Lett 13: 1475-8 (2003) The Ohio State University 2D 3D TSV
12668013 42 Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.EBI Bioorg Med Chem Lett 13: 1463-7 (2003) Aventis Pharma Deutschland GmbH 2D 3D TSV
12668012 15 From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase.EBI Bioorg Med Chem Lett 13: 1459-62 (2003) Centre de Recherche Pierre Fabre 2D 3D TSV
12668011 22 Synthesis and evaluation of a novel series of farnesyl protein transferase inhibitors as non-peptidic CAAX tetrapeptide analogues.EBI Bioorg Med Chem Lett 13: 1455-8 (2003) Centre de Recherche Pierre Fabre 2D 3D TSV
12668010 1 Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.EBI Bioorg Med Chem Lett 13: 1451-4 (2003) Oxford Centre for Molecular Sciences 2D 3D TSV
12668009 36 High-throughput synthesis and optimization of thrombin inhibitors via urazole alpha-addition and Michael addition.EBI Bioorg Med Chem Lett 13: 1445-9 (2003) Molecumetics 2D 3D TSV
12668008 34 3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors.EBI Bioorg Med Chem Lett 13: 1441-4 (2003) Merck Research Laboratories 2D 3D TSV
12668005 21 Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI Bioorg Med Chem Lett 13: 1429-32 (2003) Universidad Complutense 2D 3D TSV
12668004 76 Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.EBI Bioorg Med Chem Lett 13: 1425-8 (2003) Pfizer Global Research and Development 2D 3D TSV
12668002 57 Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK).EBI Bioorg Med Chem Lett 13: 1415-8 (2003) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
12668001 17 Peptoid mimics of agouti related protein.EBI Bioorg Med Chem Lett 13: 1409-13 (2003) University of California 2D 3D TSV
12668000 29 3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors.EBI Bioorg Med Chem Lett 13: 1403-8 (2003) Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160 062, Punjab, India. akchakraborti@niper.ac.in 2D 3D TSV
12660315 17 Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor.BDB J Pharmacol Exp Ther 306: 253-61 (2003) LCG Bioscience 2D 3D TSV
12659774 20 Synthesis of potent oxindole CDK2 inhibitors.BDB Bioorg Med Chem 11: 1873-81 (2003) Hoffmann-La Roche Inc. 2D 3D TSV
12657288 102 Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.EBI Bioorg Med Chem Lett 13: 1385-9 (2003) NIDDK 2D 3D TSV
12657284 31 Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.EBI Bioorg Med Chem Lett 13: 1367-71 (2003) Abbott Laboratories 2D 3D TSV
12657283 37 Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.EBI Bioorg Med Chem Lett 13: 1363-6 (2003) Abbott Laboratories 2D 3D TSV
12657282 13 Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.BDB Bioorg Med Chem Lett 13: 1359-62 (2003) Abbott Laboratories 2D 3D TSV
12657281 29 Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.EBI Bioorg Med Chem Lett 13: 1353-7 (2003) Merck Research Laboratories 2D 3D TSV
12657279 25 Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.EBI Bioorg Med Chem Lett 13: 1345-8 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12657278 38 Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists.EBI Bioorg Med Chem Lett 13: 1341-4 (2003) Johnson & Johnson Pharmaceutical Research and Development 2D 3D TSV
12657277 40 Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.EBI Bioorg Med Chem Lett 13: 1337-40 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12657276 2 Inhibition of telomerase by BIBR 1532 and related analogues.EBI Bioorg Med Chem Lett 13: 1333-6 (2003) University of Texas Southwestern Medical Center at Dallas 2D 3D TSV
12657274 109 Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.EBI Bioorg Med Chem Lett 13: 1325-8 (2003) Abbott Laboratories 2D 3D TSV
12657272 47 Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists.EBI Bioorg Med Chem Lett 13: 1317-20 (2003) Wyeth Research 2D 3D TSV
12657271 71 Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.EBI Bioorg Med Chem Lett 13: 1313-6 (2003) Wyeth Research 2D 3D TSV
12657270 57 Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution.EBI Bioorg Med Chem Lett 13: 1307-11 (2003) Roche Research Center 2D 3D TSV
12657269 52 Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.EBI Bioorg Med Chem Lett 13: 1301-5 (2003) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
12657268 13 Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.EBI Bioorg Med Chem Lett 13: 1297-300 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12657267 65 Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.EBI Bioorg Med Chem Lett 13: 1293-6 (2003) Abbott Laboratories 2D 3D TSV
12657266 3 [3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter.EBI Bioorg Med Chem Lett 13: 1291-2 (2003) Pfizer Inc. 2D 3D TSV
12657263 46 Phenylacetic acid derivatives as hPPAR agonists.EBI Bioorg Med Chem Lett 13: 1277-80 (2003) Merck Research Laboratories 2D 3D TSV
12657262 14 Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.EBI Bioorg Med Chem Lett 13: 1273-6 (2003) Bristol-Myers Squibb PRI 2D 3D TSV
12657261 32 Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.EBI Bioorg Med Chem Lett 13: 1269-72 (2003) Tohoku Pharmaceutical University 2D 3D TSV
12657259 2 The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.EBI Bioorg Med Chem Lett 13: 1261-4 (2003) Instituto Universitario de Bio-Orgánica, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain. 2D 3D TSV
12657255 21 Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine.EBI Bioorg Med Chem Lett 13: 1245-8 (2003) Peking University 2D 3D TSV
12657254 10 Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand.EBI Bioorg Med Chem Lett 13: 1241-4 (2003) Utrecht University 2D 3D TSV
12657252 15 Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.EBI Bioorg Med Chem Lett 13: 1231-5 (2003) Lilly Research Laboratories 2D 3D TSV
12650826 10 Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.EBI Eur J Pharmacol 465: 1-7 (2003) Kyorin University School of Medicine 2D 3D TSV
12649362 8 Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.BDB J Pharmacol Exp Ther 305: 143-50 (2003) Georgetown University 2D 3D TSV
12649361 779 L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.BDB J Pharmacol Exp Ther 305: 131-42 (2003) Case Western Reserve University 2D 3D TSV
12649353 15 Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors.BDB J Pharmacol Exp Ther 305: 57-69 (2003) Bristol-Myers Squibb Pharmaceuticals Research Institute 2D 3D TSV
12649305 4 Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).BDB J Pharmacol Exp Ther 305: 1037-44 (2003) Schering-Plough Research Institute 2D 3D TSV
12646038 19 Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.EBI J Med Chem 46: 1273-6 (2003) F. Hoffmann-LaRoche 2D 3D TSV
12646036 16 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.EBI J Med Chem 46: 1257-65 (2003) Massachusetts General Hospital 2D 3D TSV
12646033 124 Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI J Med Chem 46: 1229-41 (2003) Universit£ di Ferrara 2D 3D TSV
12646032 30 High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.EBI J Med Chem 46: 1220-8 (2003) Wayne State University 2D 3D TSV
12646029 40 New active series of growth hormone secretagogues.EBI J Med Chem 46: 1191-203 (2003) Universit£ Montpellier I et II 2D 3D TSV
12646027 43 Synthesis of novel thrombin inhibitors. Use of ring-closing metathesis reactions for synthesis of P2 cyclopentene- and cyclohexenedicarboxylic acid derivatives.EBI J Med Chem 46: 1165-79 (2003) Link£ping University 2D 3D TSV
12646026 60 Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.EBI J Med Chem 46: 1153-64 (2003) Roche Discovery Welwyn 2D 3D TSV
12646025 12 Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.EBI J Med Chem 46: 1144-52 (2003) Universidade Federal do Rio de Janeiro 2D 3D TSV
12646024 17 Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.EBI J Med Chem 46: 1133-43 (2003) Philipps-Universität Marburg 2D 3D TSV
12646022 22 Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.EBI J Med Chem 46: 1127-9 (2003) Université de Lille 2 2D 3D TSV
12646021 35 Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.EBI J Med Chem 46: 1123-6 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12646020 17 Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase.EBI J Med Chem 46: 1120-2 (2003) Ontogen Corporation 2D 3D TSV
12646019 48 Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.BDB J Med Chem 46: 1116-9 (2003) SUGEN, Inc. 2D 3D TSV
12646018 27 Synthesis and biological evaluation of non-peptidic cyclophilin ligands.EBI J Med Chem 46: 1112-5 (2003) Guilford Pharmaceuticals, Inc. 2D 3D TSV
12646017 1 Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents.EBI J Med Chem 46: 1081-111 (2003) The Feinberg School of Medicine of Northwestern University 2D 3D TSV
12643946 32 Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.EBI Bioorg Med Chem Lett 13: 1215-9 (2003) National Cancer Institute 2D 3D TSV
12643945 36 Structure-activity relationships of some opiate glycosides.EBI Bioorg Med Chem Lett 13: 1207-14 (2003) Ultrafine UFC Ltd 2D 3D TSV
12643944 26 Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives.EBI Bioorg Med Chem Lett 13: 1203-6 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12643943 43 Indanyl piperazines as melatonergic MT2 selective agents.EBI Bioorg Med Chem Lett 13: 1199-202 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12643942 82 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.EBI Bioorg Med Chem Lett 13: 1195-8 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12643941 20 N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.EBI Bioorg Med Chem Lett 13: 1191-4 (2003) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
12643939 81 2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds.EBI Bioorg Med Chem Lett 13: 1183-6 (2003) GlaxoSmithKline 2D 3D TSV
12643937 7 Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.EBI Bioorg Med Chem Lett 13: 1175-7 (2003) Purdue University 2D 3D TSV
12643934 109 Benzamide derivatives as blockers of Kv1.3 ion channel.EBI Bioorg Med Chem Lett 13: 1161-4 (2003) Merck Research Laboratories 2D 3D TSV
12643933 27 Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.EBI Bioorg Med Chem Lett 13: 1157-60 (2003) Bristol-Myers Squibb 2D 3D TSV
12643930 95 Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods.EBI Bioorg Med Chem Lett 13: 1141-5 (2003) AstraZeneca R&D 2D 3D TSV
12643929 18 Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.EBI Bioorg Med Chem Lett 13: 1137-9 (2003) Pfizer Inc. 2D 3D TSV
12643928 24 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.BDB Bioorg Med Chem Lett 13: 1133-6 (2003) Bristol-Myers Squibb Company 2D 3D TSV
12643927 164 Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.EBI Bioorg Med Chem Lett 13: 1129-32 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12643924 7 Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.BDB Bioorg Med Chem Lett 13: 1115-8 (2003) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
12643923 22 Glycine alpha-ketoamides as HCV NS3 protease inhibitors.EBI Bioorg Med Chem Lett 13: 1111-4 (2003) Pharmaceutical Research Institute 2D 3D TSV
12643919 50 Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.EBI Bioorg Med Chem Lett 13: 1093-6 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12643918 16 N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.EBI Bioorg Med Chem Lett 13: 1087-92 (2003) Seoul National University 2D 3D TSV
12643914 40 Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.EBI Bioorg Med Chem Lett 13: 1071-4 (2003) Bayer AG 2D 3D TSV
12643913 55 The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.EBI Bioorg Med Chem Lett 13: 1067-70 (2003) GlaxoSmithKline 2D 3D TSV
12643910 55 Identification of a novel series of selective 5-HT7 receptor antagonists.EBI Bioorg Med Chem Lett 13: 1055-8 (2003) GlaxoSmithKline 2D 3D TSV
12643904 12 Synthesis and binding affinity of neuropeptide Y at opiate receptors.EBI Bioorg Med Chem Lett 13: 1029-31 (2003) University of North Carolina at Wilmington 2D 3D TSV
12643903 81 Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 1023-8 (2003) Bristol-Myers Squibb Co. 2D 3D TSV
12643901 42 N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.EBI Bioorg Med Chem Lett 13: 1015-8 (2003) Genentech 2D 3D TSV
12643899 127 Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.EBI Bioorg Med Chem Lett 13: 1005-9 (2003) Universit£ degli Studi di Firenze 2D 3D TSV
12643898 4 Syntheses and biological properties of cysteine-reactive epibatidine derivatives.EBI Bioorg Med Chem Lett 13: 1001-4 (2003) Universit£ Louis Pasteur Strasbourg BP 24 2D 3D TSV
12639577 105 Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics.EBI Bioorg Med Chem Lett 13: 767-70 (2003) Bristol-Myers Squibb Company 2D 3D TSV
12639576 37 Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.EBI Bioorg Med Chem Lett 13: 761-5 (2003) Johnson & Johnson Pharmaceutical Research & Development L.L.C. 2D 3D TSV
12639574 21 Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.EBI Bioorg Med Chem Lett 13: 753-6 (2003) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12639573 9 1,4-dibenzylpiperazines possess anticocaine activity.EBI Bioorg Med Chem Lett 13: 749-51 (2003) University of Maryland 2D 3D TSV
12639571 24 Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.EBI Bioorg Med Chem Lett 13: 741-4 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12639570 1 Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate.EBI Bioorg Med Chem Lett 13: 737-9 (2003) Brown University 2D 3D TSV
12639569 23 Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.EBI Bioorg Med Chem Lett 13: 733-5 (2003) Virginia Commonwealth University 2D 3D TSV
12639568 52 Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 729-32 (2003) Millennium Pharmaceuticals Inc. 2D 3D TSV
