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3989819 13 3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1.EBI J Med Chem 28: 597-601 (1985) TBA 2D 3D TSV
3981540 8 Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine.EBI J Med Chem 28: 478-82 (1985) TBA 2D 3D TSV
3981539 3 Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.EBI J Med Chem 28: 471-7 (1985) TBA 2D 3D TSV
3973903 11 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives.EBI J Med Chem 28: 347-58 (1985) TBA 2D 3D TSV
3973902 39 Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.EBI J Med Chem 28: 303-11 (1985) TBA 2D 3D TSV
3973899 23 Structure-activity relationships of C-terminal tri- and tetrapeptide fragments that inhibit gastrin activity.EBI J Med Chem 28: 273-8 (1985) TBA 2D 3D TSV
3968685 14 Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.EBI J Med Chem 28: 209-15 (1985) TBA 2D 3D TSV
3968684 2 Analogues of aminoglutethimide: selective inhibition of aromatase.EBI J Med Chem 28: 200-4 (1985) TBA 2D 3D TSV
3965704 22 Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase.EBI J Med Chem 28: 111-6 (1985) TBA 2D 3D TSV
3965702 5 N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase.EBI J Med Chem 28: 1-2 (1985) TBA 2D 3D TSV
3959033 7 Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors.EBI J Med Chem 29: 582-4 (1986) TBA 2D 3D TSV
3959030 9 Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides.EBI J Med Chem 29: 523-30 (1986) TBA 2D 3D TSV
3950917 8 Neurochemistry of aging. 1. Toxins for an animal model of Alzheimer's disease.EBI J Med Chem 29: 376-80 (1986) TBA 2D 3D TSV
3950915 27 Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates.EBI J Med Chem 29: 354-8 (1986) TBA 2D 3D TSV
3950912 17 Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues.EBI J Med Chem 29: 318-22 (1986) TBA 2D 3D TSV
3950911 9 Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 29: 315-7 (1986) TBA 2D 3D TSV
3950903 8 Troponoids. 7. Chemistry and dopamine agonist activity of ciladopa and related aralkyltroponylpiperazines.EBI J Med Chem 29: 186-93 (1986) TBA 2D 3D TSV
3950902 36 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.EBI J Med Chem 29: 170-81 (1986) TBA 2D 3D TSV
3950901 54 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.EBI J Med Chem 29: 159-69 (1986) TBA 2D 3D TSV
3941406 1 Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors.EBI J Med Chem 29: 125-32 (1986) TBA 2D 3D TSV
3941405 15 Carboxyl-modified amino acids and peptides as protease inhibitors.EBI J Med Chem 29: 104-11 (1986) TBA 2D 3D TSV
3934383 6 Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.EBI J Med Chem 28: 1716-20 (1985) TBA 2D 3D TSV
3930740 52 Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.EBI J Med Chem 28: 1427-32 (1985) TBA 2D 3D TSV
3925146 43 Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.EBI J Med Chem 28: 841-9 (1985) TBA 2D 3D TSV
3918169 23 Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.EBI J Med Chem 28: 164-70 (1985) TBA 2D 3D TSV
3906132 27 Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines.EBI J Med Chem 28: 1870-4 (1986) TBA 2D 3D TSV
3906131 61 Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.EBI J Med Chem 28: 1779-90 (1986) TBA 2D 3D TSV
3906130 14 A uniquely potent renin inhibitor and its unanticipated plasma binding component.EBI J Med Chem 28: 1755-6 (1986) TBA 2D 3D TSV
3906126 10 Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.EBI J Med Chem 28: 1553-5 (1985) TBA 2D 3D TSV
3897541 27 New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.EBI J Med Chem 28: 1158-69 (1985) TBA 2D 3D TSV
3882966 27 Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.EBI J Med Chem 28: 263-73 (1985) TBA 2D 3D TSV
3871859 60 Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.EBI J Med Chem 28: 311-7 (1985) TBA 2D 3D TSV
3851848 14 Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.EBI J Med Chem 28: 1917-25 (1986) TBA 2D 3D TSV
3848491 5 Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.EBI J Med Chem 28: 1106-9 (1985) TBA 2D 3D TSV
3844034 3 Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase.EBI J Med Chem 28: 204-9 (1985) TBA 2D 3D TSV
3828800 17 The characterization of [3H]sulpiride binding sites in rat striatal membranes.BDB Brain Res 402: 331-8 (1987) St, Marianna University School of Medicine 2D 3D TSV
3820229 51 Hydroxamic acid inhibitors of 5-lipoxygenase.EBI J Med Chem 30: 574-80 (1987) TBA 2D 3D TSV
3820219 34 Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site.EBI J Med Chem 30: 486-94 (1987) TBA 2D 3D TSV
3806620 15 Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.EBI J Med Chem 30: 400-5 (1987) TBA 2D 3D TSV
3806609 30 Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.EBI J Med Chem 30: 254-63 (1987) TBA 2D 3D TSV
3806607 15 Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.EBI J Med Chem 30: 96-104 (1987) TBA 2D 3D TSV
