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2999408 11 Hybromet: a ligand for purifying opioid receptors.EBI J Med Chem 28: 1950-3 (1986) TBA 2D 3D TSV
2999402 192 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.EBI J Med Chem 28: 1817-28 (1986) TBA 2D 3D TSV
2999401 20 Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.EBI J Med Chem 28: 1766-71 (1986) TBA 2D 3D TSV
2999400 8 N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.EBI J Med Chem 28: 1756-9 (1986) TBA 2D 3D TSV
2999396 5 GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.EBI J Med Chem 28: 1612-7 (1985) TBA 2D 3D TSV
2999395 30 Angiotensin converting enzyme inhibitors: N-substituted D-glutamic acid gamma dipeptides.EBI J Med Chem 28: 1606-11 (1985) TBA 2D 3D TSV
2999394 21 Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.EBI J Med Chem 28: 1603-6 (1985) TBA 2D 3D TSV
2997628 56 Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985) TBA 2D 3D TSV
2995670 12 Angiotensin converting enzyme inhibitors: 1,5-benzothiazepine derivatives.EBI J Med Chem 28: 1517-21 (1985) TBA 2D 3D TSV
2995669 8 Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme.EBI J Med Chem 28: 1511-6 (1985) TBA 2D 3D TSV
2995665 3 Synthesis and activity of 5-(aminomethylene)-1,3-cyclohexanediones: enolic analogues of gamma-aminobutyric acid.EBI J Med Chem 28: 1440-6 (1985) TBA 2D 3D TSV
2995664 19 N alpha-(diphenoxyphosphoryl)-L-alanyl-L-proline, N alpha-[bis (4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline, and N alpha-[ (2-phenylethyl)phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature.EBI J Med Chem 28: 1422-7 (1985) TBA 2D 3D TSV
2995663 13 N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.EBI J Med Chem 28: 1383-4 (1985) TBA 2D 3D TSV
2993624 6 Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine.EBI J Med Chem 28: 1376-80 (1985) TBA 2D 3D TSV
2993623 19 Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.EBI J Med Chem 28: 1341-6 (1985) TBA 2D 3D TSV
2993622 18 Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.EBI J Med Chem 28: 1334-40 (1985) TBA 2D 3D TSV
2993621 34 Quantitative evaluation of the beta 2-adrenoceptor affinity of phenoxypropanolamines and phenylethanolamines.EBI J Med Chem 28: 1328-34 (1985) TBA 2D 3D TSV
2993618 19 Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.EBI J Med Chem 28: 1291-5 (1985) TBA 2D 3D TSV
2993614 21 Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.EBI J Med Chem 28: 1208-16 (1985) TBA 2D 3D TSV
2993610 3 Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists.EBI J Med Chem 28: 1145-7 (1985) TBA 2D 3D TSV
2991519 98 Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.EBI J Med Chem 28: 1071-9 (1985) TBA 2D 3D TSV
2991518 11 Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI J Med Chem 28: 1067-71 (1985) TBA 2D 3D TSV
2991517 4 Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI J Med Chem 28: 1062-6 (1985) TBA 2D 3D TSV
2990528 11 Displacement of DL-[3H]-2-amino-4-phosphonobutanoic acid ( [3H]APB) binding with methyl-substituted APB analogues and glutamate agonists.BDB Biochemistry 24: 2401-5 (1985) University of Minnesota 2D 3D TSV
2989522 2 Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.EBI J Med Chem 28: 904-10 (1985) TBA 2D 3D TSV
2989489 27 Sigma opioid receptor: characterization and co-identity with the phencyclidine receptor.BDB J Pharmacol Exp Ther 233: 597-602 (1985) Eli Lilly and Company 2D 3D TSV
2985785 3 Orally active and potent inhibitors of gamma-aminobutyric acid uptake.EBI J Med Chem 28: 653-60 (1985) TBA 2D 3D TSV
2985781 13 A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.EBI J Med Chem 28: 537-45 (1985) TBA 2D 3D TSV
2984420 49 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.EBI J Med Chem 28: 487-92 (1985) TBA 2D 3D TSV
2984419 21 Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.EBI J Med Chem 28: 434-42 (1985) TBA 2D 3D TSV
2983076 13 Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.EBI J Med Chem 28: 393-9 (1985) TBA 2D 3D TSV
2983075 24 Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids.EBI J Med Chem 28: 328-32 (1985) TBA 2D 3D TSV
2982020 1 N-[2-hydroxy-5-[2-(methylamino)ethyl]phenyl]methanesulfonamide. A potent agonist which releases intracellular calcium by activation of alpha 1-adrenoceptors.EBI J Med Chem 28: 245-8 (1985) TBA 2D 3D TSV
2981324 69 Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.EBI J Med Chem 28: 57-66 (1985) TBA 2D 3D TSV
2971798 9 [3H]SCH 23390 labels both dopamine-1 and 5-hydroxytryptamine1c receptors in the choroid plexus.BDB J Pharmacol Exp Ther 247: 343-8 (1988) University of Pennsylvania 2D 3D TSV
2970551 1 Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1] hept-2-exo-yl]heptenoic acid.EBI J Med Chem 31: 1847-54 (1988) Shionogi & Co., Ltd. 2D 3D TSV
2970550 9 Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.EBI J Med Chem 31: 1762-7 (1988) Smith Kline& French Laboratories 2D 3D TSV
2970277 11 Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine.BDB Brain Res 454: 78-88 (1988) Veterans Administration Medical Center 2D 3D TSV
2968456 2 Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity.EBI J Med Chem 31: 1466-71 (1988) CNS Line 2D 3D TSV
2968449 13 Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.BDB J Pharmacol Exp Ther 245: 786-92 (1988) Squibb Institute for Medical Research 2D 3D TSV
2967376 9 Central dopaminergic and 5-hydroxytryptaminergic effects of C3-methylated derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.EBI J Med Chem 31: 1130-40 (1988) University of Uppsala 2D 3D TSV
2966245 16 Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.EBI J Med Chem 31: 1039-43 (1988) University of Pennsylvania 2D 3D TSV
2965244 16 N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.EBI J Med Chem 31: 867-70 (1988) Virginia Commonwealth University 2D 3D TSV
2965243 4 Design, synthesis, and biological activity of a peptide mimic of vasopressin.EBI J Med Chem 31: 742-4 (1988) Smith Kline and French Laboratories 2D 3D TSV
2958621 15 Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.BDB J Pharmacol Exp Ther 242: 950-6 (1987) University of Pennsylvania 2D 3D TSV
2955118 18 Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.EBI J Med Chem 30: 1166-76 (1987) TBA 2D 3D TSV
2949077 7 (5Z)-7-(2,2-Dimethyl-4-phenyl-1,3-dioxan-cis-5-yl)heptenoi c acid: a specific thromboxane A2 receptor antagonist.EBI J Med Chem 30: 67-70 (1987) TBA 2D 3D TSV
2946863 4 Potent antagonists of vasopressin antidiuretic activity that lack the beta,beta-cyclopentamethylene-beta-mercaptopropionic acid substitution at position 1.EBI J Med Chem 29: 2425-6 (1987) TBA 2D 3D TSV
2940368 9 Potent vasopressin antagonists lacking the proline residue at position 7.EBI J Med Chem 29: 984-8 (1986) TBA 2D 3D TSV
2939243 8 Synthesis and biological properties of chitin synthetase inhibitors resistant to cellular peptidases.EBI J Med Chem 29: 802-9 (1986) TBA 2D 3D TSV
2933517 14 Novel vasopressin analogues that help define a minimum effective antagonist pharmacophore.EBI J Med Chem 28: 1759-60 (1986) TBA 2D 3D TSV
2931524 19 The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations.EBI J Med Chem 28: 1414-22 (1985) TBA 2D 3D TSV
2925675 15 A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis.BDB J Biol Chem 264: 4924-7 (1989) Nagoya University School of Medicine 2D 3D TSV
2918514 17 Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione.EBI J Med Chem 32: 651-8 (1989) Washington University School of Medicine 2D 3D TSV
2918500 23 Preparation and biodistribution of 1-[2-(3-[125I]iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl) phenyl]piperazine and 1-[2-(3-[125I]iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl] piperazine.EBI J Med Chem 32: 543-7 (1989) University of Pennsylvania 2D 3D TSV
2918498 18 Synthesis of gastrin antagonists, analogues of the C-terminal tetrapeptide of gastrin, by introduction of a beta-homo residue.EBI J Med Chem 32: 522-8 (1989) INSERM 2D 3D TSV
2918496 3 The 2-desamino and 2-desamino-2-methyl analogues of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture.EBI J Med Chem 32: 517-20 (1989) Harvard Medical School 2D 3D TSV
2913311 25 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication.EBI J Med Chem 32: 504-16 (1989) SRI International 2D 3D TSV
2913310 68 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.EBI J Med Chem 32: 493-503 (1989) SRI International 2D 3D TSV
2913308 28 Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.EBI J Med Chem 32: 478-86 (1989) University of Kansas 2D 3D TSV
2913301 17 Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.EBI J Med Chem 32: 409-17 (1989) Smith Kline & French Laboratories 2D 3D TSV
2913292 23 Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.EBI J Med Chem 32: 289-97 (1989) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
2909748 9 N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.EBI J Med Chem 32: 8-11 (1989) Warner-Lambert Company 2D 3D TSV
2909747 50 Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity.EBI J Med Chem 32: 79-84 (1989) University of Camerino 2D 3D TSV
2909744 27 Platelet activating factor antagonists: synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety.EBI J Med Chem 32: 56-64 (1989) Takeda Chemical Industries Ltd. 2D 3D TSV
2909739 17 Prostaglandin photoaffinity probes: synthesis and biological activity of azide-substituted 16-phenoxy- and 17-phenyl-PGF2 alpha prostaglandins.EBI J Med Chem 32: 256-64 (1989) University of Kentucky 2D 3D TSV