12639567 135 Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 723-8 (2003) Millennium Pharmaceuticals Inc. 2D 3D TSV
12639565 19 Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.EBI Bioorg Med Chem Lett 13: 713-7 (2003) Merck Research Laboratories 2D 3D TSV
12639564 23 Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.EBI Bioorg Med Chem Lett 13: 709-12 (2003) Schering-Plough Research Institute 2D 3D TSV
12639563 4 Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist.EBI Bioorg Med Chem Lett 13: 705-8 (2003) Schering-Plough Research Institute 2D 3D TSV
12639562 41 Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.EBI Bioorg Med Chem Lett 13: 701-4 (2003) Neurogen Corporation 2D 3D TSV
12639561 51 Orally efficacious NR2B-selective NMDA receptor antagonists.EBI Bioorg Med Chem Lett 13: 697-700 (2003) Merck Research Laboratories 2D 3D TSV
12639560 34 Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.EBI Bioorg Med Chem Lett 13: 693-6 (2003) Merck Sharp& Dohme Research Laboratories 2D 3D TSV
12639557 7 Exploring new non-sugar sulfated molecules as activators of antithrombin.EBI Bioorg Med Chem Lett 13: 679-83 (2003) Virginia Commonwealth University 2D 3D TSV
12639555 10 Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.EBI Bioorg Med Chem Lett 13: 669-73 (2003) Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. 2D 3D TSV
12639554 67 Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.EBI Bioorg Med Chem Lett 13: 665-8 (2003) GlaxoSmithKline 2D 3D TSV
12639552 25 Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.EBI Bioorg Med Chem Lett 13: 657-60 (2003) Vittal Mallya Scientific Research Foundation 2D 3D TSV
12639550 55 Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution.EBI Bioorg Med Chem Lett 13: 649-52 (2003) Roche Research Center 2D 3D TSV
12639549 2 Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate.EBI Bioorg Med Chem Lett 13: 645-7 (2003) Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602, USA. vnair@rx.uga.edu 2D 3D TSV
12639547 26 Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.BDB Bioorg Med Chem Lett 13: 637-40 (2003) GlaxoSmithKline 2D 3D TSV
12639546 30 Identification of a high-affinity phosphopeptide inhibitor of Stat3.BDB Bioorg Med Chem Lett 13: 633-6 (2003) The University of Texas at Houston 2D 3D TSV
12639545 37 Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes.EBI Bioorg Med Chem Lett 13: 629-32 (2003) University of New Orleans 2D 3D TSV
12639541 26 Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities.EBI Bioorg Med Chem Lett 13: 609-12 (2003) Seoul National University 2D 3D TSV
12639540 10 Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.EBI Bioorg Med Chem Lett 13: 605-8 (2003) Bristol-Myers Squibb Company 2D 3D TSV
12639539 26 Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.EBI Bioorg Med Chem Lett 13: 601-4 (2003) Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South Korea. hgpk@plaza.snu.ac.kr 2D 3D TSV
12639538 90 Pyridazinones as selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 13: 597-600 (2003) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12629531 203 H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.BDB Neuropsychopharmacology 28: 519-26 (2003) Case Western Reserve University 2D 3D TSV
12628671 98 Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands.BDB Bioorg Med Chem 11: 1451-64 (2003) Purdue University 2D 3D TSV
12626648 19 Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.BDB J Pharmacol Exp Ther 305: 1104-15 (2003) University of Kansas 2D 3D TSV
12620084 17 QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds.EBI J Med Chem 46: 1066-80 (2003) The Pennsylvania State University 2D 3D TSV
12620078 132 Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.EBI J Med Chem 46: 1016-30 (2003) Abbott Laboratories 2D 3D TSV
12620072 3 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.EBI J Med Chem 46: 954-66 (2003) University of Bologna 2D 3D TSV
12620070 24 Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.EBI J Med Chem 46: 925-35 (2003) Emory University 2D 3D TSV
12620068 44 Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.EBI J Med Chem 46: 917-20 (2003) Università degli Studi di Roma La Sapienza 2D 3D TSV
12620067 47 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.EBI J Med Chem 46: 913-6 (2003) AstraZeneca R& D Charnwood 2D 3D TSV
12620065 1 Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions.EBI J Med Chem 46: 883-908 (2003) The Feinberg School of Medicine of Northwestern University 2D 3D TSV
12617932 10 Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.EBI Bioorg Med Chem Lett 13: 971-5 (2003) Pharmacia Corporation 2D 3D TSV
12617929 114 The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists.EBI Bioorg Med Chem Lett 13: 955-9 (2003) Actelion Pharmaceuticals Ltd 2D 3D TSV
12617928 68 Bis-sulfonamides as endothelin receptor antagonists.EBI Bioorg Med Chem Lett 13: 951-4 (2003) Actelion Pharmaceuticals Ltd 2D 3D TSV
12617924 140 Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.EBI Bioorg Med Chem Lett 13: 931-5 (2003) Merck Research Laboratories 2D 3D TSV
12617923 3 Acylcyclohexanedione derivatives as potential in vivo sequential inhibitors of 4-hydroxyphenylpyruvate dioxygenase and GA(20) 3beta-hydroxylase.EBI Bioorg Med Chem Lett 13: 927-30 (2003) Tunghai University 2D 3D TSV
12617920 41 Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.EBI Bioorg Med Chem Lett 13: 913-8 (2003) Kyoto 619-0216 2D 3D TSV
12617917 7 Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics.EBI Bioorg Med Chem Lett 13: 901-3 (2003) Harvard Medical School 2D 3D TSV
12617916 13 Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain.EBI Bioorg Med Chem Lett 13: 895-9 (2003) National Cancer Institute 2D 3D TSV
12617914 116 N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists.EBI Bioorg Med Chem Lett 13: 885-90 (2003) Merck Research Laboratories 2D 3D TSV
12617910 6 Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.EBI Bioorg Med Chem Lett 13: 867-72 (2003) Nippon Roche Research Center 2D 3D TSV
12617909 6 Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.EBI Bioorg Med Chem Lett 13: 863-5 (2003) University of Bath 2D 3D TSV
12617906 46 Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312.EBI Bioorg Med Chem Lett 13: 851-4 (2003) Friedrich-Alexander University 2D 3D TSV
12617904 46 Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.EBI Bioorg Med Chem Lett 13: 841-5 (2003) Universit£ degli Studi di Firenze 2D 3D TSV
12617903 65 Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.EBI Bioorg Med Chem Lett 13: 837-40 (2003) Universit£ degli Studi di Firenze 2D 3D TSV
12617901 23 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.EBI Bioorg Med Chem Lett 13: 829-32 (2003) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12617898 13 Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.EBI Bioorg Med Chem Lett 13: 817-20 (2003) Seoul National University 2D 3D TSV
12617895 30 Dehydrophenylalanine derivatives as VLA-4 integrin antagonists.EBI Bioorg Med Chem Lett 13: 805-8 (2003) Celltech R&D Ltd 2D 3D TSV
12617894 6 An adjustable release rate linking strategy for cytotoxin-peptide conjugates.EBI Bioorg Med Chem Lett 13: 799-803 (2003) Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA. fuselier@tulane.edu 2D 3D TSV
12617893 28 Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors.EBI Bioorg Med Chem Lett 13: 795-8 (2003) Merck Research Laboratories 2D 3D TSV
12617892 43 Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-arginine mimetics.EBI Bioorg Med Chem Lett 13: 789-94 (2003) University of Ljubljana 2D 3D TSV
12617891 37 Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors.EBI Bioorg Med Chem Lett 13: 785-8 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12617890 9 Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics.EBI Bioorg Med Chem Lett 13: 783-4 (2003) University of Tennessee Health Science Center 2D 3D TSV
12616631 18 D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.BDB Chembiochem 4: 181-5 (2003) University of Queensland Brisbane 2D 3D TSV
12608855 25 Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.EBI J Nat Prod 66: 230-5 (2003) University of California Santa Cruz 2D 3D TSV
12606755 1 Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.EBI Mol Pharmacol 63: 489-98 (2003) University of Arizona 2D 3D TSV
12606689 25 Pharmacology of delta2 glutamate receptors: effects of pentamidine and protons.BDB J Pharmacol Exp Ther 305: 740-8 (2003) State University of New York 2D 3D TSV
12606613 4 A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand.BDB J Pharmacol Exp Ther 305: 675-9 (2003) University of Maryland 2D 3D TSV
12606605 33 Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors.BDB J Pharmacol Exp Ther 305: 825-32 (2003) Juvantia Pharma, Ltd. 2D 3D TSV
12606603 59 Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.BDB J Pharmacol Exp Ther 305: 887-96 (2003) Abbott Laboratories 2D 3D TSV
12604693 1 Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.EBI J Pharmacol Exp Ther 304: 1161-71 (2003) Merck Research Laboratories 2D 3D TSV
12593668 6 Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.EBI J Med Chem 46: 876-9 (2003) Martin-Luther-University Halle-Wittenberg 2D 3D TSV
12593666 30 Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.EBI J Med Chem 46: 868-71 (2003) Senju Pharmaceutical Co. 2D 3D TSV
12593663 146 Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.EBI J Med Chem 46: 838-49 (2003) Rensselaer Polytechnic Institute 2D 3D TSV
12593662 6 Synthesis and flow cytometric evaluation of novel 1,2,3,4-tetrahydroisoquinoline conformationally constrained analogues of nitrobenzylmercaptopurine riboside (NBMPR) designed for probing its conformation when bound to the es nucleoside transporter.EBI J Med Chem 46: 831-7 (2003) University of Tennessee Health Sciences Center 2D 3D TSV
12593661 34 Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.EBI J Med Chem 46: 820-30 (2003) MethylGene Inc. 2D 3D TSV
12593660 23 Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.EBI J Med Chem 46: 810-9 (2003) University of Arizona 2D 3D TSV
12593657 66 Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives.EBI J Med Chem 46: 768-81 (2003) Università di Genova 2D 3D TSV
12593654 48 Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.BDB J Med Chem 46: 734-46 (2003) Uppsala University 2D 3D TSV
12593651 107 Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.EBI J Med Chem 46: 702-15 (2003) Dainippon Pharmaceutical Co. Ltd. 2D 3D TSV
12593650 11 Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor.EBI J Med Chem 46: 691-701 (2003) Sumitomo Pharmaceuticals Co., Ltd 2D 3D TSV
12593649 15 Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.BDB J Med Chem 46: 685-90 (2003) Aventis Pharma 2D 3D TSV
12593648 53 Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.EBI J Med Chem 46: 681-4 (2003) Aventis Pharmaceuticals 2D 3D TSV
12593647 49 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.EBI J Med Chem 46: 677-80 (2003) Harvard University 2D 3D TSV
12593646 13 Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases.EBI J Med Chem 46: 674-6 (2003) Enanta Pharmaceuticals 2D 3D TSV
12593645 2 In vitro and in vivo characterization of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist.EBI J Med Chem 46: 670-3 (2003) Pfizer Inc. 2D 3D TSV
12593644 27 Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists.EBI J Med Chem 46: 666-9 (2003) Tsukuba Research Institute 2D 3D TSV
12573694 13 Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation.BDB Chem Biol 10: 15-24 (2003) Tohoku University 2D 3D TSV
12570387 60 Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI J Med Chem 46: 646-9 (2003) Università degli Studi di Bari 2D 3D TSV
12570386 15 Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.EBI J Med Chem 46: 642-5 (2003) National Institute on Drug Abuse 2D 3D TSV
12570383 46 3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.EBI J Med Chem 46: 623-33 (2003) GlaxoSmithKline Research and Development 2D 3D TSV
12570381 15 Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.EBI J Med Chem 46: 601-8 (2003) Columbia University 2D 3D TSV
12570380 34 Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.EBI J Med Chem 46: 591-600 (2003) Duquesne University 2D 3D TSV
12570379 6 Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.EBI J Med Chem 46: 584-90 (2003) University Centre for Pharmacy 2D 3D TSV
12570378 6 Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.EBI J Med Chem 46: 571-83 (2003) The University of Arizona 2D 3D TSV
12570376 20 Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.EBI J Med Chem 46: 542-57 (2003) Universit£ de Lille II 2D 3D TSV
12570371 33 Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.EBI J Med Chem 46: 486-98 (2003) Aventis Pharma Deutschland GmbH 2D 3D TSV
12570369 60 Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.EBI J Med Chem 46: 461-73 (2003) Merck Research Laboratories 2D 3D TSV
12570368 9 Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.EBI J Med Chem 46: 457-60 (2003) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12570367 9 Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.EBI J Med Chem 46: 453-6 (2003) Merck Research Laboratories 2D 3D TSV
12570021 16 Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.BDB Fundam Clin Pharmacol 16: 317-23 (2002) Shinshu University 2D 3D TSV
12569305 12 Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.EBI Anticancer Drugs 14: 175-81 (2003) Korea Research Institute of Chemical Technology 2D 3D TSV
12565974 3 Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.EBI Bioorg Med Chem Lett 13: 573-5 (2003) Schering Plough Research Institute 2D 3D TSV
