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9990464 64 Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.EBI Bioorg Med Chem Lett 9: 97-102 (1999) Universit£t Erlangen-N£rnberg 2D 3D TSV
9990463 69 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.EBI Bioorg Med Chem Lett 9: 91-6 (1999) Novartis Pharmaceuticals 2D 3D TSV
9990460 9 The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents.EBI Bioorg Med Chem Lett 9: 75-8 (1999) Lilly Research Laboratories 2D 3D TSV
9990454 26 Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.EBI Bioorg Med Chem Lett 9: 43-8 (1999) Instituto de Química Médica (CSIC) 2D 3D TSV
9990449 7 A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.EBI Bioorg Med Chem Lett 9: 19-24 (1999) Tokushima Bunri University 2D 3D TSV
9990447 51 Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors.EBI Bioorg Med Chem Lett 9: 7-12 (1999) Schering-Plough Research Institute 2D 3D TSV
9986723 29 N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.EBI J Med Chem 42: 526-31 (1999) Lilly Research Laboratories 2D 3D TSV
9986722 15 Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach.EBI J Med Chem 42: 515-25 (1999) INSERM 2D 3D TSV
9986720 24 Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.EBI J Med Chem 42: 497-509 (1999) University of California 2D 3D TSV
9986719 39 1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.EBI J Med Chem 42: 490-6 (1999) Università di Bari 2D 3D TSV
9986714 105 Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists.EBI J Med Chem 42: 427-37 (1999) Recordati S.p.A. 2D 3D TSV
9986712 33 A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers.EBI J Med Chem 42: 409-14 (1999) Institute of Mutagenesis and Differentiation 2D 3D TSV
9986710 28 Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.EBI J Med Chem 42: 400-4 (1999) University "La Sapienza" of Rome 2D 3D TSV
9986705 290 Identification and characterization of m1 selective muscarinic receptor antagonists1.EBI J Med Chem 42: 356-63 (1999) Warner-Lambert Company 2D 3D TSV
9986703 7 Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT2A and alpha1 receptor binding affinity.EBI J Med Chem 42: 336-45 (1999) Angelini Ricerche S.p.A. 2D 3D TSV
9986702 11 A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.EBI J Med Chem 42: 333-5 (1999) University of Pennsylvania 2D 3D TSV
9934496 27 Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.EBI Bioorg Med Chem Lett 8: 3689-92 (1999) Research Triangle Institute 2D 3D TSV
9934495 26 Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.EBI Bioorg Med Chem Lett 8: 3683-8 (1999) Corvas International, Inc. 2D 3D TSV
9934494 20 Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease.EBI Bioorg Med Chem Lett 8: 3677-82 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9934490 4 Differential activity of rosiglitazone enantiomers at PPAR gamma.EBI Bioorg Med Chem Lett 8: 3657-8 (1999) Glaxo Wellcome Research and Development 2D 3D TSV
9934488 1 Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5:7-fused, planar, aromatic heterocyclic ring system.EBI Bioorg Med Chem Lett 8: 3649-52 (1999) University of Maryland 2D 3D TSV
9934485 8 Design and synthesis of novel conformationally restricted HIV protease inhibitors.EBI Bioorg Med Chem Lett 8: 3637-42 (1999) Vertex Pharmaceuticals Inc 2D 3D TSV
9934484 32 Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors.EBI Bioorg Med Chem Lett 8: 3631-6 (1999) Vertex Pharmaceuticals Inc 2D 3D TSV
9934482 3 (2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6- pentamethylpiperidin-4-yl)-2,4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase.EBI Bioorg Med Chem Lett 8: 3621-6 (1999) SmithKline Beecham Research Unit 2D 3D TSV
9934481 9 Tricyclic ureas: a new class of HIV-1 protease inhibitors.EBI Bioorg Med Chem Lett 8: 3615-20 (1999) DuPont Pharmaceuticals Company 2D 3D TSV
9934480 5 The solid phase synthesis of a series of tri-substituted hydantoin ligands for the somatostatin SST5 receptor.EBI Bioorg Med Chem Lett 8: 3609-14 (1999) Glaxo Wellcome Cambridge Chemistry Laboratory 2D 3D TSV
9934479 17 Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety.EBI Bioorg Med Chem Lett 8: 3603-8 (1999) NV Organon Scientific Development Group 2D 3D TSV
9934475 30 The discovery of orally available thrombin inhibitors: studies towards the optimisation of CGH1668.EBI Bioorg Med Chem Lett 8: 3583-8 (1999) Novartis Horsham Research Center 2D 3D TSV
9934474 9 Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.EBI Bioorg Med Chem Lett 8: 3577-82 (1999) Pfizer Inc. 2D 3D TSV
9934473 16 Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.EBI Bioorg Med Chem Lett 8: 3571-6 (1999) Universidad de Santiago de Compostela 2D 3D TSV
9934472 12 Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors.EBI Bioorg Med Chem Lett 8: 3567-70 (1999) University of Vigo 2D 3D TSV
9934467 27 Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2' ligand.EBI Bioorg Med Chem Lett 8: 3537-42 (1999) AIDS Drug Screening and Development Laboratory, SA 2D 3D TSV
9934466 7 Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.EBI Bioorg Med Chem Lett 8: 3531-6 (1999) Abbott Laboratories 2D 3D TSV
9934463 6 Inhibition stereochemistry of hydroxamate inhibitors for thermolysin.EBI Bioorg Med Chem Lett 8: 3515-8 (1999) Pohang University of Science and Technology 2D 3D TSV
9934461 9 Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8.EBI Bioorg Med Chem Lett 8: 3505-10 (1999) University of Washington 2D 3D TSV
9934459 6 Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog.EBI Bioorg Med Chem Lett 8: 3495-8 (1999) Kwansei Gakuin University 2D 3D TSV
9934454 15 Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines.EBI Bioorg Med Chem Lett 8: 3469-74 (1999) Schering-Plough Research Institute 2D 3D TSV
9933143 11 Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 359: 7-10 (1999) Schering-Plough Research Institute 2D 3D TSV
9933142 67 Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 359: 1-6 (1999) Lilly Research Laboratories 2D 3D TSV
9928251 27 Pharmacological characterization of the constitutively activated state of the serotonin 5-HT2C receptor.BDB Ann N Y Acad Sci 861: 140-5 (1998) Albany Medical College 2D 3D TSV
9925739 2 2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid.EBI J Med Chem 42: 329-32 (1999) Northwestern University 2D 3D TSV
9925737 57 N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.EBI J Med Chem 42: 312-23 (1999) Nippon Steel Corporation 2D 3D TSV
9925736 16 Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.EBI J Med Chem 42: 305-11 (1999) The Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9925731 4 Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.EBI J Med Chem 42: 260-6 (1999) University College London 2D 3D TSV
9925730 118 Three-dimensional quantitative structure-activity relationship study on cyclic urea derivatives as HIV-1 protease inhibitors: application of comparative molecular field analysis.EBI J Med Chem 42: 249-59 (1999) Lindsley F. Kimball Research Institute of The New York Blood Center 2D 3D TSV
9925725 9 Discovery of a potent, orally active, nonsteroidal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071).EBI J Med Chem 42: 210-2 (1999) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9925723 10 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.EBI J Med Chem 42: 202-5 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9925722 18 Pharmacological treatment of obesity: therapeutic strategies.EBI J Med Chem 42: 181-201 (1999) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9925440 19 Potent 3-spiropiperidine growth hormone secretagogues.EBI Bioorg Med Chem Lett 8: 107-12 (1999) Merck Research Laboratories 2D 3D TSV
9918561 7 Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.EBI J Pharmacol Exp Ther 288: 575-81 (1999) University of Tokyo 2D 3D TSV
9914792 3 Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.EBI Jpn J Cancer Res 89: 1220-8 (1999) Kobe University 2D 3D TSV
9888842 21 Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.EBI J Med Chem 42: 173-7 (1999) Università di Milano 2D 3D TSV
9888841 1 Carboxy-substituted cinnamides: a novel series of potent, orally active LTB4 receptor antagonists.EBI J Med Chem 42: 164-72 (1999) Novartis Pharmaceuticals Corporation 2D 3D TSV
9888839 140 Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors.BDB J Med Chem 42: 135-52 (1999) DuPont Pharmaceuticals Company 2D 3D TSV
9888838 30 Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.EBI J Med Chem 42: 118-34 (1999) University of Kansas 2D 3D TSV
9888835 42 Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.EBI J Med Chem 42: 87-94 (1999) Procter and Gamble Pharmaceuticals 2D 3D TSV
9888831 83 Synthesis and structure-activity relationships of a new model of arylpiperazines. 4. 1-[omega-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene) - 2, 5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2, 5-pyrrolidinediones: study of the steric requirements of the terminal amide fragment on 5-HT1A aEBI J Med Chem 42: 36-49 (1999) Universidad Complutense 2D 3D TSV
9888830 14 Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.EBI J Med Chem 42: 25-35 (1999) National Cancer Institute 2D 3D TSV
9884068 18 Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors.BDB Br J Pharmacol 125: 1413-20 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9880084 35 Cloning and characterization of the human galanin GALR2 receptor.BDB Peptides 19: 1771-81 (1998) Synaptic Pharmaceutical Corporation 2D 3D TSV
9879510 11 Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.BDB J Enzym Inhib 13: 1-9 (1998) ORSTOM 2D 3D TSV
9876115 183 Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.BDB J Med Chem 41: 5457-65 (1998) University of Auckland 2D 3D TSV
9876114 111 Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.EBI J Med Chem 41: 5445-56 (1999) Institut für Biochemie 2D 3D TSV
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI J Med Chem 41: 5402-9 (1999) Centro de Investigación Grupo Ferrer 2D 3D TSV
9876109 44 New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities.EBI J Med Chem 41: 5393-401 (1999) Universit£ degli Studi di Torino 2D 3D TSV
9876107 9 The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.EBI J Med Chem 41: 5375-81 (1999) Institute of Cancer Research 2D 3D TSV
9876106 49 Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.EBI J Med Chem 41: 5362-74 (1999) Lilly Research Laboratories 2D 3D TSV
9876105 75 Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.EBI J Med Chem 41: 5353-61 (1999) University of Connecticut 2D 3D TSV
9873746 13 Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.EBI Bioorg Med Chem Lett 8: 3423-8 (1999) Centre de Recherche Pierre Fabre 2D 3D TSV
9873743 13 Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.EBI Bioorg Med Chem Lett 8: 3409-14 (1999) Warner-Lambert Company 2D 3D TSV
9873742 5 Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).EBI Bioorg Med Chem Lett 8: 3403-8 (1999) National Institutes of Health 2D 3D TSV
9873735 111 5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.EBI Bioorg Med Chem Lett 8: 3365-70 (1999) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9873734 8 Acceptor substrate-based selective inhibition of galactosyltransferases.EBI Bioorg Med Chem Lett 8: 3359-64 (1999) Scripps Research Institute 2D 3D TSV
9873733 24 Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors.EBI Bioorg Med Chem Lett 8: 3353-8 (1999) Scripps Research Institute 2D 3D TSV
9873730 27 Potent inhibitors of the MAP kinase p38.EBI Bioorg Med Chem Lett 8: 3335-40 (1998) R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. 2D 3D TSV
9873728 19 Synthesis of benzocycloalkane derivatives as new conformationally restricted ligands for melatonin receptors.EBI Bioorg Med Chem Lett 8: 3325-30 (1999) Université de Paris-Sud 2D 3D TSV
9873727 32 A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.BDB Bioorg Med Chem Lett 7: 1843-6 (1997) Gilead Sciences Inc. 2D 3D TSV
9873725 28 Potent, non-thiol inhibitors of farnesyltransferase.EBI Bioorg Med Chem Lett 8: 3311-6 (1999) Merck Research Laboratories 2D 3D TSV
9873724 21 Aryl C-glycosides: physiologically stable glycomimetics of sialyl Lewis X.EBI Bioorg Med Chem Lett 8: 3307-10 (1999) Sankyo Co. Ltd. 2D 3D TSV
9873718 12 Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease.EBI Bioorg Med Chem Lett 8: 3281-6 (1999) Purdue University 2D 3D TSV