3806606 48 Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists.EBI J Med Chem 30: 91-6 (1987) TBA 2D 3D TSV
3806602 12 Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzaz epi ne-7, 8-diol. 6-Position modifications.EBI J Med Chem 30: 35-40 (1987) TBA 2D 3D TSV
3806597 19 Xanthine functionalized congeners as potent ligands at A2-adenosine receptors.EBI J Med Chem 30: 211-4 (1987) TBA 2D 3D TSV
3806596 6 Studies on the active molecular species of the H2 receptor antagonists cimetidine and mifentidine.EBI J Med Chem 30: 208-11 (1987) TBA 2D 3D TSV
3806587 9 Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues.EBI J Med Chem 30: 109-16 (1987) TBA 2D 3D TSV
3806581 68 Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.EBI J Med Chem 29: 1305-8 (1987) TBA 2D 3D TSV
3806568 21 Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin.EBI J Med Chem 29: 1159-63 (1987) TBA 2D 3D TSV
3806397 13 Characterization of high affinity [3H]pirenzepine and (-)-[3H] quinuclidinyl benzilate binding to muscarinic cholinergic receptors in rabbit peripheral lung.BDB J Pharmacol Exp Ther 240: 51-8 (1987) University of Arizona 2D 3D TSV
3790168 23 Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.BDB Biochem Pharmacol 35: 4493-7 (1986) Wyeth Laboratories, Inc. 2D 3D TSV
3783611 55 Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.EBI J Med Chem 29: 2519-24 (1987) TBA 2D 3D TSV
3783606 23 Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione.EBI J Med Chem 29: 2465-72 (1987) TBA 2D 3D TSV
3783592 6 Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides.EBI J Med Chem 29: 2351-8 (1986) TBA 2D 3D TSV
3783591 130 Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.EBI J Med Chem 29: 2298-315 (1986) TBA 2D 3D TSV
3783588 51 Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.EBI J Med Chem 29: 2256-62 (1986) TBA 2D 3D TSV
3783579 9 Alkylglycidic acids: potential new hypoglycemic agents.EBI J Med Chem 29: 2184-90 (1986) TBA 2D 3D TSV
3783578 36 Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.EBI J Med Chem 29: 2174-83 (1986) TBA 2D 3D TSV
3761327 3 Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.EBI J Med Chem 29: 2117-9 (1986) TBA 2D 3D TSV
3761316 9 Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase.EBI J Med Chem 29: 1972-82 (1986) TBA 2D 3D TSV
3761310 21 Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.EBI J Med Chem 29: 1904-12 (1986) TBA 2D 3D TSV
3761308 8 Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics.EBI J Med Chem 29: 1889-95 (1986) TBA 2D 3D TSV
3761305 3 Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid.EBI J Med Chem 29: 1840-6 (1986) TBA 2D 3D TSV
3755757 3 Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues.EBI J Med Chem 29: 1743-8 (1986) TBA 2D 3D TSV
3754286 17 Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.EBI J Med Chem 29: 520-3 (1986) TBA 2D 3D TSV
3754285 1 Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.EBI J Med Chem 29: 478-82 (1986) TBA 2D 3D TSV
3754284 13 Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.EBI J Med Chem 29: 468-72 (1986) TBA 2D 3D TSV
3746818 1 Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate.EBI J Med Chem 29: 1714-20 (1986) TBA 2D 3D TSV
3746817 21 Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.EBI J Med Chem 29: 1689-96 (1986) TBA 2D 3D TSV
3746815 4 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI J Med Chem 29: 1663-8 (1986) TBA 2D 3D TSV
3746813 19 Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids.EBI J Med Chem 29: 1637-43 (1986) TBA 2D 3D TSV
3746809 2 Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.EBI J Med Chem 29: 1573-6 (1986) TBA 2D 3D TSV
3735315 5 5-(Halomethyl)-2-pyranones as irreversible inhibitors of alpha-chymotrypsin.EBI J Med Chem 29: 1483-7 (1986) TBA 2D 3D TSV
3735309 30 Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.EBI J Med Chem 29: 1406-12 (1986) TBA 2D 3D TSV
3735306 12 Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.EBI J Med Chem 29: 1374-80 (1986) TBA 2D 3D TSV
3735304 14 Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones.EBI J Med Chem 29: 1362-9 (1986) TBA 2D 3D TSV
3712378 4 Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 29: 887-9 (1986) TBA 2D 3D TSV
3712374 25 Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.EBI J Med Chem 29: 1056-61 (1986) TBA 2D 3D TSV
3712372 10 Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.EBI J Med Chem 29: 1015-22 (1986) TBA 2D 3D TSV
3712371 20 A novel class of conformationally restricted heterocyclic muscarinic agonists.EBI J Med Chem 29: 1004-9 (1986) TBA 2D 3D TSV
3702863 13 The binding of L-[3H]nicotine to a single class of high affinity sites in rat brain membranes.BDB Mol Pharmacol 29: 448-54 (1986) R. J. Reynolds Tobacco Company 2D 3D TSV
3701793 8 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives.EBI J Med Chem 29: 852-5 (1986) TBA 2D 3D TSV