12565973 33 Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides.EBI Bioorg Med Chem Lett 13: 567-71 (2003) Schering-Plough Research Institute 2D 3D TSV
12565972 69 Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 561-6 (2003) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12565970 44 Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.EBI Bioorg Med Chem Lett 13: 553-6 (2003) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
12565969 36 Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.EBI Bioorg Med Chem Lett 13: 547-51 (2003) Bristol-Myers Squibb PRI 2D 3D TSV
12565968 40 Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.EBI Bioorg Med Chem Lett 13: 543-6 (2003) Bristol-Myers Squibb PRI 2D 3D TSV
12565966 33 Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.EBI Bioorg Med Chem Lett 13: 533-8 (2003) Bristol-Myers Squibb Pharmaceuticals 2D 3D TSV
12565965 45 Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.EBI Bioorg Med Chem Lett 13: 529-32 (2003) Southern Research Institute 2D 3D TSV
12565964 4 5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.EBI Bioorg Med Chem Lett 13: 525-7 (2003) University of California 2D 3D TSV
12565962 41 Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.EBI Bioorg Med Chem Lett 13: 513-7 (2003) University of Michigan 2D 3D TSV
12565961 177 Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 507-11 (2003) Berlex Biosciences 2D 3D TSV
12565960 33 Thiophene-based vitronectin receptor antagonists.EBI Bioorg Med Chem Lett 13: 503-6 (2003) Shire BioChem Inc. 2D 3D TSV
12565959 9 1,4-Diazepane-2-ones as novel inhibitors of LFA-1.EBI Bioorg Med Chem Lett 13: 499-502 (2003) Novartis Institute for Biomedical Research 2D 3D TSV
12565955 33 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).EBI Bioorg Med Chem Lett 13: 479-83 (2003) Merck Research Laboratories 2D 3D TSV
12565952 26 p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.EBI Bioorg Med Chem Lett 13: 467-70 (2003) Department of Medicinal Chemistry, Merck& Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. julianne_hunt@merck.com 2D 3D TSV
12565948 120 Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.EBI Bioorg Med Chem Lett 13: 447-53 (2003) QSAR and Computer Chemical Laboratories, A.P.S. University, Rewa 486 003, India. vijay-agrawal@lycos.com 2D 3D TSV
12565947 1 Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists.EBI Bioorg Med Chem Lett 13: 443-6 (2003) Università di Messina 2D 3D TSV
12565946 51 Discovery of orally bioavailable NK1 receptor antagonists.EBI Bioorg Med Chem Lett 13: 437-42 (2003) UCB Pharma 2D 3D TSV
12565944 47 1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.EBI Bioorg Med Chem Lett 13: 427-31 (2003) Merck Research Laboratories 2D 3D TSV
12565943 43 A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase.EBI Bioorg Med Chem Lett 13: 423-6 (2003) PanTherix Ltd. 2D 3D TSV
12565941 27 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 13: 413-7 (2003) Drug Discovery, AmorePacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@pacific.co.kr 2D 3D TSV
12565939 38 SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition.EBI Bioorg Med Chem Lett 13: 405-8 (2003) Solvay Pharma 2D 3D TSV
12565935 5 Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.EBI Bioorg Med Chem Lett 13: 387-9 (2003) The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory 2D 3D TSV
12565933 30 Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.EBI Bioorg Med Chem Lett 13: 379-82 (2003) Pfizer Global Research and Development 2D 3D TSV
12565931 37 Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.EBI Bioorg Med Chem Lett 13: 369-73 (2003) Bristol-Myers Squibb Co. 2D 3D TSV
12565928 11 [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.EBI Bioorg Med Chem Lett 13: 351-4 (2003) Merck Research Laboratories 2D 3D TSV
12565927 24 Imidazopyrimidines, potent inhibitors of p38 MAP kinase.EBI Bioorg Med Chem Lett 13: 347-50 (2003) Johnson & Johnson Pharmaceutical Research and Development 2D 3D TSV
12565923 6 Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.EBI Bioorg Med Chem Lett 13: 331-4 (2003) Leiden University 2D 3D TSV
12565883 1 AF2 interaction with Ascaris suum body wall muscle membranes involves G-protein activation.BDB Biochem Biophys Res Commun 301: 456-9 (2003) PHARMACIA Corporation 2D 3D TSV
12542356 4 Cationic reduction of bastadin-4 to bastadin-5. Preparation of 5-[2h]-bastadin-5 by site-specific isotopic labeling.EBI J Nat Prod 66: 112-4 (2003) University of California 2D 3D TSV
12540243 29 Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.EBI J Med Chem 46: 441-4 (2003) Johnson & Johnson Pharmaceutical Research & Development L.L.C. 2D 3D TSV
12540241 5 Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.EBI J Med Chem 46: 417-26 (2003) Aristotle University of Thessaloniki 2D 3D TSV
12540239 3 Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.EBI J Med Chem 46: 399-408 (2003) GlaxoSmithKline Research and Development 2D 3D TSV
12540236 11 New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.EBI J Med Chem 46: 364-73 (2003) Georgetown University Medical Center 2D 3D TSV
12540233 16 3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.EBI J Med Chem 46: 353-5 (2003) Pfizer Inc. 2D 3D TSV
12540232 53 Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.EBI J Med Chem 46: 349-52 (2003) Merck Research Laboratories 2D 3D TSV
12540231 39 Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.EBI J Med Chem 46: 345-8 (2003) MRL Rome 2D 3D TSV
12540230 18 5-HT4 receptor ligands: applications and new prospects.EBI J Med Chem 46: 319-44 (2003) INSERM 2D 3D TSV
12538898 12 Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species.BDB Protein Sci 12: 349-60 (2003) GSK 2D 3D TSV
12538838 14 Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.BDB J Pharmacol Exp Ther 304: 818-26 (2003) Taisho Pharmaceutical Co. 2D 3D TSV
12538837 2 Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).EBI J Pharmacol Exp Ther 304: 810-7 (2003) University of Cologne 2D 3D TSV
12538813 1 Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.EBI J Pharmacol Exp Ther 304: 610-6 (2003) Kitasato University 2D 3D TSV
12538807 4 Interaction of cysteine conjugates with human and rabbit organic anion transporter 1.EBI J Pharmacol Exp Ther 304: 560-6 (2003) University of Arizona 2D 3D TSV
12534346 22 The specificities of protein kinase inhibitors: an update.BDB Biochem J 371: 199-204 (2003) University of Dundee 2D 3D TSV
12534275 32 A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.BDB Biochemistry 42: 631-8 (2003) The Johns Hopkins University 2D 3D TSV
12533678 10 Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.EBI Mol Cancer Ther 2: 105-12 (2003) Japanese Foundation for Cancer Research 2D 3D TSV
12527336 21 Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes.BDB Biochem Pharmacol 65: 435-40 (2003) Aventis Pharma 2D 3D TSV
12526824 2 Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism.EBI J Control Release 86: 279-92 (2003) The Royal Danish School of Pharmacy 2D 3D TSV
12523936 19 Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).EBI Biochem J 371: 361-7 (2003) The Netherlands Cancer Institute 2D 3D TSV
12519069 60 The role of the side chain in determining relative delta- and kappa-affinity in C5'-substituted analogues of naltrindole.EBI J Med Chem 46: 314-7 (2003) University of Bath 2D 3D TSV
12519068 32 Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.EBI J Med Chem 46: 310-3 (2003) University of Firenze 2D 3D TSV
12519067 27 Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.EBI J Med Chem 46: 303-9 (2003) Sigma Tau Pharmaceutical Industries S.p.A. 2D 3D TSV
12519065 243 Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.EBI J Med Chem 46: 265-83 (2003) H. Lundbeck A/S 2D 3D TSV
12519063 5 Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.EBI J Med Chem 46: 244-54 (2003) National Cancer Institute-Frederick 2D 3D TSV
12519062 11 Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.EBI J Med Chem 46: 237-43 (2003) University of Pennsylvania 2D 3D TSV
12519061 145 Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.BDB J Med Chem 46: 222-36 (2003) Faculte de Medecine et de Pharmacie 2D 3D TSV
12519059 10 Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.EBI J Med Chem 46: 210-3 (2003) Pfizer Global R&D 2D 3D TSV
12519058 8 Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.EBI J Med Chem 46: 207-9 (2003) University of Manchester 2D 3D TSV
12519057 22 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.EBI J Med Chem 46: 204-6 (2003) Merck Research Laboratories 2D 3D TSV
12517147 6 Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.BDB J Am Chem Soc 125: 363-73 (2003) Weizmann Institute of Science 2D 3D TSV
12513698 6 Activity of opioid ligands in cells expressing cloned mu opioid receptors.BDB BMC Pharmacol 3: 1 (2003) Molecular Research Institute 2D 3D TSV
12502370 39 New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.EBI J Med Chem 46: 161-8 (2002) Universit£ di Pisa 2D 3D TSV
12502369 8 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.EBI J Med Chem 46: 155-60 (2002) Industrial Research Limited 2D 3D TSV
12502367 17 New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.EBI J Med Chem 46: 138-47 (2002) Université de Caen 2D 3D TSV
12502366 82 Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.EBI J Med Chem 46: 125-37 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12502365 41 Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.EBI J Med Chem 46: 113-24 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12502364 17 Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.EBI J Med Chem 46: 105-12 (2002) Kissei Pharmaceutical Company Ltd. 2D 3D TSV
12502361 53 Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.EBI J Med Chem 46: 74-86 (2002) Vrije Universiteit 2D 3D TSV
12502360 23 Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor.EBI J Med Chem 46: 64-73 (2002) Johannes Gutenberg-Universität 2D 3D TSV
12502359 70 Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).EBI J Med Chem 46: 49-63 (2002) Wyeth Research 2D 3D TSV
12502358 126 The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity.EBI J Med Chem 46: 34-48 (2002) Universit£ de Montr£al 2D 3D TSV
12502354 30 Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding.EBI J Med Chem 46: 9-11 (2002) Amgen Inc. 2D 3D TSV
12502352 28 Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.EBI J Med Chem 46: 1-4 (2002) Universit£ di Siena 2D 3D TSV
12502331 28 New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica.EBI J Nat Prod 65: 1875-81 (2002) Hokuriku University 2D 3D TSV
12502307 6 Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.EBI J Nat Prod 65: 1749-53 (2002) Université de Lausanne 2D 3D TSV
12498885 9 Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition.BDB Chem Biol 9: 1323-8 (2002) Massachusetts Institute of Technology 2D 3D TSV
12482445 16 Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.EBI Bioorg Med Chem Lett 13: 301-4 (2002) University of Colorado 2D 3D TSV
12482444 38 Design and synthesis of factor Xa inhibitors and their prodrugs.EBI Bioorg Med Chem Lett 13: 297-300 (2002) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12482442 13 CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.EBI Bioorg Med Chem Lett 13: 289-91 (2003) Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, Wilmington, DE 19880, USA. argyrios.arvanitis@bms.com 2D 3D TSV
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bioorg Med Chem Lett 13: 285-8 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12482439 51 Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.EBI Bioorg Med Chem Lett 13: 277-80 (2002) Merck Research Laboratories 2D 3D TSV
12482438 50 p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.EBI Bioorg Med Chem Lett 13: 273-6 (2003) Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. natarajan@merck.com 2D 3D TSV
12482437 42 Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.EBI Bioorg Med Chem Lett 13: 269-71 (2003) Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. parikh@groton.pfizer.com 2D 3D TSV
12482435 75 Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.EBI Bioorg Med Chem Lett 13: 261-4 (2002) Ligand Pharmaceuticals, Inc. 2D 3D TSV
12482434 52 Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.EBI Bioorg Med Chem Lett 13: 257-60 (2002) Novo Nordisk A/S 2D 3D TSV
12482429 10 Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity.EBI Bioorg Med Chem Lett 13: 229-36 (2002) Tokyo University of Pharmacy & Life Science 2D 3D TSV
12482427 36 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.BDB Bioorg Med Chem Lett 13: 217-22 (2003) University of Newcastle 2D 3D TSV
12482425 20 Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.EBI Bioorg Med Chem Lett 13: 209-12 (2002) Institut Henri Beaufour 2D 3D TSV
12482423 6 [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).EBI Bioorg Med Chem Lett 13: 201-4 (2002) National Institute of Radiological Sciences 2D 3D TSV
12482418 18 New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors.EBI Bioorg Med Chem Lett 13: 175-8 (2002) University of Santiago 2D 3D TSV
12482417 23 alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.EBI Bioorg Med Chem Lett 13: 171-3 (2002) Università di Pisa 2D 3D TSV
12482416 52 Highly potent and selective alphaVbeta3-receptor antagonists: solid-phase synthesis and SAR of 1-substituted 4-amino-1H-pyrimidin-2-ones.EBI Bioorg Med Chem Lett 13: 165-9 (2002) BASF AG 2D 3D TSV
12482415 30 Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'.EBI Bioorg Med Chem Lett 13: 161-4 (2002) Merck Research Laboratories 2D 3D TSV