9873717 12 Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.EBI Bioorg Med Chem Lett 8: 3275-80 (1999) University of Toronto 2D 3D TSV
9873715 9 Thio-sugars. IV: Design and synthesis of S-linked fucoside analogs as a new class of alpha-L-fucosidase inhibitors.EBI Bioorg Med Chem Lett 8: 3265-8 (1999) University of Connecticut 2D 3D TSV
9873712 109 Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors.EBI Bioorg Med Chem Lett 8: 3251-6 (1999) Abbott Laboratory 2D 3D TSV
9873708 16 N-arylrolipram derivatives as potent and selective PDE4 inhibitors.EBI Bioorg Med Chem Lett 8: 3229-34 (1999) Novartis Horsham Research Center 2D 3D TSV
9873707 18 Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives.EBI Bioorg Med Chem Lett 8: 3223-8 (1999) GlaxoWellcome Medicines Research Center 2D 3D TSV
9873703 4 Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.EBI Bioorg Med Chem Lett 8: 3203-6 (1999) Pharmacopeia, Inc. 2D 3D TSV
9873701 27 Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.EBI Bioorg Med Chem Lett 8: 3193-8 (1999) BioChem Therapeutic Inc. 2D 3D TSV
9873697 15 Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model.EBI Bioorg Med Chem Lett 8: 3171-6 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9873696 80 Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.EBI Bioorg Med Chem Lett 8: 3165-70 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9873694 12 Syntheses and antitumor activity of cis-restricted combretastatins: 5-membered heterocyclic analogues.EBI Bioorg Med Chem Lett 8: 3153-8 (1998) Pharmaceutical Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan. 2D 3D TSV
9873693 24 N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.EBI Bioorg Med Chem Lett 8: 3149-52 (1999) Research Triangle Institute 2D 3D TSV
9873692 54 Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa.EBI Bioorg Med Chem Lett 8: 3143-8 (1999) DuPont Pharmaceuticals Company 2D 3D TSV
9873689 12 Structurally similar small molecule photoaffinity CCK-A agonists and antagonists as novel tools for directly probing 7TM receptors-ligand interactions.EBI Bioorg Med Chem Lett 8: 3127-32 (1999) Neurogen Corporation 2D 3D TSV
9873686 18 Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.EBI Bioorg Med Chem Lett 8: 3111-6 (1998) SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. 2D 3D TSV
9873682 8 Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics.EBI Bioorg Med Chem Lett 8: 3093-6 (1999) Washington University 2D 3D TSV
9873681 65 3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.EBI Bioorg Med Chem Lett 8: 3087-92 (1999) Merck Research Laboratories 2D 3D TSV
9873680 21 Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.EBI Bioorg Med Chem Lett 8: 3081-6 (1999) Merck Research Laboratories 2D 3D TSV
9873675 44 Orally active indole N-oxide PDE4 inhibitors.EBI Bioorg Med Chem Lett 8: 3053-8 (1998) Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA. 2D 3D TSV
9873668 4 Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.EBI Bioorg Med Chem Lett 8: 3019-24 (1999) Universit£ di Ferrara 2D 3D TSV
9873660 5 Preparation of biotinylated allosamidins with strong chitinase inhibitory activities.EBI Bioorg Med Chem Lett 8: 2987-90 (1998) Department of Applied Biological Chemistry, University of Tokyo, Japan. asakuda@hongo.ecc.u-tokyo.ac.jp 2D 3D TSV
9873656 17 Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity.EBI Bioorg Med Chem Lett 8: 2967-72 (1998) Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan. 2D 3D TSV
9873655 10 Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.EBI Bioorg Med Chem Lett 8: 2961-6 (1999) Université de Haute-Alsace 2D 3D TSV
9873654 37 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.EBI Bioorg Med Chem Lett 8: 2955-60 (1999) GlaxoWellcome Research and Development 2D 3D TSV
9873649 25 PDE4 inhibitors: new xanthine analogues.EBI Bioorg Med Chem Lett 8: 2925-30 (1998) Chiroscience Ltd, Cambridge Science Park, UK. johnmontana@chiroscience.com 2D 3D TSV
9873646 41 4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase.EBI Bioorg Med Chem Lett 8: 2907-12 (1999) Pharmacia& Upjohn 2D 3D TSV
9873644 74 Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.EBI Bioorg Med Chem Lett 8: 2897-902 (1999) Novo Nordisk A/S 2D 3D TSV
9873643 75 Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors.EBI Bioorg Med Chem Lett 8: 2891-6 (1999) Novartis Pharma AG 2D 3D TSV
9873639 12 Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.EBI Bioorg Med Chem Lett 8: 2871-6 (1999) Universit£ di Firenze 2D 3D TSV
9873638 6 Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain.EBI Bioorg Med Chem Lett 8: 2865-70 (1999) Novartis Pharma Inc. 2D 3D TSV
9873637 38 Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.EBI Bioorg Med Chem Lett 8: 2859-64 (1998) SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK. 2D 3D TSV
9873636 2 Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10.EBI Bioorg Med Chem Lett 8: 2855-8 (1999) Laboratoire des M£canismes Mol£culaires des Communications Cellulaires (CNRS UPR 9023) 2D 3D TSV
9873635 67 2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.EBI Bioorg Med Chem Lett 8: 2849-54 (1999) Centro de Investigación Lilly, SA 2D 3D TSV
9873633 50 MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.EBI Bioorg Med Chem Lett 8: 2839-44 (1999) DuPont Pharmaceuticals Company 2D 3D TSV
9873628 1 Design and synthesis of a pyridone-based phosphotyrosine mimetic.EBI Bioorg Med Chem Lett 8: 2813-6 (1999) Cadus Pharmaceutical Corporation 2D 3D TSV
9873627 4 Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.EBI Bioorg Med Chem Lett 8: 2809-12 (1999) University of Michigan 2D 3D TSV
9873626 1 Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.EBI Bioorg Med Chem Lett 8: 2803-8 (1999) Universit£ de Montr£al 2D 3D TSV
9873625 45 Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.EBI Bioorg Med Chem Lett 8: 2797-802 (1999) Abbott Laboratories 2D 3D TSV
9873622 1 Sialyl Lewis X-polysaccharide conjugates: targeting inflammatory lesions.EBI Bioorg Med Chem Lett 8: 2783-6 (1999) Drug Delivery System Institute, Ltd. 2D 3D TSV
9873621 48 2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 8: 2777-82 (1999) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
9873617 30 Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain).EBI Bioorg Med Chem Lett 8: 2757-62 (1999) Idun Pharmaceuticals 2D 3D TSV
9873615 10 Conformationally restricted carbamate inhibitors of horse serum butyrylcholinesterase.EBI Bioorg Med Chem Lett 8: 2747-50 (1999) National Chung-Hsing University 2D 3D TSV
9873613 15 2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors.EBI Bioorg Med Chem Lett 8: 2737-42 (1998) Rhône-Poulenc Rorer, Collegeville, PA 19426, USA. 2D 3D TSV
9873612 84 Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.EBI Bioorg Med Chem Lett 8: 2731-6 (1999) Ligand Pharmaceuticals 2D 3D TSV
9873610 48 Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.EBI Bioorg Med Chem Lett 8: 2719-24 (1999) Boehringer Ingelheim (Canada) Ltd 2D 3D TSV
9873609 15 NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.EBI Bioorg Med Chem Lett 8: 2715-8 (1999) Neurogen Corporation 2D 3D TSV
9873607 21 The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.EBI Bioorg Med Chem Lett 8: 2705-10 (1999) DuPont Pharmaceuticals Company 2D 3D TSV
9873604 72 Pyrroles and other heterocycles as inhibitors of p38 kinase.EBI Bioorg Med Chem Lett 8: 2689-94 (1999) Merck Research Laboratory 2D 3D TSV
9873603 23 Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.EBI Bioorg Med Chem Lett 8: 2685-8 (1999) University of Michigan 2D 3D TSV
9873602 11 A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine.EBI Bioorg Med Chem Lett 8: 2681-4 (1999) University of Michigan 2D 3D TSV
9873601 45 New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.EBI Bioorg Med Chem Lett 8: 2675-80 (1999) Wyeth-Ayerst Research Laboratory 2D 3D TSV
9873600 14 Thalidomide analogs and PDE4 inhibition.EBI Bioorg Med Chem Lett 8: 2669-74 (1998) Celgene Corporation, Warren, NJ 07059 USA. 2D 3D TSV
9873598 39 The synthesis and biological activity of a novel series of diazepine MMP inhibitors.EBI Bioorg Med Chem Lett 8: 2657-62 (1999) Wyeth-Ayerst Research 2D 3D TSV
9873596 18 P2-proline-derived inhibitors of calpain I.EBI Bioorg Med Chem Lett 8: 2647-52 (1999) Cephalon, Inc. 2D 3D TSV
9873594 44 Aryl sulfonamides as selective PDE4 inhibitors.EBI Bioorg Med Chem Lett 8: 2635-40 (1999) Chiroscience Ltd 2D 3D TSV
9873593 15 Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.EBI Bioorg Med Chem Lett 8: 2629-34 (1998) Chiroscience Ltd, Cambridge. 2D 3D TSV
9873592 44 Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2.EBI Bioorg Med Chem Lett 8: 2623-8 (1999) GlaxoWellcome Medicines Research Center 2D 3D TSV
9873589 6 Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase.EBI Bioorg Med Chem Lett 8: 2603-8 (1998) Krebs Institute, Department of Chemistry, University of Sheffield, UK. 2D 3D TSV
9873586 50 PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.EBI Bioorg Med Chem Lett 8: 2589-94 (1999) Cambridge University Forvie Site 2D 3D TSV
9873585 30 N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.EBI Bioorg Med Chem Lett 8: 2583-8 (1999) Freie Universit£t Berlin 2D 3D TSV
9873583 4 Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.EBI Bioorg Med Chem Lett 8: 2573-6 (1999) Université de Rennes 1 2D 3D TSV
9873581 21 Benzylamine-based selective and orally bioavailable inhibitors of thrombin.EBI Bioorg Med Chem Lett 8: 2563-8 (1999) Biotech Research Institute 2D 3D TSV
9873573 35 Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system.EBI Bioorg Med Chem Lett 8: 2521-6 (1999) Schering-Plough Research Institute 2D 3D TSV
9873569 16 Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates.EBI Bioorg Med Chem Lett 8: 2501-6 (1999) Corvas International, Inc. 2D 3D TSV
9873568 22 Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.EBI Bioorg Med Chem Lett 8: 2495-500 (1999) Merck& Co. 2D 3D TSV
9873567 28 The development of novel and selective p56lck tyrosine kinase inhibitors.EBI Bioorg Med Chem Lett 8: 2489-94 (1999) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9873565 2 H-phosphonate derivatives as novel peptide deformylase inhibitors.EBI Bioorg Med Chem Lett 8: 2479-82 (1999) Ohio State University 2D 3D TSV
9873563 67 Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.EBI Bioorg Med Chem Lett 8: 2467-72 (1999) Merck & Co. 2D 3D TSV
9873562 3 Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.EBI Bioorg Med Chem Lett 8: 2463-6 (1999) Wayne State University 2D 3D TSV
9873561 29 Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.EBI Bioorg Med Chem Lett 8: 2457-62 (1999) Solvay Pharma 2D 3D TSV
9873560 12 N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.EBI Bioorg Med Chem Lett 8: 2451-6 (1999) Pfizer Central Research 2D 3D TSV
9873554 3 NMR and topochemical studies of peptidomimetic HIV-I protease inhibitors containing a cis-epoxide amide isostere.EBI Bioorg Med Chem Lett 8: 2423-6 (1999) Biotech Research Institute 2D 3D TSV
9873552 12 Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.EBI Bioorg Med Chem Lett 8: 2415-8 (1999) Warner-Lambert Company 2D 3D TSV
9873537 71 Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.EBI Bioorg Med Chem Lett 8: 2333-8 (1999) Scripps Research Institute 2D 3D TSV
9873535 13 Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.EBI Bioorg Med Chem Lett 8: 2321-6 (1999) Molecumetics Ltd. 2D 3D TSV
9873534 36 Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.EBI Bioorg Med Chem Lett 8: 2315-20 (1999) Pharmacopeia, Inc. 2D 3D TSV
9873533 11 Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array.EBI Bioorg Med Chem Lett 8: 2309-14 (1999) Warner-Lambert Company 2D 3D TSV
9873532 31 Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis.EBI Bioorg Med Chem Lett 8: 2303-8 (1999) Affymax Research Institute 2D 3D TSV
9873531 3 Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening.EBI Bioorg Med Chem Lett 8: 2297-302 (1999) University of California 2D 3D TSV
9873527 12 Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.EBI Bioorg Med Chem Lett 8: 2273-8 (1999) Institute for Molecular Studies 2D 3D TSV
9873525 13 4-[(1H-imidazol-4-yl) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor.EBI Bioorg Med Chem Lett 8: 2263-8 (1999) Schering-Plough Research Institute 2D 3D TSV
