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Discovery of highly potent SARS-CoV-2 M
Bioorg Med Chem Lett 58: (2022)
Nanjing University Of Chinese Medicine
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Eur J Med Chem 229: (2022)
Central South University
Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors.
Eur J Med Chem 229: (2022)
Anadolu University
Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.
Eur J Med Chem 229: (2022)
Southern Medical University
Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis.
Eur J Med Chem 230: (2022)
Southern Medical University Biomedical Research Center
Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.
Eur J Med Chem 230: (2022)
West China Hospital
Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer.
Eur J Med Chem 229: (2022)
China Pharmaceutical University
Discovery of novel ?-carboline derivatives as selective AChE inhibitors with GSK-3? inhibitory property for the treatment of Alzheimer's disease.
Eur J Med Chem 229: (2022)
Shenyang Pharmaceutical University
Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation.
Bioorg Med Chem Lett 58: (2022)
Kasetsart University
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem 65: 2262-2287 (2022)
Glaxosmithkline R&D
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
J Med Chem 65: 1612-1661 (2022)
TBA
Structure-Activity Relationship Studies of New Sinapic Acid Phenethyl Ester Analogues Targeting the Biosynthesis of 5-Lipoxygenase Products: The Role of Phenolic Moiety, Ester Function, and Bioisosterism.
J Nat Prod 85: 225-236 (2022)
Universit£
Recent research results have converted gp120 binders to a therapeutic option for the treatment of HIV-1 infection. A medicinal chemistry point of view.
Eur J Med Chem 229: (2022)
University Of Siena
Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
Eur J Med Chem 229: (2022)
Shenyang Pharmaceutical University
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Eur J Med Chem 229: (2022)
Stanford University
Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapy.
Eur J Med Chem 229: (2022)
Shanghai Institute Of Pharmaceutical Industry
Design of a Potent TLX Agonist by Rational Fragment Fusion.
J Med Chem 65: 2288-2296 (2022)
Goethe University Frankfurt
Discovery of 3,4-Dihydrobenzo[
J Med Chem 65: 1786-1807 (2022)
Sichuan University
Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.
J Med Chem 65: 1867-1882 (2022)
Universidad Complutense
Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.
J Med Chem 65: 2388-2408 (2022)
Md Anderson Cancer Center
Size-Reduced Macrocyclic Analogues of [Pyr
J Med Chem 65: 531-551 (2022)
Universit£
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J Med Chem 65: 1585-1607 (2022)
Csic
A review on the treatment of multiple myeloma with small molecular agents in the past five years.
Eur J Med Chem 229: (2022)
Sichuan Academy Of Medical Science&Sichuan Provincial People'S Hospital
Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor ?t inverse agonists.
Eur J Med Chem 229: (2022)
Southeast University
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Eur J Med Chem 229: (2022)
Guizhou Medical University
Quercetin derivatives: Drug design, development, and biological activities, a review.
Eur J Med Chem 229: (2022)
Mazandaran University Of Medical Sciences
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem 65: 838-856 (2022)
Merck
Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine.
J Med Chem 65: 271-284 (2022)
Aristotle University Of Thessaloniki
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.
J Med Chem 65: 757-784 (2022)
Pfizer
Synthesis, carbonic anhydrase enzyme inhibition evaluations, and anticancer studies of sulfonamide based thiadiazole derivatives.
Bioorg Med Chem Lett 57: (2022)
Seoul National University
Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats.
J Med Chem 65: 217-233 (2022)
Institute Of Biochemistry Of The Romanian Academy
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J Med Chem 65: 785-810 (2022)
Guangzhou Medical University
Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors.
J Med Chem 65: 58-83 (2022)
Jinan University
Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K
J Med Chem 65: 303-322 (2022)
Chapman University School Of Pharmacy
ARN25068, a versatile starting point towards triple GSK-3?/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Eur J Med Chem 229: (2022)
University Of Bologna
Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding.
J Med Chem 65: 1552-1566 (2022)
Cnrs
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
J Med Chem 65: 824-837 (2022)
University Of Florence
Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia.
J Med Chem 65: 857-875 (2022)
China Pharmaceutical University
Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor ?-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.
J Med Chem 65: 592-615 (2022)
Fudan University
Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX? Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J Med Chem 65: 2548-2557 (2022)
Korea Basic Science Institute
Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway.
Eur J Med Chem 229: (2022)
Southeast University
Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics.
Eur J Med Chem 229: (2022)
China Pharmaceutical University
Discovery of new and highly effective quadruple FFA1 and PPAR?/?/? agonists as potential anti-fatty liver agents.
Eur J Med Chem 229: (2022)
Guangdong Pharmaceutical University
DYRK1A inhibitors for disease therapy: Current status and perspectives.
Eur J Med Chem 229: (2022)
West China Hospital
Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK).
Eur J Med Chem 229: (2022)
Peking University
Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.
J Med Chem 65: 285-302 (2022)
Ocean University Of China
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J Med Chem 65: 562-578 (2022)
University College London
"Clickable" Albumin Binders for Modulating the Tumor Uptake of Targeted Radiopharmaceuticals.
J Med Chem 65: 710-733 (2022)
Institute Of Radiopharmaceutical Cancer Research
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
J Med Chem 65: 163-190 (2022)
Zhengzhou University
The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus
J Nat Prod 85: 237-247 (2022)
University Of Illinois At Chicago
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
J Med Chem 65: 1567-1584 (2022)
Sanofi R&D
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na
J Med Chem 65: 485-496 (2022)
Merck
Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells.
J Med Chem 65: 507-519 (2022)
University Of California San Diego
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Eur J Med Chem 229: (2022)
Taiwan National Health Research Institutes
Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.
J Med Chem 65: 257-270 (2022)
Research Triangle Institute
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem 65: 633-664 (2022)
Gsk
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
J Med Chem 65: 1396-1417 (2022)
Manros Therapeutics & Perha Pharmaceuticals
Fragment-to-Lead Medicinal Chemistry Publications in 2020.
J Med Chem 65: 84-99 (2022)
Vrije Universiteit Amsterdam
Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J Med Chem 65: 191-216 (2022)
Athenex
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.
Eur J Med Chem 229: (2022)
Lanzhou University
Isolation and biological activity of azocine and azocane alkaloids.
Bioorg Med Chem 54: (2022)
University Of Auckland
Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor ? partial agonist.
Bioorg Med Chem 54: (2022)
Seoul National University
Identification and optimization of a novel series of selective PIP5K inhibitors.
Bioorg Med Chem 54: (2022)
Astrazeneca
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Eur J Med Chem 229: (2022)
East China University Of Science And Technology
Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.
Eur J Med Chem 228: (2022)
Janssen Research & Development
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.
Eur J Med Chem 228: (2022)
University Of Florence
Discovery of Imidazole-Based Inhibitors of
ACS Med Chem Lett 12: 1962-1967 (2021)
Montclair State University
Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals.
ACS Med Chem Lett 12: 1955-1961 (2021)
Freie Universit£T Berlin
Design, Synthesis, and Biological Evaluation of APN and AKT Dual-Target Inhibitors.
ACS Med Chem Lett 12: 1932-1941 (2021)
Shandong University
17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
ACS Med Chem Lett 12: 1920-1924 (2021)
Saarland University
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-
ACS Med Chem Lett 12: 1912-1919 (2021)
The Genomics Institute Of The Novartis Research Foundation
Novel Heteroaromatic Carboxamide Derivatives as Plasma Kallikrein Inhibitors for Treating Diabetic Complications, Ocular Diseases and Edema-Associated Diseases.
ACS Med Chem Lett 12: 1896-1897 (2021)
Smith, Gambrell & Russell
Novel Substituted Tetrazoles as ACSS2 Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 1894-1895 (2021)
Smith, Gambrell & Russell
Adenosine Receptor Antagonists as Potential Cancer Therapy.
ACS Med Chem Lett 12: 1892-1893 (2021)
Therachem Research Medilab
Dual Inhibition of IL-2-Inducible T-Cell Kinase (ITK) and Tropomyosin Receptor Kinase A (TRKA) as Potential Treatment for Atopic Dermatitis and Other Inflammatory and Autoimmune Diseases.
ACS Med Chem Lett 12: 1889-1891 (2021)
Therachem Research Medilab
Novel Difluorocyclohexyl Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Diseases.
ACS Med Chem Lett 12: 1883-1884 (2021)
Smith, Gambrell & Russell
Novel Substituted Heteroaryl Compounds for Treating Huntington's Disease.
ACS Med Chem Lett 12: 1881-1882 (2021)
Smith, Gambrell & Russell
Improved 5-HT2 Selective Receptor Modulators for the Treatment of Psychological Disorders.
ACS Med Chem Lett 12: 1876-1878 (2021)
Usona Institute
The Psychedelic Renaissance: Addressing Potential Adverse Effects in a Therapeutic Setting.
ACS Med Chem Lett 12: 1874-1875 (2021)
Usona Institute
Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 1870-1871 (2021)
Smith, Gambrell & Russell
Novel Compounds as PHD Inhibitors for Treating Heart, Lung, Liver, and Kidney Diseases.
ACS Med Chem Lett 12: 1868-1869 (2021)
Smith, Gambrell & Russell
Novel Spiropiperidine Allosteric Modulators of Nicotinic Acetylcholine Receptors for Treating Central Nervous System Disorders.
ACS Med Chem Lett 12: 1866-1867 (2021)
Smith, Gambrell & Russell
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
Bioorg Med Chem 54: (2022)
North-West University
Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from
J Nat Prod 85: 215-224 (2022)
Uppsala University
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem 65: 409-423 (2022)
University Of Dundee
Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy.
J Med Chem 64: 18025-18053 (2021)
Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre
Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect.
J Med Chem 64: 17795-17812 (2021)
University Of Copenhagen
Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent.
J Med Chem 64: 17824-17845 (2021)
Taipei Medical University
Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
Eur J Med Chem 228: (2022)
Soochow University
Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.
Eur J Med Chem 228: (2022)
Eternity Bioscience
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.
Bioorg Med Chem Lett 57: (2022)
Technical University Of Denmark
The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.
J Med Chem 64: 17656-17689 (2021)
Massachusetts General Hospital
Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.
J Med Chem 64: 18175-18192 (2021)
Sichuan University
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.
Eur J Med Chem 228: (2022)
Northwest University
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (?
Eur J Med Chem 228: (2022)
Universit£
Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.
Eur J Med Chem 228: (2022)
Gause Institute Of New Antibiotics
Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression.
J Med Chem 64: 18158-18174 (2021)
Washington University School Of Medicine
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.
J Med Chem 64: 17887-17900 (2021)
Universitat De Barcelona
Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA).
J Med Chem 65: 1933-1945 (2022)
University Of Wollongong
Discovery of the c-Jun N-Terminal Kinase Inhibitor
J Med Chem 64: 18193-18208 (2021)
Bristol Myers Squibb
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward ? and ? opioid receptors.
Bioorg Med Chem 53: (2022)
Kitasato University
Molecular design of dual inhibitors of PI3K and potential molecular target of cancer for its treatment: A review.
Eur J Med Chem 228: (2022)
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)
Synthesis and biological evaluation of quinolone derivatives as transthyretin amyloidogenesis inhibitors and fluorescence sensors.
Bioorg Med Chem 53: (2022)
Chungnam National University
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV?1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem 53: (2022)
Shandong University
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS
J Med Chem 65: 3123-3133 (2022)
Mirati Therapeutics
Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL
Eur J Med Chem 228: (2022)
Shanghai University Of Traditional Chinese Medicine
Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
J Med Chem 64: 18082-18101 (2021)
University Of California Santa Cruz
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.
J Med Chem 64: 17936-17949 (2021)
Symeres
Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer.
J Med Chem 64: 18114-18142 (2021)
Victoria University Of Wellington
Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy.
Eur J Med Chem 228: (2022)
Stony Brook University
Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.
Eur J Med Chem 228: (2022)
China Pharmaceutical University
Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships.
Eur J Med Chem 228: (2022)
Northwest A&F University
Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies.
Eur J Med Chem 228: (2022)
Jinan University
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.
Eur J Med Chem 228: (2022)
Kafrelsheikh University
Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects.
Eur J Med Chem 228: (2022)
Cairo University
Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study.
Eur J Med Chem 228: (2022)
Central China Normal University
Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1.
J Med Chem 64: 17777-17794 (2021)
Vertex Pharmaceuticals
How the structural properties of the indole derivatives are important in kinase targeted drug design?: A case study on tyrosine kinase inhibitors.
Bioorg Med Chem 53: (2022)
Dr. Harisingh Gour University
Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor.
Eur J Med Chem 228: (2022)
Zhejiang University
Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer.
Eur J Med Chem 228: (2022)
Fujian Medical University (Fmu)
A survey of the clinical pipeline in neuroscience.
Bioorg Med Chem Lett 56: (2022)
Jnana Therapeutics
Design, synthesis and biological evaluation of nitrofuran-1,3,4-oxadiazole hybrids as new antitubercular agents.
Bioorg Med Chem 53: (2022)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Bioorg Med Chem Lett 56: (2022)
University Of Tsukuba
Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.