3701787 4 4-Amino-2-(substituted methyl)-2-butenoic acids: substrates and potent inhibitors of gamma-aminobutyric acid aminotransferase.EBI J Med Chem 29: 764-70 (1986) TBA 2D 3D TSV
3681898 53 Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones.EBI J Med Chem 30: 2277-83 (1988) Medical Research Division of American Cyanamid Company 2D 3D TSV
3681891 27 Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.EBI J Med Chem 30: 2216-21 (1988) Beecham Pharmaceuticals--Research Division 2D 3D TSV
3681890 26 Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.EBI J Med Chem 30: 2208-16 (1988) University of Kansas 2D 3D TSV
3681889 15 Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT)EBI J Med Chem 30: 2191-208 (1988) University of Kansas 2D 3D TSV
3669019 11 In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.EBI J Med Chem 30: 2121-6 (1987) Abbott Laboratories 2D 3D TSV
3669017 4 Phenylephrine derivatives as leukotriene D4 antagonists.EBI J Med Chem 30: 2087-93 (1987) Wyeth Laboratories 2D 3D TSV
3669008 1 Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.EBI J Med Chem 30: 2008-12 (1987) Astra Alab AB 2D 3D TSV
3669006 10 Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.EBI J Med Chem 30: 1984-91 (1987) Sankyo Co., Ltd. 2D 3D TSV
3656361 19 Synthesis of some [N-(2-haloalkyl)amino]tetralin derivatives as potential irreversible labels for bovine anterior pituitary D2 dopamine receptors.EBI J Med Chem 30: 1879-87 (1987) Queen's Medical Centre 2D 3D TSV
3656359 18 Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin.EBI J Med Chem 30: 1858-73 (1987) University of California 2D 3D TSV
3656356 18 Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids.EBI J Med Chem 30: 1812-8 (1987) Searle Research and Development 2D 3D TSV
3656346 1 Inactivation of thymidylate synthase at an alternate high-affinity binding site.EBI J Med Chem 30: 1705-6 (1987) University of Kansas 2D 3D TSV
3647139 9 Inhibition of human sputum elastase by substituted 2-pyrones.EBI J Med Chem 30: 1017-23 (1987) TBA 2D 3D TSV
3634830 20 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin.EBI J Med Chem 29: 849-52 (1986) TBA 2D 3D TSV
3625715 18 Anticoagulant peptides: nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin.EBI J Med Chem 30: 1688-91 (1987) TBA 2D 3D TSV
3625708 21 Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.EBI J Med Chem 30: 1603-9 (1987) TBA 2D 3D TSV
3625703 38 Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.EBI J Med Chem 30: 1550-4 (1987) TBA 2D 3D TSV
3612685 51 Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines.EBI J Med Chem 30: 1359-65 (1987) TBA 2D 3D TSV
3612682 7 Inhibitors of dopamine beta-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2-thiones.EBI J Med Chem 30: 1309-13 (1987) TBA 2D 3D TSV
3599032 22 Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.EBI J Med Chem 30: 1256-61 (1987) TBA 2D 3D TSV
3599031 12 N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase.EBI J Med Chem 30: 1254-6 (1987) TBA 2D 3D TSV
3599028 46 Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.EBI J Med Chem 30: 1218-24 (1987) TBA 2D 3D TSV
3599023 29 Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.EBI J Med Chem 30: 1177-86 (1987) TBA 2D 3D TSV
3585906 6 Resolution of (+/-)-2-tetradecyloxiranecarboxylic acid. Absolute configuration and chiral synthesis of the hypoglycemic R enantiomer and biological activity of enantiomers.EBI J Med Chem 30: 1094-7 (1987) TBA 2D 3D TSV
3585903 2 Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides.EBI J Med Chem 30: 1044-54 (1987) TBA 2D 3D TSV
3585902 20 Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors.EBI J Med Chem 30: 1036-40 (1987) TBA 2D 3D TSV
3585900 4 Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity.EBI J Med Chem 30: 1023-9 (1987) TBA 2D 3D TSV
3572985 14 N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.EBI J Med Chem 30: 954-6 (1987) TBA 2D 3D TSV
3572963 11 Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin.EBI J Med Chem 30: 758-63 (1987) TBA 2D 3D TSV
3560154 32 Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.EBI J Med Chem 30: 591-7 (1987) TBA 2D 3D TSV
3550086 31 Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.EBI J Med Chem 30: 589-591 (1987) TBA 2D 3D TSV
3549712 24 The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor.BDB J Biol Chem 262: 4922-7 (1987) University of Chicago 2D 3D TSV
3546690 7 alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.EBI J Med Chem 30: 536-41 (1987) TBA 2D 3D TSV
3543362 70 Central serotonin receptors as targets for drug research.EBI J Med Chem 30: 1-12 (1987) TBA 2D 3D TSV
3543358 96 Pepstatin analogues as novel renin inhibitors.EBI J Med Chem 29: 1152-9 (1987) TBA 2D 3D TSV
3531518 17 Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.EBI J Med Chem 29: 2088-93 (1986) TBA 2D 3D TSV