9873524 37 L-tryptophan urea amides as NK1/NK2 dual antagonists.EBI Bioorg Med Chem Lett 8: 2259-62 (1999) Merck Research Laboratories 2D 3D TSV
9873523 5 C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.EBI Bioorg Med Chem Lett 8: 2253-8 (1999) Merck Research Laboratories 2D 3D TSV
9873522 8 Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630.EBI Bioorg Med Chem Lett 8: 2247-52 (1999) Takarazuka Research Institute 2D 3D TSV
9873521 52 Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity.EBI Bioorg Med Chem Lett 8: 2241-6 (1999) Takarazuka Research Institute 2D 3D TSV
9873520 27 Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.EBI Bioorg Med Chem Lett 8: 2235-40 (1999) Berlex Biosciences 2D 3D TSV
9873517 4 Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.EBI Bioorg Med Chem Lett 8: 2223-6 (1999) Clemson University 2D 3D TSV
9873513 27 Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach.EBI Bioorg Med Chem Lett 8: 2203-8 (1999) Novartis Pharma AG 2D 3D TSV
9873508 3 Conformationally restricted analogues of nicotine and anabasine.EBI Bioorg Med Chem Lett 8: 2173-8 (1999) SIBIA Neurosciences Inc. 2D 3D TSV
9873507 15 A dipyrido [2,3-b:3',2'-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine.EBI Bioorg Med Chem Lett 8: 2169-72 (1999) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
9873505 50 Novel H3 receptor antagonists. Sulfonamide homologs of histamine.EBI Bioorg Med Chem Lett 8: 2157-62 (1999) Schering-Plough Research Institute 2D 3D TSV
9873503 4 Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).EBI Bioorg Med Chem Lett 8: 2149-50 (1999) National Cancer Institute 2D 3D TSV
9873498 4 Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.EBI Bioorg Med Chem Lett 8: 2123-8 (1999) Universit£ de Montr£al 2D 3D TSV
9873497 17 Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).EBI Bioorg Med Chem Lett 8: 2117-22 (1999) Warner-Lambert Company 2D 3D TSV
9873496 80 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.EBI Bioorg Med Chem Lett 8: 2111-6 (1999) Merck Research Laboratories 2D 3D TSV
9873491 56 The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.EBI Bioorg Med Chem Lett 8: 2087-92 (1999) Abbott Laboratories 2D 3D TSV
9873489 28 Design and synthesis of conformationally-constrained MMP inhibitors.EBI Bioorg Med Chem Lett 8: 2077-80 (1999) Procter and Gamble Pharmaceuticals 2D 3D TSV
9873488 4 Kampanols: novel Ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis.EBI Bioorg Med Chem Lett 8: 2071-6 (1999) Merck Research Laboratories 2D 3D TSV
9873487 14 Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.EBI Bioorg Med Chem Lett 8: 2067-70 (1999) Warner-Lambert Company 2D 3D TSV
9873486 1 Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[[(4-chlorophenyl)sulfonyl]-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists.EBI Bioorg Med Chem Lett 8: 2061-6 (1999) Pfizer Central Research 2D 3D TSV
9873481 80 SAR of novel biarylmethylamine dopamine D4 receptor ligands.EBI Bioorg Med Chem Lett 8: 2033-8 (1999) Darmstadt 2D 3D TSV
9873480 35 Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors.EBI Bioorg Med Chem Lett 8: 2027-32 (1999) Institute for Bioorganic Research 2D 3D TSV
9873477 8 General construction pattern of histamine H3-receptor antagonists: change of a paradigm.EBI Bioorg Med Chem Lett 8: 2011-6 (1999) Freie Universität Berlin 2D 3D TSV
9873474 3 Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces.EBI Bioorg Med Chem Lett 8: 2001-2 (1999) Korea Research Institute of Bioscience and Biotechnology 2D 3D TSV
9873473 4 Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.EBI Bioorg Med Chem Lett 8: 1997-2000 (1998) Institute of Molecular and Cellular Biosciences (IMCB), University of Tokyo, Japan. 2D 3D TSV
9873472 102 Identification and characterization of m4 selective muscarinic antagonists.EBI Bioorg Med Chem Lett 8: 1991-6 (1999) Parke-Davis Pharmaceutical Research 2D 3D TSV
9873471 111 Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid.EBI Bioorg Med Chem Lett 8: 1985-90 (1999) Eli Lilly and Company 2D 3D TSV
9873464 6 A practical synthesis of 3-substituted delta 3,5(6)-steroids as new potential 5 alpha-reductase inhibitor.EBI Bioorg Med Chem Lett 8: 1949-52 (1998) Shanghai Institute of Organic Chemistry, Chinese Academy of Science, China. 2D 3D TSV
9873463 39 Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives.EBI Bioorg Med Chem Lett 8: 1943-8 (1999) Lilly Research Laboratories 2D 3D TSV
9873462 19 4-Alkylpiperidines related to SR-48968: potent antagonists of the neurokinin-2 (NK2) receptor.EBI Bioorg Med Chem Lett 8: 1935-40 (1999) ZENECA Pharmaceuticals 2D 3D TSV
9873461 18 SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities.EBI Bioorg Med Chem Lett 8: 1929-34 (1998) R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. 2D 3D TSV
9873460 14 Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.EBI Bioorg Med Chem Lett 8: 1923-8 (1998) R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. 2D 3D TSV
9873457 6 Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor.EBI Bioorg Med Chem Lett 8: 1909-12 (1999) Ajou University 2D 3D TSV
9873454 15 17 alpha-alkyl- or 17 alpha-substituted benzyl-17 beta-estradiols: a new family of estrone-sulfatase inhibitors.EBI Bioorg Med Chem Lett 8: 1891-6 (1999) Laval University 2D 3D TSV
9873453 5 Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.EBI Bioorg Med Chem Lett 8: 1887-90 (1999) University of Iowa 2D 3D TSV
9873452 1 Novel cytokine release inhibitors. Part I: Triterpenes.EBI Bioorg Med Chem Lett 8: 1883-6 (1999) Rhóne-Poulenc Rorer Central Research 2D 3D TSV
9873451 19 Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors.EBI Bioorg Med Chem Lett 8: 1877-82 (1999) Berlex Biosciences 2D 3D TSV
9873449 49 The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I.EBI Bioorg Med Chem Lett 8: 1867-72 (1998) Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA. 2D 3D TSV
9873448 1 Synthesis and anti-HIV activities of symmetrical N1,N3-dibenzyl-2-hydroxy-propane derivatives.EBI Bioorg Med Chem Lett 8: 1861-6 (1999) Université de la Méditerranée 2D 3D TSV
9873446 12 Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.EBI Bioorg Med Chem Lett 8: 1851-6 (1999) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9873445 41 Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.EBI Bioorg Med Chem Lett 8: 1845-50 (1999) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9873440 10 Modeling, synthesis and biological activity of novel antifungal agents (1).EBI Bioorg Med Chem Lett 8: 1819-24 (1998) Department of Medicinal Chemistry, Nippon Roche Research Center, Kamakura, Japan. 2D 3D TSV
9873439 18 C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.EBI Bioorg Med Chem Lett 8: 1813-8 (1999) National Taiwan University 2D 3D TSV
9873435 10 Development of new chromanol antagonists of leukotriene D4.EBI Bioorg Med Chem Lett 8: 1791-6 (1998) Central Research Division, Pfizer Inc., Groton, CT 06340, USA. 2D 3D TSV
9873433 109 trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.EBI Bioorg Med Chem Lett 8: 1781-6 (1998) Pfizer Inc, Central Research Division, Groton, CT 06340, USA. 2D 3D TSV
9873432 52 Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist.EBI Bioorg Med Chem Lett 8: 1771-6 (1999) Merck KGaA 2D 3D TSV
9873431 18 The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.EBI Bioorg Med Chem Lett 8: 1767-70 (1999) Novo Nordisk A/S 2D 3D TSV
9873429 6 Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.EBI Bioorg Med Chem Lett 8: 1757-62 (1999) National Cancer Institute 2D 3D TSV
9873427 27 Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents.EBI Bioorg Med Chem Lett 8: 1745-50 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9873425 2 Neuronorm is a potent and water soluble neurokinin A receptor antagonist.EBI Bioorg Med Chem Lett 8: 1735-40 (1999) Universit£ di Napoli Federico II 2D 3D TSV
9873422 16 C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.EBI Bioorg Med Chem Lett 8: 1719-24 (1999) Merck Research Laboratories 2D 3D TSV
9873421 30 Peptide-based inhibitors of the hepatitis C virus serine protease.EBI Bioorg Med Chem Lett 8: 1713-8 (1999) Boehringer Ingelheim (Canada) Ltd. 2D 3D TSV
9873418 16 Identification and SAR for a selective, nonpeptidyl thrombin inhibitor.EBI Bioorg Med Chem Lett 8: 1697-702 (1999) Merck Research Laboratories 2D 3D TSV
9873416 3 Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction.EBI Bioorg Med Chem Lett 8: 1689-92 (1998) GlaxoWellcome S.p.A., Medicines Research Center, Verona, Italy. 2D 3D TSV
9873414 13 Potent and efficacious thienylamidine-incorporated thrombin inhibitors.EBI Bioorg Med Chem Lett 8: 1683-6 (1999) Biotech Research Institute 2D 3D TSV
9873411 103 Identification of a potent analogue of Nazumamide A through iteration of combinatorial tetrapeptide libraries.EBI Bioorg Med Chem Lett 8: 1669-72 (1999) Central Drug Research Institute 2D 3D TSV
9873409 2 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.EBI Bioorg Med Chem Lett 8: 1661-4 (1999) Chinese Academy of Sciences 2D 3D TSV
9873407 27 Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif.EBI Bioorg Med Chem Lett 8: 1649-54 (1999) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9873405 9 Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS).EBI Bioorg Med Chem Lett 8: 1639-42 (1999) University of Rhode Island 2D 3D TSV
9873403 6 A new series of cyclic amino acids as inhibitors of S-adenosyl L-methionine synthetase.EBI Bioorg Med Chem Lett 8: 1629-34 (1999) U.M.R. 6519 2D 3D TSV
9873400 12 Diarylsulfonamides as selective, non-peptidic thrombin inhibitors.EBI Bioorg Med Chem Lett 8: 1613-8 (1999) Pharmazeutisch-Chemisches Institut der Universität 2D 3D TSV
9873397 37 In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.EBI Bioorg Med Chem Lett 8: 1595-600 (1999) 3-Dimensional Pharmaceuticals 2D 3D TSV
9873392 6 Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.EBI Bioorg Med Chem Lett 8: 1569-74 (1999) Università degli Studi 2D 3D TSV
9873391 15 Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid.EBI Bioorg Med Chem Lett 8: 1563-8 (1999) Royal Danish School of Pharmacy 2D 3D TSV
9873388 24 Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors.EBI Bioorg Med Chem Lett 8: 1551-4 (1999) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
9873386 15 Synthesis and NK1 receptor antagonistic activity of (+/-)-1-acyl-3-(3,4- dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines.EBI Bioorg Med Chem Lett 8: 1541-6 (1999) Yamanouchi Pharmaceutical Co., Ltd. 2D 3D TSV
9873385 3 A potent dipeptide inhibitor of dipeptidyl peptidase IV.EBI Bioorg Med Chem Lett 8: 1537-40 (1999) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
9873384 15 Design and synthesis of an orally active GPIIb/IIIa antagonist based on a phenylpiperazine scaffold.EBI Bioorg Med Chem Lett 8: 1531-6 (1998) Solvay Pharmaceuticals Research Laboratory, Weesp, The Netherlands. jan.vanmaarseveen@solvay.com 2D 3D TSV
9873382 4 Evaluation of phosphorus-containing inhibitors of gamma-glutamyl hydrolase.EBI Bioorg Med Chem Lett 8: 1521-4 (1999) San Francisco State University 2D 3D TSV
9873380 52 Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.EBI Bioorg Med Chem Lett 8: 1511-6 (1999) Medivir AB 2D 3D TSV
9873377 54 Isoindolinone enantiomers having affinity for the dopamine D4 receptor.EBI Bioorg Med Chem Lett 8: 1499-502 (1999) Parke-Davis Pharmaceutical Research 2D 3D TSV
9873373 20 Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases).EBI Bioorg Med Chem Lett 8: 1477-82 (1999) Institute for Drug Research 2D 3D TSV
9873371 4 Inhibition of electric eel acetylcholinesterase by porphin compounds.EBI Bioorg Med Chem Lett 8: 1467-70 (1999) Taejon National University of Technology 2D 3D TSV
9873370 5 5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.EBI Bioorg Med Chem Lett 8: 1461-6 (1999) Institute 2D 3D TSV
9873368 8 Relationship between dihedral angles of N1 and C9 substituents in 1,4-benzodiazepines and dual cholecystokinin-A and -B antagonistic activities.EBI Bioorg Med Chem Lett 8: 1449-54 (1999) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
9873367 39 Broad spectrum matrix metalloproteinase inhibitors: an examination of succinamide hydroxamate inhibitors with P1 C alpha gem-disubstitution.EBI Bioorg Med Chem Lett 8: 1443-8 (1999) Abbott Laboratories 2D 3D TSV