2909733 6 Interactions of thiol-containing androgens with human placental aromatase.EBI J Med Chem 32: 203-13 (1989) University of Washington 2D 3D TSV
2909732 7 Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin.EBI J Med Chem 32: 197-202 (1989) University of California 2D 3D TSV
2909731 3 Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells.EBI J Med Chem 32: 192-7 (1989) University of Georgia 2D 3D TSV
2909729 4 2,2-Difluoro-5-hexyne-1,4-diamine: a potent enzyme-activated inhibitor of ornithine decarboxylase.EBI J Med Chem 32: 170-3 (1989) Merrell Dow Research Institute 2D 3D TSV
2909728 5 Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition.EBI J Med Chem 32: 160-5 (1989) Pedagogical University 2D 3D TSV
2909725 42 Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.EBI J Med Chem 32: 13-6 (1989) Merck Sharp& Dohme Research Laboratories 2D 3D TSV
2905002 8 Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity.BDB J Pharmacol Exp Ther 247: 1093-102 (1988) Schering-Plough Corporation 2D 3D TSV
2905001 64 McN-5652: a highly potent inhibitor of serotonin uptake.BDB J Pharmacol Exp Ther 247: 1032-8 (1988) McNeil Pharmaceutical 2D 3D TSV
2904784 109 Neuroleptic binding to human brain receptors: relation to clinical effects.BDB Ann N Y Acad Sci 537: 435-42 (1988) Mayo Clinic and Foundation 2D 3D TSV
2903929 66 Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.EBI J Med Chem 31: 2247-56 (1989) H. Lundbeck A/S 2D 3D TSV
2903247 8 Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation.EBI J Med Chem 31: 2178-82 (1988) State University of Groningen 2D 3D TSV
2903246 39 Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.EBI J Med Chem 31: 2170-7 (1988) University of Arizona 2D 3D TSV
2903245 47 Synthesis and beta-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols.EBI J Med Chem 31: 2122-6 (1988) Universidad de Barcelona 2D 3D TSV
2902227 6 Serotonergic properties of spiroxatrine enantiomers.EBI J Med Chem 31: 1965-8 (1988) University of Arizona 2D 3D TSV
2902226 27 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2.EBI J Med Chem 31: 1934-40 (1988) Duphar Research Laboratories 2D 3D TSV
2900898 13 Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes.EBI J Med Chem 31: 1825-31 (1988) UA 498 CNRS 2D 3D TSV
2900897 2 Substituted benzamides with conformationally restricted side chains. 2. Indolizidine derivatives as central dopamine receptor antagonists.EBI J Med Chem 31: 1708-12 (1988) Beecham Pharmaceuticals Research Division 2D 3D TSV
2898533 50 Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.EBI J Med Chem 31: 1382-92 (1988) Wyeth-Ayerst Research 2D 3D TSV
2898531 20 Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.EBI J Med Chem 31: 1338-44 (1988) Harvard Medical School 2D 3D TSV
2895008 47 Comparison of the pharmacological characteristics of [3H]raclopride and [3H]SCH 23390 binding to dopamine receptors in vivo in mouse brain.BDB Eur J Pharmacol 146: 113-20 (1988) NOVO Industri A/S 2D 3D TSV
2894466 26 Atypical antipsychotic agents: patterns of activity in a series of 3-substituted 2-pyridinyl-1-piperazine derivatives.EBI J Med Chem 31: 618-24 (1988) Bristol-Myers Company 2D 3D TSV
2894455 17 Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.BDB J Pharmacol Exp Ther 244: 571-8 (1988) University of Missouri 2D 3D TSV
2892936 10 Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.EBI J Med Chem 31: 454-61 (1988) Warner-Lambert Company 2D 3D TSV
2892932 8 Conformational analysis and structural comparisons of (1R,3S)-(+)- and (1S,3R)-(-)-tefludazine, (S)-(+)- and (R)-(-)-octoclothepin, and (+)-dexclamol in relation to dopamine receptor antagonism and amine-uptake inhibition.EBI J Med Chem 31: 306-12 (1988) University of Lund 2D 3D TSV
2889830 11 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1.EBI J Med Chem 30: 2099-104 (1987) Duphar Research Laboratories 2D 3D TSV
2889829 3 Design and synthesis of phosphonate inhibitors of glutamine synthetase.EBI J Med Chem 30: 2062-7 (1987) Pennsylvania State University 2D 3D TSV
2888899 20 Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.EBI J Med Chem 30: 1906-10 (1987) Istituto Superiore di Sanit£ 2D 3D TSV
2888898 28 Antipsychotic activity of substituted gamma-carbolines.EBI J Med Chem 30: 1818-23 (1987) Wyeth Laboratories 2D 3D TSV
2888897 20 1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.EBI J Med Chem 30: 1807-12 (1987) Warner-Lambert/Parke-Davis Pharmaceutical Research 2D 3D TSV
2888894 16 N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.EBI J Med Chem 30: 1709-11 (1987) Parke-Davis Pharmaceutical Research Division 2D 3D TSV
2887659 3 Charged analogues of chlorpromazine as dopamine antagonists.EBI J Med Chem 30: 1631-5 (1987) TBA 2D 3D TSV
2887656 48 Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.EBI J Med Chem 30: 1538-42 (1987) TBA 2D 3D TSV
2885419 118 Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.EBI J Med Chem 30: 1229-39 (1987) TBA 2D 3D TSV
2885412 25 Alpha-1 adrenergic receptor binding in aortas from rat and dog: comparison of [3H]prazosin and beta-iodo-[125I]-4-hydroxyphenyl-ethyl-aminomethyl-tetralone.BDB J Pharmacol Exp Ther 241: 875-81 (1987) UnWersity of Misscuri 2D 3D TSV
2885406 68 Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain.BDB J Pharmacol Exp Ther 241: 1092-8 (1987) University of California 2D 3D TSV
2884314 28 Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines.EBI J Med Chem 30: 1100-5 (1987) TBA 2D 3D TSV
2884312 39 Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.EBI J Med Chem 30: 1003-11 (1987) TBA 2D 3D TSV
2883318 13 Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives.EBI J Med Chem 30: 814-9 (1987) TBA 2D 3D TSV
2882026 21 Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.EBI J Med Chem 30: 616-22 (1987) TBA 2D 3D TSV
2879917 29 N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.EBI J Med Chem 30: 185-93 (1987) TBA 2D 3D TSV
2879914 30 Peptides as receptor selectivity modulators of opiate pharmacophores.EBI J Med Chem 29: 1222-5 (1987) TBA 2D 3D TSV
2879912 55 Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents.EBI J Med Chem 29: 1178-83 (1987) TBA 2D 3D TSV
2878079 22 Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.EBI J Med Chem 29: 2370-5 (1986) TBA 2D 3D TSV
2878078 43 Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.EBI J Med Chem 29: 2329-34 (1986) TBA 2D 3D TSV
2877462 17 1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.BDB Proc Natl Acad Sci U S A 83: 8784-8 (1986) The Oregon Health Sciences University 2D 3D TSV
2876905 67 Further validation of in vivo and in vitro pharmacological procedures for assessing the alpha 2/alpha 1-selectivity of test compounds: (1). Alpha-adrenoceptor antagonists.BDB Eur J Pharmacol 129: 49-55 (1986) Janssen Pharmaceutica 2D 3D TSV
2876099 51 Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.EBI J Med Chem 29: 1913-7 (1986) TBA 2D 3D TSV
2875185 4 Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis.EBI J Med Chem 29: 1726-31 (1986) TBA 2D 3D TSV
2875184 11 (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.EBI J Med Chem 29: 1628-37 (1986) TBA 2D 3D TSV
2874226 23 Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives.EBI J Med Chem 29: 1476-82 (1986) TBA 2D 3D TSV
2872332 105 Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.EBI J Med Chem 29: 1065-80 (1986) TBA 2D 3D TSV
2872314 40 Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin.BDB J Pharm Pharmacol 38: 374-9 (1986) TBA 2D 3D TSV
2871191 11 Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.EBI J Med Chem 29: 655-60 (1986) TBA 2D 3D TSV
2870190 1 (1-Amino-2-propenyl) phosphonic acid, an inhibitor of alanine racemase and D-alanine:D-alanine ligase.EBI J Med Chem 29: 579-81 (1986) TBA 2D 3D TSV
2870189 11 Quantitative evaluation of the beta 2-adrenoceptor intrinsic activity of N-tert-butylphenylethanolamines.EBI J Med Chem 29: 549-54 (1986) TBA 2D 3D TSV
2869639 166 Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.BDB Acta Pharmacol Toxicol (Copenh) 58: 61-70 (1986) Astra Läkemedel AB 2D 3D TSV
2869146 35 Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.EBI J Med Chem 29: 359-69 (1986) TBA 2D 3D TSV
2867217 29 Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity.BDB J Pharmacol Exp Ther 236: 90-6 (1986) Smith Kline & French Laboratories 2D 3D TSV
2861288 17 New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.EBI J Med Chem 28: 896-900 (1985) TBA 2D 3D TSV
2857200 24 An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.EBI J Med Chem 28: 153-60 (1985) TBA 2D 3D TSV
2850065 27 Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.BDB Br J Pharmacol 95: 932-8 (1988) CIBA-GEIGY Corporation 2D 3D TSV
2848779 9 Highly potent and selective ligands for a new class H3 of histamine receptor.BDB Invest Radiol -2 (1988) Unité 109 2D 3D TSV
2848124 266 Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.EBI J Med Chem 31: 2235-46 (1989) Merck Sharp& Dohme Research Laboratories 2D 3D TSV
2846836 3 Radioiodinated benzodiazepines: agents for mapping glial tumors.EBI J Med Chem 31: 2081-6 (1988) University of Michigan Medical Center 2D 3D TSV
2845084 22 Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.EBI J Med Chem 31: 2015-21 (1988) SRI International 2D 3D TSV
