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| PMID | Data | Article Title | Citation | Organization | SD Files Download |
|---|---|---|---|---|---|
| 3989819 | 13 | 3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1. |
J Med Chem 28: 597-601 (1985) | TBA | 2D 3D TSV |
| 3981540 | 9 | Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. |
J Med Chem 28: 478-82 (1985) | TBA | 2D 3D TSV |
| 3981539 | 3 | Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase. |
J Med Chem 28: 471-7 (1985) | TBA | 2D 3D TSV |
| 3973904 | 30 | Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine. |
J Med Chem 28: 367-75 (1985) | TBA | 2D 3D TSV |
| 3973903 | 12 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives. |
J Med Chem 28: 347-58 (1985) | TBA | 2D 3D TSV |
| 3973902 | 28 | Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. |
J Med Chem 28: 303-11 (1985) | TBA | 2D 3D TSV |
| 3973899 | 23 | Structure-activity relationships of C-terminal tri- and tetrapeptide fragments that inhibit gastrin activity. |
J Med Chem 28: 273-8 (1985) | TBA | 2D 3D TSV |
| 3968685 | 7 | Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid. |
J Med Chem 28: 209-15 (1985) | TBA | 2D 3D TSV |
| 3968684 | 2 | Analogues of aminoglutethimide: selective inhibition of aromatase. |
J Med Chem 28: 200-4 (1985) | TBA | 2D 3D TSV |
| 3968682 | 20 | Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships. |
J Med Chem 28: 186-93 (1985) | TBA | 2D 3D TSV |
| 3965705 | 10 | 2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors. |
J Med Chem 28: 12-7 (1985) | TBA | 2D 3D TSV |
| 3965704 | 22 | Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase. |
J Med Chem 28: 111-6 (1985) | TBA | 2D 3D TSV |
| 3965702 | 5 | N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. |
J Med Chem 28: 1-2 (1985) | TBA | 2D 3D TSV |
| 3959033 | 7 | Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors. |
J Med Chem 29: 582-4 (1986) | TBA | 2D 3D TSV |
| 3959030 | 9 | Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides. |
J Med Chem 29: 523-30 (1986) | TBA | 2D 3D TSV |
| 3950917 | 8 | Neurochemistry of aging. 1. Toxins for an animal model of Alzheimer's disease. |
J Med Chem 29: 376-80 (1986) | TBA | 2D 3D TSV |
| 3950915 | 27 | Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates. |
J Med Chem 29: 354-8 (1986) | TBA | 2D 3D TSV |
| 3950912 | 30 | Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues. |
J Med Chem 29: 318-22 (1986) | TBA | 2D 3D TSV |
| 3950911 | 9 | Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine beta-hydroxylase. |
J Med Chem 29: 315-7 (1986) | TBA | 2D 3D TSV |
| 3950907 | 6 | Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4(5)-yl)-3(2H)-pyridazinones. |
J Med Chem 29: 261-7 (1986) | TBA | 2D 3D TSV |
| 3950904 | 26 | 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. |
J Med Chem 29: 194-9 (1986) | TBA | 2D 3D TSV |
| 3950903 | 12 | Troponoids. 7. Chemistry and dopamine agonist activity of ciladopa and related aralkyltroponylpiperazines. |
J Med Chem 29: 186-93 (1986) | TBA | 2D 3D TSV |
| 3950902 | 39 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives. |
J Med Chem 29: 170-81 (1986) | TBA | 2D 3D TSV |
| 3950901 | 57 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives. |
J Med Chem 29: 159-69 (1986) | TBA | 2D 3D TSV |
| 3941416 | 34 | Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines. |
J Med Chem 29: 8-19 (1986) | TBA | 2D 3D TSV |
| 3941414 | 30 | Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides. |
J Med Chem 29: 61-9 (1986) | TBA | 2D 3D TSV |
| 3941406 | 1 | Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors. |
J Med Chem 29: 125-32 (1986) | TBA | 2D 3D TSV |
| 3941405 | 15 | Carboxyl-modified amino acids and peptides as protease inhibitors. |
J Med Chem 29: 104-11 (1986) | TBA | 2D 3D TSV |
| 3934385 | 32 | Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. |
J Med Chem 28: 1910-6 (1985) | TBA | 2D 3D TSV |
| 3934383 | 6 | Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil. |
J Med Chem 28: 1716-20 (1985) | TBA | 2D 3D TSV |
| 3930740 | 60 | Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. |
J Med Chem 28: 1427-32 (1985) | TBA | 2D 3D TSV |
| 3925146 | 43 | Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. |
J Med Chem 28: 841-9 (1985) | TBA | 2D 3D TSV |
| 3918169 | 24 | Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors. |
J Med Chem 28: 164-70 (1985) | TBA | 2D 3D TSV |
| 3906132 | 27 | Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines. |
J Med Chem 28: 1870-4 (1986) | TBA | 2D 3D TSV |
| 3906131 | 61 | Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. |
J Med Chem 28: 1779-90 (1986) | TBA | 2D 3D TSV |
| 3906130 | 5 | A uniquely potent renin inhibitor and its unanticipated plasma binding component. |
J Med Chem 28: 1755-6 (1986) | TBA | 2D 3D TSV |
| 3906126 | 10 | Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors. |
J Med Chem 28: 1553-5 (1985) | TBA | 2D 3D TSV |
| 3897541 | 27 | New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. |
J Med Chem 28: 1158-69 (1985) | TBA | 2D 3D TSV |
| 3882966 | 28 | Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor. |
J Med Chem 28: 263-73 (1985) | TBA | 2D 3D TSV |
| 3871859 | 4 | Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. |
J Med Chem 28: 311-7 (1985) | TBA | 2D 3D TSV |
| 3851848 | 14 | Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase. |
J Med Chem 28: 1917-25 (1986) | TBA | 2D 3D TSV |
| 3848491 | 5 | Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases. |
J Med Chem 28: 1106-9 (1985) | TBA | 2D 3D TSV |
| 3844034 | 13 | Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase. |
J Med Chem 28: 204-9 (1985) | TBA | 2D 3D TSV |
| 3828800 | 17 | The characterization of [3H]sulpiride binding sites in rat striatal membranes. |
Brain Res 402: 331-8 (1987) | St, Marianna University School of Medicine | 2D 3D TSV |
| 3820229 | 51 | Hydroxamic acid inhibitors of 5-lipoxygenase. |
J Med Chem 30: 574-80 (1987) | TBA | 2D 3D TSV |
| 3820220 | 9 | Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine. |
J Med Chem 30: 494-8 (1987) | TBA | 2D 3D TSV |
| 3820219 | 34 | Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site. |
J Med Chem 30: 486-94 (1987) | TBA | 2D 3D TSV |
| 3806620 | 16 | Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters. |
J Med Chem 30: 400-5 (1987) | TBA | 2D 3D TSV |
| 3806613 | 2 | Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine. |