9871780 85 Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.EBI Bioorg Med Chem Lett 8: 1437-42 (1999) Boehringer Ingelheim (Canada) Ltd 2D 3D TSV
9871777 28 Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.EBI Bioorg Med Chem Lett 8: 1419-24 (1999) INSERM 2D 3D TSV
9871775 29 Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes.EBI Bioorg Med Chem Lett 8: 1407-12 (1999) Centre de Recherche Pierre FABRE 2D 3D TSV
9871770 16 New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors.EBI Bioorg Med Chem Lett 8: 1381-6 (1999) Centre de Recherches de Croissy 2D 3D TSV
9871768 7 Asymmetric synthesis of Boc-N-methyl-p-benzoyl-phenylalanine. Preparation of a photoreactive antagonist of substance P.EBI Bioorg Med Chem Lett 8: 1369-74 (1999) Universit£ P. et M. Curie 2D 3D TSV
9871765 14 Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.EBI Bioorg Med Chem Lett 8: 1353-8 (1999) University of Bologna 2D 3D TSV
9871763 35 High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.EBI Bioorg Med Chem Lett 8: 1343-8 (1999) Merck Sharp Laboratory 2D 3D TSV
9871762 23 Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.EBI Bioorg Med Chem Lett 8: 1337-42 (1999) Centre de Recherche Pierre Fabre 2D 3D TSV
9871752 4 A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis.EBI Bioorg Med Chem Lett 8: 1291-6 (1999) Chinese Academy of Sciences 2D 3D TSV
9871749 3 A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein.EBI Bioorg Med Chem Lett 8: 1277-80 (1999) Schering Plough Research Institute 2D 3D TSV
9871745 8 Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.EBI Bioorg Med Chem Lett 8: 1255-60 (1999) Merck Frosst Centre For Therapeutic Research 2D 3D TSV
9871744 5 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors.EBI Bioorg Med Chem Lett 8: 1249-54 (1999) Menarini Ricerche S.p.A. 2D 3D TSV
9871742 11 Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones.EBI Bioorg Med Chem Lett 8: 1237-42 (1999) Pharmacia & Upjohn 2D 3D TSV
9871737 5 Design and synthesis of bio-isosteres of thymidine triphosphate.EBI Bioorg Med Chem Lett 8: 1211-4 (1999) University of Wales Cardiff 2D 3D TSV
9871736 4 Direct synthesis of [DOTA-DPhe1]-octreotide and [DOTA-DPhe1,Tyr3]-octreotide (SMT487): two conjugates for systemic delivery of radiotherapeutical nuclides to somatostatin receptor positive tumors in man.EBI Bioorg Med Chem Lett 8: 1207-10 (1999) Novartis Pharma AG 2D 3D TSV
9871731 14 Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.EBI Bioorg Med Chem Lett 8: 1181-6 (1999) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
9871730 20 Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.EBI Bioorg Med Chem Lett 8: 1175-80 (1999) URA CNRS 1309 2D 3D TSV
9871729 7 Synthesis and anti-inflammatory activity of chalcone derivatives.EBI Bioorg Med Chem Lett 8: 1169-74 (1999) Universidad de Valencia 2D 3D TSV
9871728 27 The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.EBI Bioorg Med Chem Lett 8: 1163-8 (1999) Wyeth-Ayerst Research 2D 3D TSV
9871727 58 Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.EBI Bioorg Med Chem Lett 8: 1157-62 (1999) Affymax Research Institute 2D 3D TSV
9871726 3 A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.EBI Bioorg Med Chem Lett 8: 1153-6 (1999) Universit£ di Napoli Federico II 2D 3D TSV
9871723 1 Substrate specificity of human prolyl-4-hydroxylase.EBI Bioorg Med Chem Lett 8: 1139-44 (1999) Cornell University 2D 3D TSV
9871722 14 New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine.EBI Bioorg Med Chem Lett 8: 1133-8 (1999) Gliatech Inc. 2D 3D TSV
9871719 144 Serotonergic ergoline derivatives.EBI Bioorg Med Chem Lett 8: 1117-22 (1999) Pharmacia & Upjohn S.p.A.-CNS Research 2D 3D TSV
9871717 72 Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.EBI Bioorg Med Chem Lett 8: 1107-12 (1999) Merck Research Laboratories 2D 3D TSV
9871716 94 Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.EBI Bioorg Med Chem Lett 8: 1101-6 (1999) Merck Research Laboratories 2D 3D TSV
9871711 22 The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.BDB Bioorg Med Chem Lett 8: 1077-82 (1998) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871706 1 Potent antimitotic and cell growth inhibitory properties of substituted chalcones.EBI Bioorg Med Chem Lett 8: 1051-6 (1999) University of Manchester Institute of Science and Technology 2D 3D TSV
9871704 8 Design and synthesis of a new type of non steroidal human aromatase inhibitors.EBI Bioorg Med Chem Lett 8: 1041-4 (1999) Centre d'Etudes et de Recherche sur le Médicament de Normandie 2D 3D TSV
9871700 15 Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.EBI Bioorg Med Chem Lett 8: 1019-22 (1999) Kyushu University 2D 3D TSV
9871693 46 Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams.EBI Bioorg Med Chem Lett 8: 399-404 (1998) Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA. 2D 3D TSV
9871692 25 Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions.EBI Bioorg Med Chem Lett 8: 395-8 (1999) Lilly Research Laboratories 2D 3D TSV
9871687 6 A new strong inhibitor of beta-mannosidase.EBI Bioorg Med Chem Lett 8: 371-2 (1999) S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle. therisod@icmo.u-psud.fr 2D 3D TSV
9871686 23 Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.EBI Bioorg Med Chem Lett 8: 365-70 (1999) Glaxo Wellcome Research and Development 2D 3D TSV
9871684 2 Synthesis of novel cyclic protease inhibitors using Grubbs olefin metathesis.EBI Bioorg Med Chem Lett 8: 357-60 (1999) University of Wisconsin-Madison 2D 3D TSV
9871682 19 Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.EBI Bioorg Med Chem Lett 8: 345-50 (1999) University of Toronto 2D 3D TSV
9871680 5 Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.EBI Bioorg Med Chem Lett 8: 333-8 (1999) ProScript, Inc. 2D 3D TSV
9871678 8 Inhibition of thermolysin with nitrone-bearing substrate analogs: a new type of thermolysin inhibitors.EBI Bioorg Med Chem Lett 8: 323-6 (1999) Pohang University of Science and Technology 2D 3D TSV
9871675 36 Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium.EBI Bioorg Med Chem Lett 8: 307-12 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871674 34 Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile.EBI Bioorg Med Chem Lett 8: 301-6 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871673 79 New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.EBI Bioorg Med Chem Lett 8: 295-300 (1999) Wyeth-Ayerst Research Laboratories 2D 3D TSV
9871672 36 Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates.EBI Bioorg Med Chem Lett 8: 289-94 (1999) Warner-Lambert Company 2D 3D TSV
9871670 13 Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.EBI Bioorg Med Chem Lett 8: 281-4 (1999) Pfizer Inc. 2D 3D TSV
9871666 4 Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons.EBI Bioorg Med Chem Lett 8: 261-6 (1999) Novartis Pharma Inc. 2D 3D TSV
9871663 49 Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.EBI Bioorg Med Chem Lett 8: 249-54 (1999) Abbott Laboratories 2D 3D TSV
9871662 15 Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo.EBI Bioorg Med Chem Lett 8: 243-8 (1999) Schering-Plough Research Institute 2D 3D TSV
9871656 1 Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.EBI Bioorg Med Chem Lett 8: 209-14 (1999) CV Therapeutics Inc. 2D 3D TSV
9871653 1 Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index.EBI Bioorg Med Chem Lett 8: 195-8 (1999) Purdue University 2D 3D TSV
9871649 26 Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.EBI Bioorg Med Chem Lett 8: 175-8 (1998) Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA. 2D 3D TSV
9871640 6 S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase.EBI Bioorg Med Chem Lett 8: 133-8 (1999) Glaxo Wellcome Research and Development 2D 3D TSV
9871637 1 Investigations of azapeptides as mimetics of Leu-enkephalin.EBI Bioorg Med Chem Lett 8: 117-20 (1999) Scripps Research Institute 2D 3D TSV
9871636 17 DNA gyrase inhibitory activity of ellagic acid derivatives.EBI Bioorg Med Chem Lett 8: 97-100 (1998) R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. 2D 3D TSV
9871633 7 Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring.EBI Bioorg Med Chem Lett 8: 81-6 (1999) Fujisawa Pharmaceutical Co. Ltd. 2D 3D TSV
9871630 5 5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.EBI Bioorg Med Chem Lett 8: 65-70 (1999) Novartis Pharma AG 2D 3D TSV
9871629 6 Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors.EBI Bioorg Med Chem Lett 8: 63-4 (1999) Cinc 2D 3D TSV
9871627 20 High affinity phenylglycinol-based NK1 receptor antagonists.EBI Bioorg Med Chem Lett 8: 51-6 (1999) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9871623 48 Selective inhibition of low affinity IgE receptor (CD23) processing.EBI Bioorg Med Chem Lett 8: 29-34 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9871622 36 Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing.EBI Bioorg Med Chem Lett 8: 23-8 (1999) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9871621 26 Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster.EBI Bioorg Med Chem Lett 8: 17-22 (1999) Merck KGaA 2D 3D TSV
9871617 24 Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.EBI Bioorg Med Chem Lett 8: 555-60 (1999) University of Arizona 2D 3D TSV
9871612 8 Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.EBI Bioorg Med Chem Lett 8: 529-34 (1999) Abbott Laboratories 2D 3D TSV
9871609 45 Novel bisphosphonate inhibitors of phosphoglycerate kinase.EBI Bioorg Med Chem Lett 8: 515-20 (1998) Krebs Institute, Chemistry Department, Sheffield University, UK. 2D 3D TSV
9871607 32 Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds.EBI Bioorg Med Chem Lett 8: 505-10 (1998) Almirall Prodesfarma Research Center, Barcelona, Spain. 2D 3D TSV
9871605 43 5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists.EBI Bioorg Med Chem Lett 8: 493-8 (1999) Novartis Pharma AG 2D 3D TSV
9871604 114 Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.EBI Bioorg Med Chem Lett 8: 487-92 (1999) Hong Kong University of Science and Technology 2D 3D TSV
9871601 20 Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists.EBI Bioorg Med Chem Lett 8: 473-6 (1999) Eli Lilly and Company 2D 3D TSV
9871597 65 A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.EBI Bioorg Med Chem Lett 8: 453-8 (1999) Merck Frosst Center for Therapeutic Research 2D 3D TSV
9871596 4 alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.EBI Bioorg Med Chem Lett 8: 447-52 (1999) Georgetown University Medical Center 2D 3D TSV
9871588 5 Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR).EBI Bioorg Med Chem Lett 8: 409-14 (1999) Kingston University 2D 3D TSV
9871587 8 Solid phase synthesis of a biased mini tetrapeptoid-library for the discovery of monodentate ITAM mimics as ZAP-70 inhibitors.EBI Bioorg Med Chem Lett 8: 405-8 (1999) Preclinical Research Novartis 2D 3D TSV
9871586 7 Endothiopeptide inhibitors of HIV-1 protease.EBI Bioorg Med Chem Lett 8: 699-704 (1999) Purdue University 2D 3D TSV
9871585 23 Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.EBI Bioorg Med Chem Lett 8: 695-8 (1999) Griffith University 2D 3D TSV
9871584 13 Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.EBI Bioorg Med Chem Lett 8: 691-4 (1999) Griffith University 2D 3D TSV
9871583 7 Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.BDB Bioorg Med Chem Lett 8: 687-90 (1998) University of Illinois at Chicago 2D 3D TSV
9871581 12 Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.EBI Bioorg Med Chem Lett 8: 675-80 (1999) Centre de Recherche Pierre FABRE 2D 3D TSV
9871578 2 Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding.EBI Bioorg Med Chem Lett 8: 659-62 (1999) Pohang University of Science & Technology 2D 3D TSV
9871574 5 Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.EBI Bioorg Med Chem Lett 8: 635-40 (1998) Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France. 2D 3D TSV
9871573 15 Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor.EBI Bioorg Med Chem Lett 8: 631-4 (1999) Biotech Research Institute 2D 3D TSV
9871571 44 A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors.EBI Bioorg Med Chem Lett 8: 619-24 (1999) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
9871570 25 An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.EBI Bioorg Med Chem Lett 8: 613-8 (1999) Institute for Chemical Biology 2D 3D TSV