2845082 23 Syntheses and adrenergic activities of ring-fluorinated epinephrines.EBI J Med Chem 31: 1972-7 (1988) National Institute of Diabetes 2D 3D TSV
2845081 24 Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.EBI J Med Chem 31: 1891-7 (1988) UA 498 CNRS 2D 3D TSV
2842505 5 Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.EBI J Med Chem 31: 1798-804 (1988) Syntex Research 2D 3D TSV
2842503 110 Synthesis of (aryloxy)alkylamines. 1. Novel antisecretory agents with H+K+-ATPase inhibitory activity.EBI J Med Chem 31: 1778-85 (1988) Ortho Pharmaceutical Corporation 2D 3D TSV
2841449 9 Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor.BDB J Pharmacol Exp Ther 246: 534-41 (1988) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2840502 8 Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines.EBI J Med Chem 31: 1625-8 (1988) National Institute of Diabetes 2D 3D TSV
2840499 13 N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.EBI J Med Chem 31: 1496-500 (1988) Istituto di Genetica Biochimica ed Evoluzionistica 2D 3D TSV
2838631 9 Dinucleotide analogues as inhibitors of thymidine kinase, thymidylate kinase, and ribonucleotide reductase.EBI J Med Chem 31: 1305-8 (1988) Institute of Cancer Research 2D 3D TSV
2836591 44 Substituted 2-[(2-benzimidazolylsulfinyl)methyl]anilines as potential inhibitors of H+/K+ ATPase.EBI J Med Chem 31: 1215-20 (1988) Searle Research and Development 2D 3D TSV
2836590 34 Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.EBI J Med Chem 31: 1148-60 (1988) Princ 2D 3D TSV
2836586 2 (+/-)-4-tert-butyl-3-cyano-1-(4-ethynylphenyl)-2,6,7-trioxabi cyclo[2.2.2]octane: synthesis of a remarkably potent GABAA receptor antagonist.EBI J Med Chem 31: 1064-6 (1988) University of California 2D 3D TSV
2832605 2 Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines.EBI J Med Chem 31: 875-85 (1988) Schering-Plough Corporation 2D 3D TSV
2832604 3 Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.EBI J Med Chem 31: 836-41 (1988) University of Minnesota 2D 3D TSV
2832603 63 Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.EBI J Med Chem 31: 831-6 (1988) Parke-Davis Research Unit 2D 3D TSV
2832602 1 Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.EBI J Med Chem 31: 814-23 (1988) Ayerst Laboratories Research, Inc. 2D 3D TSV
2831365 32 Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.EBI J Med Chem 31: 641-5 (1988) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2831363 18 Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.EBI J Med Chem 31: 555-60 (1988) Eli Lilly and Company 2D 3D TSV
2828622 71 Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.EBI J Med Chem 31: 374-83 (1988) INSERM 2D 3D TSV
2825043 23 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 336: 204-10 (1987) Universität Heidelberg 2D 3D TSV
2824774 63 Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.EBI J Med Chem 30: 2175-81 (1988) University of Lausanne 2D 3D TSV
2824773 87 N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.EBI J Med Chem 30: 2169-74 (1988) University of G£teborg 2D 3D TSV
2822930 48 Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.EBI J Med Chem 30: 2094-9 (1987) Clinical Research Institute of Montreal 2D 3D TSV
2822927 18 Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.EBI J Med Chem 30: 1963-72 (1987) Warner-Lambert Company 2D 3D TSV
2822926 38 Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activiEBI J Med Chem 30: 1955-62 (1987) Warner-Lambert Company 2D 3D TSV
2810337 41 Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.EBI J Med Chem 32: 2486-92 (1989) Merck Sharp& Dohme Research Laboratory 2D 3D TSV
2810335 52 Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor cell line.EBI J Med Chem 32: 2468-74 (1989) Aston University 2D 3D TSV
2795604 3 (R)- and (S)-5,6,7,8-tetrahydro-1-hydroxy-N,N-dipropyl-9H-benzocyclohepten- 8-ylamine. Stereoselective interactions with 5-HT1A receptors in the brain.EBI J Med Chem 32: 2311-8 (1989) University of Uppsala 2D 3D TSV
2795597 22 Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.EBI J Med Chem 32: 2247-54 (1989) University of South Florida 2D 3D TSV
2795469 9 CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.BDB J Pharmacol Exp Ther 251: 47-55 (1989) CIBA-Geigy Corporation 2D 3D TSV
2795135 59 Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin.BDB J Neurosci 9: 3482-90 (1989) Stanford University 2D 3D TSV
2788743 6 Synthesis and hypolipidemic and antidiabetogenic activities of beta,beta,beta',beta'-tetrasubstituted, long-chain dioic acids.EBI J Med Chem 32: 2072-84 (1989) Hebrew University 2D 3D TSV
2783613 4 Studies on semirigid tricyclic analogues of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.EBI J Med Chem 32: 473-7 (1989) University of California 2D 3D TSV
2769691 2 Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation.EBI J Med Chem 32: 2214-21 (1989) Takeda Chemical Industries, Ltd. 2D 3D TSV
2769687 23 Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase.EBI J Med Chem 32: 2152-8 (1989) State University of New York 2D 3D TSV
2769684 1 2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase.EBI J Med Chem 32: 2138-41 (1989) Northwestern University 2D 3D TSV
2769677 2 A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase.EBI J Med Chem 32: 2038-41 (1989) Bristol Myers Co. 2D 3D TSV
2754716 106 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.EBI J Med Chem 32: 1949-58 (1989) Wellcome Research Laboratories 2D 3D TSV
2754715 24 N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?EBI J Med Chem 32: 1921-6 (1989) Virginia Commonwealth University 2D 3D TSV
2754711 52 Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.EBI J Med Chem 32: 1873-9 (1989) NIDDK 2D 3D TSV
2754709 57 Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor.EBI J Med Chem 32: 1820-35 (1989) Roche Research Center 2D 3D TSV
2754708 27 Biphenylcarboxamide derivatives as antagonists of platelet-activating factor.EBI J Med Chem 32: 1814-20 (1989) Roche Research Center 2D 3D TSV
2754707 39 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.BDB J Med Chem 32: 1805-13 (1989) Hoechst-Roussel Pharmaceuticals, Inc. 2D 3D TSV
2754696 54 Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics.EBI J Med Chem 32: 1718-24 (1989) Dr. Karl Thomae GmbH 2D 3D TSV
2754691 43 C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.EBI J Med Chem 32: 1667-73 (1989) Warner-Lambert Company 2D 3D TSV
2746503 22 Characterization of muscarinic receptors in human, guinea pig and rat lung.BDB J Pharmacol Exp Ther 250: 309-15 (1989) Université Louis Pasteur-Strasbourg 2D 3D TSV
2738892 2 Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase.EBI J Med Chem 32: 1566-71 (1989) Smith Kline& French Laboratories 2D 3D TSV
2738891 7 Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine.EBI J Med Chem 32: 1559-65 (1989) Medical University of South Carolina 2D 3D TSV
2738887 30 Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.EBI J Med Chem 32: 1522-8 (1989) Institute of Research 2D 3D TSV
2738884 27 New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.EBI J Med Chem 32: 1497-503 (1989) INSERM 2D 3D TSV
2738875 1 Oxidation of neplanocin A to the corresponding 3'-keto derivative by S-adenosylhomocysteine hydrolase.EBI J Med Chem 32: 1415-8 (1989) University of Kansas 2D 3D TSV
2724300 8 Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase.EBI J Med Chem 32: 1300-7 (1989) Rensselaer Polytechnic Institute 2D 3D TSV
2724299 20 Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives.EBI J Med Chem 32: 1265-72 (1989) Sankyo Co., Ltd. 2D 3D TSV
2724298 11 Acid-sensitive latent inhibitors for proteolytic enzymes: synthesis and characterization.EBI J Med Chem 32: 1253-9 (1989) Amherst College 2D 3D TSV
2724296 56 Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.EBI J Med Chem 32: 1231-7 (1989) National Institutes of Health 2D 3D TSV
2724295 83 Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol).EBI J Med Chem 32: 1217-30 (1989) University of California 2D 3D TSV
2724293 28 Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.EBI J Med Chem 32: 1184-90 (1989) INSERM 2D 3D TSV
2723668 2 Pentagalloylglucose, A Xanthine Oxidase Inhibitor from a Paraguayan Crude Drug, "Molle-I" (Schinus terebinthifolius)EBI J Nat Prod 52: 210-211 (1989) TBA 2D 3D TSV
2721567 26 A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260.BDB Eur J Pharmacol 162: 273-80 (1989) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2709384 17 Design and synthesis of inhibitors of N8-acetylspermidine deacetylase.EBI J Med Chem 32: 984-9 (1989) University of the Pacific 2D 3D TSV
2709379 2 A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant.EBI J Med Chem 32: 937-40 (1989) Pennsylvania State University 2D 3D TSV
2709373 51 Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.EBI J Med Chem 32: 1043-51 (1989) NIDDK 2D 3D TSV
2704370 39 Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.BDB Mol Pharmacol 35: 469-76 (1989) National Institute of Mental Health 2D 3D TSV
2704033 13 [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.EBI J Med Chem 32: 890-7 (1989) Syntex Research 2D 3D TSV
2704031 18 Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.EBI J Med Chem 32: 852-6 (1989) Medical University of South Carolina 2D 3D TSV
2704030 15 Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.EBI J Med Chem 32: 847-52 (1989) Institute of Cancer Research 2D 3D TSV