J Am Chem Soc 143: 20697-20709 (2021)
The University Of Arizona
Identification of a Hydroxypyrimidinone Compound (
J Med Chem 64: 18102-18113 (2021)
Bristol Myers Squibb
Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.
J Med Chem 64: 18054-18081 (2021)
Icahn School Of Medicine At Mount Sinai
Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies.
J Med Chem 64: 17866-17886 (2021)
Research Triangle Institute
Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy.
J Med Chem 64: 17950-17968 (2021)
China Pharmaceutical University
Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents.
Bioorg Med Chem 53: (2022)
Tsinghua University
Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors.
Eur J Med Chem 228: (2022)
National Research Centre
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.
J Med Chem 64: 17079-17097 (2021)
TBA
A
Eur J Med Chem 228: (2022)
National Institute Of Diabetes And Digestive And Kidney Disease
Evaluation of amentoflavone metabolites on PARP-1 inhibition and the potentiation on anti-proliferative effects of carboplatin in A549 cells.
Bioorg Med Chem Lett 56: (2022)
China Pharmaceutical University
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
J Med Chem 64: 17031-17050 (2021)
University Of Oxford
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-
J Med Chem 64: 17004-17030 (2021)
Lupin
Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of
J Med Chem 65: 4565-4577 (2022)
Shenyang Pharmaceutical University
Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery.
J Med Chem 65: 1445-1457 (2022)
Peking University Shenzhen Graduate School
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Eur J Med Chem 229: (2022)
Universit£
Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction.
Eur J Med Chem 229: (2022)
Huaqiao University
Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib.
Eur J Med Chem 229: (2022)
Nantong University
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.
Bioorg Med Chem 52: (2021)
Beijing Institute Of Pharmacology And Toxicology
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Bioorg Med Chem 52: (2021)
Ac Immune
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Bioorg Med Chem Lett 56: (2022)
Merck
Development of isoquinolinone derivatives as immunoproteasome inhibitors.
Bioorg Med Chem Lett 55: (2022)
University Of Messina
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M
Bioorg Med Chem Lett 56: (2022)
Vanderbilt University Medical Center
Current status of carbazole hybrids as anticancer agents.
Eur J Med Chem 229: (2022)
Hubei University
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.
Bioorg Med Chem 52: (2021)
Chengdu University Of Traditional Chinese Medicine
Modulating ?-arrestin 2 recruitment at the ?- and ?-opioid receptors using peptidomimetic ligands.
RSC Med Chem 12: 1958-1967 (2021)
The Ohio State University
Rational design of selective inhibitors of PARP4.
RSC Med Chem 12: 1950-1957 (2021)
Initial Therapeutics
Synthesis and antitumour evaluation of indole-2-carboxamides against paediatric brain cancer cells.
RSC Med Chem 12: 1910-1925 (2021)
Curtin University
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from
RSC Med Chem 12: 1894-1909 (2021)
University Of Kentucky
Design, synthesis and biological evaluation of 1,5-disubstituted ?-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders.
Eur J Med Chem 229: (2022)
National Research Council (Cnr)
Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.
J Med Chem 64: 17496-17510 (2021)
Philochem
Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe.
RSC Med Chem 12: 1935-1943 (2021)
Imperial College London
Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor.
J Med Chem 64: 17486-17495 (2021)
Second Military Medical University
High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation.
J Med Chem 65: 1505-1524 (2022)
Christian-Albrechts University Of Kiel
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor ? Agonists/Soluble Epoxide Hydrolase Inhibitors.
J Med Chem 64: 17259-17276 (2021)
Goethe-University
Identification of indole-based activators of insulin degrading enzyme.
Eur J Med Chem 228: (2022)
Univ. Lille
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.
Bioorg Med Chem 52: (2021)
St. Jude Children'S Research Hospital
Discovery of GCC5694A: A potent and selective sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes.
Bioorg Med Chem Lett 56: (2022)
Gc Pharma
Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer.
J Med Chem 64: 17413-17435 (2021)
China Pharmaceutical University
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
J Med Chem 64: 17530-17539 (2021)
University Of California San Francisco (Ucsf)
Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation.
J Med Chem 64: 17098-17114 (2021)
China Pharmaceutical University
Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer.
Eur J Med Chem 228: (2022)
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.
J Med Chem 64: 17221-17238 (2021)
Zhejiang University
Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Bioorg Med Chem 52: (2021)
Central Pharmaceutical Research Institute
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J Med Chem 64: 17146-17183 (2021)
Astrazeneca
Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
J Med Chem 65: 1352-1369 (2022)
Sanford Burnham Prebys Medical Discovery Institute
Synthesis, biological, and structural explorations of a series of ?-opioid receptor (MOR) agonists with high G protein signaling bias.
Eur J Med Chem 228: (2022)
Yantai University
The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates.
Eur J Med Chem 228: (2022)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors.
Eur J Med Chem 229: (2022)
The University Of Michigan Medical School
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
Bioorg Med Chem 52: (2021)
University Of Oulu
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer.
Bioorg Med Chem 52: (2021)
China Pharmaceutical University
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Bioorg Med Chem 52: (2021)
Yokohama City University
Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents.
Eur J Med Chem 228: (2022)
Shenyang Pharmaceutical University
Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure.
Bioorg Med Chem 52: (2021)
Kyoto Pharmaceutical University
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
J Med Chem 64: 16922-16955 (2021)
Michigan State University
C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters.
Bioorg Med Chem 51: (2021)
University Of The Punjab
Novel methyllycaconitine analogues selective for the ?4?2 over ?7 nicotinic acetylcholine receptors.
Bioorg Med Chem 51: (2021)
Australian National University
Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate.
J Med Chem 64: 17123-17145 (2021)
Lomonosov Moscow State University
2-Phenylcyclopropylmethylamine Derivatives as Dopamine D
J Med Chem 64: 17239-17258 (2021)
Shanghaitech University
In Pursuit of an Allosteric Human Tropomyosin Kinase A (
ACS Med Chem Lett 12: 1847-1852 (2021)
Veterinary Medicine Research & Development
Discovery and Development of Cyclic Peptide Inhibitors of CIB1.
ACS Med Chem Lett 12: 1832-1839 (2021)
University Of North Carolina
Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
ACS Med Chem Lett 12: 1824-1831 (2021)
University Of Pennsylvania
Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
ACS Med Chem Lett 12: 1810-1817 (2021)
Italfarmaco
Piperazinyl Bicyclic Derivatives as Selective Ligands of the ?2?-1 Subunit of Voltage-Gated Calcium Channels.
ACS Med Chem Lett 12: 1802-1809 (2021)
Welab Barcelona
Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
ACS Med Chem Lett 12: 1794-1801 (2021)
Spanish National Cancer Research Centre (Cnio)
Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12.
ACS Med Chem Lett 12: 1773-1782 (2021)
Medical College Of Wisconsin
Identification of 6-Hydroxypyrimidin-4(1
ACS Med Chem Lett 12: 1766-1772 (2021)
Bristol Myers Squibb
Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry.
ACS Med Chem Lett 12: 1759-1765 (2021)
Medical School Of Kunming University Of Science And Technology
BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.
ACS Med Chem Lett 12: 1753-1758 (2021)
Bristol Myers Squibb
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.
ACS Med Chem Lett 12: 1745-1752 (2021)
Lund University
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.
ACS Med Chem Lett 12: 1718-1725 (2021)
University Of Coimbra
Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19.
ACS Med Chem Lett 12: 1689-1693 (2021)
Dana-Farber Cancer Institute
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
ACS Med Chem Lett 12: 1678-1688 (2021)
Merck
Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer.
ACS Med Chem Lett 12: 1643-1645 (2021)
Usona Institute
Heterocyclic Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML).
ACS Med Chem Lett 12: 1641-1642 (2021)
Smith, Gambrell & Russell
Novel Substituted Piperazine Amide Compounds as Indoleamine-2,3-dioxygenase (IDO) Inhibitors.
ACS Med Chem Lett 12: 1639-1640 (2021)
Smith, Gambrell & Russell
Novel Heteroaromatic Carboxamides as Plasma Kallikrein Inhibitors for Treating Diabetic Complications, Ocular Diseases, and Edema-Associated Diseases.
ACS Med Chem Lett 12: 1637-1638 (2021)
Smith, Gambrell & Russell
Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer.
ACS Med Chem Lett 12: 1633-1634 (2021)
Usona Institute
Discovery of highly potent and selective EGFR
Eur J Med Chem 228: (2022)
Beijing Institute Of Pharmacology And Toxicology
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors.
Bioorg Med Chem 51: (2021)
California State University
Direct evidence of edge-to-face CH/? interaction for PAR-1 thrombin receptor activation.
Bioorg Med Chem 51: (2021)
Kyushu University
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites.
J Med Chem 64: 17468-17485 (2021)
Huazhong Agricultural University
New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU-6 Salt Derivatives.
ACS Med Chem Lett 12: 1703-1709 (2021)
Uniformed Services University Of The Health Sciences
The Discovery of Conformationally Constrained Bicyclic Peptidomimetics as Potent Hepatitis C NS5A Inhibitors.
ACS Med Chem Lett 12: 1649-1655 (2021)
Glaxosmithkline
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.
J Med Chem 64: 17287-17303 (2021)
Cambridge University
Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A
J Med Chem 64: 16573-16597 (2021)
Shanghaitech University
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Eur J Med Chem 228: (2022)
Universit£
Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects.
J Med Chem 64: 16801-16819 (2021)
Harbin Institute Of Technology
Inhibition of ALK2 with bicyclic pyridyllactams.
Bioorg Med Chem Lett 55: (2022)
Incyte
Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel ?-glucosidase inhibitors.
Bioorg Med Chem Lett 55: (2022)
Volgograd State Medical University
From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.
J Med Chem 65: 1481-1504 (2022)
University Of Leeds
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J Med Chem 65: 11500-11512 (2022)
Pharmaron Beijing
Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy.
RSC Med Chem 12: 1771-1779 (2021)
Tsinghua University
Estimating the cooperativity of PROTAC-induced ternary complexes using
RSC Med Chem 12: 1765-1770 (2021)
University Of Dundee
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.
RSC Med Chem 12: 1722-1730 (2021)
University Of Alberta Edmonton
-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-?-lactamases (MBLs) and the virulence factor LasB from
RSC Med Chem 12: 1698-1708 (2021)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors.
RSC Med Chem 12: 1680-1689 (2021)
University Of Wollongong
The evolution paths of some reprehensive scaffolds of ROR?t modulators, a perspective from medicinal chemistry.
Eur J Med Chem 228: (2022)
Sun Yat-Sen University
Medicinal chemistry updates of novel HDACs inhibitors (2020 to present).
Eur J Med Chem 227: (2022)
Hangzhou Normal University
Synthesis and structure-activity relationship studies of 1,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 1 (JAK1) inhibitors.
Bioorg Med Chem Lett 55: (2022)
Gwangju Institute Of Science And Technology (Gist)
Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.
Eur J Med Chem 228: (2022)
Liaocheng University
Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
Eur J Med Chem 228: (2022)
Universit£
Identification of (6S)-cyclopropyl-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxamines as new HBV capsid assembly modulators.
Eur J Med Chem 228: (2022)
Cams Key Laboratory Of Antiviral Drug Research
Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat.
Bioorg Med Chem Lett 55: (2022)
Mcgill University
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
J Med Chem 64: 16512-16529 (2021)
University Of Naples "Federico Ii
-Terphenyls as Anti-HSV-1/2 Agents from a Deep-Sea-Derived
J Nat Prod 84: 2822-2831 (2021)
Chinese Academy Of Sciences
Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase.
Bioorg Med Chem Lett 54: (2021)
Fox Chase Chemical Diversity Center
Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity.
J Med Chem 64: 16598-16608 (2021)
The University Of Queensland
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
J Med Chem 64: 16609-16625 (2021)
University Of Oxford
Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage.
J Med Chem 64: 16687-16702 (2021)
Shanghai Jiao Tong University
Repurposing old drugs as novel inhibitors of human MIF from structural and functional analysis.
Bioorg Med Chem Lett 55: (2022)
Wuhan University
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase.
Bioorg Med Chem Lett 54: (2021)
Sichuan University And Collaborative Innovation Center
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Eur J Med Chem 227: (2022)
Anhui Medical University
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and PROTAC-based degraders for cancer therapy.
Eur J Med Chem 227: (2022)
Zhengzhou University
UCH-L3 structure and function: Insights about a promising drug target.
Eur J Med Chem 227: (2022)
University Of Science And Technology
Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-).
Eur J Med Chem 227: (2022)
Zhuhai Campus Of Zunyi Medical University
Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.
J Med Chem 64: 17753-17776 (2021)
Vertex Pharmaceuticals
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y
J Med Chem 64: 16746-16769 (2021)
University Of Regensburg
Discovery of Quinazoline-2,4(1
J Med Chem 64: 16711-16730 (2021)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.
Eur J Med Chem 227: (2022)
Northwest University
Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent.
Bioorg Med Chem Lett 54: (2021)
Daiichi Sankyo
Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur J Med Chem 227: (2022)
Shinshu University
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.