9871564 60 1-[omega-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5- pyrrolidinediones as 5-HT1A receptor ligands: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.EBI Bioorg Med Chem Lett 8: 581-6 (1999) Universidad Complutense 2D 3D TSV
9871563 31 Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.EBI Bioorg Med Chem Lett 8: 575-80 (1999) Istituto di Strutturistica Chimica G. Giacomello 2D 3D TSV
9871562 2 1-Methoxy-agroclavine from Penicillium sp. WC75209, a novel inhibitor of the Lck tyrosine kinase.EBI Bioorg Med Chem Lett 8: 569-74 (1999) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9871561 1 Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.EBI Bioorg Med Chem Lett 8: 567-8 (1999) University of Pennsylvania 2D 3D TSV
9871560 17 Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.EBI Bioorg Med Chem Lett 8: 561-6 (1999) Sankyo Co., Ltd. 2D 3D TSV
9871551 48 Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.EBI Bioorg Med Chem Lett 8: 837-42 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871548 17 The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.EBI Bioorg Med Chem Lett 8: 823-8 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871547 15 L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.EBI Bioorg Med Chem Lett 8: 817-22 (1999) Merck Research Laboratories 2D 3D TSV
9871544 24 Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.EBI Bioorg Med Chem Lett 8: 799-804 (1999) National Institute of Diabetes 2D 3D TSV
9871543 17 Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.BDB Bioorg Med Chem Lett 8: 793-8 (1998) Institut Curie 2D 3D TSV
9871540 100 Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.EBI Bioorg Med Chem Lett 8: 775-80 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871538 22 (2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist.EBI Bioorg Med Chem Lett 8: 765-70 (1999) Centro de Investigación Lilly 2D 3D TSV
9871534 95 New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.EBI Bioorg Med Chem Lett 8: 745-50 (1999) Ligand Pharmaceuticals 2D 3D TSV
9871533 1 Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase.EBI Bioorg Med Chem Lett 8: 739-44 (1999) Oregon State University 2D 3D TSV
9871532 8 Solid phase synthesis of benzylamine-derived sulfonamide library.EBI Bioorg Med Chem Lett 8: 735-8 (1999) Biotech Research Institute 2D 3D TSV
9871530 41 Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.EBI Bioorg Med Chem Lett 8: 725-30 (1999) Pfizer Central Research 2D 3D TSV
9871528 9 Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2' groups.EBI Bioorg Med Chem Lett 8: 715-20 (1999) DuPont Merck Pharmaceutical Company 2D 3D TSV
9871526 8 Syntheses and kinetic evaluation of hydroxamate-based peptide inhibitors of glyoxalase I.EBI Bioorg Med Chem Lett 8: 705-10 (1999) University of Waterloo 2D 3D TSV
9871525 56 Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.EBI Bioorg Med Chem Lett 8: 983-8 (1999) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9871524 10 Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors.EBI Bioorg Med Chem Lett 8: 979-82 (1999) University of Illinois at Chicago 60607 2D 3D TSV
9871523 2 A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase.EBI Bioorg Med Chem Lett 8: 977-8 (1998) Department of Chemistry, University of Connecticut, Storrs 06269-4060, USA. 2D 3D TSV
9871521 32 Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class.EBI Bioorg Med Chem Lett 8: 965-70 (1999) Novartis Pharma AG 2D 3D TSV
9871520 30 Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).EBI Bioorg Med Chem Lett 8: 959-64 (1999) Ferring Research Institute 2D 3D TSV
9871517 7 Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds.EBI Bioorg Med Chem Lett 8: 945-50 (1999) University of Bristol 2D 3D TSV
9871514 16 Novel HIV-protease inhibitors containing beta-hydroxyether and -thioether dipeptide isostere surrogates: modification of the P3 ligand.EBI Bioorg Med Chem Lett 8: 931-4 (1999) Schering-Plough Research Institute 2D 3D TSV
9871513 1 Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation.EBI Bioorg Med Chem Lett 8: 925-30 (1999) Georgetown University Medical Center 2D 3D TSV
9871512 20 Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.EBI Bioorg Med Chem Lett 8: 919-24 (1999) Green Cross Research Laboratories 2D 3D TSV
9871511 54 Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.EBI Bioorg Med Chem Lett 8: 913-8 (1999) Green Cross Research Laboratories 2D 3D TSV
9871508 16 Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase.EBI Bioorg Med Chem Lett 8: 897-902 (1999) Novartis Pharmaceuticals 2D 3D TSV
9871507 8 Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.EBI Bioorg Med Chem Lett 8: 891-6 (1999) Abbott Laboratories 2D 3D TSV
9865942 11 Structural analysis of inhibitor binding to human carbonic anhydrase II.BDB Protein Sci 7: 2483-9 (1998) University of Pennsylvania 2D 3D TSV
9864265 14 OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats.BDB J Pharmacol Exp Ther 287: 860-7 (1998) Second Tokushima Institute of New Drug Research 2D 3D TSV
9857099 94 Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.EBI J Med Chem 41: 5320-33 (1999) Synaptic Pharmaceutical Corporation 2D 3D TSV
9857098 9 Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).EBI J Med Chem 41: 5310-9 (1999) Harvard Medical School 2D 3D TSV
9857095 12 Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.EBI J Med Chem 41: 5272-86 (1999) Western Maryland College 2D 3D TSV
9857094 32 Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.EBI J Med Chem 41: 5265-71 (1999) Trinity College 2D 3D TSV
9857092 28 Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).EBI J Med Chem 41: 5247-56 (1999) The University 2D 3D TSV
9857090 158 Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).EBI J Med Chem 41: 5198-218 (1999) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9857089 32 Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.EBI J Med Chem 41: 5188-97 (1999) Research Triangle Institute 2D 3D TSV
9857088 16 The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.EBI J Med Chem 41: 5177-87 (1999) Kennesaw State University 2D 3D TSV
9857087 63 Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.EBI J Med Chem 41: 5167-76 (1999) Vrije Universiteit Brussel 2D 3D TSV
9857086 2 Enantiospecific semisynthesis of (+)-almuheptolide-A, a novel natural heptolide inhibitor of the mammalian mitochondrial respiratory chain.EBI J Med Chem 41: 5158-66 (1999) Universidad de Valencia 2D 3D TSV
9857085 33 Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists.EBI J Med Chem 41: 5150-7 (1999) Novo Nordisk A/S 2D 3D TSV
9857084 11 A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor.EBI J Med Chem 41: 5148-9 (1999) Purdue University 2D 3D TSV
9857082 67 Immunophilins: beyond immunosuppression.EBI J Med Chem 41: 5119-43 (1999) Guilford Pharmaceuticals, Inc. 2D 3D TSV
9843408 2 Role of the cofactor calcium in the activation of outer membrane phospholipase A.BDB Biochemistry 37: 16011-8 (1998) Utrecht University 2D 3D TSV
9840420 39 Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores.BDB Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998) King's College London 2D 3D TSV
9839013 32 Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.BDB Bioorg Med Chem 6: 1835-50 (1998) CNRS 2D 3D TSV
9836627 9 Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.BDB J Med Chem 41: 5113-7 (1998) DuPont Merck Pharmaceutical Company 2D 3D TSV
9836624 64 Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.EBI J Med Chem 41: 5084-93 (1999) Virginia Commonwealth University 2D 3D TSV
9836620 94 N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.EBI J Med Chem 41: 5020-36 (1999) Glaxo Wellcome Research and Development 2D 3D TSV
9836617 30 Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives.EBI J Med Chem 41: 4995-5001 (1999) Purdue University 2D 3D TSV
9836616 92 Tetrahydro-isoquinoline-based factor Xa inhibitors.EBI J Med Chem 41: 4983-94 (1999) Boehringer Mannheim GmbH 2D 3D TSV
9836615 106 Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters.EBI J Med Chem 41: 4973-82 (1999) Georgetown University Medical Center 2D 3D TSV
9836612 32 Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands.EBI J Med Chem 41: 4950-7 (1999) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9836610 37 N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.EBI J Med Chem 41: 4933-8 (1999) Universit£ di Pisa 2D 3D TSV
9836606 12 Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.EBI J Med Chem 41: 4911-4 (1999) University of Minnesota 2D 3D TSV
9834968 38 Muscarinic receptor binding sites of the M4 subtype in porcine lung parenchyma.BDB Pharmacol Toxicol 83: 200-7 (1998) Case Western Reserve University 2D 3D TSV
9834167 2 Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis.EBI J Nat Prod 61: 1413-5 (1999) Hokkaido University 2D 3D TSV
9834166 8 Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity.EBI J Nat Prod 61: 1410-2 (1999) Virginia Polytechnic Institute and State University 2D 3D TSV
9834152 29 Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.EBI J Nat Prod 61: 1356-60 (1999) National University of Singapore 2D 3D TSV
9834151 29 Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.EBI J Nat Prod 61: 1352-5 (1999) Searle Discovery Research 2D 3D TSV
9834145 5 Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara.EBI J Nat Prod 61: 1328-31 (1999) GlaxoWellcome Research and Development 2D 3D TSV
9832156 13 Characterization of (2S,2'R,3'R)-2-(2',3'-[3H]-dicarboxycyclopropyl)glycine binding in rat brain.BDB J Neurochem 71: 2558-64 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9829999 2 Inhibition of human caspases by peptide-based and macromolecular inhibitors.BDB J Biol Chem 273: 32608-13 (1998) Merck Research Laboratories 2D 3D TSV
9822559 47 N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.EBI J Med Chem 41: 4903-9 (1998) Universitá di Bari 2D 3D TSV
9822558 25 (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.BDB J Med Chem 41: 4890-902 (1998) Schering-Plough Research Institute 2D 3D TSV
9822556 40 Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.EBI J Med Chem 41: 4873-84 (1998) Institute of Cancer Research 2D 3D TSV
9822554 14 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.EBI J Med Chem 41: 4854-60 (1998) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9822553 63 Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.EBI J Med Chem 41: 4844-53 (1998) University of Bologna 2D 3D TSV
9822552 2 Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors.EBI J Med Chem 41: 4833-43 (1998) Institut Jacques Monod (UMR CNRS 7592/Universités Paris VI and VII) 2D 3D TSV
9822550 98 Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.EBI J Med Chem 41: 4800-18 (1998) Center in Molecular Toxicology and The Vanderbilt Cancer Center 2D 3D TSV
9822549 33 Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.EBI J Med Chem 41: 4790-9 (1998) University of Washington 2D 3D TSV
9822547 41 De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.EBI J Med Chem 41: 4767-76 (1998) The University of Arizona 2D 3D TSV
9822541 15 Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.EBI J Med Chem 41: 4706-15 (1998) EP811-CNRS 2D 3D TSV
9822540 70 Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.EBI J Med Chem 41: 4693-705 (1998) Northeast Louisiana University 2D 3D TSV
9822537 9 Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel.EBI J Med Chem 41: 4677-80 (1998) University of Arizona 2D 3D TSV
9818151 33 Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.BDB Chem Biol 5: 597-608 (1998) DuPont Merck Pharmaceutical Company 2D 3D TSV
9812985 8 Transport of monoamine transmitters by the organic cation transporter type 2, OCT2.EBI J Biol Chem 273: 30915-20 (1998) University of Heidelberg 2D 3D TSV
9808712 14 Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.EBI J Pharmacol Exp Ther 287: 800-5 (1998) Kyoto University Hospital 2D 3D TSV
9808667 12 Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.BDB J Pharmacol Exp Ther 287: 448-56 (1998) The DuPont Pharmaceuticals Research Laboratories 2D 3D TSV
9804702 37 4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.EBI J Med Chem 41: 4623-35 (1998) Merck, Sharp and Dohme Research Laboratories 2D 3D TSV
9804700 10 Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist.EBI J Med Chem 41: 4607-14 (1998) Merck Research Laboratories 2D 3D TSV