3531517 17 Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.EBI J Med Chem 29: 2080-7 (1986) TBA 2D 3D TSV
3519969 66 Synthesis and alpha-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potential oral antidiabetic agents.EBI J Med Chem 29: 1038-46 (1986) TBA 2D 3D TSV
3517332 12 Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.EBI J Med Chem 29: 816-9 (1986) TBA 2D 3D TSV
3517331 10 1H NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of"enkephalinase" inhibitors. Relationships between stereochemistry and enzyme recognition.EBI J Med Chem 29: 751-7 (1986) TBA 2D 3D TSV
3514912 48 Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates.EBI J Med Chem 29: 514-9 (1986) TBA 2D 3D TSV
3512826 3 Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.EBI J Med Chem 29: 230-8 (1986) TBA 2D 3D TSV
3495664 162 Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.EBI J Med Chem 30: 1074-90 (1987) TBA 2D 3D TSV
3486976 5 Isozyme-specific enzyme inhibitors. 11. L-homocysteine-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases.EBI J Med Chem 29: 1030-8 (1986) TBA 2D 3D TSV
3486292 19 Inhibitors of dihydropteroate synthase: substituent effects in the side-chain aromatic ring of 6-[[3-(aryloxy)propyl]amino]-5-nitrosoisocytosines and synthesis and inhibitory potency of bridged 5-nitrosoisocytosine-p-aminobenzoic acid analogues.EBI J Med Chem 29: 665-70 (1986) TBA 2D 3D TSV
3475471 2 Synthesis of glycopyranosylphosphonate analogues of certain natural nucleoside diphosphate sugars as potential inhibitors of glycosyltransferases.EBI J Med Chem 30: 1383-91 (1987) TBA 2D 3D TSV
3470522 16 Folate analogues as inhibitors of thymidylate synthase.EBI J Med Chem 30: 675-8 (1987) TBA 2D 3D TSV
3462394 12 Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.EBI J Med Chem 29: 1703-9 (1986) TBA 2D 3D TSV
3457954 10 In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17 beta-ols1a.EBI J Med Chem 29: 692-8 (1986) TBA 2D 3D TSV
3419539 56 Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers.BDB Neuropharmacology 27: 399-408 (1988) Organon International 2D 3D TSV
3411600 26 Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.EBI J Med Chem 31: 1729-38 (1988) University of Kansas 2D 3D TSV
3397994 6 Synthesis, configuration, and evaluation of two conformationally restrained analogues of phencyclidine.EBI J Med Chem 31: 1571-5 (1988) National Institute of Diabetes, Digestive and Kidney Diseases 2D 3D TSV
3397993 31 Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site.EBI J Med Chem 31: 1558-66 (1988) Syntex Research 2D 3D TSV
3397992 72 Substituted benzamides. 1. Potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis.EBI J Med Chem 31: 1548-58 (1988) Bristol-Myers Company 2D 3D TSV
3397986 13 Dicarbavasopressin antagonist analogues exhibit reduced in vivo agonist activity.EBI J Med Chem 31: 1487-9 (1988) Smith Kline & French Laboratories 2D 3D TSV
3385735 32 Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.EBI J Med Chem 31: 1463-6 (1988) Nova Pharmaceutical Corporation 2D 3D TSV
3385732 8 Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.EBI J Med Chem 31: 1392-6 (1988) Northeastern University 2D 3D TSV
3385730 13 Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.EBI J Med Chem 31: 1332-7 (1988) Harvard Medical School 2D 3D TSV
3385729 7 Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.EBI J Med Chem 31: 1326-31 (1988) Harvard Medical School 2D 3D TSV
3385727 36 Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.EBI J Med Chem 31: 1312-6 (1988) Royal Danish School of Pharmacy 2D 3D TSV
3385722 19 N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.EBI J Med Chem 31: 1282-5 (1988) Warner-Lambert Company 2D 3D TSV
3385720 2 (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.EBI J Med Chem 31: 1278-9 (1988) Hoechst-Roussel Pharmaceuticals, Inc. 2D 3D TSV
3379417 5 Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.EBI J Nat Prod 51: 357-359 (1988) TBA 2D 3D TSV
3379415 15 Inhibition of Cow's Milk Xanthine Oxidase by FlavonoidsEBI J Nat Prod 51: 345-348 (1988) TBA 2D 3D TSV
3373490 5 Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).EBI J Med Chem 31: 1209-15 (1988) Cornell University 2D 3D TSV
3373486 22 Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.EBI J Med Chem 31: 1179-83 (1988) Universit£ di Camerino 2D 3D TSV
3373484 36 Tricyclic compounds as selective antimuscarinics. 2. Structure-activity relationships of M1-selective antimuscarinics related to pirenzepine.EBI J Med Chem 31: 1169-74 (1988) Dr. Karl Thomae GmbH 2D 3D TSV
3373483 39 Linear free energy relationship studies of enzyme active site binding: thymidylate synthase.EBI J Med Chem 31: 1141-7 (1988) University of Kansas 2D 3D TSV
3373482 28 Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.EBI J Med Chem 31: 1087-93 (1988) Merrell Dow Research Institute 2D 3D TSV