J Med Chem 30: 278-85 (1987) | TBA | 2D 3D TSV |
| 3806609 | 30 | Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. |
J Med Chem 30: 254-63 (1987) | TBA | 2D 3D TSV |
| 3806607 | 15 | Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists. |
J Med Chem 30: 96-104 (1987) | TBA | 2D 3D TSV |
| 3806606 | 49 | Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists. |
J Med Chem 30: 91-6 (1987) | TBA | 2D 3D TSV |
| 3806602 | 12 | Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzaz epi ne-7, 8-diol. 6-Position modifications. |
J Med Chem 30: 35-40 (1987) | TBA | 2D 3D TSV |
| 3806597 | 19 | Xanthine functionalized congeners as potent ligands at A2-adenosine receptors. |
J Med Chem 30: 211-4 (1987) | TBA | 2D 3D TSV |
| 3806596 | 6 | Studies on the active molecular species of the H2 receptor antagonists cimetidine and mifentidine. |
J Med Chem 30: 208-11 (1987) | TBA | 2D 3D TSV |
| 3806587 | 9 | Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues. |
J Med Chem 30: 109-16 (1987) | TBA | 2D 3D TSV |
| 3806581 | 68 | Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. |
J Med Chem 29: 1305-8 (1987) | TBA | 2D 3D TSV |
| 3806568 | 21 | Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin. |
J Med Chem 29: 1159-63 (1987) | TBA | 2D 3D TSV |
| 3806397 | 13 | Characterization of high affinity [3H]pirenzepine and (-)-[3H] quinuclidinyl benzilate binding to muscarinic cholinergic receptors in rabbit peripheral lung. |
J Pharmacol Exp Ther 240: 51-8 (1987) | University of Arizona | 2D 3D TSV |
| 3790168 | 23 | Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. |
Biochem Pharmacol 35: 4493-7 (1986) | Wyeth Laboratories, Inc. | 2D 3D TSV |
| 3783611 | 55 | Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin. |
J Med Chem 29: 2519-24 (1987) | TBA | 2D 3D TSV |
| 3783606 | 23 | Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione. |
J Med Chem 29: 2465-72 (1987) | TBA | 2D 3D TSV |
| 3783602 | 22 | 2,3-Dialkyl(dimethylamino)indoles: interaction with 5HT1, 5HT2, and rat stomach fundal serotonin receptors. |
J Med Chem 29: 2415-8 (1986) | TBA | 2D 3D TSV |
| 3783595 | 14 | 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
J Med Chem 29: 2375-80 (1986) | TBA | 2D 3D TSV |
| 3783592 | 6 | Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides. |
J Med Chem 29: 2351-8 (1986) | TBA | 2D 3D TSV |
| 3783591 | 225 | Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. |
J Med Chem 29: 2298-315 (1986) | TBA | 2D 3D TSV |
| 3783588 | 51 | Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase. |
J Med Chem 29: 2256-62 (1986) | TBA | 2D 3D TSV |
| 3783584 | 32 | Antibacterial activity of phosphono dipeptides related to alafosfalin. |
J Med Chem 29: 2212-7 (1986) | TBA | 2D 3D TSV |
| 3783579 | 9 | Alkylglycidic acids: potential new hypoglycemic agents. |
J Med Chem 29: 2184-90 (1986) | TBA | 2D 3D TSV |
| 3783578 | 37 | Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro. |
J Med Chem 29: 2174-83 (1986) | TBA | 2D 3D TSV |
| 3783575 | 3 | Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogues. |
J Med Chem 29: 2142-8 (1986) | TBA | 2D 3D TSV |
| 3761327 | 3 | Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase. |
J Med Chem 29: 2117-9 (1986) | TBA | 2D 3D TSV |
| 3761316 | 9 | Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase. |
J Med Chem 29: 1972-82 (1986) | TBA | 2D 3D TSV |
| 3761313 | 22 | Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility. |
J Med Chem 29: 1941-5 (1986) | TBA | 2D 3D TSV |
| 3761310 | 21 | Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. |
J Med Chem 29: 1904-12 (1986) | TBA | 2D 3D TSV |
| 3761308 | 8 | Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics. |
J Med Chem 29: 1889-95 (1986) | TBA | 2D 3D TSV |
| 3761305 | 3 | Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid. |
J Med Chem 29: 1840-6 (1986) | TBA | 2D 3D TSV |
| 3755757 | 6 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
J Med Chem 29: 1743-8 (1986) | TBA | 2D 3D TSV |
| 3754286 | 17 | Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. |
J Med Chem 29: 520-3 (1986) | TBA | 2D 3D TSV |
| 3754285 | 1 | Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. |
J Med Chem 29: 478-82 (1986) | TBA | 2D 3D TSV |
| 3754284 | 13 | Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications. |
J Med Chem 29: 468-72 (1986) | TBA | 2D 3D TSV |
| 3746818 | 1 | Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate. |
J Med Chem 29: 1714-20 (1986) | TBA | 2D 3D TSV |
| 3746817 | 21 | Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro. |
J Med Chem 29: 1689-96 (1986) | TBA | 2D 3D TSV |
| 3746815 | 15 | In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
J Med Chem 29: 1663-8 (1986) | TBA | 2D 3D TSV |
| 3746813 | 19 | Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids. |
J Med Chem 29: 1637-43 (1986) | TBA | 2D 3D TSV |
| 3746809 | 2 | Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4. |
J Med Chem 29: 1573-6 (1986) | TBA | 2D 3D TSV |
| 3735316 | 8 | N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure. |
J Med Chem 29: 1488-94 (1986) | TBA | 2D 3D TSV |
| 3735315 | 5 | 5-(Halomethyl)-2-pyranones as irreversible inhibitors of alpha-chymotrypsin. |
J Med Chem 29: 1483-7 (1986) | TBA | 2D 3D TSV |
| 3735309 | 50 | Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles. |
J Med Chem 29: 1406-12 (1986) | TBA | 2D 3D TSV |
| 3735306 | 12 | Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase. |
J Med Chem 29: 1374-80 (1986) | TBA | 2D 3D TSV |
| 3735304 | 14 | Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. |
J Med Chem 29: 1362-9 (1986) | TBA | 2D 3D TSV |
| 3712378 | 4 | Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase. |
J Med Chem 29: 887-9 (1986) | TBA | 2D 3D TSV |
| 3712374 | 25 | Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. |
J Med Chem 29: 1056-61 (1986) | TBA | 2D 3D TSV |
| 3712372 | 10 | Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine. |
J Med Chem 29: 1015-22 (1986) | TBA | 2D 3D TSV |
| 3712371 | 49 | A novel class of conformationally restricted heterocyclic muscarinic agonists. |
J Med Chem 29: 1004-9 (1986) | TBA | 2D 3D TSV |
| 3702863 | 13 | The binding of L-[3H]nicotine to a single class of high affinity sites in rat brain membranes. |
Mol Pharmacol 29: 448-54 (1986) | R. J. Reynolds Tobacco Company | 2D 3D TSV |
| 3701793 | 8 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives. |