2704029 44 Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors.EBI J Med Chem 32: 841-6 (1989) Orion Corporation Ltd. 2D 3D TSV
2704023 20 Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.EBI J Med Chem 32: 739-42 (1989) Abbott Laboratories 2D 3D TSV
2704022 8 Benzofurans as mechanism-based inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 32: 735-7 (1989) Pennsylvania State University 2D 3D TSV
2677377 3 Is there a case for P-450 inhibitors in cancer treatment?EBI J Med Chem 32: 2231-9 (1989) Janssen Research Foundation 2D 3D TSV
2666668 38 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.EBI J Med Chem 32: 1942-9 (1989) Wellcome Research Laboratories 2D 3D TSV
2666667 30 Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol.EBI J Med Chem 32: 1913-21 (1989) Schering-Plough Corporation 2D 3D TSV
2664084 17 Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein.BDB J Neurochem 53: 465-71 (1989) Albany Medical College 2D 3D TSV
2661820 18 Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond.EBI J Med Chem 32: 1652-61 (1989) Ciba-Geigy Pharmaceuticals Division 2D 3D TSV
2657067 23 Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue.EBI J Med Chem 32: 1371-8 (1989) Abbott Laboratories 2D 3D TSV
2642553 6 Rational design of enzyme inhibitors: multisubstrate analogue inhibitors.EBI J Med Chem 32: 2-7 (1989) University of Utah 2D 3D TSV
2611201 2 Dehydroquinate synthase: the use of substrate analogues to probe the late steps of the catalyzed reaction.BDB Biochemistry 28: 7572-82 (1989) Harvard University 2D 3D TSV
2585443 32 Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.EBI J Med Chem 32: 2548-54 (1989) Merck Sharp& Dohme Research Laboratories 2D 3D TSV
2585440 34 Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives.EBI J Med Chem 32: 2519-26 (1989) CIBA-GEIGY Corporation 2D 3D TSV
2585439 45 Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma.EBI J Med Chem 32: 2510-3 (1989) Merck Sharp and Dohme-Chibret 2D 3D TSV
2583244 35 Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study.BDB Eur J Pharmacol 168: 387-92 (1989) Virginia Commonwealth University 2D 3D TSV
2580950 69 Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.BDB J Neurochem 44: 1615-22 (1985) Lundbeck AIS 2D 3D TSV
2573732 43 Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics.EBI J Med Chem 32: 2573-82 (1989) Lilly Research Centre Limited 2D 3D TSV
2571732 26 Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity.EBI J Med Chem 32: 2388-96 (1989) Lilly Research Laboratory 2D 3D TSV
2571731 18 Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.EBI J Med Chem 32: 2375-81 (1989) Lilly Research Centre Limited 2D 3D TSV
2571729 15 Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.EBI J Med Chem 32: 2273-6 (1989) University of G£teborg 2D 3D TSV
2571728 14 Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.EBI J Med Chem 32: 2261-8 (1989) Vanderbilt University 2D 3D TSV
2569042 36 Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.EBI J Med Chem 32: 1963-70 (1989) Freie Universit£t Berlin 2D 3D TSV
2569041 8 5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.EBI J Med Chem 32: 1959-62 (1989) College of Pharmacy University of Iowa 2D 3D TSV
2567782 50 Highly selective kappa-opioid analgesics. 2. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide derivatives.EBI J Med Chem 32: 1620-6 (1989) Parke-Davis Research Unit 2D 3D TSV
2566685 44 Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.EBI J Med Chem 32: 1378-92 (1989) University of Wisconsin-Madison 2D 3D TSV
2565402 16 Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines.EBI J Med Chem 32: 961-8 (1989) University of California 2D 3D TSV
2565400 75 Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.EBI J Med Chem 32: 1052-6 (1989) McNeil Pharmaceutical and Janssen Research Foundation Worldwide 2D 3D TSV
2565399 25 Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents.EBI J Med Chem 32: 1024-33 (1989) Wyeth-Ayerst Research 2D 3D TSV
2563773 26 New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties.EBI J Med Chem 32: 663-71 (1989) BOC Technical Center 2D 3D TSV
2563296 38 A new series of tricyclic (aryloximino)propanolamines displaying very high selective beta 2-blocking properties.EBI J Med Chem 32: 315-20 (1989) Université de Nancy I 2D 3D TSV
2562852 6 Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.EBI J Med Chem 32: 105-18 (1989) A.H. Robins Company 2D 3D TSV
2552117 68 Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.BDB J Med Chem 32: 2344-52 (1989) Hebrew University of Jerusalem 2D 3D TSV
2552116 28 Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone.EBI J Med Chem 32: 2340-4 (1989) Abbott Laboratory 2D 3D TSV
2551039 26 Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.BDB Science 245: 1389-92 (1989) Universität Heidelberg 2D 3D TSV
2549247 39 Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity.EBI J Med Chem 32: 2221-6 (1989) CIBA-GEIGY Corporation 2D 3D TSV
2549245 1 Evaluation and synthesis of aminohydroxyisoxazoles and pyrazoles as potential glycine agonists.EBI J Med Chem 32: 2116-28 (1989) Warner-Lambert Company 2D 3D TSV
2549244 13 LH-RH antagonists: design and synthesis of a novel series of peptidomimetics.EBI J Med Chem 32: 2036-8 (1989) Abbott Laboratories 2D 3D TSV
2547939 11 Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.BDB J Pharmacol Exp Ther 250: 565-72 (1989) Abbott Laboratories 2D 3D TSV
2547766 8 Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor.BDB J Biol Chem 264: 13572-8 (1989) Merck, Sharp, and Dohme Research Laboratories 2D 3D TSV
2547074 16 Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.EBI J Med Chem 32: 1996-2002 (1989) National Institute of Digestive 2D 3D TSV
2547071 15 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.EBI J Med Chem 32: 1842-60 (1989) Roche Research Center 2D 3D TSV
2544729 8 Angiotensin converting enzyme inhibitors: spirapril and related compounds.EBI J Med Chem 32: 1600-6 (1989) Schering-Plough Corporation 2D 3D TSV
2544722 32 Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.EBI J Med Chem 32: 1450-7 (1989) Centre de Neurochimie du CNRS 2D 3D TSV
2542560 3 Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.EBI J Med Chem 32: 1392-8 (1989) National Institutes of Health 2D 3D TSV
2542557 14 Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.EBI J Med Chem 32: 1284-9 (1989) University of South Alabama 2D 3D TSV
2542556 65 Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.EBI J Med Chem 32: 1259-65 (1989) Ciba-Geigy Corporation 2D 3D TSV
2542555 74 Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.EBI J Med Chem 32: 1242-8 (1989) G. D. Searle& Co. 2D 3D TSV
2542553 31 Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.EBI J Med Chem 32: 1190-7 (1989) Merck Frosst Canada Inc. 2D 3D TSV
2542551 37 The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.EBI J Med Chem 32: 1147-56 (1989) Bristol-Myers Company 2D 3D TSV
2542550 1 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.EBI J Med Chem 32: 1145-7 (1989) G.D. Searle and Co. 2D 3D TSV
2539480 43 Design and synthesis of propranolol analogues as serotonergic agents.EBI J Med Chem 32: 859-63 (1989) Virginia Commonwealth University 2D 3D TSV
2539477 5 Computer-assisted design and synthesis of novel aldose reductase inhibitors.EBI J Med Chem 32: 757-65 (1989) Wyeth-Ayerst Research 2D 3D TSV
2537663 10 1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain.BDB Biol Psychiatry 25: 569-75 (1989) Stanford University 2D 3D TSV
2537429 32 2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.EBI J Med Chem 32: 720-7 (1989) CIBA-GEIGY Corporation 2D 3D TSV
2537427 24 Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity.EBI J Med Chem 32: 698-703 (1989) Clinical Research Institute of Montreal 2D 3D TSV
2537426 12 Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group.EBI J Med Chem 32: 638-43 (1989) University of Arizona 2D 3D TSV
2537406 2 Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.BDB J Pharmacol Exp Ther 248: 661-70 (1989) University of Arizona 2D 3D TSV
2536436 23 Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.EBI J Med Chem 32: 302-4 (1989) Smith Kline and French Laboratories 2D 3D TSV
2535877 1 Conformationally restricted analogues of atriopeptin(103-125)amide.EBI J Med Chem 32: 67-72 (1989) G. D. Searle and Company 2D 3D TSV
2532362 20 Cloning of the cDNA and gene for a human D2 dopamine receptor.BDB Proc Natl Acad Sci U S A 86: 9762-6 (1989) Oregon Health Sciences University 2D 3D TSV
2531826 24 [125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor.BDB Life Sci 45: 1821-9 (1989) NIDA Addiction Research Center 2D 3D TSV
2530338 5 Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist.BDB J Pharmacol Exp Ther 251: 557-62 (1989) Medical University of South Carolina 2D 3D TSV
2530094 94 The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.BDB Eur J Pharmacol 166: 493-504 (1989) Novo Industri A/S 2D 3D TSV
2525621 9 (+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.EBI J Med Chem 32: 1431-5 (1989) University of Pennsylvania 2D 3D TSV
2524592 9 2-Haloaporphines as potent dopamine agonists.EBI J Med Chem 32: 1198-201 (1989) Northeastern University 2D 3D TSV
2523485 34 9,11-Epoxy-9-homo-14-thiaprost-5-enoic acid derivatives: potent thromboxane A2 antagonists.EBI J Med Chem 32: 974-84 (1989) Princ 2D 3D TSV