3361583 41 Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity.EBI J Med Chem 31: 971-6 (1988) Institute of Cancer Research 2D 3D TSV
3361576 4 Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.EBI J Med Chem 31: 893-7 (1988) Centre de Neurochimie du CNRS 2D 3D TSV
3361575 65 (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase.EBI J Med Chem 31: 1052-61 (1988) Searle Research and Development 2D 3D TSV
3361572 19 Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.EBI J Med Chem 31: 1014-20 (1988) CIBA-GEIGY Corporation 2D 3D TSV
3361571 15 [1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists.EBI J Med Chem 31: 1011-4 (1988) Warner-Lambert Company 2D 3D TSV
3351861 9 Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.EBI J Med Chem 31: 824-30 (1988) University of Kansas 2D 3D TSV
3351860 56 Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.EBI J Med Chem 31: 807-14 (1988) Dynamac Corporation 2D 3D TSV
3351857 1 Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside.EBI J Med Chem 31: 786-90 (1988) Nucleic Acid Research Institute 2D 3D TSV
3351853 5 Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.EBI J Med Chem 31: 763-8 (1988) Institute 2D 3D TSV
3351851 9 Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.EBI J Med Chem 31: 752-6 (1988) University of Virginia School of Medicine 2D 3D TSV
3351850 32 125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.EBI J Med Chem 31: 745-51 (1988) University of Virginia School of Medicine 2D 3D TSV
3351845 5 Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase.EBI J Med Chem 31: 704-6 (1988) Smith Kline & French Laboratories 2D 3D TSV
3346870 12 Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.EBI J Med Chem 31: 506-9 (1988) Stauffer Chemical Company 2D 3D TSV
3346868 3 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.EBI J Med Chem 31: 500-3 (1988) University of Kansas 2D 3D TSV
3346867 3 Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.EBI J Med Chem 31: 499-500 (1988) Wellcome Research Laboratories 2D 3D TSV
3339617 34 Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists.EBI J Med Chem 31: 466-72 (1988) Hoffmann-La Roche Inc. 2D 3D TSV
3339615 51 Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.EBI J Med Chem 31: 449-54 (1988) Medical University of South Carolina 2D 3D TSV
3339613 13 Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.EBI J Med Chem 31: 433-44 (1988) University of Kansas 2D 3D TSV
3339612 9 Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives.EBI J Med Chem 31: 422-8 (1988) Sankyo Co., Ltd. 2D 3D TSV
3339608 10 Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.EBI J Med Chem 31: 390-3 (1988) Universit£ di Camerino 2D 3D TSV
3336033 5 Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase.EBI J Med Chem 31: 60-5 (1988) University of Kansas 2D 3D TSV
3336029 8 Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI J Med Chem 31: 3-5 (1988) Abbott Laboratories 2D 3D TSV
3336027 16 N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.EBI J Med Chem 31: 271-3 (1988) Warner-Lambert Company 2D 3D TSV
3336020 34 (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE.EBI J Med Chem 31: 204-12 (1988) Squibb Institute for Medical Research 2D 3D TSV
3336017 28 Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines.EBI J Med Chem 31: 176-81 (1988) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
3336016 4 Conformational requirements of substrates for activity with phenylethanolamine N-methyltransferase.EBI J Med Chem 31: 169-71 (1988) University of Kansas 2D 3D TSV
3336013 52 Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase.EBI J Med Chem 31: 117-21 (1988) University of Pittsburgh 2D 3D TSV
3316655 34 Renin inhibitors. Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogues on plasma renin.EBI J Med Chem 30: 2287-91 (1988) SANOFI Recherche 2D 3D TSV
3312605 30 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.EBI J Med Chem 30: 1998-2004 (1987) Burroughs Wellcome Co. 2D 3D TSV
3312604 33 Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond.EBI J Med Chem 30: 1978-83 (1987) Abbott Laboratories 2D 3D TSV
3309316 67 Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.EBI J Med Chem 30: 1853-7 (1987) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
3309315 8 alpha,alpha-Difluoro-beta-aminodeoxystatine-containing renin inhibitory peptides.EBI J Med Chem 30: 1837-42 (1987) Upjohn Company 2D 3D TSV
3309313 48 Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.EBI J Med Chem 30: 1729-37 (1987) Abbott Laboratories 2D 3D TSV
3305947 7 Fluoro ketone containing peptides as inhibitors of human renin.EBI J Med Chem 30: 1617-22 (1987) TBA 2D 3D TSV
3305946 30 New inhibitors of human renin that contain novel Leu-Val replacements.EBI J Med Chem 30: 1609-16 (1987) TBA 2D 3D TSV
3305945 27 Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors.EBI J Med Chem 30: 1588-95 (1987) TBA 2D 3D TSV