Eur J Med Chem 227: (2022)
University Of Louisiana At Lafayette
Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.
Eur J Med Chem 227: (2022)
Shenyang Pharmaceutical University
Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.
Eur J Med Chem 227: (2022)
Second Military Medical University
Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors.
Eur J Med Chem 227: (2022)
Astrazeneca
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE.
Eur J Med Chem 227: (2022)
University Of South Carolina
Discovery of (
J Med Chem 64: 17184-17208 (2021)
Nanjing University Of Chinese Medicine
HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites.
J Med Chem 64: 16530-16540 (2021)
Rutgers University
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem 65: 1206-1224 (2022)
Biogen
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Eur J Med Chem 227: (2022)
Ege University
Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors.
Eur J Med Chem 227: (2022)
Liaocheng University
Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy.
Eur J Med Chem 227: (2022)
China Pharmaceutical University
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
J Med Chem 65: 2956-2970 (2022)
The University Of Sydney
Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact.
J Med Chem 64: 15858-15867 (2021)
Yonsei University
Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.
Bioorg Med Chem Lett 53: (2021)
Shenyang Pharmaceutical University
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach.
J Med Chem 64: 15810-15824 (2021)
Kyoto Prefectural University Of Medicine
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
J Med Chem 65: 1458-1480 (2022)
Syros Pharmaceuticals
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
J Med Chem 65: 1171-1205 (2022)
Central University Of Punjab
Discovery of the Triazolo[1,5-
J Med Chem 64: 16187-16204 (2021)
Zhengzhou University
PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation.
Eur J Med Chem 227: (2022)
Lomonosov Moscow State University
Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry.
Eur J Med Chem 227: (2022)
National Institute Of Technology Calicut
Design, synthesis and biological evaluation of novel aminopyrazole- and 7-azaindole-based Nek1 inhibitors and their effects on zebrafish kidney development.
Bioorg Med Chem Lett 53: (2021)
Technische Universit£T Darmstadt
Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions.
J Med Chem 64: 15973-15990 (2021)
University Of Rome Tor Vergata
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem 64: 16159-16176 (2021)
Drugs For Neglected Diseases Initiative (Dndi)
Human estrogen receptor ? antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants.
Eur J Med Chem 227: (2022)
University Of Kragujevac
Design and synthesis of new potent 5-HT
Eur J Med Chem 227: (2022)
Cracow University Of Technology
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/?-synuclein aggregation inhibitors with neuroprotective effects.
Eur J Med Chem 227: (2022)
German University In Cairo
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Eur J Med Chem 227: (2022)
Csir-Indian Institute Of Integrative Medicine
Discovery of structurally distinct tricyclic M
Bioorg Med Chem Lett 53: (2021)
Vanderbilt University
Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase.
Bioorg Med Chem Lett 53: (2021)
Tohoku Medical And Pharmaceutical University
Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J Med Chem 64: 15772-15786 (2021)
Moffitt Cancer Center
Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract.
J Med Chem 64: 15799-15809 (2021)
Swiss Federal Institute Of Technology (Eth Z£Rich)
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA
J Med Chem 64: 15549-15581 (2021)
Bristol Myers Squibb
Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2? (HIF-2?) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia.
J Med Chem 64: 17384-17402 (2021)
China Pharmaceutical University
Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein.
J Med Chem 64: 16147-16158 (2021)
University Of California Riverside
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J Med Chem 64: 15949-15972 (2021)
Astex Pharmaceuticals
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem 64: 16770-16800 (2021)
Merck
Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.
Eur J Med Chem 227: (2022)
Southwest Jiaotong University
Discovery and optimization of new 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline derivatives as potent influenza virus PA
Eur J Med Chem 227: (2022)
South China Agricultural University
NO-HDAC dual inhibitors.
Eur J Med Chem 227: (2022)
Mashhad University Of Medical Sciences
Exploring disordered loops in DprE1 provides a functional site to combat drug-resistance in Mycobacterium strains.
Eur J Med Chem 227: (2022)
Northwest A&F University
Structure-activity relationship study of hydroxyethylamine isostere and P1' site structure of peptide mimetic BACE1 inhibitors.
Bioorg Med Chem 50: (2021)
Kyoto Pharmaceutical University
Bradykinin-Potentiating Peptide-Paclitaxel Conjugate Directed at Ectopically Expressed Angiotensin-Converting Enzyme in Triple-Negative Breast Cancer.
J Med Chem 64: 17051-17062 (2021)
Hong Kong Baptist University
Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38?, and B-Raf.
J Med Chem 64: 15651-15670 (2021)
Glaxosmithkline
Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
Eur J Med Chem 227: (2022)
Universidad De Alcal£
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
Eur J Med Chem 227: (2022)
Isf College Of Pharmacy
Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y
Eur J Med Chem 227: (2022)
Soochow University
Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.
Eur J Med Chem 227: (2022)
Peking Union Medical College & Chinese Academy Of Medical Sciences
Novel 5-fluorouracil sensitizers for colorectal cancer therapy: Design and synthesis of S1P receptor 2 (S1PR2) antagonists.
Eur J Med Chem 227: (2022)
Ocean University Of China
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Eur J Med Chem 227: (2022)
Shenyang Pharmaceutical University
Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase.
Eur J Med Chem 227: (2022)
Universit£
Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy.
J Med Chem 64: 16626-16640 (2021)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
ACS Med Chem Lett 12: 1605-1612 (2021)
Emory University
Potent Anti-Inflammatory, Arylpyrazole-Based Glucocorticoid Receptor Agonists That Do Not Impair Insulin Secretion.
ACS Med Chem Lett 12: 1568-1577 (2021)
University Of Tennessee
Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma.
ACS Med Chem Lett 12: 1559-1567 (2021)
Northwestern University
-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.
ACS Med Chem Lett 12: 1546-1552 (2021)
Reaction Biology
Novel HDAC1 and HDAC2 Inhibitors for Treating Diseases.
ACS Med Chem Lett 12: 1532-1533 (2021)
Smith, Gambrell & Russell
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors.
ACS Med Chem Lett 12: 1530-1531 (2021)
Smith, Gambrell & Russell
Novel Substituted Tetrahydroquinoline Compounds as Indoleamine-2,3-dioxygenase (IDO) Inhibitors.
ACS Med Chem Lett 12: 1524-1525 (2021)
Smith, Gambrell & Russell
Psilocin Derivatives as Serotonergic Psychedelic Agents for the Treatment of CNS Disorders.
ACS Med Chem Lett 12: 1519-1520 (2021)
Usona Institute
Modulation of KRAS Mutant by Inhibiting PLK1 Kinase in Cancer Therapeutics.
ACS Med Chem Lett 12: 1514-1516 (2021)
Usona Institute
Dual Inhibition of KRAS G12C and G12D Mutants as a Potential Treatment in Cancer Therapy.
ACS Med Chem Lett 12: 1512-1513 (2021)
Usona Institute
Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase ? (PI3K?).
J Med Chem 65: 1418-1444 (2022)
Arcus Biosciences
Discovery of 1-Amino-1
J Med Chem 64: 16242-16270 (2021)
Henan Normal University
Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J Med Chem 64: 15629-15638 (2021)
Boehringer Ingelheim Pharma
Posttranslational modifications of ?-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
RSC Med Chem 12: 1574-1584 (2021)
The University Of Queensland
Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks.
RSC Med Chem 12: 1540-1554 (2021)
Bharati Vidyapeeth'S College Of Pharmacy
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.
ACS Med Chem Lett 12: 1578-1584 (2021)
University Of Helsinki
Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
ACS Med Chem Lett 12: 1539-1545 (2021)
Epizyme
Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.
Bioorg Med Chem 50: (2021)
Jinan University
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors.
J Med Chem 64: 16020-16045 (2021)
Universit£
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
J Med Chem 65: 1370-1383 (2022)
Eberhard Karls Universit£T T£Bingen
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.
J Med Chem 64: 15111-15125 (2021)
Soochow University
Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation.
J Med Chem 64: 15503-15514 (2021)
Central China Normal University
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile.
J Med Chem 64: 15069-15090 (2021)
Zhejiang University
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.
J Med Chem (2021)
University Of Illinois At Chicago
Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas.
J Med Chem 64: 15170-15188 (2021)
Chinese Academy Of Sciences
Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases.
Eur J Med Chem 227: (2022)
Taipei Medical University
Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
J Med Chem 64: 15912-15935 (2021)
Korea Institute Of Science & Technology (Kist)
Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization.
J Med Chem 64: 16282-16292 (2021)
Qingdao University Medical College
Development of 2-(5,6,7-Trifluoro-1
J Med Chem 64: 14968-14982 (2021)
University Of British Columbia
VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.
Eur J Med Chem 227: (2022)
The Affiliated Hospital Of Qingdao University
Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors.
Eur J Med Chem 227: (2022)
East China Normal University
Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2.
Eur J Med Chem 227: (2022)
Shenyang Pharmaceutical University
Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space.
Eur J Med Chem 227: (2022)
Gachon University
Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.
Eur J Med Chem 227: (2022)
Shandong University
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation
J Med Chem 64: 15402-15419 (2021)
Biogen
Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins.
J Med Chem 64: 15477-15502 (2021)
University Of Dundee
Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design.
J Med Chem 64: 15868-15882 (2021)
National Institute Of Health Sciences
A patent review on SARS coronavirus main protease (3CLpro) inhibitors.
ChemMedChem (2021)
Experimental Drug Development Centre
Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease.
Eur J Med Chem 226: (2021)
China Pharmaceutical University
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.
J Med Chem 64: 15262-15279 (2021)
Novartis Pharma
Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J Med Chem 64: 15334-15348 (2021)
The State University Of New Jersey
Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.
J Med Chem 64: 15379-15401 (2021)
West China Hospital Of Sichuan University
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem 64: 15189-15213 (2021)
Astrazeneca
Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of ?-Secretase-Substrate Interaction.
J Med Chem 64: 15367-15378 (2021)
University Of Kansas
Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.
J Med Chem 64: 14942-14954 (2021)
China Pharmaceutical University
Discovery of 6-[(3
J Med Chem 64: 15141-15169 (2021)
University Of Texas Md Anderson Cancer Center
Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable ROR? Agonists with Antitumor Activity.
J Med Chem 64: 14983-14996 (2021)
Shanghai Hengrui Pharmaceutical
Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D
J Med Chem 64: 15313-15333 (2021)
National Institute On Drug Abuse - Intramural Research Program
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.
J Med Chem 64: 14930-14941 (2021)
Cytokinetics
Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis.
Eur J Med Chem 226: (2021)
Shanghaitech University
Effect of phenylurea hydroxamic acids on histone deacetylase and VEGFR-2.
Bioorg Med Chem 50: (2021)
Taipei Medical University
Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure.
Bioorg Med Chem 50: (2021)
Northeastern University
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
J Med Chem 64: 15126-15140 (2021)
Goethe University Frankfurt
Optimization of bifunctional piperidinamide derivatives as ?
Eur J Med Chem 226: (2021)
Huazhong University Of Science And Technology
Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs.
Eur J Med Chem 226: (2021)
University Of Chinese Academy Of Sciences
Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors.
Bioorg Med Chem Lett 53: (2021)
China Pharmaceutical University
Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis.
Bioorg Med Chem 49: (2021)
Ono Pharmaceutical
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-?-lactamase inhibitors with re-sensitization activity.
Eur J Med Chem 226: (2021)
Cnrs
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Eur J Med Chem 226: (2021)
Fudan University
Zinc enzymes in medicinal chemistry.
Eur J Med Chem 226: (2021)
Hefei University Of Technology
Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
Eur J Med Chem 226: (2021)
University Of Pisa
Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
Bioorg Med Chem Lett 52: (2021)
Acerta Pharma
Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2.
J Med Chem 64: 14955-14967 (2021)
University Of Toronto
Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis.
J Med Chem 65: 1047-1131 (2022)
University Of Edinburgh
Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.
J Med Chem 64: 15280-15296 (2021)
Guizhou Medical University
Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery".
J Med Chem 64: 15582-15592 (2021)
Jinan University
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).
Eur J Med Chem 226: (2021)
Nanjing University Of Chinese Medicine
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with
J Med Chem 64: 15214-15249 (2021)
The Ohio State University
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
J Med Chem 64: 14773-14792 (2021)
TBA
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J Med Chem 64: 14540-14556 (2021)
University Of Tennessee Health Science Center
Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.
Eur J Med Chem 226: (2021)
China Pharmaceutical University
Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold.
Bioorg Med Chem Lett 52: (2021)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.
J Med Chem 64: 14526-14539 (2021)
Soochow University
Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers.
J Med Chem 64: 14153-14164 (2021)
Carna Biosciences
Synthesis of Norgestomet and its 17?-isomer and evaluation of their agonistic activities against progesterone receptor.
Bioorg Med Chem 49: (2021)
National Institute Of Health Sciences
Design, synthesis and biological evaluation of new thiazole scaffolds as potential TRPM8 antagonists.
Bioorg Med Chem Lett 52: (2021)
Dipartimento Di Scienze Fisiche E Chimiche Universit£
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).