2522994 7 A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity.EBI J Med Chem 32: 880-4 (1989) Smith Kline & French Laboratories 2D 3D TSV
2522993 2 Synthesis and D2 dopaminergic activity of pyrrolidinium, tetrahydrothiophenium, and tetrahydrothiophene analogues of sulpiride.EBI J Med Chem 32: 874-80 (1989) Ohio State University 2D 3D TSV
2522991 8 Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.EBI J Med Chem 32: 779-83 (1989) University of Uppsala 2D 3D TSV
2522989 13 Carboxyalkyl dipeptides with atrial natriuretic factor potentiating and antihypertensive activity.EBI J Med Chem 32: 737-9 (1989) Schering-Plough Research 2D 3D TSV
2521519 26 Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.EBI J Med Chem 32: 391-6 (1989) Smith Kline & French Laboratories 2D 3D TSV
2521252 15 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites.EBI J Med Chem 32: 253-6 (1989) Virginia Commonwealth University 2D 3D TSV
2507784 24 Tetrapeptide inhibitors of the IgA1 proteinases from type I Neisseria gonorrhoeae.EBI J Med Chem 32: 2407-11 (1989) University Hospital 2D 3D TSV
2504921 7 Design of potential anti-HIV agents. 1. Mannosidase inhibitors.EBI J Med Chem 32: 2084-9 (1989) CSIRO Division of Chemicals and Polymers 2D 3D TSV
2502633 23 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 11. Quinolylmethyl analogues with basic substituents conveying specificity.EBI J Med Chem 32: 1936-42 (1989) Wellcome Research Laboratories 2D 3D TSV
2502632 71 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 10. 2,4-Diamino-5-(6-quinolylmethyl)- and -[(tetrahydro-6-quinolyl)methyl]pyrimidine derivatives. Further specificity studies.EBI J Med Chem 32: 1927-35 (1989) Wellcome Research Laboratories 2D 3D TSV
2502631 142 On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.EBI J Med Chem 32: 1895-905 (1989) Pomona College 2D 3D TSV
2502629 81 Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.EBI J Med Chem 32: 1836-42 (1989) Rorer Central Research 2D 3D TSV
2498518 10 Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.EBI J Med Chem 32: 1277-83 (1989) University of South Alabama 2D 3D TSV
2498517 31 Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.EBI J Med Chem 32: 1208-13 (1989) Pfizer Inc. 2D 3D TSV
2498516 2 N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.EBI J Med Chem 32: 1176-83 (1989) Wyeth-Ayerst Research 2D 3D TSV
2498315 4 Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide.BDB J Biol Chem 264: 8520-8 (1989) University of California, San Diego 2D 3D TSV
2496231 2 Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine.EBI J Med Chem 32: 997-1001 (1989) Institute 2D 3D TSV
2496229 34 Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety.EBI J Med Chem 32: 1033-8 (1989) Auburn University 2D 3D TSV
2491890 62 N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase.EBI J Med Chem 32: 145-51 (1989) Auburn University 2D 3D TSV
2479745 5 A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.EBI J Med Chem 32: 2507-9 (1989) Showa University 2D 3D TSV
2465410 3 Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.EBI J Med Chem 32: 583-93 (1989) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
2464062 10 Full agonists of CCK8 containing a nonhydrolyzable sulfated tyrosine residue.EBI J Med Chem 32: 445-9 (1989) INSERM 2D 3D TSV
2447278 15 Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.EBI J Med Chem 31: 181-5 (1988) University of South Alabama 2D 3D TSV
2444704 14 Hybrid bivalent ligands with opiate and enkephalin pharmacophores.EBI J Med Chem 30: 1991-4 (1987) University of Minnesota 2D 3D TSV
2441057 11 Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.EBI J Med Chem 30: 1529-32 (1987) TBA 2D 3D TSV
2438407 7 Investigation of peripheral cholecystokinin receptor heterogeneity by cyclic and related linear analogues of CCK26-33: synthesis and biological properties.EBI J Med Chem 30: 962-8 (1987) TBA 2D 3D TSV
2435905 19 Structural aspects of ryanodine action and selectivity.EBI J Med Chem 30: 710-6 (1987) TBA 2D 3D TSV
2435904 12 Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11- dicarboxylates as calcium entry antagonists: new conformationally restrained analogues of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation.EBI J Med Chem 30: 690-5 (1987) TBA 2D 3D TSV
2435903 4 Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters.EBI J Med Chem 30: 635-40 (1987) TBA 2D 3D TSV
2435902 2 Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects.EBI J Med Chem 30: 627-35 (1987) TBA 2D 3D TSV
2433445 4 [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.EBI J Med Chem 29: 1284-8 (1987) TBA 2D 3D TSV
2433443 9 Antagonists of substance P. Further modifications of substance P antagonists obtained by replacing either positions 7, 9 or 7, 8 and 11 of SP with D-amino acid residues.EBI J Med Chem 29: 1171-8 (1987) TBA 2D 3D TSV
2431143 10 Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties.EBI J Med Chem 29: 2262-7 (1986) TBA 2D 3D TSV
2428979 11 Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.EBI J Med Chem 29: 1872-6 (1986) TBA 2D 3D TSV
2423691 20 Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine.EBI J Med Chem 29: 972-8 (1986) TBA 2D 3D TSV
2423690 7 Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.EBI J Med Chem 29: 1080-7 (1986) TBA 2D 3D TSV
2419545 57 Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder.BDB J Pharmacol Exp Ther 236: 819-31 (1986) National Institutes of Health 2D 3D TSV
2416923 20 Arginine-vasopressin analogues with high antidiuretic/vasopressor selectivity. Synthesis, biological activity, and receptor binding affinity of arginine-vasopressin analogues with substitutions in positions 1, 2, 4, 7, and 8.EBI J Med Chem 29: 96-9 (1986) TBA 2D 3D TSV
2415793 55 A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum.BDB Life Sci 37: 1971-83 (1985) Université Catholique de Louvain 2D 3D TSV
2415705 4 Opioid receptor interactions and conformations of the 6 alpha and 6 beta epimers of oxymorphamine. Solid-state conformation of 6 alpha-oxymorphamine.EBI J Med Chem 28: 1652-6 (1985) TBA 2D 3D TSV
2409281 9 10-Ketonaltrexone and 10-ketooxymorphone.EBI J Med Chem 28: 974-6 (1985) TBA 2D 3D TSV
2405159 49 Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites.EBI J Med Chem 33: 838-45 (1990) Warner-Lambert Company 2D 3D TSV
2405158 38 Aporphines as antagonists of dopamine D-1 receptors.EBI J Med Chem 33: 600-7 (1990) Lilly Research Laboratories 2D 3D TSV
2405157 7 Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine.EBI J Med Chem 33: 521-6 (1990) Research Biochemicals Inc. 2D 3D TSV
2404121 19 Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites.EBI J Med Chem 33: 371-4 (1990) Abbott Laboratories 2D 3D TSV
2391706 22 Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.EBI J Med Chem 33: 2673-9 (1990) Institute of Cancer Research 2D 3D TSV
2391695 10 Approaches to isozyme-specific inhibitors. 17. Attachment of a selectivity-inducing substituent to a multisubstrate adduct. Implications for facilitated design of potent, isozyme-selective inhibitors.EBI J Med Chem 33: 2545-51 (1990) Institute for Cancer Research 2D 3D TSV
2391693 17 Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.EBI J Med Chem 33: 2529-35 (1990) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2391692 27 Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.EBI J Med Chem 33: 2522-8 (1990) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2391691 51 Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.EBI J Med Chem 33: 2513-21 (1990) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2391688 9 7-Oxabicyclo[2.2.1]heptyl carboxylic acids as thromboxane A2 antagonists: aza omega-chain analogues.EBI J Med Chem 33: 2465-76 (1990) Princ 2D 3D TSV
2391687 8 Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.EBI J Med Chem 33: 2452-5 (1990) Institute of Cancer Research 2D 3D TSV
2391685 1 N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride.EBI J Med Chem 33: 2430-7 (1990) Washington University School of Medicine 2D 3D TSV
2391679 3 Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol.EBI J Med Chem 33: 2319-21 (1990) Washington University School of Medicine 2D 3D TSV
2385234 35 Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain.BDB Mol Pharmacol 38: 267-73 (1990) Université Libre de Bruxelles 2D 3D TSV
2374150 109 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.EBI J Med Chem 33: 2240-54 (1990) Pfizer Central Research 2D 3D TSV
2374147 16 Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.EBI J Med Chem 33: 2211-5 (1990) National Institute of Diabetes 2D 3D TSV
2374141 33 Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads.EBI J Med Chem 33: 2108-13 (1990) Istituto De Angeli 2D 3D TSV
2374139 44 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.EBI J Med Chem 33: 2087-93 (1990) Pfizer Inc. 2D 3D TSV
2362285 23 Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.EBI J Med Chem 33: 2045-51 (1990) Warner-Lambert Company 2D 3D TSV
2362282 7 Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.EBI J Med Chem 33: 2024-7 (1990) University of Maryland 2D 3D TSV
2362277 4 Inhibition of ornithine decarboxylase by the isomers of 1,4-dimethylputrescine.EBI J Med Chem 33: 1969-74 (1990) Universidad de Buenos Aires 2D 3D TSV
2362273 1 Conformational restriction of angiotensin II: cyclic analogues having high potency.EBI J Med Chem 33: 1935-40 (1990) G. D. Searle and Company 2D 3D TSV