3302256 45 Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides.EBI J Med Chem 30: 1287-95 (1987) TBA 2D 3D TSV
3298652 19 Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.EBI J Med Chem 30: 1224-8 (1987) TBA 2D 3D TSV
3295239 9 Renin inhibitors. Design of angiotensinogen transition-state analogues containing novel. (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid.EBI J Med Chem 30: 976-82 (1987) TBA 2D 3D TSV
3290486 7 Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site.EBI J Med Chem 31: 1377-82 (1988) Upjohn Company 2D 3D TSV
3290485 7 Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction.EBI J Med Chem 31: 1369-76 (1988) Upjohn Company 2D 3D TSV
3284585 2 Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements.BDB Biochemistry 27: 1604-10 (1988) Monsanto Agricultural Company 2D 3D TSV
3279211 16 Design of potent cyclic gonadotropin releasing hormone antagonists.EBI J Med Chem 31: 677-82 (1988) Salk Institute 2D 3D TSV
3279210 19 Renin inhibitors containing psi[CH2O] pseudopeptide inserts.EBI J Med Chem 31: 671-7 (1988) Upjohn Company 2D 3D TSV
3279206 16 New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.EBI J Med Chem 31: 532-9 (1988) Abbott Laboratories 2D 3D TSV
3276890 28 Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.EBI J Med Chem 31: 284-95 (1988) Abbott Laboratories 2D 3D TSV
3275777 34 Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.EBI J Med Chem 31: 18-30 (1988) Upjohn Company 2D 3D TSV
3275776 45 Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.EBI J Med Chem 31: 129-37 (1988) Pennsylvania State University 2D 3D TSV
3272174 7 Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.BDB Neuron 1: 403-10 (1988) National Institute of Mental Health 2D 3D TSV
3263503 3 A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]Iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor.EBI J Med Chem 31: 2069-71 (1988) Northeastern University 2D 3D TSV
3260955 14 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine.EBI J Med Chem 31: 1566-70 (1988) Northwestern University 2D 3D TSV
3258925 5 Melanin concentrating hormone analogues: contraction of the cyclic structure. 1. Agonist activity.EBI J Med Chem 31: 949-54 (1988) University of Arizona 2D 3D TSV
3257523 13 N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.EBI J Med Chem 31: 370-4 (1988) CNRS-CERCOA 2D 3D TSV
3252029 9 Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling.BDB J Pharmacol Exp Ther 244: 1150-6 (1988) University of Illinois at Chicago 2D 3D TSV
3216901 5 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 337: 687-9 (1988) Pharmakologisches Institut, Heidelberg 2D 3D TSV
3208837 3 2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.BDB Eur J Pharmacol 156: 157-60 (1988) Pharmakologisches Institut 2D 3D TSV
3207677 1 Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.BDB Biochemistry 27: 7301-10 (1988) University of Wisconsin 2D 3D TSV
3193422 8 Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine.EBI J Med Chem 31: 2297-300 (1989) NIDDK 2D 3D TSV
3184128 21 Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.EBI J Med Chem 31: 2221-7 (1988) Ortho Pharmaceutical Corporation 2D 3D TSV
3184126 46 Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.EBI J Med Chem 31: 2193-9 (1988) University of Wisconsin 2D 3D TSV
3184124 28 Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.EBI J Med Chem 31: 2164-9 (1988) Southern Research Institute 2D 3D TSV
3184122 10 A pyrimidine-based"flexible" bisubstrate analogue inhibitor of human thymidylate synthase.EBI J Med Chem 31: 2126-32 (1988) University of Utah 2D 3D TSV
3172141 15 Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.EBI J Med Chem 31: 2034-9 (1988) Merrell Dow Research Institute 2D 3D TSV
3172140 14 (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors.EBI J Med Chem 31: 2027-33 (1988) Vanderbilt University 2D 3D TSV
3172133 9 Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase.EBI J Med Chem 31: 1984-6 (1988) University of Kansas 2D 3D TSV
3172131 23 Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.EBI J Med Chem 31: 1968-71 (1988) Virginia Commonwealth University 2D 3D TSV
3172130 35 Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI J Med Chem 31: 1960-4 (1988) Abbott Laboratories 2D 3D TSV
3172121 7 Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase.EBI J Med Chem 31: 1869-71 (1988) Squibb Institute for Medical Research 2D 3D TSV
3165132 1 Nucleosides of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogues of enzymes in pyrimidine nucleoside metabolism.EBI J Med Chem 31: 1575-9 (1988) Washington State University 2D 3D TSV
3156993 4 Novel photoaffinity label for the dopamine D2 receptor: synthesis of 4-azido-5-iodo-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl] benzamide (iodoazidoclebopride, IAC) and the corresponding 125I-labeled analogue (125IAC).EBI J Med Chem 28: 405-7 (1985) TBA 2D 3D TSV