12477359 78 Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.EBI J Med Chem 45: 5755-75 (2002) Novo Nordisk A/S 2D 3D TSV
12477358 40 Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.EBI J Med Chem 45: 5745-54 (2002) The Royal Danish School of Pharmacy 2D 3D TSV
12477357 96 Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position.EBI J Med Chem 45: 5736-44 (2002) University of Florida 2D 3D TSV
12477356 137 Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.EBI J Med Chem 45: 5727-35 (2002) Universit£ degli Studi di Bari 2D 3D TSV
12477354 8 Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.EBI J Med Chem 45: 5710-20 (2002) Università degli Studi di Firenze 2D 3D TSV
12477352 85 Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.EBI J Med Chem 45: 5687-93 (2002) Novartis Pharma AG 2D 3D TSV
12477351 41 Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).EBI J Med Chem 45: 5671-86 (2002) Bulgarian Academy of Sciences 2D 3D TSV
12477350 47 Metal-dependent inhibition of HIV-1 integrase.EBI J Med Chem 45: 5661-70 (2002) University of Southern California 2D 3D TSV
12477349 26 In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.EBI J Med Chem 45: 5655-60 (2002) Institute for Biochemistry 2D 3D TSV
12477347 16 Binding model for nonpeptide antagonists of alpha(v)beta(3) integrin.EBI J Med Chem 45: 5640-8 (2002) Merck Research Laboratories 2D 3D TSV
12477346 30 NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.EBI J Med Chem 45: 5628-39 (2002) Abbott Laboratories 2D 3D TSV
12477343 8 Identification of arodyn, a novel acetylated dynorphin A-(1-11) analogue, as a kappa opioid receptor antagonist.EBI J Med Chem 45: 5617-9 (2002) University of Maryland 2D 3D TSV
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI J Med Chem 45: 5609-16 (2002) Merck Research Laboratories 2D 3D TSV
12475240 2 Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.EBI Biochemistry 41: 14916-14924 (2002) UCLA and the Wadsworth Veterans Administration Hospital 2D 3D TSV
12467634 67 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors.EBI Bioorg Med Chem Lett 13: 139-41 (2002) currently NAEJA Pharmaceutical Inc. 2D 3D TSV
12467633 58 Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: histidine substitution.EBI Bioorg Med Chem Lett 13: 133-7 (2002) Roche Research Center 2D 3D TSV
12467632 13 Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands.EBI Bioorg Med Chem Lett 13: 129-31 (2003) Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, DE 19880, USA. argyrios.arvanitis@bms.com 2D 3D TSV
12467631 32 Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.EBI Bioorg Med Chem Lett 13: 125-8 (2003) Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, DE 19880, USA. argyrios.arvanitis@bms.com 2D 3D TSV
12467630 25 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.EBI Bioorg Med Chem Lett 13: 119-23 (2002) Merck Research Laboratories 2D 3D TSV
12467628 118 Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.EBI Bioorg Med Chem Lett 13: 111-3 (2002) Banyu Tsukuba Research Institute 2D 3D TSV
12467627 7 Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model.EBI Bioorg Med Chem Lett 13: 107-10 (2002) Attenuon, L.L.C. 2D 3D TSV
12467625 32 N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.EBI Bioorg Med Chem Lett 13: 97-100 (2002) Chinese Academy of Sciences 2D 3D TSV
12467624 9 Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.EBI Bioorg Med Chem Lett 13: 93-6 (2002) Kyoto Pharmaceutical University 2D 3D TSV
12467623 38 Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.EBI Bioorg Med Chem Lett 13: 87-91 (2003) Department of Chemistry, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan. 2D 3D TSV
12467622 5 Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.EBI Bioorg Med Chem Lett 13: 83-6 (2002) The University of Tokyo 2D 3D TSV
12467619 12 Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.EBI Bioorg Med Chem Lett 13: 69-73 (2002) Facultés Universitaires Notre-Dame de la Paix 2D 3D TSV
12467617 17 New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability.EBI Bioorg Med Chem Lett 13: 61-4 (2003) Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. chika_kikuchi@meiji.co.jp 2D 3D TSV
12467613 15 Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.EBI Bioorg Med Chem Lett 13: 43-6 (2002) DiSCAFF 2D 3D TSV
12467612 1 Synthesis and gamma-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres.EBI Bioorg Med Chem Lett 13: 37-41 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
12467610 1 Identification of a stable chymase inhibitor using a pharmacophore-Based database search.EBI Bioorg Med Chem Lett 13: 25-9 (2002) TOA EIYO Ltd. 2D 3D TSV
12466002 3 Etoricoxib.BDB Drugs 62: 2637 (2002) Adis International Limited 2D 3D TSV
12459025 84 Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.EBI J Med Chem 45: 5576-93 (2002) University of California 2D 3D TSV
12459023 46 Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.EBI J Med Chem 45: 5556-63 (2002) University of Cagliari 2D 3D TSV
12459018 6 Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.EBI J Med Chem 45: 5506-13 (2002) National Institute of Environmental Health Sciences 2D 3D TSV
12459017 132 A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.EBI J Med Chem 45: 5492-505 (2002) GlaxoSmithKline Research and Development 2D 3D TSV
12459015 68 Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.EBI J Med Chem 45: 5471-82 (2002) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
12459011 94 Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.EBI J Med Chem 45: 5430-9 (2002) Uppsala University 2D 3D TSV
12459007 13 Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.EBI J Med Chem 45: 5415-8 (2002) Schering-Plough Research Institute 2D 3D TSV
12444712 3 Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I.EBI J Nat Prod 65: 1715-8 (2002) University of Puerto Rico 2D 3D TSV
12444711 3 Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes.EBI J Nat Prod 65: 1712-4 (2002) Shizuoka University 2D 3D TSV
12444693 5 Triterpenoid constituents isolated from the bark of Abies sachalinensis.EBI J Nat Prod 65: 1657-9 (2002) Osaka University of Pharmaceutical Sciences 2D 3D TSV
12444671 10 Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata.EBI J Nat Prod 65: 1526-9 (2002) Università di Salerno 2D 3D TSV
12444669 10 Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.EBI J Nat Prod 65: 1517-21 (2002) Uppsala University 2D 3D TSV
12443792 51 Characterization of mono- and diaminopyrimidine derivatives as novel, nonpeptide gonadotropin releasing hormone (GnRH) receptor antagonists.EBI Bioorg Med Chem Lett 12: 3635-9 (2002) Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals 2D 3D TSV
12443791 14 Inhibition of amine oxidases activity by 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.EBI Bioorg Med Chem Lett 12: 3629-33 (2002) Università di Roma La Sapienza 2D 3D TSV
12443790 3 Silanediol-based inhibitor of thermolysin.EBI Bioorg Med Chem Lett 12: 3625-7 (2002) State University of New York 2D 3D TSV
12443787 2 Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.EBI Bioorg Med Chem Lett 12: 3611-3 (2002) Institutet 2D 3D TSV
12443785 4 Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.EBI Bioorg Med Chem Lett 12: 3601-4 (2002) Université de Lille 2 2D 3D TSV
12443784 12 Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group.EBI Bioorg Med Chem Lett 12: 3595-9 (2002) British Biotech Pharmaceuticals Limited 2D 3D TSV
12443781 22 Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.EBI Bioorg Med Chem Lett 12: 3583-6 (2002) National Hellenic Research Foundation 2D 3D TSV
12443779 44 2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.EBI Bioorg Med Chem Lett 12: 3573-7 (2002) Johnson& Johnson Pharmaceutical Research& Development 2D 3D TSV
12443777 63 Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.EBI Bioorg Med Chem Lett 12: 3565-7 (2002) Biovitrum AB 2D 3D TSV
12443774 12 Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies.EBI Bioorg Med Chem Lett 12: 3551-5 (2002) University of Bari 2D 3D TSV
12443771 19 Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.BDB Bioorg Med Chem Lett 12: 3537-41 (2002) Merck Research Laboratories 2D 3D TSV
12438541 27 SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization.BDB J Pharmacol Exp Ther 303: 1171-9 (2002) Sanofi-Synthélabo Recherche 2D 3D TSV
12438527 3 Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.BDB J Pharmacol Exp Ther 303: 1052-60 (2002) Merck Sharp and Dohme 2D 3D TSV
12438526 1 [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.BDB J Pharmacol Exp Ther 303: 1044-51 (2002) Merck Research Laboratories 2D 3D TSV
12438515 20 The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.EBI J Pharmacol Exp Ther 303: 959-68 (2002) University of Manitoba 2D 3D TSV
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Neuropsychopharmacology 27: 699-711 (2002) Lilly Research Laboratories 2D 3D TSV
12431069 11 Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.EBI J Med Chem 45: 5410-3 (2002) Università di Messina 2D 3D TSV
12431066 6 Adenosine 5'-O-(1-boranotriphosphate) derivatives as novel P2Y(1) receptor agonists.EBI J Med Chem 45: 5384-96 (2002) Bar-Ilan University 2D 3D TSV
12431065 72 Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.EBI J Med Chem 45: 5378-83 (2002) University of Innsbruck 2D 3D TSV
12431064 43 Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)- 5-[2-[(3-substituted)-1-azetidinyl]ethyl]-2-piperidones. 1. Selective antagonists of the neurokinin-2 receptor.EBI J Med Chem 45: 5365-77 (2002) Pfizer Inc. 2D 3D TSV
12431063 8 Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphenyl)-2-phenylethenes.EBI J Med Chem 45: 5358-64 (2002) Free University of Berlin 2D 3D TSV
12431062 33 Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.EBI J Med Chem 45: 5353-7 (2002) Universit£ de Montr£al 2D 3D TSV
12431059 27 Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides.EBI J Med Chem 45: 5321-9 (2002) National Research Council of Canada 2D 3D TSV
12431057 8 Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles.EBI J Med Chem 45: 5303-10 (2002) Johnson & Johnson Pharmaceutical Research & Development 2D 3D TSV
12431056 9 Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases.EBI J Med Chem 45: 5295-302 (2002) Pohang University of Science and Technology 2D 3D TSV
12431055 52 Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.EBI J Med Chem 45: 5287-94 (2002) University of Arizona 2D 3D TSV
12431054 28 Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.EBI J Med Chem 45: 5280-6 (2002) Purdue Pharma L. P. 2D 3D TSV
12431053 293 Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.BDB J Med Chem 45: 5260-79 (2002) Teva Pharmaceutical Industries 2D 3D TSV
12431052 22 Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.EBI J Med Chem 45: 5249-59 (2002) Chinese Academy of Sciences 2D 3D TSV
12431051 114 Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).BDB J Med Chem 45: 5233-48 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12431050 76 Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.BDB J Med Chem 45: 5224-32 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12419810 6 Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight.BDB J Biol Chem 278: 1831-6 (2003) University of Padova 2D 3D TSV
12419391 8 A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 3491-5 (2002) Neurocrine Biosciences, Inc. 2D 3D TSV
12419390 37 New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.EBI Bioorg Med Chem Lett 12: 3487-90 (2002) Wyeth Research 2D 3D TSV
12419389 13 Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.EBI Bioorg Med Chem Lett 12: 3483-6 (2002) Merck Research Laboratories 2D 3D TSV
12419388 25 Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.EBI Bioorg Med Chem Lett 12: 3479-82 (2002) Schering-Plough Research Institute 2D 3D TSV
12419386 5 Synthesis of [difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B.EBI Bioorg Med Chem Lett 12: 3471-4 (2002) University of Waterloo 2D 3D TSV
12419385 48 The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists.EBI Bioorg Med Chem Lett 12: 3467-70 (2002) Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals 2D 3D TSV
12419382 51 Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships.EBI Bioorg Med Chem Lett 12: 3453-7 (2002) University of Florida 2D 3D TSV
12419381 95 Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.EBI Bioorg Med Chem Lett 12: 3449-52 (2002) GlaxoSmithKline Research and Development 2D 3D TSV
12419380 24 Trifluoromethyl ketones as inhibitors of histone deacetylase.EBI Bioorg Med Chem Lett 12: 3443-7 (2002) Cancer Research, Abbott Laboratories, Abbott Park, IL 60064, USA. robin.r.frey@abbott.com 2D 3D TSV
12419377 5 Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease.BDB Bioorg Med Chem Lett 12: 3431-3 (2002) GlaxoSmithKline 2D 3D TSV
12419375 21 Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists.EBI Bioorg Med Chem Lett 12: 3421-4 (2002) Bayer Research Center 2D 3D TSV
12419374 45 6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.EBI Bioorg Med Chem Lett 12: 3417-9 (2002) currently NAEJA Pharmaceutical Inc. 2D 3D TSV
12419373 18 Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors.EBI Bioorg Med Chem Lett 12: 3413-5 (2002) currently NAEJA Pharmaceutical Inc. 2D 3D TSV
12419367 5 Natural PTP1B inhibitors from Broussonetia papyrifera.EBI Bioorg Med Chem Lett 12: 3387-90 (2002) Chinese Academy of Sciences 2D 3D TSV
12419366 27 Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.EBI Bioorg Med Chem Lett 12: 3383-6 (2002) Pharmacia Corporation 2D 3D TSV
12419362 19 Chemical modification of reveromycin A and its biological activities.EBI Bioorg Med Chem Lett 12: 3363-6 (2002) Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan. tshimizu@postman.riken.go.jp 2D 3D TSV