J Med Chem 29: 852-5 (1986) | TBA | 2D 3D TSV |
| 3701787 | 4 | 4-Amino-2-(substituted methyl)-2-butenoic acids: substrates and potent inhibitors of gamma-aminobutyric acid aminotransferase. |
J Med Chem 29: 764-70 (1986) | TBA | 2D 3D TSV |
| 3701782 | 6 | Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone. |
J Med Chem 29: 635-40 (1986) | TBA | 2D 3D TSV |
| 3701781 | 14 | Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. |
J Med Chem 29: 630-4 (1986) | TBA | 2D 3D TSV |
| 3681898 | 53 | Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. |
J Med Chem 30: 2277-83 (1988) | Medical Research Division of American Cyanamid Company | 2D 3D TSV |
| 3681891 | 27 | Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity. |
J Med Chem 30: 2216-21 (1988) | Beecham Pharmaceuticals--Research Division | 2D 3D TSV |
| 3681890 | 26 | Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site. |
J Med Chem 30: 2208-16 (1988) | University of Kansas | 2D 3D TSV |
| 3681889 | 15 | Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) |
J Med Chem 30: 2191-208 (1988) | University of Kansas | 2D 3D TSV |
| 3669019 | 11 | In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. |
J Med Chem 30: 2121-6 (1987) | Abbott Laboratories | 2D 3D TSV |
| 3669017 | 8 | Phenylephrine derivatives as leukotriene D4 antagonists. |
J Med Chem 30: 2087-93 (1987) | Wyeth Laboratories | 2D 3D TSV |
| 3669008 | 1 | Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine. |
J Med Chem 30: 2008-12 (1987) | Astra Alab AB | 2D 3D TSV |
| 3669006 | 10 | Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives. |
J Med Chem 30: 1984-91 (1987) | Sankyo Co., Ltd. | 2D 3D TSV |
| 3656361 | 19 | Synthesis of some [N-(2-haloalkyl)amino]tetralin derivatives as potential irreversible labels for bovine anterior pituitary D2 dopamine receptors. |
J Med Chem 30: 1879-87 (1987) | Queen's Medical Centre | 2D 3D TSV |
| 3656359 | 1 | Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin. |
J Med Chem 30: 1858-73 (1987) | University of California | 2D 3D TSV |
| 3656356 | 18 | Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids. |
J Med Chem 30: 1812-8 (1987) | Searle Research and Development | 2D 3D TSV |
| 3656349 | 10 | Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914). |
J Med Chem 30: 1724-8 (1987) | Warner-Lambert/Parke-Davis Pharmaceutical Research | 2D 3D TSV |
| 3656346 | 1 | Inactivation of thymidylate synthase at an alternate high-affinity binding site. |
J Med Chem 30: 1705-6 (1987) | University of Kansas | 2D 3D TSV |
| 3647139 | 9 | Inhibition of human sputum elastase by substituted 2-pyrones. |
J Med Chem 30: 1017-23 (1987) | TBA | 2D 3D TSV |
| 3637247 | 6 | Peptidyl carbamates incorporating amino acid isosteres as novel elastase inhibitors. |
J Med Chem 29: 1468-76 (1986) | TBA | 2D 3D TSV |
| 3634830 | 20 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. |
J Med Chem 29: 849-52 (1986) | TBA | 2D 3D TSV |
| 3625715 | 21 | Anticoagulant peptides: nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin. |
J Med Chem 30: 1688-91 (1987) | TBA | 2D 3D TSV |
| 3625708 | 21 | Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase. |
J Med Chem 30: 1603-9 (1987) | TBA | 2D 3D TSV |
| 3625703 | 38 | Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents. |
J Med Chem 30: 1550-4 (1987) | TBA | 2D 3D TSV |
| 3612685 | 51 | Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. |
J Med Chem 30: 1359-65 (1987) | TBA | 2D 3D TSV |
| 3612682 | 7 | Inhibitors of dopamine beta-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2-thiones. |
J Med Chem 30: 1309-13 (1987) | TBA | 2D 3D TSV |
| 3599032 | 22 | Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. |
J Med Chem 30: 1256-61 (1987) | TBA | 2D 3D TSV |
| 3599031 | 12 | N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. |
J Med Chem 30: 1254-6 (1987) | TBA | 2D 3D TSV |
| 3599028 | 46 | Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. |
J Med Chem 30: 1218-24 (1987) | TBA | 2D 3D TSV |
| 3599023 | 29 | Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. |
J Med Chem 30: 1177-86 (1987) | TBA | 2D 3D TSV |
| 3585906 | 6 | Resolution of (+/-)-2-tetradecyloxiranecarboxylic acid. Absolute configuration and chiral synthesis of the hypoglycemic R enantiomer and biological activity of enantiomers. |
J Med Chem 30: 1094-7 (1987) | TBA | 2D 3D TSV |
| 3585903 | 2 | Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides. |
J Med Chem 30: 1044-54 (1987) | TBA | 2D 3D TSV |
| 3585902 | 20 | Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors. |
J Med Chem 30: 1036-40 (1987) | TBA | 2D 3D TSV |
| 3585900 | 10 | Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity. |
J Med Chem 30: 1023-9 (1987) | TBA | 2D 3D TSV |
| 3572985 | 28 | N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors. |
J Med Chem 30: 954-6 (1987) | TBA | 2D 3D TSV |
| 3572981 | 12 | N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. |
J Med Chem 30: 930-2 (1987) | TBA | 2D 3D TSV |
| 3572977 | 13 | Isozyme-specific enzyme inhibitors. 13. S-[5'(R)-[(N-triphosphoamino)methyl]adenosyl]-L-homocysteine, a potent inhibitor of rat methionine adenosyltransferases. |
J Med Chem 30: 888-94 (1987) | TBA | 2D 3D TSV |
| 3572973 | 1 | Kinetics of solvolysis and muscarinic actions of an N-methyl-N-(2-bromoethyl)amino analogue of oxotremorine. |
J Med Chem 30: 852-4 (1987) | TBA | 2D 3D TSV |
| 3572963 | 11 | Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin. |
J Med Chem 30: 758-63 (1987) | TBA | 2D 3D TSV |
| 3560164 | 14 | Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors. |
J Med Chem 30: 729-32 (1987) | TBA | 2D 3D TSV |
| 3560162 | 3 | Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds. |
J Med Chem 30: 696-704 (1987) | TBA | 2D 3D TSV |
| 3560154 | 15 | Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors. |
J Med Chem 30: 591-7 (1987) | TBA | 2D 3D TSV |
| 3550086 | 31 | Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation. |
J Med Chem 30: 589-591 (1987) | TBA | 2D 3D TSV |
| 3549712 | 24 | The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. |
J Biol Chem 262: 4922-7 (1987) | University of Chicago | 2D 3D TSV |
| 3546690 | 7 | alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model. |
J Med Chem 30: 536-41 (1987) | TBA | 2D 3D TSV |
| 3543362 | 184 | Central serotonin receptors as targets for drug research. |
J Med Chem 30: 1-12 (1987) | TBA | 2D 3D TSV |
| 3543358 | 96 | Pepstatin analogues as novel renin inhibitors. |