9804698 44 A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation.EBI J Med Chem 41: 4587-98 (1998) Fujisawa Pharmaceutical Ltd. 2D 3D TSV
9804697 61 Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.EBI J Med Chem 41: 4577-86 (1998) Northwestern University Medical School 2D 3D TSV
9804696 2 Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.EBI J Med Chem 41: 4567-76 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9804694 4 Synthesis and enzymic evaluation of 4-mercapto-6-oxo-1, 4-azaphosphinane-2-carboxylic acid 4-oxide as an inhibitor of mammalian dihydroorotase.EBI J Med Chem 41: 4550-5 (1998) University of Sydney 2D 3D TSV
9804693 20 Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity.EBI J Med Chem 41: 4542-9 (1998) University of Kiel 2D 3D TSV
9804692 75 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.EBI J Med Chem 41: 4533-41 (1998) Duquesne University 2D 3D TSV
9804689 40 Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.EBI J Med Chem 41: 4492-501 (1998) Merck Research Laboratories 2D 3D TSV
9804688 51 Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.EBI J Med Chem 41: 4486-91 (1998) University of Minnesota 2D 3D TSV
9804686 16 Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.EBI J Med Chem 41: 4466-74 (1998) Merck Research Laboratories 2D 3D TSV
9804685 142 Pharmacophoric search and 3D-QSAR comparative molecular field analysis studies on agonists of melatonin sheep receptors.EBI J Med Chem 41: 4453-65 (1998) Universit£ d'Orl£ans 2D 3D TSV
9804684 18 Highly potent bisphosphonate ligands for phosphoglycerate kinase.EBI J Med Chem 41: 4439-52 (1998) University of Sheffield 2D 3D TSV
9804682 12 TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.EBI J Med Chem 41: 4429-32 (1998) Institut f£r Bioanorganische und Radiopharmazeutische Chemie 2D 3D TSV
9802391 31 The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4.BDB Regul Pept 29-37 (1998) Uppsala University 2D 3D TSV
9802390 14 Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor.BDB Regul Pept 23-8 (1998) Uppsala University 2D 3D TSV
9793839 6 A new series of S-adenosyl-L-methionine synthetase inhibitors.BDB J Enzym Inhib 13: 361-7 (1998) Laboratoire de chimie bioorganique 2D 3D TSV
9784163 9 Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.EBI J Nat Prod 61: 1257-62 (1998) University of Illinois at Chicago 2D 3D TSV
9784154 12 Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.EBI J Nat Prod 61: 1212-5 (1998) Uppsala University 2D 3D TSV
9784116 31 Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands.EBI J Med Chem 41: 4408-20 (1998) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
9784115 15 Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol.EBI J Med Chem 41: 4400-7 (1998) Organix, Inc. 2D 3D TSV
9784114 32 CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors.EBI J Med Chem 41: 4385-99 (1998) University of Texas at Austin 2D 3D TSV
9784112 87 Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.BDB J Med Chem 41: 4365-77 (1998) Parke-Davis Pharmaceutical Research 2D 3D TSV
9784110 81 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.EBI J Med Chem 41: 4354-9 (1998) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9784108 22 Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity.EBI J Med Chem 41: 4329-42 (1998) Warner-Lambert Company 2D 3D TSV
9784106 22 Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones.EBI J Med Chem 41: 4309-16 (1998) Chugai Pharmaceutical Company, Ltd. 2D 3D TSV
9784105 68 Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.EBI J Med Chem 41: 4301-8 (1998) Takeda Chemical Industries, Ltd. 2D 3D TSV
9784104 30 Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase.EBI J Med Chem 41: 4288-300 (1998) Abbott Laboratories 2D 3D TSV
9784103 42 Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.EBI J Med Chem 41: 4279-87 (1998) Kanebo 2D 3D TSV
9784099 84 Design of benzamidine-type inhibitors of factor Xa.EBI J Med Chem 41: 4240-50 (1998) Institut für Biochemie 2D 3D TSV
9784098 8 Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements.EBI J Med Chem 41: 4232-9 (1998) Takeda Chemical Industries, Ltd. 2D 3D TSV
9784095 4 Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis.EBI J Med Chem 41: 4207-15 (1998) Saint Louis University School of Medicine 2D 3D TSV
9784094 8 Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors.EBI J Med Chem 41: 4199-206 (1998) National Institute on Drug Abuse 2D 3D TSV
9784093 2 6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor.EBI J Med Chem 41: 4196-8 (1998) The R.W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9784092 15 Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor.EBI J Med Chem 41: 4190-5 (1998) Takeda Chemical Industries, Ltd. 2D 3D TSV
9784091 25 Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.EBI J Med Chem 41: 4186-9 (1998) University of Bologna 2D 3D TSV
9776361 16 SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.BDB Br J Pharmacol 125: 202-8 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9767653 7 4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity.EBI J Med Chem 41: 4171-6 (1998) Freie Universität Berlin 2D 3D TSV
9767652 12 N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.EBI J Med Chem 41: 4165-70 (1998) University of Crete 2D 3D TSV
9767650 48 Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.EBI J Med Chem 41: 4150-60 (1998) University of Bologna 2D 3D TSV
9767649 24 N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.EBI J Med Chem 41: 4143-9 (1998) Research Triangle Institute 2D 3D TSV
9767648 275 Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.EBI J Med Chem 41: 4130-42 (1998) University of Wisconsin-Milwaukee 2D 3D TSV
9767647 47 Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.EBI J Med Chem 41: 4118-29 (1998) Dainippon Pharmaceutical Company, Ltd. 2D 3D TSV
9767643 127 A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.EBI J Med Chem 41: 4062-79 (1998) Fujisawa Pharmaceutical Company, Ltd. 2D 3D TSV
9767642 76 A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man.EBI J Med Chem 41: 4053-61 (1998) Fujisawa Pharmaceutical Company, Ltd. 2D 3D TSV
9767641 11 New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: orally active series of N-alkylated amidines with a 6,6-bicyclic template.EBI J Med Chem 41: 4036-52 (1998) Mitsui Pharmaceuticals Inc. 2D 3D TSV
9767638 24 Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.EBI J Med Chem 41: 4001-11 (1998) University of Vienna 2D 3D TSV
9767637 31 A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds.EBI J Med Chem 41: 3994-4000 (1998) Vrije Universiteit 2D 3D TSV
9767636 38 A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives.EBI J Med Chem 41: 3987-93 (1998) Vrije Universiteit 2D 3D TSV
9767635 42 Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.BDB J Med Chem 41: 3976-86 (1998) University of Bologna 2D 3D TSV
9767634 15 Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.EBI J Med Chem 41: 3972-5 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9767633 76 Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.EBI J Med Chem 41: 3961-71 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9767632 27 Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.EBI J Med Chem 41: 3948-60 (1998) Universit£ di Roma"La Sapienza" 2D 3D TSV
9767631 19 N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands.EBI J Med Chem 41: 3940-7 (1998) Università di Bari 2D 3D TSV
9767630 9 Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations.EBI J Med Chem 41: 3928-39 (1998) Yale University 2D 3D TSV
9767629 8 Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.EBI J Med Chem 41: 3923-7 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9767628 31 Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.EBI J Med Chem 41: 3919-22 (1998) GlaxoWellcome Medicines Research Centre 2D 3D TSV
9756510 4 Reduced folate derivatives are endogenous substrates for cMOAT in rats.EBI Am J Physiol 275: 789-96 (1998) University of Tokyo 2D 3D TSV
9755050 1 Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain.EBI Am J Physiol 275: 967-75 (1998) Medical College of Georgia 2D 3D TSV
9753691 10 Structural basis of inhibitor selectivity in MAP kinases.BDB Structure 6: 1117-28 (1998) University of Texas Southwestern Medical Center at Dallas 2D 3D TSV
9753615 1 Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.EBI Biochem Biophys Res Commun 250: 246-51 (1998) State University of New Jersey 2D 3D TSV
9753439 5 Thermodynamic analysis of the binding of the polyglutamate chain of 5-formyltetrahydropteroylpolyglutamates to serine hydroxymethyltransferase.BDB Biochemistry 37: 13536-42 (1998) Virginia Commonwealth University 2D 3D TSV
9751076 2 Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.EBI Biochem Pharmacol 56: 719-27 (1998) Lilly Research Laboratories 2D 3D TSV
9748367 11 Novel peptidyl phosphorus derivatives as inhibitors of human calpain I.EBI J Med Chem 41: 3912-6 (1998) Cephalon, Inc. 2D 3D TSV
9748366 6 Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent.EBI J Med Chem 41: 3909-11 (1998) University of Utah 2D 3D TSV
9748363 30 Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.EBI J Med Chem 41: 3879-87 (1998) University of New Mexico School of Medicine 2D 3D TSV
9748360 3 Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).EBI J Med Chem 41: 3857-64 (1998) Brigham Young University 2D 3D TSV
9748356 28 Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.EBI J Med Chem 41: 3812-20 (1998) Université de Neuchâtel 2D 3D TSV
9748354 30 Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV.EBI J Med Chem 41: 3793-803 (1998) Pharmacia & Upjohn 2D 3D TSV
9748353 13 Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors. Use of L-mannaric acid as a peptidomimetic scaffold.EBI J Med Chem 41: 3782-92 (1998) Linköping University 2D 3D TSV
9748351 16 New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.EBI J Med Chem 41: 3763-72 (1998) Universita' di Siena 2D 3D TSV
9733984 2 Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter.EBI Biochim Biophys Acta 1373: 277-81 (1998) University of Oxford 2D 3D TSV
9733501 33 Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.EBI J Med Chem 41: 3753-7 (1998) University of Oklahoma Health Sciences Center 2D 3D TSV
9733496 20 Novel orally active growth hormone secretagogues.EBI J Med Chem 41: 3705-14 (1998) Novo Nordisk A/S 2D 3D TSV
9733494 12 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.EBI J Med Chem 41: 3690-8 (1998) National Institute on Drug Abuse 2D 3D TSV
9733492 54 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.EBI J Med Chem 41: 3675-83 (1998) Pfizer Inc. 2D 3D TSV
9733491 21 Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.EBI J Med Chem 41: 3664-74 (1998) Novartis Pharma AG 2D 3D TSV
9733487 18 2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.BDB J Med Chem 41: 3624-34 (1998) Universita degli Studi di Milano 2D 3D TSV
9733486 91 Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.EBI J Med Chem 41: 3609-23 (1998) Washington University 2D 3D TSV
9733485 16 Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.EBI J Med Chem 41: 3596-608 (1998) University of Hawaii 2D 3D TSV
9733484 39 ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.EBI J Med Chem 41: 3582-95 (1998) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
9733482 31 Discovery of potent, achiral matrix metalloproteinase inhibitors.EBI J Med Chem 41: 3568-71 (1998) Procter and Gamble Pharmaceuticals 2D 3D TSV
9733481 31 Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.EBI J Med Chem 41: 3563-7 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9733480 93 Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.EBI J Med Chem 41: 3557-62 (1998) Berlex Biosciences 2D 3D TSV
9733479 18 (Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.EBI J Med Chem 41: 3551-6 (1998) Berlex Biosciences 2D 3D TSV
9724791 24 Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.BDB Proc Natl Acad Sci U S A 95: 10836-41 (1998) Merck Research Laboratories 2D 3D TSV
9722565 43 Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.BDB J Biol Chem 273: 23321-6 (1998) Synaptic Pharmaceutical Corporation 2D 3D TSV