2362270 3 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.EBI J Med Chem 33: 1924-9 (1990) Beecham Pharmaceuticals Research Division 2D 3D TSV
2362269 15 2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.EBI J Med Chem 33: 1919-24 (1990) CIBA-GEIGY Corporation 2D 3D TSV
2362265 40 Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.BDB J Med Chem 33: 1880-7 (1990) Tsukuba Research Laboratories 2D 3D TSV
2362264 12 1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 33: 1866-73 (1990) Merrell Dow Research Institute 2D 3D TSV
2362262 1 Vinblastine and vincristine are inhibitors of monoamine oxidase B.EBI J Med Chem 33: 1845-8 (1990) University of Iowa 2D 3D TSV
2342073 8 Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase.EBI J Med Chem 33: 1790-7 (1990) Northwestern University 2D 3D TSV
2342072 22 Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles.EBI J Med Chem 33: 1781-90 (1990) ICI Pharmaceuticals Group 2D 3D TSV
2342066 5 A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties.EBI J Med Chem 33: 1708-13 (1990) Center for Bio-Pharmaceutical Sciences 2D 3D TSV
2342064 6 Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol.EBI J Med Chem 33: 1698-701 (1990) State University of New York 2D 3D TSV
2342054 19 Angiotensin-converting enzyme inhibitors. 9. Novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity.EBI J Med Chem 33: 1600-6 (1990) Rorer Central Research 2D 3D TSV
2342053 21 Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.EBI J Med Chem 33: 1594-600 (1990) Merrell Dow Research Institute 2D 3D TSV
2338642 17 [3H]TA-3090, a selective benzothiazepine-type calcium channel receptor antagonist: in vitro characterization.BDB J Pharmacol Exp Ther 253: 461-5 (1990) Marion Merrell Dow Inc. 2D 3D TSV
2329573 8 Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.EBI J Med Chem 33: 1510-5 (1990) Princ 2D 3D TSV
2329571 12 Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.EBI J Med Chem 33: 1491-6 (1990) Sankyo Company Ltd. 2D 3D TSV
2329568 30 (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogues of (S)-1-[6-amino-2 [[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline.EBI J Med Chem 33: 1459-69 (1990) Squibb Institute for Medical Research 2D 3D TSV
2329556 3 Polyamine analogues with antitumor activity.EBI J Med Chem 33: 1369-75 (1990) Merrell Dow Research Institute 2D 3D TSV
2319567 29 Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.EBI J Med Chem 33: 1252-7 (1990) University of North Carolina 2D 3D TSV
2319562 12 Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.EBI J Med Chem 33: 1163-70 (1990) Molecular Therapeutics Inc. 2D 3D TSV
2319556 16 Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1- yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities.EBI J Med Chem 33: 1087-90 (1990) Berlex Laboratories 2D 3D TSV
2308149 218 Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.EBI J Med Chem 33: 992-8 (1990) Abbott Laboratories 2D 3D TSV
2308147 54 Small peptide inhibitors of smooth muscle myosin light chain kinase.EBI J Med Chem 33: 964-72 (1990) Schering-Plough Research 2D 3D TSV
2308145 24 Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids.EBI J Med Chem 33: 943-50 (1990) Smith Kline & French Laboratories 2D 3D TSV
2308144 1 Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors.EBI J Med Chem 33: 937-42 (1990) Smith Kline& French Laboratories 2D 3D TSV
2308143 2 Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids.EBI J Med Chem 33: 931-6 (1990) Northwestern University 2D 3D TSV
2299645 27 Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site.EBI J Med Chem 33: 781-9 (1990) Smith Kline & French Laboratories 2D 3D TSV
2299642 12 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. Trans-6-[2-(substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones.EBI J Med Chem 33: 758-65 (1990) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2299641 20 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.EBI J Med Chem 33: 755-8 (1990) Virginia Commonwealth University 2D 3D TSV
2299640 23 Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides.EBI J Med Chem 33: 749-54 (1990) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2299633 6 Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.EBI J Med Chem 33: 673-7 (1990) SRI International 2D 3D TSV
2299629 24 Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines.EBI J Med Chem 33: 646-52 (1990) Wyeth Research UK 2D 3D TSV
2299627 54 Novel glutamic acid derived cholecystokinin receptor ligands.EBI J Med Chem 33: 591-5 (1990) Merck Sharp& Dohme Research Laboratories 2D 3D TSV
2299625 34 Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.EBI J Med Chem 33: 567-71 (1990) NIDDK 2D 3D TSV
2299624 12 Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.EBI J Med Chem 33: 561-7 (1990) Wellcome Research Laboratories 2D 3D TSV
2299617 174 Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase.EBI J Med Chem 33: 464-79 (1990) Syntex Research 2D 3D TSV
2296036 48 Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.EBI J Med Chem 33: 52-60 (1990) Hoechst AG 2D 3D TSV
2296032 68 Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.EBI J Med Chem 33: 416-29 (1990) Lilly Research Laboratories 2D 3D TSV
2296031 33 Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.EBI J Med Chem 33: 394-407 (1990) Merrell Dow Research Institute 2D 3D TSV
2296027 11 Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.EBI J Med Chem 33: 31-8 (1990) Warner-Lambert Company 2D 3D TSV
2296023 47 1-(substituted-benzyl)imidazole-2(3H)-thione inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 33: 274-81 (1990) University of Illinois 2D 3D TSV
2296020 18 Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.EBI J Med Chem 33: 212-5 (1990) SRI International 2D 3D TSV
2296019 155 Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.EBI J Med Chem 33: 21-31 (1990) Warner-Lambert Company 2D 3D TSV
2296014 42 Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.EBI J Med Chem 33: 147-52 (1990) University of Texas 2D 3D TSV
2296012 10 Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.EBI J Med Chem 33: 13-6 (1990) Pfizer Central Research 2D 3D TSV
2296011 3 A novel, nonsteroidal inhibitor of androgen binding to the rat androgen binding protein: diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene] propanedioate.EBI J Med Chem 33: 129-32 (1990) Sterling Research Group 2D 3D TSV
2296008 13 Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.EBI J Med Chem 33: 11-3 (1990) Merrell Dow Research Institute 2D 3D TSV
2296006 7 Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors.EBI J Med Chem 33: 101-5 (1990) Ohio State University 2D 3D TSV
2258903 13 Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.EBI J Med Chem 33: 3176-81 (1991) Lilly Research Laboratories 2D 3D TSV
2258897 12 A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.EBI J Med Chem 33: 3127-30 (1991) Merrell Dow Research Institute 2D 3D TSV
2250662 140 Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells.BDB Mol Pharmacol 38: 805-15 (1990) Glaxo Group Research Ltd. 2D 3D TSV
2231609 13 Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.EBI J Med Chem 33: 3079-86 (1990) Medical College of Ohio 2D 3D TSV
2231608 41 Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.EBI J Med Chem 33: 3072-8 (1990) ICI Pharmaceuticals 2D 3D TSV
2231607 10 Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.EBI J Med Chem 33: 3067-71 (1990) Institute of Cancer Research 2D 3D TSV
2231606 39 Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.EBI J Med Chem 33: 3060-7 (1990) ICI Pharmaceuticals Mereside 2D 3D TSV
2231604 59 Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid.EBI J Med Chem 33: 3050-5 (1990) Institute of Cancer Research 2D 3D TSV
2231596 27 Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.EBI J Med Chem 33: 2982-99 (1990) Bristol-Myers Squibb Company 2D 3D TSV
2231595 40 Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses.EBI J Med Chem 33: 2956-61 (1990) Abbott Laboratories 2D 3D TSV
2231594 28 Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.EBI J Med Chem 33: 2952-6 (1990) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
2231592 35 Mechanism and inhibition of cytochrome P-450 aromatase.EBI J Med Chem 33: 2933-42 (1990) Johns Hopkins University School of Medicine 2D 3D TSV
2213835 33 7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.EBI J Med Chem 33: 2822-8 (1990) National Institute of Diabetes 2D 3D TSV
2213834 19 Imidazodiazepinediones: a new class of adenosine receptor antagonists.EBI J Med Chem 33: 2818-21 (1990) National Institute of Diabetes 2D 3D TSV
2213832 82 Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.EBI J Med Chem 33: 2793-7 (1990) McNeil Pharmaceutical 2D 3D TSV
2213830 16 Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.EBI J Med Chem 33: 2777-84 (1990) Virginia Commonwealth University 2D 3D TSV
2213827 48 Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.EBI J Med Chem 33: 2744-9 (1990) Centre de Recherches de Vitry 2D 3D TSV
2213826 17 Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase).EBI J Med Chem 33: 2734-44 (1990) University of Minnesota 2D 3D TSV
2213824 20 Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.EBI J Med Chem 33: 2715-20 (1990) Pfizer central Research 2D 3D TSV
2213822 12 Structure-based, C2 symmetric inhibitors of HIV protease.EBI J Med Chem 33: 2687-9 (1990) Abbott Laboratories 2D 3D TSV