3143010 28 Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.EBI J Med Chem 31: 2277-88 (1989) Abbott Laboratories 2D 3D TSV
3143009 50 Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency.EBI J Med Chem 31: 2264-76 (1989) Abbott Laboratories 2D 3D TSV
3139864 10 Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus.BDB J Pharmacol Exp Ther 247: 169-73 (1988) Vanderbilt University 2D 3D TSV
3137345 18 Synthesis and biological activity of some transition-state inhibitors of human renin.EBI J Med Chem 31: 1839-46 (1988) Ciba-Geigy Limited 2D 3D TSV
3137344 19 Phosphinic acid inhibitors of D-alanyl-D-alanine ligase.EBI J Med Chem 31: 1772-8 (1988) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
3135406 21 Substrate analogue inhibitors of the IgA1 proteinases from Neisseria gonorrhoeae.EBI J Med Chem 31: 1647-51 (1988) University Hospital 2D 3D TSV
3133478 8 4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.EBI J Med Chem 31: 1453-62 (1988) Centre de Recherches Roussel Uclaf 2D 3D TSV
3132968 3 Glucosamine synthetase from Escherichia coli: kinetic mechanism and inhibition by N3-fumaroyl-L-2,3-diaminopropionic derivatives.BDB Biochemistry 27: 2282-7 (1988) ENSCP 2D 3D TSV
3130534 3 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.BDB Life Sci 42: 1941-54 (1988) Tokushima Research Institute 2D 3D TSV
3127589 28 Inhibition of copper-dependent amine oxidases by some hydrazides of pyrrol-1-ylbenzoic and pyrrol-1-ylphenylacetic acids.EBI J Med Chem 31: 802-6 (1988) Università di Roma "La Sapienza" 2D 3D TSV
3127587 31 New human renin inhibitors containing an unnatural amino acid, norstatine.EBI J Med Chem 31: 701-4 (1988) Kissei Pharmaceutical Co., Ltd. 2D 3D TSV
3126296 40 Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.EBI J Med Chem 31: 625-9 (1988) University of Wisconsin 2D 3D TSV
3123692 5 Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase.EBI J Med Chem 31: 330-5 (1988) Nucleic Acid Research Institute 2D 3D TSV
3121857 116 Spiro hydantoin aldose reductase inhibitors.EBI J Med Chem 31: 230-43 (1988) Pfizer Central Research 2D 3D TSV
3121855 21 Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.EBI J Med Chem 31: 150-3 (1988) SRI International 2D 3D TSV
3121854 21 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents.EBI J Med Chem 31: 122-9 (1988) Burroughs Wellcome Co. 2D 3D TSV
3118024 35 Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.EBI J Med Chem 30: 2137-44 (1987) Abbott Laboratories 2D 3D TSV
3114491 18 Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines.EBI J Med Chem 30: 1595-8 (1987) TBA 2D 3D TSV
3112397 5 Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.EBI J Med Chem 30: 1463-9 (1987) TBA 2D 3D TSV
3100803 16 Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres.EBI J Med Chem 30: 374-83 (1987) TBA 2D 3D TSV
3100802 151 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes.EBI J Med Chem 30: 348-56 (1987) TBA 2D 3D TSV
3100801 9 Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine.EBI J Med Chem 30: 286-95 (1987) TBA 2D 3D TSV
3100797 21 Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.EBI J Med Chem 29: 1263-9 (1987) TBA 2D 3D TSV
3100794 6 Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.EBI J Med Chem 29: 1131-3 (1987) TBA 2D 3D TSV
3097318 4 Synthesis and biological evaluation of irreversible inhibitors of aldose reductase.EBI J Med Chem 29: 2384-9 (1986) TBA 2D 3D TSV
3097317 19 Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.EBI J Med Chem 29: 2347-51 (1986) TBA 2D 3D TSV
3093681 7 Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase.EBI J Med Chem 29: 2034-7 (1986) TBA 2D 3D TSV
3093680 13 Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives.EBI J Med Chem 29: 2024-8 (1986) TBA 2D 3D TSV
3091835 3 Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine.EBI J Med Chem 29: 1804-6 (1986) TBA 2D 3D TSV
3091834 6 Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin.EBI J Med Chem 29: 1786-9 (1986) TBA 2D 3D TSV
3091832 28 Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).EBI J Med Chem 29: 1754-60 (1986) TBA 2D 3D TSV
3091830 31 Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene.EBI J Med Chem 29: 1643-50 (1986) TBA 2D 3D TSV
3090264 25 Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.EBI J Med Chem 29: 1429-35 (1986) TBA 2D 3D TSV
3086557 19 Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones.EBI J Med Chem 29: 1094-9 (1986) TBA 2D 3D TSV
3084785 14 Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.EBI J Med Chem 29: 676-81 (1986) TBA 2D 3D TSV
3084783 6 Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase.EBI J Med Chem 29: 627-9 (1986) TBA 2D 3D TSV
3081722 40 Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.EBI J Med Chem 29: 342-6 (1986) TBA 2D 3D TSV