J Med Chem 29: 1152-9 (1987) | TBA | 2D 3D TSV |
| 3531518 | 17 | Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo. |
J Med Chem 29: 2088-93 (1986) | TBA | 2D 3D TSV |
| 3531517 | 17 | Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues. |
J Med Chem 29: 2080-7 (1986) | TBA | 2D 3D TSV |
| 3519969 | 66 | Synthesis and alpha-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potential oral antidiabetic agents. |
J Med Chem 29: 1038-46 (1986) | TBA | 2D 3D TSV |
| 3517332 | 12 | Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents. |
J Med Chem 29: 816-9 (1986) | TBA | 2D 3D TSV |
| 3517331 | 10 | 1H NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of"enkephalinase" inhibitors. Relationships between stereochemistry and enzyme recognition. |
J Med Chem 29: 751-7 (1986) | TBA | 2D 3D TSV |
| 3514912 | 48 | Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. |
J Med Chem 29: 514-9 (1986) | TBA | 2D 3D TSV |
| 3512826 | 3 | Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate. |
J Med Chem 29: 230-8 (1986) | TBA | 2D 3D TSV |
| 3498043 | 12 | Isozyme-specific enzyme inhibitors. 14. 5'(R)-C-[(L-homocystein-S-yl)methyl]adenosine 5'-(beta,gamma-imidotriphosphate), a potent inhibitor of rat methionine adenosyltransferases. |
J Med Chem 30: 1599-603 (1987) | TBA | 2D 3D TSV |
| 3495664 | 164 | Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. |
J Med Chem 30: 1074-90 (1987) | TBA | 2D 3D TSV |
| 3494849 | 3 | 6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent. |
J Med Chem 30: 805-9 (1987) | TBA | 2D 3D TSV |
| 3488405 | 12 | Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. |
J Med Chem 29: 1436-41 (1986) | TBA | 2D 3D TSV |
| 3486976 | 16 | Isozyme-specific enzyme inhibitors. 11. L-homocysteine-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases. |
J Med Chem 29: 1030-8 (1986) | TBA | 2D 3D TSV |
| 3486292 | 19 | Inhibitors of dihydropteroate synthase: substituent effects in the side-chain aromatic ring of 6-[[3-(aryloxy)propyl]amino]-5-nitrosoisocytosines and synthesis and inhibitory potency of bridged 5-nitrosoisocytosine-p-aminobenzoic acid analogues. |
J Med Chem 29: 665-70 (1986) | TBA | 2D 3D TSV |
| 3475471 | 2 | Synthesis of glycopyranosylphosphonate analogues of certain natural nucleoside diphosphate sugars as potential inhibitors of glycosyltransferases. |
J Med Chem 30: 1383-91 (1987) | TBA | 2D 3D TSV |
| 3470522 | 16 | Folate analogues as inhibitors of thymidylate synthase. |
J Med Chem 30: 675-8 (1987) | TBA | 2D 3D TSV |
| 3462394 | 12 | Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate. |
J Med Chem 29: 1703-9 (1986) | TBA | 2D 3D TSV |
| 3457954 | 10 | In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17 beta-ols1a. |
J Med Chem 29: 692-8 (1986) | TBA | 2D 3D TSV |
| 3419539 | 56 | Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. |
Neuropharmacology 27: 399-408 (1988) | Organon International | 2D 3D TSV |
| 3411600 | 26 | Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. |
J Med Chem 31: 1729-38 (1988) | University of Kansas | 2D 3D TSV |
| 3397994 | 6 | Synthesis, configuration, and evaluation of two conformationally restrained analogues of phencyclidine. |
J Med Chem 31: 1571-5 (1988) | National Institute of Diabetes, Digestive and Kidney Diseases | 2D 3D TSV |
| 3397993 | 37 | Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site. |
J Med Chem 31: 1558-66 (1988) | Syntex Research | 2D 3D TSV |
| 3397992 | 73 | Substituted benzamides. 1. Potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis. |
J Med Chem 31: 1548-58 (1988) | Bristol-Myers Company | 2D 3D TSV |
| 3397986 | 14 | Dicarbavasopressin antagonist analogues exhibit reduced in vivo agonist activity. |
J Med Chem 31: 1487-9 (1988) | Smith Kline & French Laboratories | 2D 3D TSV |
| 3385736 | 9 | Synthesis and estrogen receptor selectivity of 1,1-bis(4-hydroxyphenyl)-2-(p-halophenyl)ethylenes. |
J Med Chem 31: 1471-5 (1988) | University of Georgia | 2D 3D TSV |
| 3385735 | 32 | Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
J Med Chem 31: 1463-6 (1988) | Nova Pharmaceutical Corporation | 2D 3D TSV |
| 3385733 | 28 | Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. |
J Med Chem 31: 1406-12 (1988) | Purdue University | 2D 3D TSV |
| 3385732 | 12 | Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
J Med Chem 31: 1392-6 (1988) | Northeastern University | 2D 3D TSV |
| 3385731 | 12 | Cardiotonic agents. Synthesis and inotropic activity of a series of isoquinolin-3-ol derivatives. |
J Med Chem 31: 1363-8 (1988) | Ortho Pharmaceutical Corporation | 2D 3D TSV |
| 3385730 | 13 | Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity. |
J Med Chem 31: 1332-7 (1988) | Harvard Medical School | 2D 3D TSV |
| 3385729 | 7 | Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition. |
J Med Chem 31: 1326-31 (1988) | Harvard Medical School | 2D 3D TSV |
| 3385727 | 48 | Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. |
J Med Chem 31: 1312-6 (1988) | Royal Danish School of Pharmacy | 2D 3D TSV |
| 3385722 | 42 | N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
J Med Chem 31: 1282-5 (1988) | Warner-Lambert Company | 2D 3D TSV |
| 3385720 | 2 | (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity. |
J Med Chem 31: 1278-9 (1988) | Hoechst-Roussel Pharmaceuticals, Inc. | 2D 3D TSV |
| 3379417 | 5 | Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri. |
J Nat Prod 51: 357-359 (1988) | TBA | 2D 3D TSV |
| 3379415 | 15 | Inhibition of Cow's Milk Xanthine Oxidase by Flavonoids |
J Nat Prod 51: 345-348 (1988) | TBA | 2D 3D TSV |
| 3373490 | 7 | Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s). |
J Med Chem 31: 1209-15 (1988) | Cornell University | 2D 3D TSV |
| 3373486 | 44 | Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
J Med Chem 31: 1179-83 (1988) | Universit£ di Camerino | 2D 3D TSV |
| 3373484 | 36 | Tricyclic compounds as selective antimuscarinics. 2. Structure-activity relationships of M1-selective antimuscarinics related to pirenzepine. |
J Med Chem 31: 1169-74 (1988) | Dr. Karl Thomae GmbH | 2D 3D TSV |
| 3373483 | 39 | Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. |
J Med Chem 31: 1141-7 (1988) | University of Kansas | 2D 3D TSV |
| 3373482 | 50 | Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. |
J Med Chem 31: 1087-93 (1988) | Merrell Dow Research Institute | 2D 3D TSV |