J Med Chem 64: 14311-14331 (2021)
Hong Kong Polytechnic University
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
J Med Chem 64: 14477-14497 (2021)
National Health Research Institutes
Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.
J Med Chem 64: 14142-14152 (2021)
Cytokinetics
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
J Med Chem 64: 14192-14216 (2021)
Sichuan University
A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases.
Bioorg Med Chem 49: (2021)
Birla Institute Of Technology
N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties.
Eur J Med Chem 226: (2021)
Peking University
Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines.
Bioorg Med Chem 49: (2021)
Universiti Kuala Lumpur
Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
Bioorg Med Chem 49: (2021)
Experimental Drug Development Centre
Shining light on the histamine H
Bioorg Med Chem Lett 52: (2021)
University Of Regensburg
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase II? poison.
Eur J Med Chem 226: (2021)
Yeungnam University
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Eur J Med Chem 226: (2021)
Hong Kong Polytechnic University
Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).
J Med Chem 64: 14757-14772 (2021)
Vanderbilt University School Of Medicine
Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus
J Nat Prod 84: 2727-2737 (2021)
Chinese Academy Of Sciences
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem 64: 14603-14619 (2021)
Emd Serono Research & Development Institute
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
J Med Chem 64: 14860-14875 (2021)
University Of Minnesota
The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity.
Bioorg Med Chem 48: (2021)
Heidelberg University
Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.
Eur J Med Chem 226: (2021)
Shandong University
Searching for an ideal SERM: Mining tamoxifen structure-activity relationships.
Bioorg Med Chem Lett 52: (2021)
University Of Texas At Austin
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists.
Bioorg Med Chem Lett 52: (2021)
Shionogi
A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease.
J Med Chem 64: 15091-15110 (2021)
Johns Hopkins University School Of Medicine
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.
Eur J Med Chem 226: (2021)
Yanbian University College Of Pharmacy
Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors.
Bioorg Med Chem 48: (2021)
Chinese Academy Of Sciences
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
J Med Chem 64: 14620-14646 (2021)
Universit£T Leipzig
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem 64: 14557-14586 (2021)
Galapagos
Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists.
Eur J Med Chem 226: (2021)
European Institute For Molecular Imaging (Eimi)
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization.
Eur J Med Chem 226: (2021)
University Of Salerno
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-
J Med Chem 64: 14498-14512 (2021)
Astrazeneca
Discovery of Novel UDP-
J Med Chem 64: 14377-14425 (2021)
X-Biotix Therapeutics
Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.
Bioorg Med Chem 48: (2021)
Universidad Ju£Rez Del Estado De Durango
1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.
Bioorg Med Chem Lett 52: (2021)
University Of Florence
Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor.
Bioorg Med Chem Lett 52: (2021)
China Pharmaceutical University
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg Med Chem Lett 51: (2021)
Bristol Myers Squibb Research And Development
Discovery of thiazolidin-4-one analogue as selective GSK-3? inhibitor through structure based virtual screening.
Bioorg Med Chem Lett 52: (2021)
Central University Of Rajasthan
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.
Bioorg Med Chem Lett 51: (2021)
Charles University
Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.
J Med Chem 64: 14266-14282 (2021)
Max Delbr�Ck Center For Molecular Medicine In The Helmholtz Gemeinschaft (Mdc)
Discovery of Extremely Selective Fused Pyridine-Derived ?-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
J Med Chem 64: 14165-14174 (2021)
Shionogi Pharmaceutical Research Center
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
J Med Chem 64: 14175-14191 (2021)
Janssen Research & Development
Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.
J Med Chem 64: 14426-14447 (2021)
Forum Pharmaceuticals
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
J Med Chem 64: 14344-14357 (2021)
University Of Toyama
Design, synthesis, and biological evaluation of novel Bcr-Abl
Bioorg Med Chem 48: (2021)
Xi'An Jiaotong University
Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.
J Med Chem 64: 14895-14911 (2021)
Zhengzhou University
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Bioorg Med Chem 48: (2021)
Kingston University
Discovery of bilirubin as novel P2X7R antagonist with anti-tumor activity.
Bioorg Med Chem Lett 51: (2021)
Zhengzhou University
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
J Med Chem 64: 14247-14265 (2021)
Bristol Myers Squibb
Design and Development of a Chemical Probe for Pseudokinase Ca
J Med Chem 64: 14358-14376 (2021)
Goethe University Frankfurt Am Main
Pillar[5]arene-Based Polycationic Glyco[2]rotaxanes Designed as
J Med Chem 64: 14728-14744 (2021)
University Of Namur (Unamur)
Enhancing the Pharmacokinetic Profile of Interleukin 2 through Site-Specific Conjugation to a Selective Small-Molecule Transthyretin Ligand.
J Med Chem 64: 14876-14886 (2021)
University Of The Pacific
N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation.
Eur J Med Chem 226: (2021)
Lanzhou University
Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.
Eur J Med Chem 226: (2021)
Tsinghua University
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur J Med Chem 226: (2021)
Seoul National University
Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists.
Eur J Med Chem 226: (2021)
Queen Mary University Of London
Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton.
Bioorg Med Chem 47: (2021)
Shanghai Institute Of Pharmaceutical Industry
Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
Eur J Med Chem 226: (2021)
Weifang Medical University
Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects.
Bioorg Med Chem 47: (2021)
Shenyang Pharmaceutical University
4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors.
Bioorg Med Chem Lett 51: (2021)
Daiichi Sankyo
Update on the Development of MNK Inhibitors as Therapeutic Agents.
J Med Chem 65: 983-1007 (2022)
A*Star
Discovery of a Novel BCL-X
J Med Chem 64: 14230-14246 (2021)
University Of Florida
Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745.
ACS Med Chem Lett 12: 1498-1502 (2021)
Glaxosmithkline
Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives.
ACS Med Chem Lett 12: 1464-1469 (2021)
Osaka University
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
ACS Med Chem Lett 12: 1435-1440 (2021)
Merck
Interleukin-17A Peptide Aptamers with an Unexpected Binding Moiety Selected by cDNA Display under Heterogenous Conditions.
ACS Med Chem Lett 12: 1427-1434 (2021)
Saitama University
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
ACS Med Chem Lett 12: 1413-1420 (2021)
Bristol-Myers Squibb
Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
ACS Med Chem Lett 12: 1396-1404 (2021)
Glaxosmithkline
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
ACS Med Chem Lett 12: 1389-1395 (2021)
Cognition Therapeutics
Novel Substituted 1,6-Naphthyridines as CDK 5 Inhibitors for Treating Kidney Diseases.
ACS Med Chem Lett 12: 1363-1364 (2021)
Smith, Gambrell & Russell
Novel Substituted Heterocyclic Carboxamides as Adrenoreceptor ADRAC2 Inhibitors for Treating Diseases.
ACS Med Chem Lett 12: 1361-1362 (2021)
Smith, Gambrell & Russell
Spiro(isobenzofuranazetidine) Compounds for Treating Autoimmune Diseases.
ACS Med Chem Lett 12: 1359-1360 (2021)
Smith, Gambrell & Russell
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.
Eur J Med Chem 226: (2021)
The Hong Kong University Of Science And Technology
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT
Eur J Med Chem 225: (2021)
Jagiellonian University Medical College
Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem 64: 14129-14141 (2021)
Carna Biosciences
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
J Med Chem 64: 14702-14714 (2021)
Purdue University
Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity.
ACS Med Chem Lett 12: 1478-1485 (2021)
National Institute Of Chemistry
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
ACS Med Chem Lett 12: 1380-1388 (2021)
Quantitative Biosciences
Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN.
J Med Chem 64: 14332-14343 (2021)
Universit£
Peptidylarginine deiminases 4 as a promising target in drug discovery.
Eur J Med Chem 226: (2021)
Zhejiang Ocean University
Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.
J Med Chem 64: 13736-13751 (2021)
Hainan University
Discovery of G Protein-Biased Antagonists against 5-HT
J Med Chem 64: 13766-13779 (2021)
Korea Institute Of Science And Technology
Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1.
Eur J Med Chem 226: (2021)
Guang Xi University Of Chinese Medicine
Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease.
Eur J Med Chem 225: (2021)
Shandong University
Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
J Med Chem 64: 13918-13932 (2021)
Guangxi University Of Chinese Medicine
Optimization of 4,6-Disubstituted Pyrido[3,2-
J Med Chem 64: 13719-13735 (2021)
Shenyang Pharmaceutical University
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
J Med Chem 64: 13902-13917 (2021)
University Of Minnesota
Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction.
J Med Chem 64: 13439-13450 (2021)
Universit£
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K? with a Novel Binding Mode.
J Med Chem 64: 13780-13792 (2021)
Glaxosmithkline R&D
Discovery of novel BTK PROTACs for B-Cell lymphomas.
Eur J Med Chem 225: (2021)
Fudan University
SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases.
Bioorg Med Chem 47: (2021)
Johannes Gutenberg-University
Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.
Eur J Med Chem 226: (2021)
Lille Neuroscience And Cognition Research Center
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Eur J Med Chem 225: (2021)
South China University Of Technology
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Bioorg Med Chem 46: (2021)
University Of California Santa Cruz
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.
Eur J Med Chem 225: (2021)
University Of Florence
Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Bioorg Med Chem Lett 51: (2021)
H. Lee Moffitt Cancer Center And Research Institute
Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.
J Med Chem 64: 13633-13657 (2021)
Anhui Medical University
Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
J Med Chem 64: 13451-13474 (2021)
Johann Wolfgang Goethe University
?/Sulfono-?-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged In Vivo Activity.
J Med Chem 64: 13893-13901 (2021)
University Of South Florida
Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells.
J Med Chem 64: 13475-13486 (2021)
Fudan University
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
J Med Chem 64: 13873-13892 (2021)
University Of Health Sciences & Pharmacy At St. Louis
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem 46: (2021)
University Of California Santa Cruz
Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.
Eur J Med Chem 225: (2021)
Guizhou Medical University
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-? (ROR?) Agonist for Use in Treating Cancer.
J Med Chem 64: 13410-13428 (2021)
Lycera
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.
J Med Chem 64: 13604-13621 (2021)
Shandong University
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
J Med Chem 64: 13572-13587 (2021)
East China University Of Science & Technology
Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
J Nat Prod 84: 2544-2553 (2021)
Taipei Chang Gung Memorial Hospital
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
J Med Chem 65: 1770-1785 (2022)
Bristol Myers Squibb
Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.
Bioorg Med Chem 46: (2021)
Kyoto University
Oxadiazepinone HBV capsid assembly modulators.
Bioorg Med Chem Lett 52: (2021)
Novira Therapeutics
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.
J Med Chem 64: 13830-13840 (2021)
Shanghaitech University
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
J Med Chem 64: 13704-13718 (2021)
Astrazeneca
Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
J Med Chem 64: 13551-13571 (2021)
National Center For Advancing Translational Sciences
Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.
Eur J Med Chem 225: (2021)
Zhejiang University
Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure-activity relationships.
Eur J Med Chem 225: (2021)
University Of Ljubljana
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.
Eur J Med Chem 225: (2021)
Kafrelsheikh University
Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A.
Bioorg Med Chem 46: (2021)
Trinity College
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Bioorg Med Chem Lett 50: (2021)
Emd Serono Research And Development Institute
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease.
Bioorg Med Chem 46: (2021)
Indian Institute Of Technology (Banaras Hindu University)
Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction.
Bioorg Med Chem 46: (2021)
China Pharmaceutical University
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies.
Bioorg Med Chem 46: (2021)
King Saud University
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Eur J Med Chem 225: (2021)
University Of Arkansas For Medical Sciences
Optimization of an Imidazo[1,2-
J Med Chem 64: 13524-13539 (2021)
Astrazeneca
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.
J Med Chem 64: 14647-14663 (2021)
Chinese Academy Of Sciences
Haloperidol Metabolite II Valproate Ester (
J Med Chem 64: 13622-13632 (2021)
University Of Catania
Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools.
J Med Chem 64: 13752-13765 (2021)
Shanghaitech University
Discovery of Potent Antiallergic Agents Based on an
J Med Chem 64: 13588-13603 (2021)
Chinese Academy Of Sciences
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
J Med Chem 64: 13356-13372 (2021)
China Medical University
Potent Inhibition of HIF1? and p300 Interaction by a Constrained Peptide Derived from CITED2.
J Med Chem 64: 13693-13703 (2021)
Peking University Shenzhen Graduate School
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent
J Med Chem 64: 13373-13393 (2021)
University Of Catania
Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1? inhibitor for cancer therapy.
Bioorg Med Chem Lett 50: (2021)
Dalian University Of Technology
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent
J Med Chem 64: 13327-13355 (2021)
Istituto Italiano Di Tecnologia (Iit)
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT
J Med Chem 64: 13279-13298 (2021)
Jagiellonian University Medical College
Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects.