12419361 23 Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.EBI Bioorg Med Chem Lett 12: 3359-62 (2002) GlaxoSmithKline Medicines Research Centre 2D 3D TSV
12408728 6 Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.EBI J Med Chem 45: 5182-5 (2002) Université de Liège 2D 3D TSV
12408727 38 Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.EBI J Med Chem 45: 5173-81 (2002) Duquesne University 2D 3D TSV
12408725 1 Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging.EBI J Med Chem 45: 5150-6 (2002) Forschungszentrum Jülich GmbH 2D 3D TSV
12408724 79 New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.EBI J Med Chem 45: 5136-49 (2002) University of Liège 2D 3D TSV
12408719 21 Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).EBI J Med Chem 45: 5081-9 (2002) Daiichi Fine Chemical Co. Ltd. 2D 3D TSV
12408715 97 Synthesis and biological evaluation of 7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as functionally selective ligands of the benzodiazepine receptor site on the GABA(A) receptor.EBI J Med Chem 45: 5043-51 (2002) Neurogen Corporation 2D 3D TSV
12408713 54 Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.EBI J Med Chem 45: 5030-6 (2002) Università di Pisa 2D 3D TSV
12408711 112 Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.BDB J Med Chem 45: 5005-22 (2002) Sunesis Pharmaceuticals 2D 3D TSV
12408710 2 Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study.EBI J Med Chem 45: 4995-5004 (2002) Universidade Federal do Rio de Janeiro 2D 3D TSV
12408709 11 Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics.EBI J Med Chem 45: 4984-94 (2002) Technische Universität München 2D 3D TSV
12408708 7 Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.EBI J Med Chem 45: 4975-83 (2002) The University of Liverpool 2D 3D TSV
12408707 32 Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.EBI J Med Chem 45: 4961-74 (2002) Pfizer Global Research and Development 2D 3D TSV
12408705 73 Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.EBI J Med Chem 45: 4954-7 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12401496 89 Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.BDB Chem Biol 9: 1119-28 (2002) Nippon Roche Research Center 2D 3D TSV
12398547 9 Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.EBI J Nat Prod 65: 1479-85 (2002) University of Bonn 2D 3D TSV
12398542 6 Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.EBI J Nat Prod 65: 1452-6 (2002) National Cheng Kung University 2D 3D TSV
12392747 36 SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.EBI Bioorg Med Chem Lett 12: 3341-4 (2002) GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK. ian_t_forbes@gsk.com 2D 3D TSV
12392746 18 3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.EBI Bioorg Med Chem Lett 12: 3337-9 (2002) Pharmacia 2D 3D TSV
12392744 36 Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 3329-32 (2002) Merck Research Laboratories 2D 3D TSV
12392743 17 Capped dipeptide alpha-ketoacid inhibitors of the HCV NS3 protease.EBI Bioorg Med Chem Lett 12: 3325-8 (2002) IRBM, MRL Rome 2D 3D TSV
12392741 7 Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.EBI Bioorg Med Chem Lett 12: 3317-20 (2002) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12392739 41 Novel human histamine H(3) receptor antagonists.EBI Bioorg Med Chem Lett 12: 3309-12 (2002) Johnson and Johnson Pharmaceutical Research and Development 2D 3D TSV
12392738 15 The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.EBI Bioorg Med Chem Lett 12: 3305-8 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12392735 30 Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.EBI Bioorg Med Chem Lett 12: 3291-6 (2002) Institut de Recherches Servier 2D 3D TSV
12392734 5 Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library.EBI Bioorg Med Chem Lett 12: 3287-90 (2002) University College Dublin 2D 3D TSV
12392733 13 Synthesis and biological activity of olomoucine II.EBI Bioorg Med Chem Lett 12: 3283-6 (2002) Palack£ University and Institute of Experimental Botany 2D 3D TSV
12392732 5 Discovery and biological characterization of capromorelin analogues with extended half-lives.EBI Bioorg Med Chem Lett 12: 3279-82 (2002) Pfizer Global Research & Development 2D 3D TSV
12392730 10 Synthesis and muscarinic M(2) subtype antagonistic activity of enantiomeric pairs of 3-demethylhimbacine (3-norhimbacine) and its C(4)-epimer.EBI Bioorg Med Chem Lett 12: 3271-3 (2002) Kyorin Pharmaceutical Co. Ltd. 2D 3D TSV
12388666 301 Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.BDB J Pharmacol Exp Ther 303: 791-804 (2002) Institut de Recherches Servier 2D 3D TSV
12388623 149 Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors.BDB J Pharmacol Exp Ther 303: 445-60 (2002) NIH 2D 3D TSV
12383018 46 Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.EBI J Med Chem 45: 4923-30 (2002) Pharmazeutisches Institut der Universit£t Freiburg 2D 3D TSV
12383013 44 Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists.EBI J Med Chem 45: 4875-87 (2002) Universit£ degli Studi di Genova 2D 3D TSV
12383010 114 Computer-aided design of selective COX-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole derivatives.EBI J Med Chem 45: 4847-57 (2002) University of Hyderabad 2D 3D TSV
12383009 2 Kappa-opioid receptor model in a phospholipid bilayer: molecular dynamics simulation.EBI J Med Chem 45: 4838-46 (2002) University of Catania 2D 3D TSV
12383007 100 Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.EBI J Med Chem 45: 4816-27 (2002) Chinese Academy of Sciences 2D 3D TSV
12383006 24 Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.EBI J Med Chem 45: 4806-15 (2002) Universidad Complutense 2D 3D TSV
12372541 16 Synthesis of potent and highly selective inhibitors of human tryptase.EBI Bioorg Med Chem Lett 12: 3235-8 (2002) The Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. william.slusarchyk@bms.com 2D 3D TSV
12372540 21 Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.EBI Bioorg Med Chem Lett 12: 3229-33 (2002) The Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. james.sutton@bms.com 2D 3D TSV
12372538 22 Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists.EBI Bioorg Med Chem Lett 12: 3219-22 (2002) GlaxoSmithKline 2D 3D TSV
12372534 2 Two selective novel triterpene glycosides from sea cucumber, Telenata Ananas: inhibitors of chemokine receptor-5.EBI Bioorg Med Chem Lett 12: 3203-5 (2002) Schering Plough Research Institute 2D 3D TSV
12372533 69 P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.EBI Bioorg Med Chem Lett 12: 3199-202 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12372532 45 Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.EBI Bioorg Med Chem Lett 12: 3195-8 (2002) UCB Pharma SA 2D 3D TSV
12372531 6 Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.EBI Bioorg Med Chem Lett 12: 3191-3 (2002) Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co. Ltd., 16-13, Kita-kasai 1-chome, Edogawa-ku, 134, Tokyo, Japan. okihi10g@daiichipharm.co.jp 2D 3D TSV
12372530 76 Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI Bioorg Med Chem Lett 12: 3187-90 (2002) Bayer AG 2D 3D TSV
12372529 21 Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.EBI Bioorg Med Chem Lett 12: 3183-6 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12372528 15 New irreversible adenosine A(1) antagonists based on FSCPX.EBI Bioorg Med Chem Lett 12: 3179-82 (2002) Monash University (Parkville Campus) 2D 3D TSV
12372527 27 Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin.EBI Bioorg Med Chem Lett 12: 3175-8 (2002) Institute for Molecular Studies 2D 3D TSV
12372525 2 A mechanism-based probe for gp120-Hydrolyzing antibodies.EBI Bioorg Med Chem Lett 12: 3167-70 (2002) University of Texas-Houston Medical School 2D 3D TSV
12372524 74 Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines.EBI Bioorg Med Chem Lett 12: 3161-5 (2002) Schering-Plough Research Institute 2D 3D TSV
12372523 134 Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.EBI Bioorg Med Chem Lett 12: 3157-60 (2002) Schering Plough Research Institute 2D 3D TSV
12372522 51 Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.EBI Bioorg Med Chem Lett 12: 3153-6 (2002) Bristol Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12372521 21 Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.EBI Bioorg Med Chem Lett 12: 3149-52 (2002) Schering-Plough Research Institute 2D 3D TSV
12372520 37 Synthesis and biological activity of retinoic acid receptor-alpha specific amides.EBI Bioorg Med Chem Lett 12: 3145-8 (2002) Allergan Inc. 2D 3D TSV
12372519 22 Synthesis and structure--activity relationship of novel aminotetralin derivatives with high micro selective opioid affinity.EBI Bioorg Med Chem Lett 12: 3141-3 (2002) Shire Biochem 2D 3D TSV
12372517 92 Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.EBI Bioorg Med Chem Lett 12: 3129-33 (2002) Celera 2D 3D TSV
12372516 14 A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.EBI Bioorg Med Chem Lett 12: 3125-8 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12372513 102 Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.EBI Bioorg Med Chem Lett 12: 3111-5 (2002) Neurogen Corporation 2D 3D TSV
12372512 239 Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.EBI Bioorg Med Chem Lett 12: 3105-9 (2002) Neurogen Corporation 2D 3D TSV
12372510 28 Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.EBI Bioorg Med Chem Lett 12: 3097-9 (2002) EGIS Pharmaceuticals Ltd. 2D 3D TSV
12372508 20 Hydroxamate based inhibitors of adenylyl cyclase. Part 2: the effect of cyclic linkers on P-site binding.EBI Bioorg Med Chem Lett 12: 3089-92 (2002) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12372507 30 Hydroxamate based inhibitors of adenylyl cyclase. Part 1: the effect of acyclic linkers on P-site binding.EBI Bioorg Med Chem Lett 12: 3085-8 (2002) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12372506 41 Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.EBI Bioorg Med Chem Lett 12: 3081-4 (2002) Johnson and Johnson Pharmaceutical Research and Development 2D 3D TSV
12372505 120 Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.EBI Bioorg Med Chem Lett 12: 3077-9 (2002) Neuroscience-Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA. 2D 3D TSV
12372504 15 Parallel solution- and solid-phase synthesis of spiropyrrolo-pyrroles as novel neurokinin receptor ligands.EBI Bioorg Med Chem Lett 12: 3073-6 (2002) F. Hoffmann-La Roche AG, Pharma Research, CH-4070, Basel, Switzerland. konrad.bleicher@roche.com 2D 3D TSV
12372503 76 bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.EBI Bioorg Med Chem Lett 12: 3067-71 (2002) University of Kentucky 2D 3D TSV
12372501 21 Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.EBI Bioorg Med Chem Lett 12: 3059-62 (2002) Novartis Institute for Biomedical Research 2D 3D TSV
12372500 108 Synthesis and evaluation of potent pyrrolidine H(3) antagonists.EBI Bioorg Med Chem Lett 12: 3055-8 (2002) Abbott Laboratories 2D 3D TSV
12372498 23 alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.EBI Bioorg Med Chem Lett 12: 3047-50 (2002) The Ohio State University 2D 3D TSV
12372497 40 Structure-Activity relationships of 2-substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids as a novel class of endothelin receptor antagonists.EBI Bioorg Med Chem Lett 12: 3041-5 (2002) Tsukuba Research Institute 2D 3D TSV
12371880 66 Solvent and guest isotope effects on complexation thermodynamics of alpha-, beta-, and 6-amino-6-deoxy-beta-cyclodextrins.BDB J Am Chem Soc 124: 12361-71 (2002) Japan Science and Technology Agency 2D 3D TSV
12365460 11 2-styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study.BDB J Enzyme Inhib Med Chem 17: 45-8 (2002) University of Porto-Rua Anibal Cunha 2D 3D TSV
12362366 50 Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.BDB Chembiochem 3: 999-1009 (2002) Aventis Pharmaceuticals 2D 3D TSV
12361407 4 Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.EBI J Med Chem 45: 4794-8 (2002) Université de Lille 2 2D 3D TSV
12361405 1 Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.EBI J Med Chem 45: 4774-85 (2002) Purdue University 2D 3D TSV
12361403 6 Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues.EBI J Med Chem 45: 4755-61 (2002) Research Triangle Institute 2D 3D TSV
12361401 60 Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists.EBI J Med Chem 45: 4737-47 (2002) Salk Institute 2D 3D TSV
12361399 17 Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.EBI J Med Chem 45: 4724-31 (2002) Universita di Camerino 2D 3D TSV
12361398 19 New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).EBI J Med Chem 45: 4716-23 (2002) University of Pennsylvania 2D 3D TSV
12361396 15 Imidazole inhibitors of cytokine release: probing substituents in the 2 position.EBI J Med Chem 45: 4695-705 (2002) Eberhard-Karls-University Tübingen 2D 3D TSV
12361393 24 Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.EBI J Med Chem 45: 4669-78 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12361392 62 Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.EBI J Med Chem 45: 4655-68 (2002) Universit£ degli Studi di Sassari 2D 3D TSV
12361388 47 Cyclosporins: structure-activity relationships for the inhibition of the human FPR1 formylpeptide receptor.EBI J Med Chem 45: 4613-28 (2002) Strasbourg 1 University 2D 3D TSV
12361387 59 Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.EBI J Med Chem 45: 4598-612 (2002) Strasbourg 1 University 2D 3D TSV
12361386 113 Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.EBI J Med Chem 45: 4594-7 (2002) Friedrich-Alexander University 2D 3D TSV