9722499 3 Recent natural products based drug development: a pharmaceutical industry perspective.EBI J Nat Prod 61: 1053-71 (1998) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9720804 9 Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.BDB Br J Pharmacol 124: 1300-6 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9719606 38 Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.EBI J Med Chem 41: 3530-8 (1998) NOVARTIS Pharma AG 2D 3D TSV
9719605 62 New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.EBI J Med Chem 41: 3515-29 (1998) Procter & Gamble Pharmaceuticals 2D 3D TSV
9719604 11 Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.EBI J Med Chem 41: 3507-14 (1998) Hokkaido University 2D 3D TSV
9719603 39 Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.EBI J Med Chem 41: 3499-506 (1998) University of Oregon 2D 3D TSV
9719602 24 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy.EBI J Med Chem 41: 3493-8 (1998) University of Bristol 2D 3D TSV
9719600 21 Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class.BDB J Med Chem 41: 3467-76 (1998) Upjohn 2D 3D TSV
9719599 18 Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.EBI J Med Chem 41: 3461-6 (1998) Ligand Pharmaceuticals Inc. 2D 3D TSV
9719597 12 Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain.EBI J Med Chem 41: 3442-9 (1998) Novartis Pharma Inc. 2D 3D TSV
9719595 120 Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.EBI J Med Chem 41: 3426-34 (1998) Duquesne University 2D 3D TSV
9719594 13 Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.EBI J Med Chem 41: 3417-25 (1998) University of Queensland 2D 3D TSV
9719591 22 New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development.EBI J Med Chem 41: 3387-401 (1998) Ciba-Geigy AG 2D 3D TSV
9719589 13 4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.EBI J Med Chem 41: 3367-72 (1998) Eisai Company, Ltd. 2D 3D TSV
9719581 3 3-Deoxy-D-myo-inositol 1-phosphate, 1-phosphonate, and ether lipid analogues as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth.EBI J Med Chem 41: 3303-6 (1998) Georgetown University Medical Center 2D 3D TSV
9706043 6 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.EBI Pharm Res 15: 1154-9 (1998) University of Michigan 2D 3D TSV
9703475 19 Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.EBI J Med Chem 41: 3298-302 (1998) Cambridge NeuroScience, Inc. 2D 3D TSV
9703474 21 Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.EBI J Med Chem 41: 3293-7 (1998) Organix Inc. 2D 3D TSV
9703473 207 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.BDB J Med Chem 41: 3276-92 (1998) Parke-Davis Pharmaceutical Research 2D 3D TSV
9703472 112 Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).EBI J Med Chem 41: 3261-75 (1998) Abbott Laboratories 2D 3D TSV
9703471 13 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.EBI J Med Chem 41: 3253-60 (1998) Institute of Cancer Research 2D 3D TSV
9703468 6 Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.EBI J Med Chem 41: 3232-8 (1998) Universit£ di Salerno 2D 3D TSV
9703466 35 Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.EBI J Med Chem 41: 3210-9 (1998) Merck Research Laboratories 2D 3D TSV
9703465 98 Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.EBI J Med Chem 41: 3202-9 (1998) National Cancer Institute 2D 3D TSV
9703464 40 Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.EBI J Med Chem 41: 3186-201 (1998) National Institute of Diabetes 2D 3D TSV
9703463 102 Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.EBI J Med Chem 41: 3174-85 (1998) Universit£ di Ferrara 2D 3D TSV
9703462 98 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.EBI J Med Chem 41: 3159-73 (1998) Novartis Institute for Medical Sciences 2D 3D TSV
9703460 52 Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.EBI J Med Chem 41: 3128-41 (1998) National Taiwan University 2D 3D TSV
9703459 5 Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential.EBI J Med Chem 41: 3103-27 (1998) Merck Research Laboratories 2D 3D TSV
9700760 21 Interaction of agonist peptide [3H]Tyr-D-Ala-Phe-Phe-NH2 with mu-opioid receptor in rat brain and CHO-mu/1 cell line.BDB Peptides 19: 1091-8 (1998) Hungarian Academy of Sciences 2D 3D TSV
9696422 45 Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.BDB Eur J Pharmacol 350: 311-6 (1998) The Royal Danish School of Pharmacy 2D 3D TSV
9694973 63 Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data.BDB J Pharmacol Exp Ther 286: 1094-102 (1998) Alcon Laboratories Inc. 2D 3D TSV
9694962 65 Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.BDB J Pharmacol Exp Ther 286: 1007-13 (1998) Memorial Sloan-Kettering Cancer Center 2D 3D TSV
9694916 7 Nonpeptide endothelin receptor antagonists. XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist.BDB J Pharmacol Exp Ther 286: 650-6 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9687576 1 Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.EBI Mol Pharmacol 54: 342-52 (1998) Institut f£r Physiologie 2D 3D TSV
9687574 21 Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function.BDB Mol Pharmacol 54: 322-33 (1998) Georgetown University 2D 3D TSV
9686407 633 Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.BDB NIDA Res Monogr 178: 440-66 (1998) SRI International 2D 3D TSV
9685247 3 Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its"hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine.EBI J Med Chem 41: 3078-83 (1998) Brigham Young University 2D 3D TSV
9685245 22 Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.EBI J Med Chem 41: 3048-61 (1998) Cambridge NeuroScience Inc. 2D 3D TSV
9685244 15 Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8).EBI J Med Chem 41: 3041-7 (1998) Boehringer Mannheim GmbH 2D 3D TSV
9685243 10 A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17alpha-substituted seco-D 5beta-androstane as cassaine analogues.EBI J Med Chem 41: 3033-40 (1998) Prassis Istituto di Ricerche Sigma-Tau 2D 3D TSV
9685241 2 Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.EBI J Med Chem 41: 3015-21 (1998) Pharmaceutical Research Center 2D 3D TSV
9685236 132 Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.EBI J Med Chem 41: 2972-84 (1998) Boehringer Ingelheim Pharmaceuticals Inc. 2D 3D TSV
9685235 165 Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes.BDB J Med Chem 41: 2960-71 (1998) Boehringer Ingelheim Pharmaceuticals Inc. 2D 3D TSV
9685232 26 Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.EBI J Med Chem 41: 2934-8 (1998) Pfizer Inc. 2D 3D TSV
9677382 10 Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T.BDB J Biol Chem 273: 19573-8 (1998) University of Notre Dame 2D 3D TSV
9677277 22 A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.EBI J Nat Prod 61: 931-5 (1998) Istituto per la Chimica di Molecole di Interesse Biologico CNR 2D 3D TSV
9677265 19 Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.EBI J Nat Prod 61: 867-71 (1998) Seoul National University 2D 3D TSV
9677190 49 Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.EBI Science 281: 533-538 (1998) University of California 2D 3D TSV
9669506 12 Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.BDB Eur J Pharmacol 349: 129-32 (1998) McGill University 2D 3D TSV
9667978 12 Prodrugs of nitroxyl and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase.EBI J Med Chem 41: 2903-9 (1998) St. Cloud State University; and the Department of Medicinal Chemistry 2D 3D TSV
9667976 58 beta-Lactam derivatives as inhibitors of human cytomegalovirus protease.EBI J Med Chem 41: 2882-91 (1998) Boehringer Ingelheim (Canada) Ltd. 2D 3D TSV
9667975 86 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.EBI J Med Chem 41: 2872-81 (1998) Southern Research Institute 2D 3D TSV
9667974 150 N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.EBI J Med Chem 41: 2858-71 (1998) Glaxo Wellcome Research and Development 2D 3D TSV
9667973 35 Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.EBI J Med Chem 41: 2846-57 (1998) Université Paris-Sud 2D 3D TSV
9667972 119 Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.EBI J Med Chem 41: 2835-45 (1998) National Institute of Diabetes 2D 3D TSV
9667970 1 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.EBI J Med Chem 41: 2806-18 (1998) Agouron Pharmaceuticals, Inc. 2D 3D TSV
9667969 21 Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.EBI J Med Chem 41: 2786-805 (1998) Agouron Pharmaceuticals, Inc. 2D 3D TSV
9667968 18 Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.EBI J Med Chem 41: 2779-85 (1998) Ligand Pharmaceuticals Inc. 2D 3D TSV
9667967 65 Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.EBI J Med Chem 41: 2765-78 (1998) Yamanouchi Pharmaceutical Company, Ltd. 2D 3D TSV
9667965 29 Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.EBI J Med Chem 41: 2745-53 (1998) Rhône-Poulenc Rorer 2D 3D TSV
9667964 38 Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.EBI J Med Chem 41: 2732-44 (1998) Rh£ne-Poulenc Rorer 2D 3D TSV
9667962 28 Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.EBI J Med Chem 41: 2709-19 (1998) Lilly Research Laboratories 2D 3D TSV
9667958 40 Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.EBI J Med Chem 41: 2679-85 (1998) University of California at San Diego 2D 3D TSV
9667957 5 Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.EBI J Med Chem 41: 2676-8 (1998) Hokkaido University 2D 3D TSV
9667955 24 Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.EBI J Med Chem 41: 2667-70 (1998) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9667954 47 D-amino acid containing, high-affinity inhibitors of recombinant human calpain I.EBI J Med Chem 41: 2663-6 (1998) Cephalon, Inc. 2D 3D TSV
9655904 1 In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase.BDB J Pharmacol Exp Ther 286: 569-77 (1998) Parke-Davis Pharmaceutical Research 2D 3D TSV
9653897 59 Characterization of alpha1-adrenoceptor subtypes in the pig.BDB Eur J Pharmacol 347: 301-9 (1998) Uppsala University 2D 3D TSV
9653548 6 A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.BDB Chem Biol 5: 299-306 (1998) University of California, San Francisco 2D 3D TSV
9652348 146 [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.BDB Eur J Pharmacol 348: 311-20 (1998) Novartis Pharma 2D 3D TSV
9651171 29 N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase.EBI J Med Chem 41: 2651-6 (1998) Merck Research Laboratories 2D 3D TSV
9651169 49 Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.EBI J Med Chem 41: 2636-42 (1998) Abbott Laboratories 2D 3D TSV
9651168 12 Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics.EBI J Med Chem 41: 2631-5 (1998) University of California at San Diego 2D 3D TSV
9651167 20 In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study.EBI J Med Chem 41: 2626-30 (1998) Seoul National University 2D 3D TSV
9651163 268 Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.EBI J Med Chem 41: 2588-603 (1998) SUGEN, Inc. 2D 3D TSV
9651161 4 Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine).EBI J Med Chem 41: 2572-8 (1998) National Cancer Institute 2D 3D TSV
9651160 52 Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.EBI J Med Chem 41: 2565-71 (1998) Hokuriku University 2D 3D TSV
9651158 158 Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptorsEBI J Med Chem 41: 2537-52 (1998) University of Wisconsin-Milwaukee 2D 3D TSV
9651157 52 Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.EBI J Med Chem 41: 2524-36 (1998) Warner-Lambert Company 2D 3D TSV
9651155 5 Pharmacophores incorporating numerous excluded volumes defined by X-ray crystallographic structure in three-dimensional database searching: application to the thyroid hormone receptor.BDB J Med Chem 41: 2503-12 (1998) Karo Bio AB 2D 3D TSV
9651154 54 Design of a new class of orally active fibrinogen receptor antagonists.EBI J Med Chem 41: 2492-502 (1998) Rhône-Poulenc Rorer Central Research 2D 3D TSV
9651152 20 Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.EBI J Med Chem 41: 2461-80 (1998) Hoechst Marion Roussel Inc. 2D 3D TSV
9651151 54 Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.BDB J Med Chem 41: 2451-60 (1998) Gilead Sciences Inc. 2D 3D TSV
9651150 18 Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents.EBI J Med Chem 41: 2445-50 (1998) The George Washington University Medical Center 2D 3D TSV
9651149 54 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.EBI J Med Chem 41: 2442-4 (1998) Wyeth-Ayerst Research 2D 3D TSV
9650799 159 [125I]Tyr10-cortistatin14 labels all five somatostatin receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 357: 483-9 (1998) Novartis Pharma AG 2D 3D TSV