| 3361583 | 5 | Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity. |
J Med Chem 31: 971-6 (1988) | Institute of Cancer Research | 2D 3D TSV |
| 3361576 | 4 | Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. |
J Med Chem 31: 893-7 (1988) | Centre de Neurochimie du CNRS | 2D 3D TSV |
| 3361575 | 65 | (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase. |
J Med Chem 31: 1052-61 (1988) | Searle Research and Development | 2D 3D TSV |
| 3361572 | 38 | Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists. |
J Med Chem 31: 1014-20 (1988) | CIBA-GEIGY Corporation | 2D 3D TSV |
| 3361571 | 30 | [1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists. |
J Med Chem 31: 1011-4 (1988) | Warner-Lambert Company | 2D 3D TSV |
| 3351861 | 9 | Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. |
J Med Chem 31: 824-30 (1988) | University of Kansas | 2D 3D TSV |
| 3351860 | 56 | Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes. |
J Med Chem 31: 807-14 (1988) | Dynamac Corporation | 2D 3D TSV |
| 3351857 | 1 | Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside. |
J Med Chem 31: 786-90 (1988) | Nucleic Acid Research Institute | 2D 3D TSV |
| 3351856 | 3 | Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines. |
J Med Chem 31: 779-85 (1988) | Kyowa Hakko Kogyo Co., Ltd. | 2D 3D TSV |
| 3351853 | 5 | Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies. |
J Med Chem 31: 763-8 (1988) | Institute | 2D 3D TSV |
| 3351851 | 9 | Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine. |
J Med Chem 31: 752-6 (1988) | University of Virginia School of Medicine | 2D 3D TSV |
| 3351850 | 46 | 125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors. |
J Med Chem 31: 745-51 (1988) | University of Virginia School of Medicine | 2D 3D TSV |
| 3351845 | 5 | Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase. |
J Med Chem 31: 704-6 (1988) | Smith Kline & French Laboratories | 2D 3D TSV |
| 3346882 | 6 | 6- and 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine agonists with autoreceptor selectivity. |
J Med Chem 31: 688-91 (1988) | Warner-Lambert Company | 2D 3D TSV |
| 3346878 | 22 | 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
J Med Chem 31: 613-7 (1988) | National Institute of Diabetes, Digestive and Kidney Diseases | 2D 3D TSV |
| 3346873 | 24 | Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
J Med Chem 31: 577-82 (1988) | University of Uppsala | 2D 3D TSV |
| 3346870 | 12 | Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids. |
J Med Chem 31: 506-9 (1988) | Stauffer Chemical Company | 2D 3D TSV |
| 3346869 | 16 | 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
J Med Chem 31: 503-6 (1988) | Warner-Lambert Company | 2D 3D TSV |
| 3346868 | 3 | 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase. |
J Med Chem 31: 500-3 (1988) | University of Kansas | 2D 3D TSV |
| 3346867 | 6 | Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors. |
J Med Chem 31: 499-500 (1988) | Wellcome Research Laboratories | 2D 3D TSV |
| 3339617 | 34 | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. |
J Med Chem 31: 466-72 (1988) | Hoffmann-La Roche Inc. | 2D 3D TSV |
| 3339615 | 51 | Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. |
J Med Chem 31: 449-54 (1988) | Medical University of South Carolina | 2D 3D TSV |
| 3339613 | 13 | Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines. |
J Med Chem 31: 433-44 (1988) | University of Kansas | 2D 3D TSV |
| 3339612 | 9 | Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives. |
J Med Chem 31: 422-8 (1988) | Sankyo Co., Ltd. | 2D 3D TSV |
| 3339608 | 10 | Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine. |
J Med Chem 31: 390-3 (1988) | Universit£ di Camerino | 2D 3D TSV |
| 3339603 | 9 | Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series. |
J Med Chem 31: 300-5 (1988) | University of Oslo | 2D 3D TSV |
| 3336036 | 83 | New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships. |
J Med Chem 31: 84-91 (1988) | Ono Pharmaceutical Co., Ltd. | 2D 3D TSV |
| 3336033 | 5 | Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase. |
J Med Chem 31: 60-5 (1988) | University of Kansas | 2D 3D TSV |
| 3336029 | 8 | Orally active hydroxamic acid inhibitors of leukotriene biosynthesis. |
J Med Chem 31: 3-5 (1988) | Abbott Laboratories | 2D 3D TSV |
| 3336027 | 32 | N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
J Med Chem 31: 271-3 (1988) | Warner-Lambert Company | 2D 3D TSV |
| 3336026 | 18 | Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines. |
J Med Chem 31: 264-8 (1988) | Merck Sharp& Dohme Research Laboratories | 2D 3D TSV |
| 3336020 | 34 | (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE. |
J Med Chem 31: 204-12 (1988) | Squibb Institute for Medical Research | 2D 3D TSV |
| 3336017 | 28 | Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines. |
J Med Chem 31: 176-81 (1988) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 3336016 | 4 | Conformational requirements of substrates for activity with phenylethanolamine N-methyltransferase. |
J Med Chem 31: 169-71 (1988) | University of Kansas | 2D 3D TSV |
| 3336015 | 8 | Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine. |
J Med Chem 31: 164-8 (1988) | University of California | 2D 3D TSV |
| 3336013 | 52 | Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase. |
J Med Chem 31: 117-21 (1988) | University of Pittsburgh | 2D 3D TSV |
| 3316655 | 34 | Renin inhibitors. Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogues on plasma renin. |
J Med Chem 30: 2287-91 (1988) | SANOFI Recherche | 2D 3D TSV |
| 3312605 | 30 | 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity. |
J Med Chem 30: 1998-2004 (1987) | Burroughs Wellcome Co. | 2D 3D TSV |
| 3312604 | 33 | Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond. |
J Med Chem 30: 1978-83 (1987) | Abbott Laboratories | 2D 3D TSV |
| 3309316 | 50 | Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini. |
J Med Chem 30: 1853-7 (1987) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 3309315 | 8 | alpha,alpha-Difluoro-beta-aminodeoxystatine-containing renin inhibitory peptides. |
J Med Chem 30: 1837-42 (1987) | Upjohn Company | 2D 3D TSV |
| 3309313 | 48 | Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. |
J Med Chem 30: 1729-37 (1987) | Abbott Laboratories | 2D 3D TSV |
| 3305947 | 7 | Fluoro ketone containing peptides as inhibitors of human renin. |
J Med Chem 30: 1617-22 (1987) | TBA | 2D 3D TSV |