J Med Chem 64: 13394-13409 (2021)
Lanzhou University
A sulfonyl fluoride derivative inhibits EGFR
Eur J Med Chem 225: (2021)
University Of Parma
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J Med Chem 64: 13807-13829 (2021)
Astrazeneca
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
J Med Chem 64: 13259-13278 (2021)
University Of Campinas (Unicamp)
Structure-Based Optimization of Quinazolines as Cruzain and
J Med Chem 64: 13054-13071 (2021)
Federal University Of Minas Gerais (Ufmg)
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT
Eur J Med Chem 225: (2021)
Jagiellonian University Medical College
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Eur J Med Chem 225: (2021)
Xihua University
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds.
Bioorg Med Chem Lett 50: (2021)
Vanderbilt University
Dual High-Resolution ?-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from
J Nat Prod 84: 2454-2467 (2021)
University Of Copenhagen
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
J Med Chem 64: 12670-12679 (2021)
Bristol Myers Squibb
?-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.
J Med Chem 64: 12917-12937 (2021)
Emory University
Synthesis and biological evaluation of
RSC Med Chem 12: 1414-1427 (2021)
Beijing University Of Technology
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
RSC Med Chem 12: 1374-1380 (2021)
Shanghai Institute Of Technology
Discovery, synthesis and biological characterization of a series of
RSC Med Chem 12: 1366-1373 (2021)
University Of Nebraska
Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment.
RSC Med Chem 12: 1352-1365 (2021)
Southern Illinois University Edwardsville
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
J Med Chem 64: 12630-12650 (2021)
China Pharmaceutical University
Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from
J Nat Prod 84: 2420-2426 (2021)
Korea Research Institute Of Bioscience And Biotechnology (Kribb)
Discovery of the first-in-class dual PPAR?/? partial agonist for the treatment of metabolic syndrome.
Eur J Med Chem 225: (2021)
Guangdong Pharmaceutical University
Discovery of 1,2,4-triazine dithiocarbamate derivatives as NEDDylation agonists to inhibit gastric cancers.
Eur J Med Chem 225: (2021)
Zhengzhou University
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Eur J Med Chem 225: (2021)
Children'S Hospital Affiliated To Zhengzhou University
Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27.
Eur J Med Chem 225: (2021)
University Of Bonn
Design, synthesis, and pharmacological evaluation of sinomenine derivatives on rings A and C: Novel compounds screening for aplastic anemia targeting on cytotoxic T lymphocyte.
Eur J Med Chem 225: (2021)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease.
Eur J Med Chem 225: (2021)
Baylor College Of Medicine
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
Eur J Med Chem 225: (2021)
Ghent University
Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (
J Med Chem 64: 12893-12902 (2021)
Takeda California
Functional Characterization of the Nemertide ? Family of Peptide Toxins.
J Nat Prod 84: 2121-2128 (2021)
Uppsala University
Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of
J Nat Prod 84: 2374-2379 (2021)
Southwest Jiaotong University
Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors.
Bioorg Med Chem 46: (2021)
Lanzhou University
Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors.
Eur J Med Chem 225: (2021)
Shandong University
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
J Med Chem 64: 12582-12602 (2021)
Medicines For Malaria Venture
Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
J Med Chem 64: 12453-12468 (2021)
TBA
Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
J Med Chem 64: 12603-12629 (2021)
Jagiellonian University Medical College
Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A
J Med Chem 64: 12525-12536 (2021)
Ewha Womans University
Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.
J Med Chem 64: 12877-12892 (2021)
Southeast University
Virtual screening and biological evaluation of PPAR? antagonists as potential anti-prostate cancer agents.
Bioorg Med Chem 46: (2021)
University Of Nebraska Medical Center
Optimization of a Series of RIPK2 PROTACs.
J Med Chem 64: 12978-13003 (2021)
Glaxosmithkline
Discovery of Novel Dihydrothiopyrano[4,3-
J Med Chem 64: 13658-13675 (2021)
Shandong University
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J Med Chem 64: 12738-12760 (2021)
University Of Zurich
Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors.
Bioorg Med Chem 46: (2021)
Shenyang Pharmaceutical University
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
J Med Chem 64: 12723-12737 (2021)
Bayer
Configurational Assignment of a Flexible Benzo[
J Nat Prod 84: 2594-2599 (2021)
Chungnam National University
DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M
Proc Natl Acad Sci U S A 118: (2021)
Baylor College Of Medicine
Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury.
Eur J Med Chem 225: (2021)
Zhejiang University
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Bioorg Med Chem Lett 50: (2021)
Genentech
Potent Inhibition of Nicotinamide
J Med Chem 64: 12938-12963 (2021)
Leiden University
Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
J Med Chem 64: 13004-13024 (2021)
Zentalis Pharmaceuticals
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.
ACS Med Chem Lett 12: 1245-1252 (2021)
Janssen Research And Development
Discovery of 4-aminoquinolines as highly selective TGF?R1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology.
Eur J Med Chem 225: (2021)
University Of Arkansas For Medical Sciences
Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT
Eur J Med Chem 225: (2021)
Sunshine Lake Pharma
Cysteine proteases as potential targets for anti-trypanosomatid drug discovery.
Bioorg Med Chem 46: (2021)
Universidade De Mogi Das Cruzes (Umc)
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Eur J Med Chem 225: (2021)
University Of Barcelona
Design, synthesis and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability.
Bioorg Med Chem Lett 50: (2021)
Winthrop University
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.
Bioorg Med Chem Lett 50: (2021)
Australian National University
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing.
Eur J Med Chem 225: (2021)
Henan University Of Chinese Medicine
Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specfic inhibitors.
Eur J Med Chem 225: (2021)
Peking University
Identification of unprecedented ATP-competitive choline kinase inhibitors.
Bioorg Med Chem Lett 51: (2021)
Nerviano Medical Sciences
Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor.
J Med Chem 64: 13038-13053 (2021)
The Ohio State University
Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.
J Med Chem 64: 13025-13037 (2021)
Nova University Lisbon
Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells.
J Med Chem 64: 12651-12669 (2021)
University Of North Carolina Wilmington
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity.
J Med Chem 64: 12506-12524 (2021)
The First Affiliated Hospital Of Xi'An Jiao Tong University
Discovery of
J Med Chem 64: 12548-12571 (2021)
China Pharmaceutical University
Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
ACS Pharmacol Transl Sci 4: 1408-1421 (2021)
The University Of Arizona
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M
ACS Med Chem Lett 12: 1342-1349 (2021)
Vanderbilt University
Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against
ACS Med Chem Lett 12: 1333-1341 (2021)
University Of Cape Town
Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease.
ACS Med Chem Lett 12: 1318-1324 (2021)
Scripps Research
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
ACS Med Chem Lett 12: 1308-1317 (2021)
Glaxosmithkline R&D
Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay.
ACS Med Chem Lett 12: 1288-1294 (2021)
Merck
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS Med Chem Lett 12: 1283-1287 (2021)
Tri-Institutional Institutional Therapeutics Discovery Institute
Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 ? (PKG1?).
ACS Med Chem Lett 12: 1275-1282 (2021)
Merck
Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening.
ACS Med Chem Lett 12: 1261-1266 (2021)
Fraunhofer Institute For Translational Medicine And Phamacology Itmp
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
ACS Med Chem Lett 12: 1230-1237 (2021)
Genentech
Novel Heterocyclic Compounds as Delta-5-Desaturase Inhibitors for Treating Metabolic and Cardiovascular Diseases.
ACS Med Chem Lett 12: 1218-1219 (2021)
Smith, Gambrell & Russell
Targeting the KRAS G12D Mutant as Potential Therapy in Cancer.
ACS Med Chem Lett 12: 1212-1213 (2021)
Usona Institute
Small Molecule Inhibitors of KRAS G12C Mutant.
ACS Med Chem Lett 12: 1210-1211 (2021)
Usona Institute
Novel Carbazoles for Treating Inflammatory and Autoimmune Diseases.
ACS Med Chem Lett 12: 1208-1209 (2021)
Smith, Gambrell & Russell
Novel Histone Deacetylase 6 Inhibitors for Treating Alzheimer's Disease and Cancer.
ACS Med Chem Lett 12: 1202-1203 (2021)
Smith, Gambrell & Russell
Novel Bromodomain Inhibitors for Treating Cancer, Fibrosis, and Inflammatory Disorders.
ACS Med Chem Lett 12: 1200-1201 (2021)
Smith, Gambrell & Russell
Novel Histone Deacetylase Inhibitors for Treating HIV Infection.
ACS Med Chem Lett 12: 1196-1197 (2021)
Smith, Gambrell & Russell
Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists May Provide a Superior Treatment for Pain and Migraine.
ACS Med Chem Lett 12: 1193-1195 (2021)
Therachem Research Medilab
The Potential of c-KIT Kinase inhibitors in Cancer Treatment.
ACS Med Chem Lett 12: 1191-1192 (2021)
Therachem Research Medilab
Cannabinoid Receptor Agonists for the Potential Treatment of Pain, Neurological Disorders, Fibrotic Diseases, Obesity, and Many More.
ACS Med Chem Lett 12: 1188-1190 (2021)
Therachem Research Medilab
Small Molecule Inhibitors of KRAS Mutant as a Therapeutic Strategy for the Treatment of Cancer.
ACS Med Chem Lett 12: 1183-1185 (2021)
Usona Institute
Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer.
Eur J Med Chem 225: (2021)
Laboratory For Marine Drugs And Bioproducts Of Qingdao National Laboratory For Marine Science And Technology
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
ACS Med Chem Lett 12: 1325-1332 (2021)
Yale University
Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5
J Med Chem 64: 12181-12199 (2021)
Chinese Academy Of Sciences
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
J Med Chem 64: 11972-11989 (2021)
University Of Massachusetts Medical School
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer.
J Med Chem 64: 12089-12108 (2021)
China Pharmaceutical University
Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.
Eur J Med Chem 225: (2021)
Shandong University
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.
Bioorg Med Chem 46: (2021)
China Pharmaceutical University
Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists.
Bioorg Med Chem Lett 50: (2021)
Bristol-Myers Squibb
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
J Med Chem 64: 11747-11773 (2021)
University Of Arkansas For Medical Sciences
Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7.
Bioorg Med Chem Lett 50: (2021)
Pfizer
Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.
Eur J Med Chem 225: (2021)
Sichuan Normal University
Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia.
Eur J Med Chem 225: (2021)
Universit£
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Eur J Med Chem 225: (2021)
Martin-Luther University Of Halle-Wittenberg
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 49: (2021)
Tianjin University Of Traditional Chinese Medicine
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.
Bioorg Med Chem Lett 49: (2021)
Merck
Evaluation of ?-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.
Bioorg Med Chem 46: (2021)
University Of Jena
Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.
Eur J Med Chem 225: (2021)
Henan Normal University
Synthesis and evaluation of novel and potent protease activated receptor 4 (PAR4) antagonists based on a quinazolin-4(3H)-one scaffold.
Eur J Med Chem 225: (2021)
China Pharmaceutical University
Synthesis, activity and mechanism for double-ring conjugated enones.
Bioorg Med Chem Lett 49: (2021)
Hainan Normal University
Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi.
Eur J Med Chem 225: (2021)
Shenyang Pharmaceutical University
Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies.
J Med Chem 64: 12397-12413 (2021)
Research Triangle Institute
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem 64: 12286-12303 (2021)
Astex Pharmaceuticals
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem 64: 12200-12227 (2021)
Glaxosmithkline
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase ?.
J Med Chem 64: 12304-12321 (2021)
Novartis Institutes For Biomedical Research
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the ?-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
J Med Chem 64: 12109-12131 (2021)
H. Lee Moffitt Cancer Center And Research Institute
Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity.
J Med Chem 64: 12261-12272 (2021)
University Of Milano-Bicocca
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
J Med Chem 64: 12322-12358 (2021)
Johannes Gutenberg University
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
J Med Chem 64: 13215-13258 (2021)
Merck
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
J Med Chem 64: 12075-12088 (2021)
Fujian Medical University
Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of ?7 Nicotinic Acetylcholine Receptors.
J Med Chem 64: 12379-12396 (2021)
Peking University
Synthesis and biological evaluation of selective survivin inhibitors derived from the MX-106 hydroxyquinoline scaffold.
Eur J Med Chem 224: (2021)
University Of Tennessee Health Science Center
Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with ?-ketoamide warheads.
Eur J Med Chem 224: (2021)
The Czech Academy Of Sciences
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.
Eur J Med Chem 223: (2021)
Anhui Medical University
Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity.
Bioorg Med Chem Lett 52: (2021)
Zhejiang Ocean University
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors.
Bioorg Med Chem Lett 49: (2021)
Bal?Kesir University
Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors.
Eur J Med Chem 224: (2021)
"G. D'Annunzio" University
Gemfibrozil derivatives as activators of soluble guanylyl cyclase - A structure-activity study.
Eur J Med Chem 224: (2021)
Baylor University
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library.
Bioorg Med Chem 45: (2021)
The University Of Hong Kong
Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds.
Bioorg Med Chem 45: (2021)
La Trobe University
Concise solid-phase synthesis enables derivatisation of YEATS domain cyclopeptide inhibitors for improved cellular uptake.
Bioorg Med Chem 45: (2021)
The University Of Hong Kong
Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives.
Eur J Med Chem 224: (2021)
Shenyang Pharmaceutical University
Balanced dual acting compounds targeting aromatase and estrogen receptor ? as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.