2213013 14 Biexponential kinetics of (R)-alpha-[3H]methylhistamine binding to the rat brain H3 histamine receptor.BDB J Neurochem 55: 1612-6 (1990) Schering-Plough Research 2D 3D TSV
2202829 18 Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence.EBI J Med Chem 33: 2560-8 (1990) ICI Pharmaceuticals 2D 3D TSV
2202828 28 Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp.EBI J Med Chem 33: 2552-60 (1990) ICI Pharmaceuticals 2D 3D TSV
2202827 53 Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.EBI J Med Chem 33: 2311-9 (1990) NIDDK 2D 3D TSV
2200122 1 Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.BDB Science 249: 527-33 (1990) Abbott Laboratories 2D 3D TSV
2197413 8 Potent renin inhibitory peptides containing hydrophilic end groups.EBI J Med Chem 33: 2276-83 (1990) Upjohn Company 2D 3D TSV
2197411 13 Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin.EBI J Med Chem 33: 2080-6 (1990) Upjohn Company 2D 3D TSV
2194033 33 Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.EBI J Med Chem 33: 1962-9 (1990) Abbott Laboratories 2D 3D TSV
2188581 23 Muscarinic receptor subtypes.BDB Annu Rev Pharmacol Toxicol 30: 633-73 (1990) National Institute for Medical Research 2D 3D TSV
2187995 6 O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism.EBI J Med Chem 33: 1620-34 (1990) State University 2D 3D TSV
2187994 40 Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.EBI J Med Chem 33: 1582-90 (1990) Abbott Laboratories 2D 3D TSV
2184238 14 Renin inhibitory peptides. A beta-aspartyl residue as a replacement for the histidyl residue at the P-2 site.EBI J Med Chem 33: 1337-43 (1990) Upjohn Company 2D 3D TSV
2184237 17 Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease.EBI J Med Chem 33: 1285-8 (1990) University of Wisconsin-Madison 2D 3D TSV
2177154 43 Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation.BDB Neurochem Res 15: 899-904 (1990) Biological Research Center of Hungarian Academy of Sciences 2D 3D TSV
2176210 48 Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.BDB J Biol Chem 265: 22255-61 (1990) Ciba-Geigy Ltd. 2D 3D TSV
2175357 11 4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.EBI J Med Chem 33: 3205-10 (1991) ALTER, S.A. 2D 3D TSV
2172775 11 Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.BDB Mol Pharmacol 38: 681-8 (1990) Neurogenetic Corporation 2D 3D TSV
2172674 5 Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.BDB Life Sci 47: 1001-13 (1990) University of Arizona 2D 3D TSV
2172538 58 Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.EBI J Med Chem 33: 3100-10 (1990) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
2170652 25 Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics.EBI J Med Chem 33: 2876-82 (1990) Anaquest Pharmaceuticals 2D 3D TSV
2170651 13 Propenyl carboxamide derivatives as antagonists of platelet activating factor.EBI J Med Chem 33: 2856-64 (1990) Hoffmann-La Roche Inc. 2D 3D TSV
2170650 4 Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.EBI J Med Chem 33: 2841-5 (1990) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
2170649 1 The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency.EBI J Med Chem 33: 2828-41 (1990) Rorer Central Research 2D 3D TSV
2170648 2 Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain.EBI J Med Chem 33: 2807-13 (1990) Lilly Research Laboratories 2D 3D TSV
2167979 31 Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.EBI J Med Chem 33: 2456-64 (1990) Universit£ Louis Pasteur 2D 3D TSV
2167976 33 Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide.EBI J Med Chem 33: 2321-3 (1990) Merck 2D 3D TSV
2165166 13 Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.EBI J Med Chem 33: 2286-96 (1990) University of Washington 2D 3D TSV
2163451 30 Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.EBI J Med Chem 33: 1843-5 (1990) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2160538 81 Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.EBI J Med Chem 33: 1714-20 (1990) University of Minnesota 2D 3D TSV
2160536 13 Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.EBI J Med Chem 33: 1606-15 (1990) Rorer Central Research 2D 3D TSV
2157010 36 Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity.EBI J Med Chem 33: 1194-200 (1990) Rorer Central Research 2D 3D TSV
2157009 29 Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.EBI J Med Chem 33: 1186-94 (1990) Rorer Central Research 2D 3D TSV
2156995 27 Functional validation of platelet-activating factor receptor sites characterized biochemically by a specific and reproducible [3H]platelet-activating factor binding in human platelets.BDB J Pharmacol Exp Ther 252: 1221-7 (1990) Rhone-Poulenc Sante 2D 3D TSV
2156866 14 Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.BDB J Biol Chem 265: 5267-72 (1990) Nagoya University School of Medicine 2D 3D TSV
2155320 20 Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site.EBI J Med Chem 33: 1069-76 (1990) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
2153827 6 Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides.EBI J Med Chem 33: 741-8 (1990) NIDDK 2D 3D TSV
2153826 5 Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.EBI J Med Chem 33: 737-41 (1990) University of Washington 2D 3D TSV
2153825 83 Synthesis and inhibitory potency of peptides corresponding to the subunit 2 C-terminal region of herpes virus ribonucleotide reductases.EBI J Med Chem 33: 723-30 (1990) Notre-Dame Hospital Research 2D 3D TSV
2153824 20 Synthesis and biological activity of atrial natriuretic factor analogues: effect of modifications to the disulfide bridge.EBI J Med Chem 33: 661-7 (1990) Bio Mega Laboratories 2D 3D TSV
2153817 96 Antiulcer agents. 4-substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K(+)-ATPase.EBI J Med Chem 33: 543-52 (1990) Pfizer Inc. 2D 3D TSV
2153816 23 Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines.EBI J Med Chem 33: 527-33 (1990) Smith Kline & French Research Ltd. 2D 3D TSV
2153214 4 GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.EBI J Med Chem 33: 71-7 (1990) Royal Danish School of Pharmacy 2D 3D TSV
2153213 28 Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.EBI J Med Chem 33: 61-70 (1990) Hoechst AG 2D 3D TSV
2153212 68 Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.EBI J Med Chem 33: 450-5 (1990) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2153208 3 Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives.EBI J Med Chem 33: 286-91 (1990) Parke-Davis Research Unit 2D 3D TSV
2153207 31 Phosphoramidate peptide inhibitors of human skin fibroblast collagenase.EBI J Med Chem 33: 263-73 (1990) University of Kentucky 2D 3D TSV
2153206 19 Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.EBI J Med Chem 33: 258-63 (1990) Michigan Cancer Foundation 2D 3D TSV
2153205 10 [D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.EBI J Med Chem 33: 249-53 (1990) University of Arizona 2D 3D TSV
2153203 60 Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.EBI J Med Chem 33: 203-6 (1990) University of Massachusetts Medical School 2D 3D TSV
2147956 18 Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.EBI J Med Chem 33: 3122-4 (1991) Research Biochemicals Inc. 2D 3D TSV
2145434 11 An initial three-component pharmacophore for specific serotonin-3 receptor ligands.EBI J Med Chem 33: 2721-5 (1990) Pfizer Inc. 2D 3D TSV
2142737 7 4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.EBI J Med Chem 33: 2255-9 (1990) State University of New York 2D 3D TSV
2140414 5 9,11-epoxy-9-homoprosta-5-enoic acid analogues as thromboxane A2 receptor antagonists.EBI J Med Chem 33: 1741-8 (1990) Squibb Institute for Medical Research 2D 3D TSV
2140413 6 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.EBI J Med Chem 33: 1541-4 (1990) TBA 2D 3D TSV
2139469 31 Characterization of D1 dopamine receptors in the bovine pineal gland with [3H]SCH 23390.BDB J Pharmacol Exp Ther 253: 214-20 (1990) University of Nebraska 2D 3D TSV
2138666 21 Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand.BDB J Pharmacol Exp Ther 252: 1108-16 (1990) Department of Veterans Affairs Medical Center 2D 3D TSV
2137880 7 Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT1A receptor.EBI J Med Chem 33: 950-5 (1990) Mount Sinai School of Medicine 2D 3D TSV
2137193 4 Molecular cloning and expression of a dopamine D2 receptor from human retina.BDB Mol Pharmacol 37: 1-6 (1990) National Institute of Neurological Disorders and Stroke 2D 3D TSV
2136920 39 New leupeptin analogues: synthesis and inhibition data.EBI J Med Chem 33: 86-93 (1990) University of Arkansas 2D 3D TSV
2136919 22 Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain.EBI J Med Chem 33: 39-44 (1990) Northeastern University 2D 3D TSV
2136918 11 Synthesis and serotonin binding site studies of some conformationally restricted indolylethylamine analogues based on 2-amino-3-(3'-indolyl)bicyclo[2.2.2]octane.EBI J Med Chem 33: 386-94 (1990) Polytechnic University 2D 3D TSV
2136916 26 Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.EBI J Med Chem 33: 171-8 (1990) University of Pennsylvania 2D 3D TSV
2120444 6 Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin.EBI J Med Chem 33: 2925-9 (1990) Uppsala University 2D 3D TSV
2120443 1 (Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.EBI J Med Chem 33: 2892-9 (1990) Wyeth-Ayerst Research 2D 3D TSV