| 3305946 | 31 | New inhibitors of human renin that contain novel Leu-Val replacements. |
J Med Chem 30: 1609-16 (1987) | TBA | 2D 3D TSV |
| 3305945 | 27 | Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors. |
J Med Chem 30: 1588-95 (1987) | TBA | 2D 3D TSV |
| 3302256 | 45 | Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides. |
J Med Chem 30: 1287-95 (1987) | TBA | 2D 3D TSV |
| 3298652 | 19 | Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site. |
J Med Chem 30: 1224-8 (1987) | TBA | 2D 3D TSV |
| 3295239 | 9 | Renin inhibitors. Design of angiotensinogen transition-state analogues containing novel. (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid. |
J Med Chem 30: 976-82 (1987) | TBA | 2D 3D TSV |
| 3290487 | 113 | The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules. |
J Med Chem 31: 1396-406 (1988) | Uniroyal Chemical Co., Inc. | 2D 3D TSV |
| 3290486 | 7 | Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site. |
J Med Chem 31: 1377-82 (1988) | Upjohn Company | 2D 3D TSV |
| 3290485 | 7 | Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction. |
J Med Chem 31: 1369-76 (1988) | Upjohn Company | 2D 3D TSV |
| 3284585 | 2 | Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements. |
Biochemistry 27: 1604-10 (1988) | Monsanto Agricultural Company | 2D 3D TSV |
| 3279211 | 16 | Design of potent cyclic gonadotropin releasing hormone antagonists. |
J Med Chem 31: 677-82 (1988) | Salk Institute | 2D 3D TSV |
| 3279210 | 19 | Renin inhibitors containing psi[CH2O] pseudopeptide inserts. |
J Med Chem 31: 671-7 (1988) | Upjohn Company | 2D 3D TSV |
| 3279206 | 16 | New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site. |
J Med Chem 31: 532-9 (1988) | Abbott Laboratories | 2D 3D TSV |
| 3276891 | 61 | Quantitative structure-activity relationships for the inhibition of Escherichia coli dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. |
J Med Chem 31: 366-70 (1988) | Beijing Medical University | 2D 3D TSV |
| 3276890 | 28 | Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. |
J Med Chem 31: 284-95 (1988) | Abbott Laboratories | 2D 3D TSV |
| 3275777 | 34 | Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions. |
J Med Chem 31: 18-30 (1988) | Upjohn Company | 2D 3D TSV |
| 3275776 | 45 | Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. |
J Med Chem 31: 129-37 (1988) | Pennsylvania State University | 2D 3D TSV |
| 3272174 | 7 | Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. |
Neuron 1: 403-10 (1988) | National Institute of Mental Health | 2D 3D TSV |
| 3263503 | 3 | A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]Iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor. |
J Med Chem 31: 2069-71 (1988) | Northeastern University | 2D 3D TSV |
| 3260955 | 14 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine. |
J Med Chem 31: 1566-70 (1988) | Northwestern University | 2D 3D TSV |
| 3258925 | 8 | Melanin concentrating hormone analogues: contraction of the cyclic structure. 1. Agonist activity. |
J Med Chem 31: 949-54 (1988) | University of Arizona | 2D 3D TSV |
| 3257524 | 16 | Toward the synthesis of isozyme-specific enzyme inhibitors. Potent inhibitors of rat methionine adenosyltransferases. Effect of one-atom elongation of the ribose-P alpha bridge in two covalent adducts of L-methionine and beta,gamma-imido-ATP. |
J Med Chem 31: 384-9 (1988) | Fox Chase Cancer Center | 2D 3D TSV |
| 3257523 | 13 | N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases. |
J Med Chem 31: 370-4 (1988) | CNRS-CERCOA | 2D 3D TSV |
| 3252029 | 9 | Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling. |
J Pharmacol Exp Ther 244: 1150-6 (1988) | University of Illinois at Chicago | 2D 3D TSV |
| 3216901 | 5 | 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. |
Naunyn Schmiedebergs Arch Pharmacol 337: 687-9 (1988) | Pharmakologisches Institut, Heidelberg | 2D 3D TSV |
| 3208837 | 3 | 2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors. |
Eur J Pharmacol 156: 157-60 (1988) | Pharmakologisches Institut | 2D 3D TSV |
| 3207677 | 1 | Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases. |
Biochemistry 27: 7301-10 (1988) | University of Wisconsin | 2D 3D TSV |
| 3193422 | 8 | Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine. |
J Med Chem 31: 2297-300 (1989) | NIDDK | 2D 3D TSV |
| 3184128 | 22 | Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity. |
J Med Chem 31: 2221-7 (1988) | Ortho Pharmaceutical Corporation | 2D 3D TSV |
| 3184126 | 46 | Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues. |
J Med Chem 31: 2193-9 (1988) | University of Wisconsin | 2D 3D TSV |
| 3184124 | 28 | Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase. |
J Med Chem 31: 2164-9 (1988) | Southern Research Institute | 2D 3D TSV |
| 3184122 | 10 | A pyrimidine-based"flexible" bisubstrate analogue inhibitor of human thymidylate synthase. |
J Med Chem 31: 2126-32 (1988) | University of Utah | 2D 3D TSV |
| 3172141 | 35 | Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. |
J Med Chem 31: 2034-9 (1988) | Merrell Dow Research Institute | 2D 3D TSV |
| 3172140 | 14 | (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors. |
J Med Chem 31: 2027-33 (1988) | Vanderbilt University | 2D 3D TSV |
| 3172133 | 9 | Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase. |
J Med Chem 31: 1984-6 (1988) | University of Kansas | 2D 3D TSV |
| 3172131 | 23 | Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. |
J Med Chem 31: 1968-71 (1988) | Virginia Commonwealth University | 2D 3D TSV |
| 3172130 | 35 | Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis. |
J Med Chem 31: 1960-4 (1988) | Abbott Laboratories | 2D 3D TSV |
| 3172121 | 7 | Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase. |
J Med Chem 31: 1869-71 (1988) | Squibb Institute for Medical Research | 2D 3D TSV |
| 3165132 | 1 | Nucleosides of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogues of enzymes in pyrimidine nucleoside metabolism. |
J Med Chem 31: 1575-9 (1988) | Washington State University | 2D 3D TSV |
| 3156993 | 10 | Novel photoaffinity label for the dopamine D2 receptor: synthesis of 4-azido-5-iodo-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl] benzamide (iodoazidoclebopride, IAC) and the corresponding 125I-labeled analogue (125IAC). |
J Med Chem 28: 405-7 (1985) | TBA | 2D 3D TSV |
| 3143010 | 28 | Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability. |