12361385 34 Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.EBI J Med Chem 45: 4589-93 (2002) Merck & Co. 2D 3D TSV
12358520 27 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.BDB J Am Chem Soc 124: 11852-3 (2002) Millennium Pharmaceuticals 2D 3D TSV
12270195 15 Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.EBI Bioorg Med Chem Lett 12: 3009-13 (2002) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12270193 23 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.EBI Bioorg Med Chem Lett 12: 3001-4 (2002) Merck Research Laboratories 2D 3D TSV
12270192 15 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.EBI Bioorg Med Chem Lett 12: 2997-3000 (2002) Merck Research Laboratories 2D 3D TSV
12270191 36 General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain.EBI Bioorg Med Chem Lett 12: 2993-6 (2002) University of California 2D 3D TSV
12270190 18 Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors.BDB Bioorg Med Chem Lett 12: 2989-92 (2002) Wyeth Research 2D 3D TSV
12270187 12 Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as K(ATP) channel agonists.EBI Bioorg Med Chem Lett 12: 2977-80 (2002) GlaxoSmithKline Research and Development 2D 3D TSV
12270186 99 Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.EBI Bioorg Med Chem Lett 12: 2973-5 (2002) Idun Pharmaceuticals, Inc. 2D 3D TSV
12270185 257 Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.EBI Bioorg Med Chem Lett 12: 2969-71 (2002) Idun Pharmaceuticals, Inc. 2D 3D TSV
12270184 34 Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines.EBI Bioorg Med Chem Lett 12: 2963-7 (2002) Wyeth Research 2D 3D TSV
12270183 45 Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines.EBI Bioorg Med Chem Lett 12: 2957-61 (2002) Wyeth Research 2D 3D TSV
12270180 2 Successful bridging from a peptide to a non peptide antagonist at the human tachykinin NK-2 receptor.EBI Bioorg Med Chem Lett 12: 2945-8 (2002) Menarini Ricerche S.p.A. 2D 3D TSV
12270178 74 Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.EBI Bioorg Med Chem Lett 12: 2935-9 (2002) CV Therapeutics 2D 3D TSV
12270177 23 Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.EBI Bioorg Med Chem Lett 12: 2931-4 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12270176 41 Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates.EBI Bioorg Med Chem Lett 12: 2925-30 (2002) Department of Medicinal Chemistry, Corvas International, Inc., 3030 Science Park Road, San Diego, CA 92121, USA. 2D 3D TSV
12270175 13 Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).EBI Bioorg Med Chem Lett 12: 2919-23 (2002) Cancer Research Area, Abbott Laboratories, Dept. 47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mike.curtin@abbott.com 2D 3D TSV
12270174 34 Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.EBI Bioorg Med Chem Lett 12: 2913-7 (2002) Genentech 2D 3D TSV
12270173 23 Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones.EBI Bioorg Med Chem Lett 12: 2907-11 (2002) Universit£ de Montr£al 2D 3D TSV
12270171 14 Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents.EBI Bioorg Med Chem Lett 12: 2893-7 (2002) Wyeth Research 2D 3D TSV
12270170 42 Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors.EBI Bioorg Med Chem Lett 12: 2887-91 (2002) Celera 2D 3D TSV
12270169 13 Albumin affinity tags increase peptide half-life in vivo.EBI Bioorg Med Chem Lett 12: 2883-6 (2002) Genentech 2D 3D TSV
12270168 40 Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.EBI Bioorg Med Chem Lett 12: 2879-82 (2002) Bristol-Myers Squibb PRI 2D 3D TSV
12270167 43 Solid-phase synthesis and investigation of benzofurans as selective estrogen receptor modulators.EBI Bioorg Med Chem Lett 12: 2875-8 (2002) Bayer Research Center 2D 3D TSV
12270166 8 Synthesis and muscarinic M2 subtype antagonistic activity of unnatural ent-himbacine and an enantiomeric pair of (2'S,6'R)-diepihimbacine.EBI Bioorg Med Chem Lett 12: 2871-3 (2002) Kyorin Pharmaceutical Company Ltd. 2D 3D TSV
12270165 80 Benzodiazepine inhibitors of the MMPs and TACE.EBI Bioorg Med Chem Lett 12: 2867-70 (2002) Wyeth Research 2D 3D TSV
12270163 5 Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.EBI Bioorg Med Chem Lett 12: 2859-61 (2002) UPRES EA 1085 2D 3D TSV
12270162 4 Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.EBI Bioorg Med Chem Lett 12: 2855-8 (2002) Merck Research Laboratories 2D 3D TSV
12270156 8 Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.EBI Bioorg Med Chem Lett 12: 2829-31 (2002) Cephalon, Inc. 2D 3D TSV
12270155 56 Development of potent and selective dipeptidyl peptidase II inhibitors.EBI Bioorg Med Chem Lett 12: 2825-8 (2002) University of Antwerp (UIA) 2D 3D TSV
12270152 24 Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-alpha-DL-fucopyranosylamine.EBI Bioorg Med Chem Lett 12: 2811-4 (2002) Keio University 2D 3D TSV
12244092 12 Structural basis for Chk1 inhibition by UCN-01.BDB J Biol Chem 277: 46609-15 (2002) GlaxoSmithKline 2D 3D TSV
12240953 8 Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).EBI Pharm Res 19: 1244-7 (2002) University of California 2D 3D TSV
12238937 13 Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.EBI J Med Chem 45: 4581-4 (2002) University of Kuopio 2D 3D TSV
12238936 17 Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.EBI J Med Chem 45: 4571-80 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12238935 1 4-Substituted D-glutamic acid analogues: the first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activity.EBI J Med Chem 45: 4559-70 (2002) Eli Lilly and Co. 2D 3D TSV
12238932 5 Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues.EBI J Med Chem 45: 4531-9 (2002) Northwestern University 2D 3D TSV
12238930 94 Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.EBI J Med Chem 45: 4513-23 (2002) Kyowa Hakko Kogyo Co., Ltd. 2D 3D TSV
12238929 2 Enhancement of nucleoside cytotoxicity through nucleotide prodrugs.EBI J Med Chem 45: 4505-12 (2002) Southern Research Institute 2D 3D TSV
12238926 99 Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.EBI J Med Chem 45: 4471-84 (2002) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
12238924 145 Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.EBI J Med Chem 45: 4443-59 (2002) Novo Nordisk A/S 2D 3D TSV
12238922 28 Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.EBI J Med Chem 45: 4419-32 (2002) Research and Development 2D 3D TSV
12238919 19 A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol.EBI J Med Chem 45: 4398-401 (2002) Pfizer Global Research and Development 2D 3D TSV
12238918 22 N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.EBI J Med Chem 45: 4395-7 (2002) Abbott Laboratories 2D 3D TSV
12238915 18 Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.EBI J Med Chem 45: 4383-6 (2002) Lilly Research Laboratories 2D 3D TSV
12238914 48 6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.EBI J Med Chem 45: 4379-82 (2002) Women's Health Research Institute 2D 3D TSV
12237342 2 High affinity antagonists of the vanilloid receptor.BDB Mol Pharmacol 62: 947-56 (2002) National Cancer Institute 2D 3D TSV
12237339 2 Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1.EBI Mol Pharmacol 62: 921-6 (2002) University of Rochester School of Medicine 2D 3D TSV
12235229 26 Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist.BDB J Pharmacol Exp Ther 303: 29-35 (2002) University of Arkansas 2D 3D TSV
12232544 79 [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine].BDB Encephale 28: 350-5 Emory University 2D 3D TSV
12223444 6 A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.BDB FASEB J 16: 1829-31 (2002) CHUL 2D 3D TSV
12217375 6 Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.EBI Bioorg Med Chem Lett 12: 2781-4 (2002) National Institutes of Health 2D 3D TSV
12217372 23 Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.BDB Bioorg Med Chem Lett 12: 2767-70 (2002) Merck Research Laboratories 2D 3D TSV
12217371 12 8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitors.BDB Bioorg Med Chem Lett 12: 2011-4 (2002) Wyeth-Ayerst Research 2D 3D TSV
12217369 16 Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 12: 2753-6 (2002) University of Alberta 2D 3D TSV
12217362 10 Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.EBI Bioorg Med Chem Lett 12: 2719-22 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
12217360 27 Design and characterization of non-phosphopeptide inhibitors for Src family SH2 domains.EBI Bioorg Med Chem Lett 12: 2711-4 (2002) Mogam Biotechnology Research Institute 2D 3D TSV
12217358 31 Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part.EBI Bioorg Med Chem Lett 12: 2703-5 (2002) University of Antwerp (UIA) 2D 3D TSV
12217356 6 Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.EBI Bioorg Med Chem Lett 12: 2695-8 (2002) Ghent University 2D 3D TSV
12217355 39 Analogue based design of MMP-13 (Collagenase-3) inhibitors.EBI Bioorg Med Chem Lett 12: 2689-93 (2002) gvk bioSciences Pvt. Ltd. 2D 3D TSV
12217351 135 Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.BDB Bioorg Med Chem Lett 12: 2667-72 (2002) Universita degli Studi di Firenze 2D 3D TSV
12213078 31 Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.EBI J Med Chem 45: 4371-4 (2002) NIDDK 2D 3D TSV
12213077 18 Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.EBI J Med Chem 45: 4359-70 (2002) Duke University 2D 3D TSV
12213075 70 Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).EBI J Med Chem 45: 4344-9 (2002) Purdue University 2D 3D TSV
12213072 29 2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.EBI J Med Chem 45: 4310-20 (2002) Novartis Research Institute Vienna 2D 3D TSV
12213069 33 Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).EBI J Med Chem 45: 4276-81 (2002) Universita' degli Studi di Siena 2D 3D TSV
12213067 10 N-[(2-Sulfo)-9-fluorenylmethoxycarbonyl](3)-gentamicin C(1) is a long-acting prodrug derivative.EBI J Med Chem 45: 4264-70 (2002) Institute of Science 2D 3D TSV
12213066 41 Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.EBI J Med Chem 45: 4254-63 (2002) Instituto de Qu£mica M£dica (CSIC) 2D 3D TSV
12213064 33 Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.EBI J Med Chem 45: 4240-5 (2002) The Royal Danish School of Pharmacy 2D 3D TSV
12213063 4 Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.EBI J Med Chem 45: 4222-39 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12213062 70 Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists.EBI J Med Chem 45: 4212-21 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12213061 23 Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.EBI J Med Chem 45: 4202-11 (2002) University of Gda£?sk 2D 3D TSV
12213059 26 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.EBI J Med Chem 45: 4171-87 (2002) Novo Nordisk Research and Development 2D 3D TSV
12213056 42 Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.EBI J Med Chem 45: 4128-39 (2002) Universidad de Navarra 2D 3D TSV
12213055 71 Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter.EBI J Med Chem 45: 4119-27 (2002) National Institute on Drug Abuse-Intramural Research Program/NIH 2D 3D TSV
12213054 38 Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI J Med Chem 45: 4110-8 (2002) Drew University 2D 3D TSV
12213053 117 Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI J Med Chem 45: 4097-109 (2002) Drew University 2D 3D TSV
12213052 15 Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction.EBI J Med Chem 45: 4094-6 (2002) Johnson& Johnson Pharmaceutical Research& Development 2D 3D TSV
12213051 207 Purine and pyrimidine (P2) receptors as drug targets.EBI J Med Chem 45: 4057-93 (2002) National Institute of Diabetes 2D 3D TSV
12210991 24 Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.BDB Chembiochem 3: 897-901 (2002) New York University 2D 3D TSV
12206858 11 SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.BDB Eur J Pharmacol 450: 191-202 (2002) Schering-Plough Research Institute 2D 3D TSV
12204688 18 A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors.BDB Chem Biol 9: 891-6 (2002) The Scripps Research Institute 2D 3D TSV
12196020 3 X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.BDB Biochemistry 41: 10810-8 (2002) Weizmann Institute of Science 2D 3D TSV
12193020 9 New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.EBI J Nat Prod 65: 1151-5 (2002) Kyoto Pharmaceutical University 2D 3D TSV
12193019 2 Naturally occurring cembranes from an Australian sarcophyton species.EBI J Nat Prod 65: 1147-50 (2002) AstraZeneca R&D Griffith University 2D 3D TSV
12192085 52 Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.BDB Proc Natl Acad Sci U S A 99: 11934-9 (2002) Case Western Reserve University 2D 3D TSV
12190325 13 Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.EBI J Med Chem 45: 4038-46 (2002) Columbia University 2D 3D TSV
12190324 15 Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.EBI J Med Chem 45: 4029-37 (2002) Research Triangle Institute 2D 3D TSV
12190321 55 Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties.EBI J Med Chem 45: 4000-10 (2002) Freie Universit£t Berlin 2D 3D TSV
12190319 15 Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.EBI J Med Chem 45: 3972-83 (2002) AstraZeneca Pharmaceuticals LP 2D 3D TSV
12190316 15 Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.EBI J Med Chem 45: 3946-52 (2002) Brown University 2D 3D TSV
12190315 43 Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach.EBI J Med Chem 45: 3934-45 (2002) Instituto de Qu£mica M£dica (C.S.I.C.) 2D 3D TSV
12190314 15 Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18.EBI J Med Chem 45: 3928-33 (2002) D�partement d'Ing�nierie et d'Etudes des Prot�ines 2D 3D TSV