Eur J Med Chem 224: (2021)
Alma Mater Studiorum-University Of Bologna
Induction of apoptosis, cytotoxicity and radiosensitization by novel 3,4-dihydroquinazolinone derivatives.
Bioorg Med Chem Lett 49: (2021)
National Center For Radiation Research And Technology (Ncrrt)
Discovery of the Selective Protein Kinase C-? Kinase Inhibitor, CC-90005.
J Med Chem 64: 11886-11903 (2021)
Bristol Myers Squibb
Deglycase-activity oriented screening to identify DJ-1 inhibitors.
RSC Med Chem 12: 1232-1238 (2021)
Tri-Institutional Phd Program In Chemical Biology
The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis.
RSC Med Chem 12: 1222-1231 (2021)
Hec Pharma.
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy.
RSC Med Chem 12: 1187-1206 (2021)
University Of Bonn
Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.
RSC Med Chem 12: 1174-1186 (2021)
National Institutes Of Drug Abuse - Intramural Research Program
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
RSC Med Chem 12: 1164-1173 (2021)
Merck
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties.
RSC Med Chem 12: 1154-1163 (2021)
University Of Bras£Lia
1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
Bioorg Med Chem Lett 47: (2021)
Effector Therapeutics
Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer.
J Med Chem 64: 12022-12048 (2021)
West China Hospital Of Sichuan University
Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL
J Med Chem 65: 2880-2904 (2021)
Cleveland Clinic
Discovery of 3,5-Dimethyl-4-Sulfonyl-1
J Med Chem 64: 11330-11353 (2021)
China Pharmaceutical University
Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.
J Med Chem 64: 11729-11745 (2021)
Saint Louis University
Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
J Med Chem 64: 11709-11728 (2021)
University Of Sussex
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem 64: 11148-11168 (2021)
The Broad Institute Of Mit And Harvard
Why All the Fury over Furin?
J Med Chem 65: 2747-2784 (2022)
University Of Michigan
Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives.
Eur J Med Chem 224: (2021)
Chinese Academy Of Sciences
Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.
J Med Chem 64: 10967-10980 (2021)
Universit£
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death.
J Med Chem 64: 11445-11459 (2021)
University Of Campania "L. Vanvitelli
Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
J Med Chem 64: 11288-11301 (2021)
National Health Research Institutes
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
J Med Chem 65: 1313-1328 (2022)
University Of North Carolina At Chapel Hill
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
Bioorg Med Chem 45: (2021)
Emory University School Of Medicine
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus.
Eur J Med Chem 224: (2021)
Fudan University
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3K?-specific inhibitors for the treatment of hematologic malignancies.
Bioorg Med Chem 45: (2021)
Sungkyunkwan University
Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen.
Bioorg Med Chem Lett 49: (2021)
The Scripps Research Institute
Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.
Eur J Med Chem 224: (2021)
Yantai University
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.
J Med Chem 65: 2836-2847 (2022)
University Of Groningen
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2
J Med Chem 64: 11014-11044 (2021)
Takeda Pharmaceutical
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.
Bioorg Med Chem Lett 51: (2021)
Shenyang Pharmaceutical University
Identification of Thieno[3,2-
J Med Chem 64: 11934-11957 (2021)
Yonsei University College Of Medicine
Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
J Med Chem 65: 1008-1046 (2022)
H. R. Patel Institute Of Pharmaceutical Education And Research
Molecular Plasticity of Crystalline CK2?' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity.
J Med Chem 65: 1302-1312 (2022)
Universit£T Zu K£Ln
Synthesis and Biological Evaluation of Falcarinol-Type Analogues as Potential Calcium Channel Blockers.
J Nat Prod 84: 2138-2148 (2021)
Southwest Medical University
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.
Eur J Med Chem 224: (2021)
University Of Salerno
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Eur J Med Chem 224: (2021)
Sichuan University
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem 44: (2021)
Biogen
Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy.
Bioorg Med Chem Lett 49: (2021)
Anhui University Of Chinese Medicine
Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
J Med Chem 64: 11614-11636 (2021)
Jagiellonian University
Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells.
Eur J Med Chem 224: (2021)
Southern Medical University
Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL.
Bioorg Med Chem Lett 49: (2021)
Oberlin College
Chemical update on the potential for serotonin 5-HT
Bioorg Med Chem Lett 49: (2021)
Jagiellonian University
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
J Med Chem 64: 10934-10950 (2021)
University Of Kentucky
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H
J Med Chem 64: 11695-11708 (2021)
University Of Regensburg
Plant-Derived Cyclotides Modulate ?-Opioid Receptor Signaling.
J Nat Prod 84: 2238-2248 (2021)
Medical University Of Vienna
Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment.
J Med Chem 64: 10908-10918 (2021)
Tampere University
Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Bioorg Med Chem 45: (2021)
University Of Arkansas For Medical Sciences
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Eur J Med Chem 224: (2021)
National Health Research Institutes
Discovery of tert-amine-based ROR?t agonists.
Eur J Med Chem 224: (2021)
Fudan University
Impact of ?-modifications on the activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Bioorg Med Chem 44: (2021)
University Of Iowa
Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease.
Eur J Med Chem 224: (2021)
Griffith University
Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.
Bioorg Med Chem Lett 48: (2021)
Northern Illinois University
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR.
J Med Chem 64: 11219-11228 (2021)
University Of South Florida
NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
J Med Chem 64: 11229-11246 (2021)
University Of California
Structural insights in galectin-1-glycan recognition: Relevance of the glycosidic linkage and the N-acetylation pattern of sugar moieties.
Bioorg Med Chem 44: (2021)
Universidad De La Republica
Structural Insights into Notum Covalent Inhibition.
J Med Chem 64: 11354-11363 (2021)
University Of Oxford
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem 64: 11302-11329 (2021)
University Of Texas
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
J Med Chem 64: 11129-11147 (2021)
Ontario Institute For Cancer Research
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
J Med Chem 64: 11267-11287 (2021)
Texas A&M University
Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents.
Bioorg Med Chem Lett 48: (2021)
Southeast University
Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity.
Bioorg Med Chem Lett 48: (2021)
Fudan University
Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.
J Med Chem 64: 11432-11444 (2021)
Institute Of Biomedical Chemistry
Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective.
J Med Chem 64: 10537-10556 (2021)
China Pharmaceutical University
Design, Synthesis, and Characterization of Novel
J Med Chem 64: 11418-11431 (2021)
Instituto Nacional De Tecnolog£A Industrial
Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag.
J Med Chem 64: 11637-11650 (2021)
Dana Farber Cancer Institute
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
J Med Chem 64: 11496-11526 (2021)
University Of Innsbruck
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
J Med Chem 64: 11570-11596 (2021)
Janssen Research And Development
Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain.
J Med Chem 64: 10997-11013 (2021)
Texas A&M University
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from
J Nat Prod 84: 2303-2311 (2021)
Nanchang University
Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
J Med Chem 64: 10878-10889 (2021)
Janssen Research & Development
Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.
Eur J Med Chem 224: (2021)
Federal University Of Alagoas
Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease.
Bioorg Med Chem 44: (2021)
Zhejiang University
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.
Bioorg Med Chem 44: (2021)
Japan Tobacco
8-Hydroxyquinolin-2(1H)-one analogues as potential ?
Eur J Med Chem 224: (2021)
Shenyang Pharmaceutical University
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett 48: (2021)
Seoul National University
Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B.
Bioorg Med Chem Lett 48: (2021)
Shinshu University
A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors.
Bioorg Med Chem Lett 48: 128263 (2021)
A*Star
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors.
Bioorg Med Chem Lett 48: (2021)
Eisai
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem 64: 11090-11128 (2021)
Bristol Myers Squibb
Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer.
J Med Chem 64: 11045-11062 (2021)
University Of Tennessee Health Science Center
Mapping Chromone-3-Phenylcarboxamide Pharmacophore:
J Med Chem 64: 11169-11182 (2021)
Universit£
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem 64: 10666-10679 (2021)
Incyte
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
ACS Med Chem Lett 12: 1173-1180 (2021)
Ewha Womans University
DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry.
ACS Med Chem Lett 12: 1166-1172 (2021)
Glaxosmithkline
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett 12: 1143-1150 (2021)
Bristol Myers Squibb Research And Development
Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and
ACS Med Chem Lett 12: 1137-1142 (2021)
Sanofi
Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation.
ACS Med Chem Lett 12: 1130-1136 (2021)
Baruch S. Blumberg Institute
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
ACS Med Chem Lett 12: 1124-1129 (2021)
Biogen
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
ACS Med Chem Lett 12: 1116-1123 (2021)
Chinook Therapeutics
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
ACS Med Chem Lett 12: 1108-1115 (2021)
Abbvie
Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
ACS Med Chem Lett 12: 1093-1101 (2021)
Shionogi Pharmaceutical Research Center
Novel Diacylglycerol Acetyltransferase 2 Inhibitors for Treating Liver Diseases.
ACS Med Chem Lett 12: 1073-1074 (2021)
Smith, Gambrell & Russell
Novel Triazatricycle Compounds for Treating Autoimmune Diseases.
ACS Med Chem Lett 12: 1071-1072 (2021)
Smith, Gambrell & Russell
Novel Dihydrooxadiazinones as PDE3 Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 1069-1070 (2021)
Smith, Gambrell & Russell
Novel Pyridazines as Autotaxin Inhibitors for Treating Inflammatory Airway or Fibrotic Diseases.
ACS Med Chem Lett 12: 1067-1068 (2021)
Smith, Gambrell & Russell
Novel METTL3 Modulators for Treating Acute Myeloid Leukemia (AML).
ACS Med Chem Lett 12: 1061-1062 (2021)
Smith, Gambrell & Russell
Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9.
J Med Chem 64: 10834-10848 (2021)
Universit£
Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues.
Eur J Med Chem 224: (2021)
University Of Otago
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
J Med Chem 64: 10849-10877 (2021)
University Of North Carolina At Chapel Hill
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
J Med Chem 64: 11651-11674 (2021)
Bayer Pharma
Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.
ACS Med Chem Lett 12: 1151-1158 (2021)
Universit£
A "Two-Birds-One-Stone" Approach toward the Design of Bifunctional Human Immunodeficiency Virus Type 1 Entry Inhibitors Targeting the CCR5 Coreceptor and gp41 N-Terminal Heptad Repeat Region.
J Med Chem 64: 11460-11471 (2021)
Beijing Institute Of Pharmacology And Toxicology
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
J Med Chem 64: 10711-10741 (2021)
Glaxosmithkline
Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia.
J Med Chem 64: 11527-11542 (2021)
Takeda California
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
ACS Med Chem Lett 12: 1102-1107 (2021)
Latvian Institute Of Organic Synthesis
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
J Med Chem 64: 10102-10123 (2021)
University Of Oxford
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem 64: 10772-10805 (2021)
Glaxosmithkline
Synthesis and Characterization of New V
J Med Chem 64: 10445-10468 (2021)
Gedeon Richter
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
J Med Chem 64: 10286-10296 (2021)
Yantai University
Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation.
Bioorg Med Chem 44: (2021)
The State University Of New Jersey
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.
J Med Chem 64: 9943-9959 (2021)
Southern Medical University
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.
J Med Chem 64: 10806-10833 (2021)
Glaxosmithkline
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem 64: 11841-11856 (2021)
Genentech
Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements.
Eur J Med Chem 224: (2021)
Moscow State University
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Bioorg Med Chem 44: (2021)
Universidad De Alcal£
Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives.
Bioorg Med Chem Lett 48: (2021)
Egyptian National Research Centre
Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis.
Eur J Med Chem 224: (2021)
Bolderbiopath
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Eur J Med Chem 224: (2021)
Cairo University
Peptidomimetic ?-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and
J Med Chem (2021)
University Of Alberta
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3K? inhibitor: Design, synthesis and biological evaluation.
Eur J Med Chem 223: (2021)
Fudan University
Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.
Eur J Med Chem 223: (2021)
Nankai University
Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors.
Eur J Med Chem 224: (2021)
Korea Institute Of Science And Technology
Synthetic access to thiolane-based therapeutics and biological activity studies.
Eur J Med Chem 224: (2021)
Goa University
Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC.
Eur J Med Chem 224: (2021)
Chongqing Medical University
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies.
Bioorg Med Chem Lett 48: (2021)
Jamia Millia Islamia
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity.
J Med Chem 64: 10350-10370 (2021)
Universidad De Sevilla
Propionamide Derivatives as Dual ?-Opioid Receptor Agonists and ?
J Med Chem 64: 10139-10154 (2021)
Esteve Pharmaceuticals
4-Methyl-1,2,3-Triazoles as
J Med Chem 64: 10497-10511 (2021)
University Of Minnesota
Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.
J Med Chem 64: 10059-10101 (2021)
The University Of Tokyo
Identification of a Series of
J Med Chem 64: 10742-10771 (2021)
Glaxosmithkline
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (?5i).
J Med Chem 64: 10230-10245 (2021)
Merck
Structure-Based Optimization of 3-Phenyl-
J Med Chem 64: 10260-10285 (2021)
Fudan University
Recent research and development of NDM-1 inhibitors.