J Med Chem 31: 2277-88 (1989) | Abbott Laboratories | 2D 3D TSV |
| 3143009 | 50 | Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency. |
J Med Chem 31: 2264-76 (1989) | Abbott Laboratories | 2D 3D TSV |
| 3139864 | 10 | Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus. |
J Pharmacol Exp Ther 247: 169-73 (1988) | Vanderbilt University | 2D 3D TSV |
| 3137345 | 19 | Synthesis and biological activity of some transition-state inhibitors of human renin. |
J Med Chem 31: 1839-46 (1988) | Ciba-Geigy Limited | 2D 3D TSV |
| 3137344 | 21 | Phosphinic acid inhibitors of D-alanyl-D-alanine ligase. |
J Med Chem 31: 1772-8 (1988) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
| 3135406 | 21 | Substrate analogue inhibitors of the IgA1 proteinases from Neisseria gonorrhoeae. |
J Med Chem 31: 1647-51 (1988) | University Hospital | 2D 3D TSV |
| 3133478 | 16 | 4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities. |
J Med Chem 31: 1453-62 (1988) | Centre de Recherches Roussel Uclaf | 2D 3D TSV |
| 3132968 | 3 | Glucosamine synthetase from Escherichia coli: kinetic mechanism and inhibition by N3-fumaroyl-L-2,3-diaminopropionic derivatives. |
Biochemistry 27: 2282-7 (1988) | ENSCP | 2D 3D TSV |
| 3130534 | 3 | 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. |
Life Sci 42: 1941-54 (1988) | Tokushima Research Institute | 2D 3D TSV |
| 3127587 | 33 | New human renin inhibitors containing an unnatural amino acid, norstatine. |
J Med Chem 31: 701-4 (1988) | Kissei Pharmaceutical Co., Ltd. | 2D 3D TSV |
| 3126296 | 43 | Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases. |
J Med Chem 31: 625-9 (1988) | University of Wisconsin | 2D 3D TSV |
| 3123692 | 6 | Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase. |
J Med Chem 31: 330-5 (1988) | Nucleic Acid Research Institute | 2D 3D TSV |
| 3121857 | 128 | Spiro hydantoin aldose reductase inhibitors. |
J Med Chem 31: 230-43 (1988) | Pfizer Central Research | 2D 3D TSV |
| 3121855 | 21 | Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. |
J Med Chem 31: 150-3 (1988) | SRI International | 2D 3D TSV |
| 3121854 | 21 | 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents. |
J Med Chem 31: 122-9 (1988) | Burroughs Wellcome Co. | 2D 3D TSV |
| 3118024 | 35 | Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement. |
J Med Chem 30: 2137-44 (1987) | Abbott Laboratories | 2D 3D TSV |
| 3114491 | 18 | Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines. |
J Med Chem 30: 1595-8 (1987) | TBA | 2D 3D TSV |
| 3112397 | 5 | Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate. |
J Med Chem 30: 1463-9 (1987) | TBA | 2D 3D TSV |
| 3104589 | 2 | Benzimidazole derivatives with atypical antiinflammatory activity. |
J Med Chem 30: 726-9 (1987) | TBA | 2D 3D TSV |
| 3100803 | 16 | Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres. |
J Med Chem 30: 374-83 (1987) | TBA | 2D 3D TSV |
| 3100802 | 151 | 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes. |
J Med Chem 30: 348-56 (1987) | TBA | 2D 3D TSV |
| 3100801 | 9 | Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine. |
J Med Chem 30: 286-95 (1987) | TBA | 2D 3D TSV |
| 3100797 | 21 | Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives. |
J Med Chem 29: 1263-9 (1987) | TBA | 2D 3D TSV |
| 3100794 | 6 | Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity. |
J Med Chem 29: 1131-3 (1987) | TBA | 2D 3D TSV |
| 3097318 | 4 | Synthesis and biological evaluation of irreversible inhibitors of aldose reductase. |
J Med Chem 29: 2384-9 (1986) | TBA | 2D 3D TSV |
| 3097317 | 19 | Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids. |
J Med Chem 29: 2347-51 (1986) | TBA | 2D 3D TSV |
| 3093681 | 7 | Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase. |
J Med Chem 29: 2034-7 (1986) | TBA | 2D 3D TSV |
| 3093680 | 13 | Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. |
J Med Chem 29: 2024-8 (1986) | TBA | 2D 3D TSV |
| 3091835 | 3 | Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine. |
J Med Chem 29: 1804-6 (1986) | TBA | 2D 3D TSV |
| 3091834 | 6 | Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin. |
J Med Chem 29: 1786-9 (1986) | TBA | 2D 3D TSV |
| 3091832 | 28 | Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF). |
J Med Chem 29: 1754-60 (1986) | TBA | 2D 3D TSV |
| 3091830 | 41 | Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene. |
J Med Chem 29: 1643-50 (1986) | TBA | 2D 3D TSV |
| 3090264 | 28 | Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors. |
J Med Chem 29: 1429-35 (1986) | TBA | 2D 3D TSV |
| 3086558 | 4 | Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents. |
J Med Chem 29: 1099-113 (1986) | TBA | 2D 3D TSV |
| 3086557 | 19 | Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones. |
J Med Chem 29: 1094-9 (1986) | TBA | 2D 3D TSV |
| 3084785 | 14 | Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. |
J Med Chem 29: 676-81 (1986) | TBA | 2D 3D TSV |
| 3084783 | 6 | Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase. |
J Med Chem 29: 627-9 (1986) | TBA | 2D 3D TSV |
| 3081722 | 47 | Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. |
J Med Chem 29: 342-6 (1986) | TBA | 2D 3D TSV |
| 3079831 | 7 | (beta-Chloro-alpha-aminoethyl)phosphonic acids as inhibitors of alanine racemase and D-alanine:D-alanine ligase. |
J Med Chem 29: 148-51 (1986) | TBA | 2D 3D TSV |
| 3069127 | 1 | Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase. |
Biochemistry 27: 8050-6 (1988) | Pennsylvania State University | 2D 3D TSV |
| 3050089 | 24 | Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands. |
J Med Chem 31: 1941-6 (1988) | University of North Carolina | 2D 3D TSV |
| 3050088 | 47 | Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency. |
J Med Chem 31: 1918-23 (1988) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 3045321 | 8 | Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2. |
J Med Chem 31: 1768-72 (1988) | Smith Kline& French Laboratories | 2D 3D TSV |
| 3045320 | 37 | Design of rat renin inhibitory peptides. |
J Med Chem 31: 1679-86 (1988) | Massachusetts General Hospital | 2D 3D TSV |
| 3039139 | 3 | X-ray crystal structure of the opioid ligand naltrexonazine. |
J Med Chem 30: 1489-94 (1987) | TBA | 2D 3D TSV |
| 3039138 | 23 | Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives. |
J Med Chem 30: 1482-9 (1987) | TBA | 2D 3D TSV |
| 3039137 | 20 | Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. |