12190313 94 Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.BDB J Med Chem 45: 3905-27 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12190312 67 Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.EBI J Med Chem 45: 3891-904 (2002) Pharmacia 2D 3D TSV
12190311 37 Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).EBI J Med Chem 45: 3878-90 (2002) GSK 2D 3D TSV
12190310 27 Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography.EBI J Med Chem 45: 3865-77 (2002) Pfizer Central Research 2D 3D TSV
12190309 14 Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.EBI J Med Chem 45: 3854-64 (2002) Schering-Plough Research Institute 2D 3D TSV
12190308 36 Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.EBI J Med Chem 45: 3844-53 (2002) University of Bologna 2D 3D TSV
12190306 14 Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.EBI J Med Chem 45: 3829-35 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12190304 10 Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.EBI J Med Chem 45: 3820-3 (2002) University of Maryland 2D 3D TSV
12190302 9 Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.EBI J Med Chem 45: 3813-5 (2002) Biovitrum 2D 3D TSV
12183686 38 Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.BDB J Pharmacol Exp Ther 302: 1246-52 (2002) University of Miami 2D 3D TSV
12182878 12 The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors.EBI Bioorg Med Chem Lett 12: 2643-6 (2002) The Schering Plough Research Institute 2D 3D TSV
12182871 3 Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.EBI Bioorg Med Chem Lett 12: 2607-9 (2002) Universidade de Vigo 2D 3D TSV
12182870 54 The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.EBI Bioorg Med Chem Lett 12: 2603-6 (2002) GlaxoSmithKline 2D 3D TSV
12182866 83 8-Aryl xanthines potent inhibitors of phosphodiesterase 5.EBI Bioorg Med Chem Lett 12: 2587-90 (2002) Novartis Horsham Research Centre 2D 3D TSV
12182865 88 Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.EBI Bioorg Med Chem Lett 12: 2583-6 (2002) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
12182862 56 Novel piperidinium and pyridinium agents as water-soluble acetylcholinesterase inhibitors for the reversal of neuromuscular blockade.EBI Bioorg Med Chem Lett 12: 2569-72 (2002) Organon Laboratories Ltd. 2D 3D TSV
12182861 37 Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Bioorg Med Chem Lett 12: 2565-8 (2002) Organon Laboratories Ltd. 2D 3D TSV
12182860 72 Dihydroquinolines as novel n-NOS inhibitors.EBI Bioorg Med Chem Lett 12: 2561-4 (2002) Schering AG 2D 3D TSV
12182858 11 Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group.EBI Bioorg Med Chem Lett 12: 2553-6 (2002) University of Antwerp (UIA) 2D 3D TSV
12182857 5 Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: new selective ligands of the 5-HT(7) receptor.BDB Bioorg Med Chem Lett 12: 2549-52 (2002) Meiji Seika Kaisha, Ltd. 2D 3D TSV
12182856 18 Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.EBI Bioorg Med Chem Lett 12: 2545-8 (2002) AtheroGenics, Inc. 2D 3D TSV
12182854 45 A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold.EBI Bioorg Med Chem Lett 12: 2535-9 (2002) Universit£ Libre de Bruxelles 2D 3D TSV
12182851 15 Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands.EBI Bioorg Med Chem Lett 12: 2519-22 (2002) F. Hoffmann-La Roche AG, Pharma Research, CH-4070, Basel, Switzerland. konrad.bleicher@roche.com 2D 3D TSV
12182850 19 Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.EBI Bioorg Med Chem Lett 12: 2515-8 (2002) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
12182847 12 Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-site: structural variants of the C-terminal Phe.EBI Bioorg Med Chem Lett 12: 2501-5 (2002) University of Nottingham 2D 3D TSV
12176106 20 A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.BDB Eur J Pharmacol 450: 37-41 (2002) Aventis Pharmaceuticals, Inc. 2D 3D TSV
12176030 12 Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.EBI Biochem Biophys Res Commun 296: 644-50 (2002) Kyushu University 2D 3D TSV
12166952 6 Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide.EBI J Med Chem 45: 3805-8 (2002) Otsuka Pharmaceutical Company 2D 3D TSV
12166951 146 Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.EBI J Med Chem 45: 3794-804 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12166950 208 Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.EBI J Med Chem 45: 3772-93 (2002) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12166947 30 Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.EBI J Med Chem 45: 3746-54 (2002) University of California 2D 3D TSV
12166944 48 Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.EBI J Med Chem 45: 3709-20 (2002) Utrecht University 2D 3D TSV
12166943 81 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI J Med Chem 45: 3703-8 (2002) Nutrition Research Institute 2D 3D TSV
12166942 4 The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.EBI J Med Chem 45: 3692-702 (2002) Institute of Cancer Research 2D 3D TSV
12166941 42 Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.BDB J Med Chem 45: 3684-91 (2002) National Institutes of Health 2D 3D TSV
12166939 6 (+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist.EBI J Med Chem 45: 3660-8 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12166938 8 Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.EBI J Med Chem 45: 3649-59 (2002) Kennesaw State University 2D 3D TSV
12166937 26 Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.EBI J Med Chem 45: 3639-48 (2002) Abbott Laboratories 2D 3D TSV
12166933 24 Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.EBI J Med Chem 45: 3603-11 (2002) Università di Pisa 2D 3D TSV
12166932 14 Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.BDB J Med Chem 45: 3588-602 (2002) University of Marburg 2D 3D TSV
12166931 13 Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.EBI J Med Chem 45: 3583-7 (2002) Universit£ degli Studi di Firenze 2D 3D TSV
12166930 21 Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI J Med Chem 45: 3579-82 (2002) TBA 2D 3D TSV
12166927 6 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.EBI J Med Chem 45: 3569-72 (2002) TBA 2D 3D TSV
12161164 14 Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.EBI Bioorg Med Chem Lett 12: 2487-90 (2002) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
12161162 69 N-Aroyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 2479-82 (2002) Hoffmann-La Roche Inc. 2D 3D TSV
12161161 94 N-Cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 2475-8 (2002) Roche Research Center 2D 3D TSV
12161160 15 Investigation of the PDZ domain ligand binding site using chemically modified peptides.EBI Bioorg Med Chem Lett 12: 2471-4 (2002) University of California 2D 3D TSV
12161158 11 Non-peptide alpha(v)beta(3) antagonists. Part 4: potent and orally bioavailable chain-shortened RGD mimetics.EBI Bioorg Med Chem Lett 12: 2463-5 (2002) Merck Research Laboratories 2D 3D TSV
12161155 33 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.EBI Bioorg Med Chem Lett 12: 2451-4 (2002) NPS Pharmaceuticals Inc. 2D 3D TSV
12161154 11 An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.EBI Bioorg Med Chem Lett 12: 2447-50 (2002) The Ohio State University 2D 3D TSV
12161153 39 Arylpiperazine substituted heterocycles as selective alpha(1a) adrenergic antagonists.EBI Bioorg Med Chem Lett 12: 2443-6 (2002) Johnson & Johnson Pharmaceutical Research and Development LLC 2D 3D TSV
12161148 17 Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.EBI Bioorg Med Chem Lett 12: 2423-6 (2002) Merck Research Laboratories 2D 3D TSV
12161147 5 Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.EBI Bioorg Med Chem Lett 12: 2419-22 (2002) Merck Research Laboratories 2D 3D TSV
12161144 23 Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitution.EBI Bioorg Med Chem Lett 12: 2407-10 (2002) Roche Research Center 2D 3D TSV
12161142 34 C-3 Amido-indole cannabinoid receptor modulators.EBI Bioorg Med Chem Lett 12: 2399-402 (2002) Bristol-Myers Squibb 2D 3D TSV
12161140 12 Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.EBI Bioorg Med Chem Lett 12: 2391-4 (2002) Kingston University 2D 3D TSV
12161139 11 Synthesis and dopamine transporter binding affinities of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes.EBI Bioorg Med Chem Lett 12: 2387-90 (2002) University of New Orleans 2D 3D TSV
12161137 39 Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.EBI Bioorg Med Chem Lett 12: 2377-80 (2002) Friedrich-Alexander University 2D 3D TSV
12161135 17 Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines.EBI Bioorg Med Chem Lett 12: 2367-70 (2002) Xenova Ltd. 2D 3D TSV
12161132 102 Preparation of oxime dual NK(1)/NK(2) antagonists with reduced NK(3) affinity.EBI Bioorg Med Chem Lett 12: 2355-8 (2002) Schering-Plough Research Institute 2D 3D TSV
12161131 1 Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.EBI Bioorg Med Chem Lett 12: 2349-53 (2002) Minase Research Institute 2D 3D TSV
12161128 35 Synthesis of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid derivatives: new leads as selective beta-galactosidase inhibitors.EBI Bioorg Med Chem Lett 12: 2335-9 (2002) Universidad de Sevilla 2D 3D TSV
12161123 13 A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.EBI Bioorg Med Chem Lett 12: 2313-6 (2002) Korea Institute of Science& Technology 2D 3D TSV
12161118 28 Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.EBI Bioorg Med Chem Lett 12: 2291-4 (2002) Fukui Research Institute 2D 3D TSV
12161117 2 3-Pyrroline containing arylacetamides: a novel series of remarkably selective kappa-agonists.EBI Bioorg Med Chem Lett 12: 2287-90 (2002) Chinese Academy of Sciences 2D 3D TSV
12161114 64 3D-QSAR studies on 4-hydroxyphenylpyruvate dioxygenase inhibitors by comparative molecular field analysis (CoMFA).EBI Bioorg Med Chem Lett 12: 2271-5 (2002) Zhejiang University 2D 3D TSV
12161113 8 L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models.EBI Bioorg Med Chem Lett 12: 2267-9 (2002) Minase Research Institute 2D 3D TSV
12161112 14 Design, synthesis and biological activity of carbohydrate-containing peptidomimetics as new ligands for the human tachykinin NK-2 receptor.EBI Bioorg Med Chem Lett 12: 2263-6 (2002) Universita' di Firenze 2D 3D TSV
12144928 11 Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase.BDB Chem Biol 9: 839-47 (2002) Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique 2D 3D TSV
12141869 2 Agonodepsides a and B: two new depsides from a filamentous fungus F7524.EBI J Nat Prod 65: 1037-8 (2002) Institute of Molecular and Cell Biology 2D 3D TSV
12141863 1 Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis.EBI J Nat Prod 65: 1016-20 (2002) Chinese Academy of Sciences 2D 3D TSV
12139467 17 Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands.BDB J Med Chem 45: 3558-68 (2002) Guilford Pharmaceuticals, Inc. 2D 3D TSV
12139466 11 Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.EBI J Med Chem 45: 3549-57 (2002) Guilford Pharmaceuticals, Inc. 2D 3D TSV
12139463 24 Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.EBI J Med Chem 45: 3524-30 (2002) Research Triangle Institute 2D 3D TSV
12139462 34 Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.EBI J Med Chem 45: 3509-23 (2002) AstraZeneca 2D 3D TSV
12139459 74 Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.EBI J Med Chem 45: 3482-90 (2002) Pfizer Inc. 2D 3D TSV
12139455 78 Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.EBI J Med Chem 45: 3451-7 (2002) Genentech Inc. 2D 3D TSV
12139454 56 Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.EBI J Med Chem 45: 3440-50 (2002) University of Bonn 2D 3D TSV
12139451 41 Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.EBI J Med Chem 45: 3406-17 (2002) Saarland University 2D 3D TSV
12139450 29 Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.EBI J Med Chem 45: 3394-405 (2002) Boehringer Ingelheim Pharmaceuticals Inc. 2D 3D TSV
12139449 114 Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.BDB J Med Chem 45: 3381-93 (2002) University of Newcastle 2D 3D TSV
12139447 6 (4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding mode.EBI J Med Chem 45: 3356-65 (2002) Free University of Berlin 2D 3D TSV
12139445 36 Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.EBI J Med Chem 45: 3337-44 (2002) Instituto de Química Médica (CSIC) 2D 3D TSV
12134946 6 Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?EBI Pharm Res 19: 773-9 (2002) The University of Kansas 2D 3D TSV
12134945 9 Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?EBI Pharm Res 19: 765-72 (2002) The University of Kansas 2D 3D TSV
12130738 11 SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties.BDB J Pharmacol Exp Ther 302: 731-41 (2002) Sanofi-Synthelabo Recherche 2D 3D TSV
12130733 17 Reboxetine: functional inhibition of monoamine transporters and nicotinic acetylcholine receptors.BDB J Pharmacol Exp Ther 302: 687-95 (2002) University of Kentucky 2D 3D TSV
12130730 8 Characterization of methotrexate transport and its drug interactions with human organic anion transporters.EBI J Pharmacol Exp Ther 302: 666-71 (2002) Kyorin University School of Medicine 2D 3D TSV
12130727 2 Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.EBI J Pharmacol Exp Ther 302: 645-50 (2002) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology 2D 3D TSV
12127545 4 Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.EBI Bioorg Med Chem Lett 12: 2233-6 (2002) The University of Iowa 2D 3D TSV
12127543 26 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.EBI Bioorg Med Chem Lett 12: 2225-8 (2002) Southern Research Institute 2D 3D TSV
12127538 26 N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.EBI Bioorg Med Chem Lett 12: 2205-8 (2002) Merck Research Laboratories 2D 3D TSV