Eur J Med Chem 223: (2021)
University Of Electronic Science And Technology Of China
Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation.
Eur J Med Chem 223: (2021)
Lund University
Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity.
Eur J Med Chem 223: (2021)
China Pharmaceutical University
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Bioorg Med Chem 44: (2021)
University Of Toyama
Studies on the affinity of 6-[(
RSC Med Chem 12: 1000-1004 (2021)
Helmholtz-Zentrum Dresden-Rossendor
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach.
RSC Med Chem 12: 960-969 (2021)
The Scripps Research Institute
Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit.
RSC Med Chem 12: 943-959 (2021)
Monash University (Parkville Campus)
Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.
Eur J Med Chem 223: (2021)
University Of Pisa
Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis.
Eur J Med Chem 223: (2021)
Shenyang Pharmaceutical University
Noncovalent EGFR T790M/L858R inhibitors based on diphenylpyrimidine scaffold: Design, synthesis, and bioactivity evaluation for the treatment of NSCLC.
Eur J Med Chem 223: (2021)
Dalian Medical University
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors.
Bioorg Med Chem 44: (2021)
Universidad De Granada
Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates.
Bioorg Med Chem 44: (2021)
Fudan University School Of Pharmacy
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.
Bioorg Med Chem 44: (2021)
Universit£
Synthesis and biological evaluation of selenogefitinib for reducing bleomycin-induced pulmonary fibrosis.
Bioorg Med Chem Lett 48: (2021)
Dalian Medical University
Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents.
Eur J Med Chem 223: (2021)
Fudan University
A Photohormone for Light-Dependent Control of PPAR? in Live Cells.
J Med Chem 64: 10393-10402 (2021)
Goethe-University Frankfurt
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease.
J Med Chem 64: 10047-10058 (2021)
Wichita State University
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3? Inhibitors.
J Med Chem 65: 1283-1301 (2022)
Eberhard Karls University T£Bingen
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-?B-Inducing Kinase.
J Med Chem 64: 10001-10018 (2021)
Newcastle University Centre For Cancer
Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells.
J Med Chem 64: 9916-9925 (2021)
University Of South Carolina
Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3? inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine.
Eur J Med Chem 223: (2021)
China Pharmaceutical University
Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.
J Med Chem 64: 10297-10311 (2021)
Fudan University
Feature-Based Molecular Networking for the Targeted Identification of G
J Nat Prod 84: 1941-1953 (2021)
University Of Bonn
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.
J Med Chem 64: 9906-9915 (2021)
The University Of Queensland
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
J Med Chem 64: 10333-10349 (2021)
University Of Michigan
Discovery of novel 2,3,5-trisubstituted pyridine analogs as potent inhibitors of IL-1? via modulation of the p38 MAPK signaling pathway.
Eur J Med Chem 223: (2021)
Allinky Biopharma
Nanomolar inhibition of human OGA by 2-acetamido-2-deoxy-d-glucono-1,5-lactone semicarbazone derivatives.
Eur J Med Chem 223: (2021)
University Of Debrecen
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
J Med Chem 64: 10403-10417 (2021)
Cnrs Erl 9195
Design and Synthesis of Pyrrolo[2,3-
J Med Chem 64: 10312-10332 (2021)
Vernalis (R&D)
Synthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives as potential SSRIs.
Eur J Med Chem 223: (2021)
Sunshine Lake Pharma
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors.
Bioorg Med Chem Lett 47: (2021)
Yonsei University
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma.
J Med Chem 64: 9217-9237 (2021)
Chinese Academy Of Sciences
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).
J Med Chem 64: 9120-9140 (2021)
China Pharmaceutical University
Structure-guided design and development of novel N-phenylpyrimidin-2-amine derivatives as potential c-Met inhibitors.
Eur J Med Chem 223: (2021)
Hebei University Of Science And Technology
Design and synthesis of the first indole-based blockers of Panx-1 channel.
Eur J Med Chem 223: (2021)
University Of Florence
Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.
Eur J Med Chem 223: (2021)
China Pharmaceutical University
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.
Eur J Med Chem 223: (2021)
University Of Genova
Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors.
Eur J Med Chem 223: (2021)
Shenyang Pharmaceutical University
Synthesis and evaluation of adenosine derivatives as A
Eur J Med Chem 223: (2021)
Institute Of Medical Biology Pas
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Bioorg Med Chem Lett 47: (2021)
Merck
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.
J Med Chem 64: 9525-9536 (2021)
Goethe University Frankfurt
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the ?-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
J Med Chem 64: 9042-9055 (2021)
Medical University Of Vienna
Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship.
Eur J Med Chem 223: (2021)
Zunyi Medical University
Discovery of Methylene Thioacetal-Incorporated ?-RgIA Analogues as Potent and Stable Antagonists of the Human ?9?10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
J Med Chem 64: 9513-9524 (2021)
University Of Utah
Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB
J Med Chem 64: 9354-9364 (2021)
Universitat De Barcelona
Rational Design of Photochromic Analogues of Tricyclic Drugs.
J Med Chem 64: 9259-9270 (2021)
Institute For Bioengineering Of Catalonia (Ibec)
Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors.
J Med Chem 64: 9567-9576 (2021)
Nagoya City University
Ferulic acid amide derivatives with varying inhibition of amyloid-? oligomerization and fibrillization.
Bioorg Med Chem 43: (2021)
University Of Toronto
Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-?B and TAK1 activities: Cheminformatics tools RDKit applied in drug design.
Eur J Med Chem 223: (2021)
China Pharmaceutical University
Recent advances of quinones as a privileged structure in drug discovery.
Eur J Med Chem 223: (2021)
Jinan Second People'S Hospital
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread.
Eur J Med Chem 223: (2021)
Aix-Marseille Universit£
Discovery of quinuclidine modulators of cellular progranulin.
Bioorg Med Chem Lett 47: (2021)
Arkuda Therapeutics
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Bioorg Med Chem Lett 47: (2021)
Shenyang Pharmaceutical University
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.
Bioorg Med Chem Lett 49: (2021)
Kakatiya University
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model.
J Med Chem 64: 9302-9320 (2021)
Julius Maximilian University Of W£Rzburg
Withanolide Derivative 2,3-Dihydro-3?-methoxy Withaferin-A Modulates the Circadian Clock via Interaction with RAR-Related Orphan Receptor ? (RORa).
J Nat Prod 84: 1882-1888 (2021)
National Institute Of Advanced Industrial Science And Technology (Aist)
Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide - A new caspase-activating proapoptotic agent.
Eur J Med Chem 222: (2021)
Saint Petersburg State University
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.
Eur J Med Chem 222: (2021)
Chinese Academy Of Sciences
Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.
Eur J Med Chem 222: (2021)
University Of Minnesota
Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors.
Eur J Med Chem 223: (2021)
Peking Union Medical College And Chinese Academy Of Medical Sciences
Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction.
Eur J Med Chem 223: (2021)
Zhejiang University
Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.
Eur J Med Chem 223: (2021)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors.
Eur J Med Chem 223: (2021)
Chinese Academy Of Medical Science And Peking Union Medical College
l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue.
Bioorg Med Chem Lett 47: (2021)
Universidade Federal De Mato Grosso Do Sul
Intracellular fluorescence competition assay for inhibitor engagement of histone deacetylase.
Bioorg Med Chem Lett 47: (2021)
University Of Notre Dame
Synthesis of NVS-BPTF-1 and evaluation of its biological activity.
Bioorg Med Chem Lett 47: (2021)
Universit£
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
J Med Chem 64: 8971-8991 (2021)
Vernalis (R&D)
Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
J Med Chem 64: 9271-9278 (2021)
University Of Utah
Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis.
J Med Chem 64: 9537-9549 (2021)
Sun Yat-Sen University
Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9.
J Med Chem 64: 9279-9301 (2021)
Csir-Indian Institute Of Chemical Biology
Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay.
ACS Med Chem Lett 12: 1024-1029 (2021)
Okayama University Graduate School Of Medicine
Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.
ACS Med Chem Lett 12: 1017-1023 (2021)
Qingdao University Of Science And Technology
Structure-Based Design of A-1293102, a Potent and Selective BCL-X
ACS Med Chem Lett 12: 1011-1016 (2021)
Abbvie
Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors.
ACS Med Chem Lett 12: 1005-1010 (2021)
Glaxosmithkline
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
ACS Med Chem Lett 12: 996-1004 (2021)
University Of Michigan
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
ACS Med Chem Lett 12: 969-975 (2021)
Bristol Myers Squibb
Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors.
ACS Med Chem Lett 12: 955-960 (2021)
Vertex Pharmaceuticals
5-Fluoronicotinamide Derivatives as HDAC6 Inhibitors for Treating Heart Diseases.
ACS Med Chem Lett 12: 953-954 (2021)
Smith, Gambrell & Russell
Novel Bromodomain BRD4 Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 951-952 (2021)
Smith, Gambrell & Russell
Novel CFTR Modulators for Treating Cystic Fibrosis.
ACS Med Chem Lett 12: 949-950 (2021)
Smith, Gambrell & Russell
Benzo[d]thiazol-5-yl Compounds as O-GlcNAcase Inhibitors for Treating Alzheimer's Disease.
ACS Med Chem Lett 12: 947-948 (2021)
Smith, Gambrell & Russell
Novel Small Molecule RNA m6A Demethylase AlkBH5 Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 856-857 (2021)
Smith, Gambrell & Russell
Synthesis, optimization, in vitro and in vivo study of bicyclic substituted amine as MenA inhibitor.
Bioorg Med Chem Lett 47: (2021)
University Of Nebraska Medical Center
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Bioorg Med Chem Lett 47: (2021)
Glenmark Research Centre
Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells.
Bioorg Med Chem Lett 47: (2021)
Harbin Medical University
Benzoheterocyclic Oxime Carbamates Active against
J Med Chem 64: 9444-9457 (2021)
University Of Cape Town
Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.
J Med Chem 64: 9010-9041 (2021)
Albany College Of Pharmacy And Health Sciences
Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.
J Med Chem 64: 8951-8970 (2021)
National Clinical Research Center For Geriatrics
Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile.
J Med Chem 64: 9152-9165 (2021)
Shanghaitech University
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
J Med Chem 64: 9550-9566 (2021)
TBA
"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.
Bioorg Med Chem 42: (2021)
University Of Warsaw
Discovery and Optimization of a Novel 2
J Med Chem 64: 9078-9099 (2021)
Nankai University
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.
Bioorg Med Chem 42: (2021)
Al-Azhar University
The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies.
RSC Med Chem 12: 779-790 (2021)
University Of Birmingham
Phenyl bioisosteres in medicinal chemistry: discovery of novel ?-secretase modulators as a potential treatment for Alzheimer's disease.
RSC Med Chem 12: 758-766 (2021)
Roche Innovation Center Basel
Development of Covalent, Clickable Probes for Adenosine A
J Med Chem 64: 8161-8178 (2021)
Monash University
Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
Eur J Med Chem 222: (2021)
Ningxia Medical University
Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.
Eur J Med Chem 222: (2021)
Chinese Academy Of Sciences
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity.
Eur J Med Chem 222: (2021)
Al-Azhar University
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.
Bioorg Med Chem 42: (2021)
Josai University
Design, synthesis, and biological evaluation of novel bifunctional thyrointegrin antagonists for neuroblastoma.
Bioorg Med Chem 42: (2021)
Pharmaceutical Research Institute
Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR? with potential anti-diabetic efficacy.
Eur J Med Chem 222: (2021)
Xiamen University
Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor ?t agonists.
Eur J Med Chem 222: (2021)
Fudan University
Benzofuranyl-2-imidazoles as imidazoline I
Eur J Med Chem 222: (2021)
University Of Barcelona
Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease.
Eur J Med Chem 222: (2021)
University Health Network
Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M
Bioorg Med Chem Lett 47: (2021)
Vanderbilt University School Of Medicine
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem 42: (2021)
University Of Sharjah
Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.
Eur J Med Chem 222: (2021)
Alexandria University
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as A? antiaggregant.
Eur J Med Chem 222: (2021)
Shanghai Jiao Tong University (Sjtu)
Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors.
Bioorg Med Chem Lett 46: (2021)
University Of Kragujevac
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
J Med Chem 64: 8727-8738 (2021)
Goethe-University Frankfurt
Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[
J Med Chem 64: 8391-8409 (2021)
China Pharmaceutical University
A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles.
Eur J Med Chem 222: (2021)
Minia University
HTS-based discovery and optimization of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor.
Eur J Med Chem 222: (2021)
Gedeon Richter
Diterpenoids with Aromatase Inhibitory Activity from the Rhizomes of
J Nat Prod 84: 1738-1747 (2021)
Chulabhorn Royal Academy
Abolishing Dopamine D
J Med Chem 64: 8684-8709 (2021)
University Of Regensburg
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
J Med Chem 64: 8263-8271 (2021)
Purdue University
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
J Med Chem 64: 8303-8332 (2021)
Sichuan University
Adenosine A
J Med Chem 64: 8246-8262 (2021)
Heinrich Heine University Duesseldorf
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.