J Med Chem 30: 1469-74 (1987) | TBA | 2D 3D TSV |
| 3039136 | 328 | Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
J Med Chem 30: 1433-54 (1987) | TBA | 2D 3D TSV |
| 3039135 | 16 | Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones. |
J Med Chem 30: 1421-6 (1987) | TBA | 2D 3D TSV |
| 3039133 | 9 | Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues. |
J Med Chem 30: 1378-82 (1987) | TBA | 2D 3D TSV |
| 3039132 | 26 | Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. |
J Med Chem 30: 1342-7 (1987) | TBA | 2D 3D TSV |
| 3037080 | 8 | Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor. |
J Med Chem 30: 1241-4 (1987) | TBA | 2D 3D TSV |
| 3035180 | 44 | Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. |
J Med Chem 30: 992-8 (1987) | TBA | 2D 3D TSV |
| 3035179 | 5 | High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid. |
J Med Chem 30: 959-61 (1987) | TBA | 2D 3D TSV |
| 3033464 | 11 | Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17. |
Mol Pharmacol 31: 326-33 (1987) | Burroughs Wellcome Company | 2D 3D TSV |
| 3033248 | 3 | Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists. |
J Med Chem 30: 947-50 (1987) | TBA | 2D 3D TSV |
| 3033247 | 1 | Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues. |
J Med Chem 30: 943-7 (1987) | TBA | 2D 3D TSV |
| 3033245 | 28 | Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives. |
J Med Chem 30: 911-8 (1987) | TBA | 2D 3D TSV |
| 3033244 | 8 | 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. |
J Med Chem 30: 867-71 (1987) | TBA | 2D 3D TSV |
| 3031294 | 10 | Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites. |
J Med Chem 30: 743-6 (1987) | TBA | 2D 3D TSV |
| 3027341 | 10 | 5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. |
J Med Chem 30: 409-19 (1987) | TBA | 2D 3D TSV |
| 3027339 | 89 | Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856). |
J Med Chem 30: 303-18 (1987) | TBA | 2D 3D TSV |
| 3027338 | 20 | Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide. |
J Med Chem 30: 295-303 (1987) | TBA | 2D 3D TSV |
| 3027337 | 1 | Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists. |
J Med Chem 30: 239-49 (1987) | TBA | 2D 3D TSV |
| 3027332 | 18 | Substituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis. |
J Med Chem 30: 173-8 (1987) | TBA | 2D 3D TSV |
| 3027330 | 7 | Structure-activity relationships of kadsurenone analogues. |
J Med Chem 30: 136-42 (1987) | TBA | 2D 3D TSV |
| 3027327 | 3 | Spin probes as mechanistic inhibitors and active site probes of thymidylate synthetase. |
J Med Chem 29: 1237-42 (1987) | TBA | 2D 3D TSV |
| 3023614 | 8 | Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. |
J Med Chem 29: 2504-11 (1986) | TBA | 2D 3D TSV |
| 3023609 | 14 | Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. |
J Med Chem 29: 2136-41 (1986) | TBA | 2D 3D TSV |
| 3020250 | 4 | Synthesis and adrenergic activity of ring-fluorinated phenylephrines. |
J Med Chem 29: 1982-8 (1986) | TBA | 2D 3D TSV |
| 3020249 | 29 | Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types. |
J Med Chem 29: 1953-61 (1986) | TBA | 2D 3D TSV |
| 3020247 | 10 | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. |
J Med Chem 29: 1917-21 (1986) | TBA | 2D 3D TSV |
| 3020246 | 11 | Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. |
J Med Chem 29: 1868-71 (1986) | TBA | 2D 3D TSV |
| 3020245 | 4 | Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors. |
J Med Chem 29: 1861-4 (1986) | TBA | 2D 3D TSV |
| 3020244 | 45 | Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors. |
J Med Chem 29: 1855-61 (1986) | TBA | 2D 3D TSV |
| 3018244 | 91 | N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors. |
J Med Chem 29: 1683-9 (1986) | TBA | 2D 3D TSV |
| 3016270 | 40 | Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
J Med Chem 29: 1520-4 (1986) | TBA | 2D 3D TSV |
| 3016269 | 31 | Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. |
J Med Chem 29: 1512-6 (1986) | TBA | 2D 3D TSV |
| 3016267 | 46 | Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists. |
J Med Chem 29: 1442-52 (1986) | TBA | 2D 3D TSV |
| 3016265 | 94 | 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors. |
J Med Chem 29: 1394-8 (1986) | TBA | 2D 3D TSV |
| 3016248 | 49 | Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine. |
J Pharmacol Exp Ther 238: 739-48 (1986) | The Johns Hopkins University | 2D 3D TSV |
| 3014519 | 39 | Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. |
Proc Natl Acad Sci U S A 83: 4918-22 (1986) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 3012085 | 3 | Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity. |
J Med Chem 29: 1087-93 (1986) | TBA | 2D 3D TSV |
| 3012084 | 7 | Indole-phenol bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analogue of labetalol. |
J Med Chem 29: 1009-15 (1986) | TBA | 2D 3D TSV |
| 3012067 | 36 | (-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines. |
J Pharmacol Exp Ther 237: 731-8 (1986) | Johns Hopkins University | 2D 3D TSV |
| 3011801 | 22 | Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. |
J Biol Chem 261: 7819-23 (1986) | University of Oulu | 2D 3D TSV |
| 3010074 | 129 | Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes. |
Mol Pharmacol 29: 331-46 (1986) | Warner-Lambert/Parke-Davis Pharmaceutical Research | 2D 3D TSV |
| 3009814 | 15 | Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihypertensive activity. |
J Med Chem 29: 784-96 (1986) | TBA | 2D 3D TSV |
| 3009813 | 3 | Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan. |
J Med Chem 29: 748-51 (1986) | TBA | 2D 3D TSV |
| 3009454 | 8 | Photoaffinity labeling of the Ah receptor. |
J Biol Chem 261: 6352-65 (1986) | University of Wisconsin | 2D 3D TSV |
| 3007760 | 93 | N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
J Med Chem 29: 531-7 (1986) | TBA | 2D 3D TSV |
| 3005576 | 27 | Angiotensin converting enzyme inhibitors as antihypertensive agents: 1-[(2-mercaptocycloalkyl)carbonyl]-L-prolines. |
J Med Chem 29: 411-7 (1986) | TBA | 2D 3D TSV |
| 3005574 | 34 | Ribose-modified adenosine analogues as adenosine receptor agonists. |
J Med Chem 29: 346-53 (1986) | TBA | 2D 3D TSV |
| 3005569 | 17 | Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations. |
J Med Chem 29: 251-60 (1986) | TBA | 2D 3D TSV |
| 3005567 | 7 | Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. |
J Med Chem 29: 224-9 (1986) | TBA | 2D 3D TSV |
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