12127537 16 Design and synthesis of novel inhibitors of gelatinase B.EBI Bioorg Med Chem Lett 12: 2201-4 (2002) University of California 2D 3D TSV
12127536 22 Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.EBI Bioorg Med Chem Lett 12: 2197-200 (2002) Merck Research Laboratories 2D 3D TSV
12127534 8 Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II.EBI Bioorg Med Chem Lett 12: 2189-92 (2002) Guilford Pharmaceuticals Inc. 2D 3D TSV
12127533 23 Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 2185-7 (2002) Neurocrine Biosciences, Inc. 2D 3D TSV
12127532 22 Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 2179-83 (2002) Neurocrine Biosciences, Inc. 2D 3D TSV
12127526 75 Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases.BDB Bioorg Med Chem Lett 12: 2153-7 (2002) SUGEN, Inc. 2D 3D TSV
12127524 39 Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.EBI Bioorg Med Chem Lett 12: 2145-8 (2002) Johnson & Johnson Pharmaceutical Research and Development LLC 2D 3D TSV
12127523 22 N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 2141-4 (2002) Merck Research Laboratories 2D 3D TSV
12127522 30 Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.EBI Bioorg Med Chem Lett 12: 2137-40 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
12127521 33 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.EBI Bioorg Med Chem Lett 12: 2133-6 (2002) Neurogen Corporation 2D 3D TSV
12127519 40 Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.EBI Bioorg Med Chem Lett 12: 2125-8 (2002) The Schering Plough Research Institute 2D 3D TSV
12127518 23 The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.EBI Bioorg Med Chem Lett 12: 2121-3 (2002) Abbott Laboratories 2D 3D TSV
12127516 41 Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.EBI Bioorg Med Chem Lett 12: 2113-6 (2002) Abbott GmbH & Co. KG 2D 3D TSV
12127515 29 SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.EBI Bioorg Med Chem Lett 12: 2109-12 (2002) Novartis Pharma AG 2D 3D TSV
12127511 13 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase.EBI Bioorg Med Chem Lett 12: 2093-5 (2002) NOVARTIS Research Institute 2D 3D TSV
12127510 2 Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.EBI Bioorg Med Chem Lett 12: 2089-92 (2002) Kyoto University 2D 3D TSV
12127507 11 A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones.EBI Bioorg Med Chem Lett 12: 2073-7 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12127505 28 Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.EBI Bioorg Med Chem Lett 12: 2065-8 (2002) Novartis Pharma AG 2D 3D TSV
12113838 36 Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification.EBI Bioorg Med Chem Lett 12: 2043-6 (2002) Millennium Pharmaceuticals, Inc. 2D 3D TSV
12113836 162 Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.EBI Bioorg Med Chem Lett 12: 2035-7 (2002) Abbott Laboratories 2D 3D TSV
12113835 176 Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1.EBI Bioorg Med Chem Lett 12: 2031-4 (2002) Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA. ramin.faghih@abbott.com 2D 3D TSV
12113834 64 The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.EBI Bioorg Med Chem Lett 12: 2027-30 (2002) Merck Research Laboratories 2D 3D TSV
12113833 183 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.EBI Bioorg Med Chem Lett 12: 2023-6 (2002) Celera 2D 3D TSV
12113832 120 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.EBI Bioorg Med Chem Lett 12: 2019-22 (2002) Celera 2D 3D TSV
12113830 13 Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.BDB Bioorg Med Chem Lett 12: 2011-4 (2002) Wyeth Research 2D 3D TSV
12113828 63 N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.EBI Bioorg Med Chem Lett 12: 2001-5 (2002) INSERM 2D 3D TSV
12113827 7 Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity.EBI Bioorg Med Chem Lett 12: 1997-9 (2002) Purdue University 2D 3D TSV
12113826 23 Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy.BDB Bioorg Med Chem Lett 12: 1993-6 (2002) University of Illinois at Chicago 2D 3D TSV
12113820 4 Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.EBI Bioorg Med Chem Lett 12: 1967-71 (2002) Wyeth Research 2D 3D TSV
12113816 7 The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production.EBI Bioorg Med Chem Lett 12: 1951-4 (2002) Universidad de Valencia 2D 3D TSV
12113814 60 Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.EBI Bioorg Med Chem Lett 12: 1941-6 (2002) Korea Research Institute of Chemical Technology 2D 3D TSV
12113813 53 2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.EBI Bioorg Med Chem Lett 12: 1937-40 (2002) Friedrich-Alexander University 2D 3D TSV
12113810 20 Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.EBI Bioorg Med Chem Lett 12: 1925-8 (2002) Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. thonda@shina.sankyo.co.jp 2D 3D TSV
12113809 12 Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.EBI Bioorg Med Chem Lett 12: 1921-4 (2002) Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. thonda@shina.sankyo.co.jp 2D 3D TSV
12113806 40 Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.EBI Bioorg Med Chem Lett 12: 1909-12 (2002) Department of Organic Chemistry, Ghent University, Krijgslaan 281, Belgium. 2D 3D TSV
12110997 380 In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.BDB Psychopharmacology (Berl) 162: 193-202 (2002) Westfälische Wilhelms-Universitä Muenster, 2D 3D TSV
12110607 24 Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.EBI Br J Pharmacol 136: 829-36 (2002) University of Bonn 2D 3D TSV
12109915 5 Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres.EBI J Med Chem 45: 3321-4 (2002) Université de la Méditerranée 2D 3D TSV
12109914 24 Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.EBI J Med Chem 45: 3310-20 (2002) University of California 2D 3D TSV
12109913 25 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.EBI J Med Chem 45: 3296-309 (2002) Westfälische Wilhelms-Universität Münster 2D 3D TSV
12109912 9 Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.EBI J Med Chem 45: 3286-95 (2002) University of Bologna 2D 3D TSV
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI J Med Chem 45: 3280-5 (2002) University Center for Pharmacy 2D 3D TSV
12109910 8 N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.EBI J Med Chem 45: 3271-9 (2002) Universit£ di Camerino 2D 3D TSV
12109908 29 Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).BDB J Med Chem 45: 3246-56 (2002) GlaxoSmithKline 2D 3D TSV
12109907 8 Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.EBI J Med Chem 45: 3235-45 (2002) University of Bath 2D 3D TSV
12109906 9 Structure-based approach for binding site identification on AmpC beta-lactamase.EBI J Med Chem 45: 3222-34 (2002) Northwestern University 2D 3D TSV
12109905 54 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.EBI J Med Chem 45: 3210-21 (2002) University of Chicago Medical Center 2D 3D TSV
12109903 50 Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.EBI J Med Chem 45: 3184-94 (2002) National Cancer Institute/NIH 2D 3D TSV
12109902 15 Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.EBI J Med Chem 45: 3171-83 (2002) Parc Club Orsay Universit£ 2D 3D TSV
12109901 45 SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.EBI J Med Chem 45: 3161-70 (2002) Georgetown University Medical Center 2D 3D TSV
12093278 30 Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.BDB Biochemistry 41: 8613-9 (2002) The Johns Hopkins University 2D 3D TSV
12089149 1 Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.EBI J Biol Chem 277: 36262-71 (2002) Kyorin University 2D 3D TSV
12086500 59 Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.EBI J Med Chem 45: 3143-60 (2002) Schering-Plough Research Institute 2D 3D TSV
12086497 64 Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.EBI J Med Chem 45: 3112-29 (2002) Chiron Corporation 2D 3D TSV
12086493 120 Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.EBI J Med Chem 45: 3073-81 (2002) University of Florida 2D 3D TSV
12086491 116 Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives.EBI J Med Chem 45: 3057-66 (2002) Pharmaceutical Research Institute 2D 3D TSV
12086490 5 Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues.EBI J Med Chem 45: 3048-56 (2002) University of Missouri-Columbia 2D 3D TSV
12086487 28 Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.EBI J Med Chem 45: 3022-31 (2002) University of Groningen 2D 3D TSV
12086486 45 Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives.EBI J Med Chem 45: 3009-21 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
12086485 10 Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.EBI J Med Chem 45: 2994-3008 (2002) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
12086484 13 Identification of potent and novel alpha4beta1 antagonists using in silico screening.EBI J Med Chem 45: 2988-93 (2002) Biogen Inc. 2D 3D TSV
12086480 65 Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.EBI J Med Chem 45: 2923-41 (2002) Aventis Pharma 2D 3D TSV
12086479 11 Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis.EBI J Med Chem 45: 2915-22 (2002) Aventis Pharma 2D 3D TSV
12086475 1 Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties.EBI J Med Chem 45: 2887-90 (2002) University of Minnesota 2D 3D TSV
12085361 7 Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.EBI Hepatology 36: 164-72 (2002) University Hospital 2D 3D TSV
12067561 97 CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.EBI Bioorg Med Chem Lett 12: 1785-9 (2002) Bristol-Myers Squibb Company 2D 3D TSV
12067559 34 Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.EBI Bioorg Med Chem Lett 12: 1775-8 (2002) University of Michigan 2D 3D TSV
12067558 15 High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.EBI Bioorg Med Chem Lett 12: 1771-4 (2002) Lundbeck Research USA, Inc. 2D 3D TSV
12067557 24 Discovery of potent and selective small molecule NPY Y5 receptor antagonists.EBI Bioorg Med Chem Lett 12: 1767-9 (2002) Lundbeck Research USA, Inc. 2D 3D TSV
12067556 8 Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds.EBI Bioorg Med Chem Lett 12: 1763-6 (2002) University College Dublin 2D 3D TSV
12067555 31 4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II.EBI Bioorg Med Chem Lett 12: 1759-62 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
12067554 27 4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists I.EBI Bioorg Med Chem Lett 12: 1755-8 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
12067547 16 Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors.EBI Bioorg Med Chem Lett 12: 1727-30 (2002) F. Hoffmann-La Roche Ltd. 2D 3D TSV
12067545 22 Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.EBI Bioorg Med Chem Lett 12: 1719-22 (2002) GlaxoSmithKline Research and Development 2D 3D TSV
12067543 11 Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.EBI Bioorg Med Chem Lett 12: 1709-13 (2002) Tunghai University 2D 3D TSV
12065740 8 8-Carboxamidocyclazocine: a long-acting, novel benzomorphan.BDB J Pharmacol Exp Ther 302: 374-80 (2002) University of Rochester 2D 3D TSV
12065738 9 Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties.BDB J Pharmacol Exp Ther 302: 359-68 (2002) Bayer AG 2D 3D TSV
12065734 57 A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.BDB J Pharmacol Exp Ther 302: 328-36 (2002) University of North Carolina at Chapel Hill 2D 3D TSV
12065700 14 Biochemistry and pharmacology of epitope-tagged alpha(1)-adrenergic receptor subtypes.BDB J Pharmacol Exp Ther 302: 58-65 (2002) Emory University 2D 3D TSV
12065655 26 Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5.BDB J Neurochem 81: 462-71 (2002) Uppsala University 2D 3D TSV
12065583 3 Identification of a novel human eicosanoid receptor coupled to G(i/o).BDB J Biol Chem 277: 31459-65 (2002) Tanabe Seiyaku Co. Ltd. 2D 3D TSV
12063169 4 Role of human organic anion transporter 4 in the transport of ochratoxin A.EBI Biochim Biophys Acta 1590: 64-75 (2002) Kyorin University School of Medicine 2D 3D TSV
12061890 26 Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.EBI J Med Chem 45: 2877-85 (2002) MethylGene Inc. 2D 3D TSV
12061886 11 Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.EBI J Med Chem 45: 2841-9 (2002) National Institute on Drug Abuse 2D 3D TSV
12061885 22 Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.EBI J Med Chem 45: 2832-40 (2002) University of California 2D 3D TSV
12061882 83 Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.EBI J Med Chem 45: 2801-10 (2002) University of Florida 2D 3D TSV
12061881 94 Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.EBI J Med Chem 45: 2788-800 (2002) Institut de Chimie Pharmaceutique Albert Lespagnol 2D 3D TSV
12061878 100 Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.BDB J Med Chem 45: 2749-69 (2002) Aventis Pharma Deutschland GmbH 2D 3D TSV
12061874 60 Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).EBI J Med Chem 45: 2708-19 (2002) Research Triangle Institute 2D 3D TSV
12061873 79 Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.EBI J Med Chem 45: 2695-707 (2002) University of California-San Francisco 2D 3D TSV
12057671 16 Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.BDB Bioorg Med Chem 10: 2807-16 (2002) Purdue University 2D 3D TSV
12054506 26 The motilin pharmacophore in CHO cells expressing the human motilin receptor.BDB Biochem Biophys Res Commun 293: 1223-7 (2002) Katholieke Universiteit Leuven 2D 3D TSV
12044152 4 DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.BDB Biochemistry 41: 7217-23 (2002) UMR CNRS 6032 2D 3D TSV
12039591 63 Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck - a selectivity insight.BDB Bioorg Med Chem Lett 12: 1687-90 (2002) Abbott Bioresearch Center 2D