J Med Chem 64: 8579-8598 (2021)
"Sapienza" Universit£
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
Eur J Med Chem 222: (2021)
The Czech Academy Of Sciences
Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.
J Med Chem 64: 8486-8509 (2021)
University Of Toronto Mississauga
Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.
J Med Chem 64: 8806-8825 (2021)
Research Triangle Institute
Macrolide Inspired Macrocycles as Modulators of the IL-17A/IL-17RA Interaction.
J Med Chem 64: 8354-8383 (2021)
Fidelta
Inhibition of BACE1 and Amyloid-? Aggregation by Meroterpenoids from the Mushroom
J Nat Prod 84: 1748-1754 (2021)
Meiji Pharmaceutical University
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3?/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Eur J Med Chem 222: (2021)
Shenyang Pharmaceutical University
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKK? phosphorylation for pancreatic cancer therapy.
Eur J Med Chem 222: (2021)
Eppley Institute For Cancer Research
Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.
J Med Chem 64: 8437-8446 (2021)
University Of California At Santa Cruz
Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.
J Med Chem 64: 8447-8473 (2021)
Southern Medical University
Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives.
J Med Chem 64: 8272-8286 (2021)
Gwangju Institute Of Science And Technology (Gist)
A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
RSC Med Chem 11: 1402-1412 (2020)
Stanford University School
Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2.
RSC Med Chem 11: 1379-1385 (2020)
Redx Anti-Infectives
Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1.
RSC Med Chem 11: 1366-1378 (2020)
Redx Anti-Infectives
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors.
RSC Med Chem 11: 1275-1284 (2020)
University Of S£O Paulo Avenue Trabalhador Sancarlense
Hormone-like conopeptides - new tools for pharmaceutical design.
RSC Med Chem 11: 1235-1251 (2020)
University Of Queensland
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.
Bioorg Med Chem 42: (2021)
X-Chem
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Eur J Med Chem 222: (2021)
Guizhou Medical University
Design, synthesis and biological evaluation of N-anthraniloyl tryptamine derivatives as pleiotropic molecules for the therapy of malignant glioma.
Eur J Med Chem 222: (2021)
Lanzhou University
Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors.
Bioorg Med Chem Lett 47: (2021)
China Pharmaceutical University
Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists.
Bioorg Med Chem Lett 47: (2021)
Janssen Research & Development
Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett 47: (2021)
Merck
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
Bioorg Med Chem 42: (2021)
Shandong University
Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.
Bioorg Med Chem Lett 46: (2021)
University Of Pittsburgh
Development of peptide epoxyketones as selective immunoproteasome inhibitors.
Eur J Med Chem 221: (2021)
Zhejiang University
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
J Med Chem 64: 8142-8160 (2021)
Johann Wolfgang Goethe University
Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.
Eur J Med Chem 221: (2021)
Shenyang Pharmaceutical University
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
J Med Chem 64: 8287-8302 (2021)
Bar-Ilan University
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem 64: 8076-8100 (2021)
Lilly Research Laboratories
Homophymamide A, Heterodetic Cyclic Tetrapeptide from a
J Nat Prod 84: 1848-1853 (2021)
The University Of Tokyo
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.
J Med Chem 65: 955-982 (2022)
Eberhard Karls University T£Bingen
Discovery of AZD8154, a Dual PI3K?? Inhibitor for the Treatment of Asthma.
J Med Chem 64: 8053-8075 (2021)
Astrazeneca
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-
J Med Chem 64: 8644-8665 (2021)
Shanghai Institute Of Materia Medica
Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine.
J Med Chem 64: 8607-8620 (2021)
Gedeon Richter
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
J Med Chem 64: 8194-8207 (2021)
Nanjing University Of Chinese Medicine
Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity.
Bioorg Med Chem Lett 46: (2021)
Guangzhou Medical University
Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies.
Bioorg Med Chem 41: (2021)
Kongju National University
Discovery and optimization of selective RET inhibitors via scaffold hopping.
Bioorg Med Chem Lett 47: (2021)
Guangzhou Baiyunshan Pharmaceutical Holdings
Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
J Med Chem 64: 7390-7403 (2021)
China Pharmaceutical University
Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ER?+ Breast Cancer.
J Med Chem 64: 7575-7595 (2021)
Nanjing University Of Chinese Medicine
Discovery of 1,5-Dihydro-4
ACS Med Chem Lett 12: 836-845 (2021)
Zhejiang University
Azatricyclic Inverse Agonists of ROR?t That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
ACS Med Chem Lett 12: 827-835 (2021)
Bristol Myers Squibb
Discovery of a Novel Class of ERR? Agonists.
ACS Med Chem Lett 12: 817-821 (2021)
Daiichi Sankyo
Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells.
ACS Med Chem Lett 12: 798-804 (2021)
University Of Alberta
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
ACS Med Chem Lett 12: 791-797 (2021)
Genentech
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
ACS Med Chem Lett 12: 782-790 (2021)
Janssen Research & Development
Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
ACS Med Chem Lett 12: 768-773 (2021)
University Of Groningen
Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation.
ACS Med Chem Lett 12: 758-767 (2021)
Marshall University
Discovery of Selective Transforming Growth Factor ? Type II Receptor Inhibitors as Antifibrosis Agents.
ACS Med Chem Lett 12: 745-751 (2021)
Japan Tobacco
Discovery of a Potent and Selective Covalent p300/CBP Inhibitor.
ACS Med Chem Lett 12: 726-731 (2021)
Abbvie
Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors.
ACS Med Chem Lett 12: 696-703 (2021)
Peking University Health Science Center
Novel Thienopyrimidines as Acetyl-CoA Carboxylase Inhibitors for Treating Liver Diseases.
ACS Med Chem Lett 12: 694-695 (2021)
Smith, Gambrell & Russell
Novel Heterobicyclic Carboxamides for Treating Eye Diseases.
ACS Med Chem Lett 12: 692-693 (2021)
Smith, Gambrell & Russell
Novel Amide Compounds as KIF18A Inhibitors for Treating Cancer.
ACS Med Chem Lett 12: 690-691 (2021)
Smith, Gambrell & Russell
Novel Pyrazolo[3,4-
ACS Med Chem Lett 12: 683-684 (2021)
Smith, Gambrell & Russell
Novel Substituted Exomethylene-oxindoles as HPK1 Inhibitors.
ACS Med Chem Lett 12: 681-682 (2021)
Smith, Gambrell & Russell
Pyrrolo-pyridazine Derivatives as Muscarinic M
ACS Med Chem Lett 12: 677-678 (2021)
Temple University School Of Pharmacy
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.
Bioorg Med Chem Lett 45: (2021)
University Of Florence
Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine.
Eur J Med Chem 220: (2021)
Polish Academy Of Sciences
Structure-activity relationships of pyrimidine nucleotides containing a 5'-?,?-methylene diphosphonate at the P2Y
Bioorg Med Chem Lett 45: (2021)
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation.
Bioorg Med Chem Lett 45: (2021)
Sichuan University
Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy.
J Med Chem 64: 7507-7532 (2021)
Beijing Advanced Innovation Center For Human Brain Protection
Drugging the undruggable: a computational chemist's view of KRAS
RSC Med Chem 12: 609-614 (2021)
Astrazeneca
Assessment of the rules related to gaining activity against Gram-negative bacteria.
RSC Med Chem 12: 593-601 (2021)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors.
RSC Med Chem 12: 584-592 (2021)
Universit£
Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives.
RSC Med Chem 12: 430-438 (2021)
University Bangkok
Structural modifications that increase gut restriction of bile acid derivatives.
RSC Med Chem 12: 394-405 (2021)
University Of Minnesota
Synthesis and
RSC Med Chem 12: 237-244 (2021)
Wilhelms-Universit�T M�Nster Corrensstr
Deacylcortivazol-like pyrazole regioisomers reveal a more accommodating expanded binding pocket for the glucocorticoid receptor.
RSC Med Chem 12: 203-212 (2021)
University Of Iowa
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series.
RSC Med Chem 12: 129-136 (2021)
University Of North Carolina
Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.
RSC Med Chem 12: 120-128 (2021)
Instituto De Qu£Mica Rosario
Identification of P218 as a potent inhibitor of
RSC Med Chem 12: 103-109 (2021)
Universidade Estadual De Campinas (Unicamp)
Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases.
RSC Med Chem 12: 95-102 (2021)
University Of Georgia
Synthesis and Pharmacological Evaluation of Tetrahydro-?-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase.
J Med Chem 64: 7667-7690 (2021)
Shanghai Institute Of Materia Medica (Simm)
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
J Med Chem 64: 7853-7876 (2021)
The University Of Sydney
Discovery of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors for the treatment of glaucoma.
Bioorg Med Chem Lett 45: (2021)
Sichuan University
Identification of aryl sulfonamides as novel and potent inhibitors of Na
Bioorg Med Chem Lett 45: (2021)
Xenon Pharmaceuticals
Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer.
J Med Chem 64: 7468-7482 (2021)
China Pharmaceutical University
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their
J Med Chem 64: 7809-7838 (2021)
University Of Ljubljana
Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability.
RSC Med Chem 12: 579-583 (2021)
University Of Basel
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Eur J Med Chem 220: (2021)
University Of North Carolina At Chapel Hill
Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a
J Nat Prod 84: 1831-1837 (2021)
Yangzhou University
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.
J Med Chem 64: 7839-7852 (2021)
Huazhong University Of Science And Technology
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
J Med Chem 64: 7691-7701 (2021)
Merck
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
J Med Chem 64: 7404-7421 (2021)
Chinese Academy Of Sciences
Design, Synthesis, and Evaluation of
J Med Chem 64: 7646-7666 (2021)
China Pharmaceutical University
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors.
Bioorg Med Chem 41: (2021)
University Of Colorado Anschutz Medical Campus
Discovery of G Protein-Biased Ligands against 5-HT
J Med Chem 64: 7453-7467 (2021)
Korea Institute Of Science And Technology
Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries.
Bioorg Med Chem 41: (2021)
University Of Florence
Contemporary advances of cyclic molecules proposed for inflammation.
Eur J Med Chem 221: (2021)
Dpsr University
Design, Synthesis, and Structure-Activity Relationship of
J Med Chem 64: 7371-7389 (2021)
Southern Medical University
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
J Med Chem 64: 7189-7209 (2021)
China Pharmaceutical University
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
J Med Chem 64: 7241-7260 (2021)
Novartis Institutes For Biomedical Research
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.
J Med Chem 64: 7702-7723 (2021)
Virginia Commonwealth University
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3? Inhibitors for the Treatment of Acute Promyelocytic Leukemia.
J Med Chem 64: 7341-7358 (2021)
Fudan University
Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.
J Med Chem 64: 7483-7506 (2021)
China Pharmaceutical University
Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics.
Eur J Med Chem 221: (2021)
University Of Naples "Federico Ii
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).
Bioorg Med Chem 41: (2021)
Gsk
Discovery of novel modulators for the PPAR? (peroxisome proliferator activated receptor ?): Potential therapies for nonalcoholic fatty liver disease.
Bioorg Med Chem 41: (2021)
City Of Hope National Medical Center
Aurora kinase inhibitors as potential anticancer agents: Recent advances.
Eur J Med Chem 221: (2021)
Isf College Of Pharmacy
Optimization of
J Med Chem 64: 7760-7777 (2021)
China Pharmaceutical University
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
J Med Chem 64: 7596-7616 (2021)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences
Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids.
Bioorg Med Chem 41: (2021)
Research Triangle Institute
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
Eur J Med Chem 221: (2021)
Jagiellonian University Medical College
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor.
Bioorg Med Chem Lett 44: (2021)
Sumitomo Dainippon Pharma.
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study.
Bioorg Med Chem Lett 44: (2021)
Malnad College Of Engineering
Discovery of a Candidate Containing an (
J Med Chem 64: 7434-7452 (2021)
Peking Union Medical College And Chinese Academy Of Medical Sciences
Novel Dual-Target ?-Opioid Receptor and Dopamine D
J Med Chem 64: 7778-7808 (2021)
National Institute On Drug Abuse-Intramural Research Program
Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.
Bioorg Med Chem 41: (2021)
Takeda Pharmaceutical
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
J Med Chem 64: 7312-7330 (2021)
Taiwan National Health Research Institutes
Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor ?t.
J Med Chem 64: 9238-9258 (2021)
Technische Universiteit Eindhoven
Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
J Med Chem 64: 7617-7629 (2021)
Sun Yat-Sen University
Re-emerging Aspartic Protease Targets: Examining
J Med Chem 64: 6706-6719 (2021)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences
Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their
J Med Chem 64: 6949-6971 (2021)
Bharati Vidyapeeth'S College Of Pharmacy
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma.
Eur J Med Chem 221: (2021)
Universit£
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
J Med Chem 64: 6902-6923 (2021)
Takeda Pharmaceuticals International
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Bioorg Med Chem 41: (2021)
Pfizer
A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities.
Bioorg Med Chem 41: (2021)
Tongji University
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Eur J Med Chem 221: (2021)
Central University Of Punjab
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