2120440 22 Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.EBI J Med Chem 33: 2707-14 (1990) Kissei Pharmaceutical Company, Ltd. 2D 3D TSV
2118184 14 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 2. Synthesis, biological properties and molecular modeling of hydroxyethylene isostere derivatives.EBI J Med Chem 33: 2335-42 (1990) ICI Pharmaceuticals 2D 3D TSV
2118183 18 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 1. Synthesis and biological properties of alkyl alcohol and statine derivatives.EBI J Med Chem 33: 2326-34 (1990) ICI Pharmaceuticals 2D 3D TSV
2115589 1 Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid.EBI J Med Chem 33: 2296-304 (1990) A.H. Robins Company 2D 3D TSV
2115586 16 Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI J Med Chem 33: 2070-2 (1990) Warner-Lambert Company 2D 3D TSV
2113951 68 1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.EBI J Med Chem 33: 2019-24 (1990) Pfizer Central Research 2D 3D TSV
2113949 62 Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.EBI J Med Chem 33: 1892-8 (1990) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
2113948 11 Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.EBI J Med Chem 33: 1859-65 (1990) Pfizer Central Research 2D 3D TSV
2105396 14 New inhibitors of renin that contain novel phosphostatine Leu-Val replacements.EBI J Med Chem 33: 534-42 (1990) Abbott Laboratories 2D 3D TSV
2104936 77 2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.EBI J Med Chem 33: 360-70 (1990) E. I. du Pont de Nemours and Company, Inc. 2D 3D TSV
2104935 6 N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.EBI J Med Chem 33: 240-5 (1990) Wyeth-Ayerst Research 2D 3D TSV
2078271 20 The main features of central 5-HT1 receptors.BDB Neuropsychopharmacology 3: 349-60 INSERM U.288 2D 3D TSV
2067592 83 Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling.BDB Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991) Universität Heidelberg 2D 3D TSV
2067002 17 New pepstatin analogues: synthesis and pepsin inhibition.EBI J Med Chem 34: 2298-300 (1991) University of Arkansas 2D 3D TSV
2066996 4 Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity.EBI J Med Chem 34: 2226-30 (1991) Universit£ di Camerino 2D 3D TSV
2066994 25 Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.EBI J Med Chem 34: 2209-18 (1991) ICI Pharmaceuticals 2D 3D TSV
2066991 40 Syntheses of 5,7,8- and 5,6,7-trioxygenated 3-alkyl-3',4'-dihydroxyflavones and their inhibitory activities against arachidonate 5-lipoxygenase.EBI J Med Chem 34: 2169-76 (1991) University of Tokushima 2D 3D TSV
2066989 89 4-hydroxythiazole inhibitors of 5-lipoxygenase.EBI J Med Chem 34: 2158-65 (1991) Abbott Laboratories 2D 3D TSV
2066986 137 Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine.EBI J Med Chem 34: 2133-45 (1991) NIDDK 2D 3D TSV
2066983 10 Determination of dissociation constants of high affinity (pM) human renin inhibitors: application to analogues of ditekiren (U-71,038).EBI J Med Chem 34: 2107-12 (1991) Upjohn Laboratories 2D 3D TSV
2066982 42 Gastrin releasing peptide antagonists with improved potency and stability.EBI J Med Chem 34: 2102-7 (1991) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
2066981 2 Stereospecific synthesis of (R)- and (S)-S-adenosyl-1,8-diamino-3-thiooctane, a potent inhibitor of polyamine biosynthesis. Comparison of asymmetric induction vs enantiomeric synthesis.EBI J Med Chem 34: 2094-101 (1991) University of Michigan 2D 3D TSV
2066977 8 Identification and synthesis of a receptor binding site of human anaphylatoxin C5a.EBI J Med Chem 34: 2068-71 (1991) Abbott Laboratories 2D 3D TSV
2066966 31 Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.EBI J Med Chem 34: 1935-43 (1991) Warner-Lambert Company 2D 3D TSV
2066965 28 Design of enzyme inhibitors using iterative protein crystallographic analysis.EBI J Med Chem 34: 1925-34 (1991) Agouron Pharmaceuticals, Inc. 2D 3D TSV
2061928 2 Isoprenyl phosphinylformates: new inhibitors of squalene synthetase.EBI J Med Chem 34: 1912-4 (1991) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
2061926 1 2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase.EBI J Med Chem 34: 1879-84 (1991) Institute of Technology 2D 3D TSV
2061922 30 New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.EBI J Med Chem 34: 1805-18 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2061919 5 Dexamethasone 21-(beta-isothiocyanatoethyl) thioether: a new affinity label for glucocorticoid receptors.EBI J Med Chem 34: 1762-7 (1991) NIDDK 2D 3D TSV
2033599 8 Novel time-dependent inhibitors of human placental aromatase.EBI J Med Chem 34: 1748-50 (1991) Marion Merrell Dow Research Institute 2D 3D TSV
2033595 5 Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor.EBI J Med Chem 34: 1728-31 (1991) Research Biochemicals Inc. 2D 3D TSV
2033585 37 Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.EBI J Med Chem 34: 1594-605 (1991) ICI Pharmaceuticals 2D 3D TSV
2033583 10 Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.EBI J Med Chem 34: 1582-4 (1991) University of Iowa 2D 3D TSV
2033582 2 Phosphonate-containing inhibitors of tyrosine-specific protein kinases.EBI J Med Chem 34: 1577-81 (1991) National Cancer Institute 2D 3D TSV
2033577 1 Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes .EBI J Med Chem 34: 1531-8 (1991) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
2017157 12 Regulation of dopamine D2 receptors by sodium and pH.BDB Mol Pharmacol 39: 570-8 (1991) Medical Research Service 2D 3D TSV
2016730 14 1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.EBI J Med Chem 34: 1514-7 (1991) SmithKline Beecham Pharmaceuticals 2D 3D TSV
2016728 43 Quinazolinone cholecystokinin-B receptor ligands.EBI J Med Chem 34: 1505-8 (1991) Lilly Research Laboratories 2D 3D TSV
2016727 30 Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.EBI J Med Chem 34: 1503-5 (1991) Institute for Biomedical Research 2D 3D TSV
2016726 5 New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation.EBI J Med Chem 34: 1483-92 (1991) Katholieke Universiteit Leuven 2D 3D TSV
2016725 34 New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.EBI J Med Chem 34: 1476-82 (1991) Universit£ Catholique de Louvain 2D 3D TSV
2016722 8 Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.EBI J Med Chem 34: 1447-54 (1991) Harvard Medical School 2D 3D TSV
2016721 35 Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.EBI J Med Chem 34: 1440-6 (1991) Roche Research Center 2D 3D TSV
2016720 4 Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.EBI J Med Chem 34: 1436-40 (1991) Research Triangle Institute 2D 3D TSV
2016719 34 1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity.EBI J Med Chem 34: 1431-5 (1991) Nova Pharmaceutical Corporation 2D 3D TSV
2016714 3 Receptor-based design of novel dihydrofolate reductase inhibitors: benzimidazole and indole derivatives.EBI J Med Chem 34: 1383-94 (1991) Wellcome Research Laboratories 2D 3D TSV
2016711 5 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.EBI J Med Chem 34: 1363-8 (1991) SRI International 2D 3D TSV
2016709 8 Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids.EBI J Med Chem 34: 1344-9 (1991) Johns Hopkins University School of Medicine 2D 3D TSV
2016708 26 2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.EBI J Med Chem 34: 1340-4 (1991) University of South Florida 2D 3D TSV
2016707 34 2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.EBI J Med Chem 34: 1334-9 (1991) University of South Florida 2D 3D TSV
2016706 29 Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.EBI J Med Chem 34: 1329-34 (1991) CIBA-GEIGY AG. 2D 3D TSV
2005579 23 N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain.BDB J Pharmacol Exp Ther 256: 1173-81 (1991) University of California 2D 3D TSV
2002476 5 Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.EBI J Med Chem 34: 978-84 (1991) Institute of Cancer Research 2D 3D TSV
2002469 80 Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.EBI J Med Chem 34: 887-900 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2002468 8 Synthesis and ligand binding of cocaine isomers at the cocaine receptor.EBI J Med Chem 34: 883-6 (1991) Research Triangle Institute 2D 3D TSV
2002466 13 Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.BDB J Med Chem 34: 1228-30 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
2002465 14 L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.BDB J Med Chem 34: 1225-8 (1991) Merck Research Laboratories 2D 3D TSV
2002464 16 Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes.EBI J Med Chem 34: 1222-5 (1991) University of Wisconsin-Madison 2D 3D TSV
2002463 78 Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.EBI J Med Chem 34: 1209-21 (1991) Roche Research Center 2D 3D TSV
2002461 26 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.EBI J Med Chem 34: 1202-6 (1991) Center for Bio-Pharmaceutical Sciences 2D 3D TSV
2002459 28 Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.EBI J Med Chem 34: 1187-92 (1991) Universit£ di Camerino 2D 3D TSV
2002454 32 Carboxylic acids and tetrazoles as isosteric replacements for sulfate in cholecystokinin analogues.EBI J Med Chem 34: 1125-36 (1991) Roche Research Center 2D 3D TSV
2002448 50 N6-substituted adenosine receptor agonists: potential antihypertensive agents.EBI J Med Chem 34: 1043-9 (1991) Warner-Lambert Company 2D 3D TSV

BDB Curated by BindingDB
EBI Curated by ChEMBL