3079831 5 (beta-Chloro-alpha-aminoethyl)phosphonic acids as inhibitors of alanine racemase and D-alanine:D-alanine ligase.EBI J Med Chem 29: 148-51 (1986) TBA 2D 3D TSV
3069127 1 Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase.BDB Biochemistry 27: 8050-6 (1988) Pennsylvania State University 2D 3D TSV
3050089 24 Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.EBI J Med Chem 31: 1941-6 (1988) University of North Carolina 2D 3D TSV
3050088 47 Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.EBI J Med Chem 31: 1918-23 (1988) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
3045321 8 Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2.EBI J Med Chem 31: 1768-72 (1988) Smith Kline& French Laboratories 2D 3D TSV
3045320 37 Design of rat renin inhibitory peptides.EBI J Med Chem 31: 1679-86 (1988) Massachusetts General Hospital 2D 3D TSV
3039137 20 Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.EBI J Med Chem 30: 1469-74 (1987) TBA 2D 3D TSV
3039136 259 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI J Med Chem 30: 1433-54 (1987) TBA 2D 3D TSV
3035180 39 Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids.EBI J Med Chem 30: 992-8 (1987) TBA 2D 3D TSV
3035179 5 High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid.EBI J Med Chem 30: 959-61 (1987) TBA 2D 3D TSV
3033464 11 Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17.BDB Mol Pharmacol 31: 326-33 (1987) Burroughs Wellcome Company 2D 3D TSV
3033248 3 Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists.EBI J Med Chem 30: 947-50 (1987) TBA 2D 3D TSV
3033247 1 Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues.EBI J Med Chem 30: 943-7 (1987) TBA 2D 3D TSV
3033245 1 Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives.EBI J Med Chem 30: 911-8 (1987) TBA 2D 3D TSV
3033244 8 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent.EBI J Med Chem 30: 867-71 (1987) TBA 2D 3D TSV
3031294 10 Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites.EBI J Med Chem 30: 743-6 (1987) TBA 2D 3D TSV
3027341 10 5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.EBI J Med Chem 30: 409-19 (1987) TBA 2D 3D TSV
3027337 1 Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists.EBI J Med Chem 30: 239-49 (1987) TBA 2D 3D TSV
3027330 7 Structure-activity relationships of kadsurenone analogues.EBI J Med Chem 30: 136-42 (1987) TBA 2D 3D TSV
3027327 3 Spin probes as mechanistic inhibitors and active site probes of thymidylate synthetase.EBI J Med Chem 29: 1237-42 (1987) TBA 2D 3D TSV
3020249 28 Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.EBI J Med Chem 29: 1953-61 (1986) TBA 2D 3D TSV
3020247 10 Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists.EBI J Med Chem 29: 1917-21 (1986) TBA 2D 3D TSV
3020244 45 Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.EBI J Med Chem 29: 1855-61 (1986) TBA 2D 3D TSV
3018244 33 N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.EBI J Med Chem 29: 1683-9 (1986) TBA 2D 3D TSV
3016270 20 Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.EBI J Med Chem 29: 1520-4 (1986) TBA 2D 3D TSV
3016269 31 Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.EBI J Med Chem 29: 1512-6 (1986) TBA 2D 3D TSV
3016248 49 Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.BDB J Pharmacol Exp Ther 238: 739-48 (1986) The Johns Hopkins University 2D 3D TSV
3014519 39 Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.BDB Proc Natl Acad Sci U S A 83: 4918-22 (1986) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
3012084 7 Indole-phenol bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analogue of labetalol.EBI J Med Chem 29: 1009-15 (1986) TBA 2D 3D TSV
3012067 36 (-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.BDB J Pharmacol Exp Ther 237: 731-8 (1986) Johns Hopkins University 2D 3D TSV
3011801 22 Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase.BDB J Biol Chem 261: 7819-23 (1986) University of Oulu 2D 3D TSV
3010074 129 Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.BDB Mol Pharmacol 29: 331-46 (1986) Warner-Lambert/Parke-Davis Pharmaceutical Research 2D 3D TSV
3009814 56 Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihypertensive activity.EBI J Med Chem 29: 784-96 (1986) TBA 2D 3D TSV
3009454 8 Photoaffinity labeling of the Ah receptor.BDB J Biol Chem 261: 6352-65 (1986) University of Wisconsin 2D 3D TSV
3007760 44 N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.EBI J Med Chem 29: 531-7 (1986) TBA 2D 3D TSV
3005576 27 Angiotensin converting enzyme inhibitors as antihypertensive agents: 1-[(2-mercaptocycloalkyl)carbonyl]-L-prolines.EBI J Med Chem 29: 411-7 (1986) TBA 2D 3D TSV
3005574 18 Ribose-modified adenosine analogues as adenosine receptor agonists.EBI J Med Chem 29: 346-53 (1986) TBA 2D 3D TSV
3005569 16 Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.EBI J Med Chem 29: 251-60 (1986) TBA 2D 3D TSV

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