9647472 5 Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells.BDB Br J Pharmacol 124: 485-92 (1998) Universit&aagrove; degli Studi di Milano 2D 3D TSV
9644051 4 Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine.EBI J Nat Prod 61: 709-12 (1998) Universidad de Valencia 2D 3D TSV
9636058 4 Calorimetric investigation of ethidium and netropsin binding to chicken erythrocyte chromatin.BDB Biochemistry 37: 9119-26 (1998) Universite de Liege 2D 3D TSV
9632375 8 Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane.EBI J Med Chem 41: 2430-5 (1998) University of New Orleans 2D 3D TSV
9632374 3 Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation.EBI J Med Chem 41: 2424-9 (1998) University of California 2D 3D TSV
9632373 52 Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.EBI J Med Chem 41: 2411-23 (1998) Dupont Merck Pharmaceutical Company 2D 3D TSV
9632372 60 Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas.EBI J Med Chem 41: 2390-410 (1998) Fujisawa Pharmaceutical Co. Ltd. 2D 3D TSV
9632371 28 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies.EBI J Med Chem 41: 2380-9 (1998) University of Oklahoma Health Sciences Center 2D 3D TSV
9632370 34 Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine.BDB J Med Chem 41: 2371-9 (1998) University of North Carolina at Chapel Hill 2D 3D TSV
9632369 45 Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.EBI J Med Chem 41: 2361-70 (1998) Wake Forest University School of Medicine 2D 3D TSV
9632368 30 GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.EBI J Med Chem 41: 2345-60 (1998) Nippon Steel Corporation 2D 3D TSV
9632367 10 Auxiliary agents for the peroral administration of peptide and protein drugs: synthesis and evaluation of novel pepstatin analogues.EBI J Med Chem 41: 2339-44 (1998) Institute of Pharmaceutical Chemistry 2D 3D TSV
9632363 5 Studies on selectin blockers. 6. Discovery of homologous fucose sugar unit necessary for E-selectin binding.EBI J Med Chem 41: 2302-7 (1998) Kanebo 2D 3D TSV
9632361 4 Synthesis and glutathione S-transferase structure-affinity relationships of nonpeptide and peptidase-stable glutathione analogues.EBI J Med Chem 41: 2278-88 (1998) Université Sidi Mohamed Ben Abdellah 2D 3D TSV
9632358 45 Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design.EBI J Med Chem 41: 2252-60 (1998) University of Arizona 2D 3D TSV
9632357 59 Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.EBI J Med Chem 41: 2243-51 (1998) Virginia Commonwealth University 2D 3D TSV
9632352 7 A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors.EBI J Med Chem 41: 2201-6 (1998) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9632351 36 Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.EBI J Med Chem 41: 2194-200 (1998) Affymax Research Institute 2D 3D TSV
9632349 38 Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.EBI J Med Chem 41: 2180-3 (1998) Pharmacia & Upjohn 2D 3D TSV
9632348 37 Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.EBI J Med Chem 41: 2175-9 (1998) Merck Research Laboratories 2D 3D TSV
9629473 34 Structure-activity relationship of HIV-1 protease inhibitors containing AHPBA. Part III: Modification of P2 site.BDB Bioorg Med Chem 6: 595-604 (1998) Sankyo Co. Ltd. 2D 3D TSV
9626023 49 Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs.BDB Am J Med 104: 413-21 (1998) Dallas Department of Veterans Affairs Medical Center 2D 3D TSV
9622556 63 Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.EBI J Med Chem 41: 2146-63 (1998) Merck Research Laboratories 2D 3D TSV
9622555 25 Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.EBI J Med Chem 41: 2134-45 (1998) Purdue University 2D 3D TSV
9622554 59 Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.EBI J Med Chem 41: 2126-33 (1998) Università di Ferrara 2D 3D TSV
9622553 42 Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site.EBI J Med Chem 41: 2118-25 (1998) The Wellcome Research Laboratories 2D 3D TSV
9622551 14 Specific and irreversible cyclopeptide inhibitors of dipeptidyl peptidase IV activity of the T-cell activation antigen CD26.EBI J Med Chem 41: 2100-10 (1998) Universit£ de Versailles 2D 3D TSV
9622549 23 New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.BDB J Med Chem 41: 2076-89 (1998) Purdue University 2D 3D TSV
9622548 8 Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.EBI J Med Chem 41: 2068-75 (1998) 3-Dimensional Pharmaceuticals Inc. 2D 3D TSV
9622546 109 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.EBI J Med Chem 41: 2047-55 (1998) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9622545 41 Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.EBI J Med Chem 41: 2040-6 (1998) Max-Delbr�ck-Centrum f�r Molekulare Medizin 2D 3D TSV
9622543 26 Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency.EBI J Med Chem 41: 2019-28 (1998) The DuPont Merck Pharmaceutical Company 2D 3D TSV
9622542 119 Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.EBI J Med Chem 41: 2010-8 (1998) Institut de Chimie Pharmaceutique 2D 3D TSV
9622541 97 Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.EBI J Med Chem 41: 1997-2009 (1998) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
9618903 37 Melatonin receptor pharmacology: toward subtype specificity.BDB Biol Cell 89: 531-7 (1997) King's College 2D 3D TSV
9618428 39 GR196429: a nonindolic agonist at high-affinity melatonin receptors.BDB J Pharmacol Exp Ther 285: 1239-45 (1998) Glaxo Wellcome Research and Development, Ltd. 2D 3D TSV
9605427 113 Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding.BDB Biochem Pharmacol 55: 1035-43 (1998) Roche Bioscience 2D 3D TSV
9603189 31 Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.BDB J Neurochem 70: 2252-61 (1998) Université de Paris-Sud 2D 3D TSV
9601024 12 Energetic roles of hydrogen bonds at the ureido oxygen binding pocket in the streptavidin-biotin complex.BDB Biochemistry 37: 7657-63 (1998) University of Washington 2D 3D TSV
9600857 1 Calorimetric studies of E. coli SSB protein-single-stranded DNA interactions. Effects of monovalent salts on binding enthalpy.BDB J Mol Biol 278: 999-1014 (1998) Washington University School of Medicine 2D 3D TSV
9600011 111 The elucidation of somatostatin receptor functions: a current view.BDB Rev Physiol Biochem Pharmacol 133: 55-108 (1998) German Institute of Human Nutrition 2D 3D TSV
9599274 4 Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella.EBI J Nat Prod 61: 667-70 (1998) The University of Tokyo 2D 3D TSV
9599261 12 Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis.EBI J Nat Prod 61: 625-8 (1998) Hokuriku University 2D 3D TSV
9599251 6 Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra.EBI J Nat Prod 61: 571-5 (1998) Universit£ degli Studi di Napoli"Federico II" 2D 3D TSV
9599247 57 Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.EBI J Med Chem 41: 1980-90 (1998) Research Triangle Institute 2D 3D TSV
9599246 28 (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.EBI J Med Chem 41: 1970-9 (1998) University of Virginia 2D 3D TSV
9599245 23 Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton.EBI J Med Chem 41: 1962-9 (1998) Georgetown University Medical Center 2D 3D TSV
9599243 4 Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives.BDB J Med Chem 41: 1943-55 (1998) Eli Lilly and Company 2D 3D TSV
9599242 23 (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.EBI J Med Chem 41: 1934-42 (1998) Astra Arcus AB 2D 3D TSV
9599238 10 Synthesis and structure-activity relationships of bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPase.EBI J Med Chem 41: 1883-93 (1998) SmithKline Beecham SpA 2D 3D TSV
9599235 10 Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors.EBI J Med Chem 41: 1846-54 (1998) Università degli Studi di Bari 2D 3D TSV
9599228 27 32-Ascomycinyloxyacetic acid derived immunosuppressants. Independence of immunophilin binding and immunosuppressive potency.EBI J Med Chem 41: 1764-76 (1998) Abbott Laboratories 2D 3D TSV
9599227 57 Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.EBI J Med Chem 41: 1752-63 (1998) Warner-Lambert Company 2D 3D TSV
9599226 25 Macrocyclic amino carboxylates as selective MMP-8 inhibitors.EBI J Med Chem 41: 1749-51 (1998) The DuPont Merck Pharmaceutical Co. 2D 3D TSV
9599225 9 Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.EBI J Med Chem 41: 1745-8 (1998) The DuPont Merck Pharmaceutical Company 2D 3D TSV
9599224 10 Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.EBI J Med Chem 41: 1741-4 (1998) Novartis Pharma Inc. 2D 3D TSV
9584223 27 Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.BDB Mol Pharmacol 53: 950-62 (1998) University of Bath 2D 3D TSV
9577836 119 Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.BDB Mol Psychiatry 3: 123-34 (1998) University of Toronto 2D 3D TSV
9572899 19 Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase.EBI J Med Chem 41: 1729-40 (1998) University of Leipzig 2D 3D TSV
9572897 49 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.EBI J Med Chem 41: 1708-15 (1998) Universit£ di Camerino 2D 3D TSV
9572896 20 Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.EBI J Med Chem 41: 1702-7 (1998) Universit£ di Camerino 2D 3D TSV
9572895 108 Inhibition of human alcohol dehydrogenases by formamides.EBI J Med Chem 41: 1696-701 (1998) The University of Iowa 2D 3D TSV
9572893 64 Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.EBI J Med Chem 41: 1679-87 (1998) University of Alabama at Birmingham 2D 3D TSV
9572889 39 Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.EBI J Med Chem 41: 1641-50 (1998) Georgetown University Medical Center 2D 3D TSV
9572886 38 Synthesis and adrenergic activity of a new series of N-aryl dicyclopropyl ketone oxime ethers: SAR and stereochemical aspects.EBI J Med Chem 41: 1613-8 (1998) University of Grenoble 2D 3D TSV
9572884 7 Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors.EBI J Med Chem 41: 1581-97 (1998) Frederick Biomedical Supercomputing Center 2D 3D TSV
9572883 32 (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.EBI J Med Chem 41: 1574-80 (1998) University of Catania 2D 3D TSV
9572882 18 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.EBI J Med Chem 41: 1568-73 (1998) SmithKline Beecham S.p.A. 2D 3D TSV
9572881 4 Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.EBI J Med Chem 41: 1561-7 (1998) Schering-Plough Research Institute 2D 3D TSV
9572880 44 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.EBI J Med Chem 41: 1557-60 (1998) University of Camerino 2D 3D TSV
9572302 8 In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits.BDB J Neurochem 70: 2147-55 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9554884 72 Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.EBI J Med Chem 41: 1513-23 (1998) Novartis Pharmaceuticals Corporation 2D 3D TSV
9554881 11 Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.EBI J Med Chem 41: 1476-96 (1998) University of Tokyo 2D 3D TSV
9554879 26 Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.EBI J Med Chem 41: 1456-66 (1998) National Institute of Diabetes 2D 3D TSV
9554878 35 Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.BDB J Med Chem 41: 1446-55 (1998) The DuPont Merck Pharmaceutical Company 2D 3D TSV
9554877 9 Development of a three-dimensional CysLT1 (LTD4) antagonist model with an incorporated amino acid residue from the receptor.EBI J Med Chem 41: 1439-45 (1998) Vrije Universiteit 2D 3D TSV
9554876 23 Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists.EBI J Med Chem 41: 1428-38 (1998) Vrije Universiteit 2D 3D TSV
9554874 43 Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.EBI J Med Chem 41: 1409-16 (1998) Duquesne University 2D 3D TSV
9554871 43 Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.EBI J Med Chem 41: 1382-91 (1998) University of Pennsylvania 2D 3D TSV
9554869 15 Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.EBI J Med Chem 41: 1367-70 (1998) University of Manchester 2D 3D TSV
9554868 40 2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).EBI J Med Chem 41: 1361-6 (1998) Pfizer Inc. 2D 3D TSV
9554867 18 (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.EBI J Med Chem 41: 1357-60 (1998) Pharmacia & Upjohn 2D 3D TSV
9551716 1 Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.BDB Eur J Pharmacol 343: 67-77 (1998) INSERM 2D 3D TSV
9548853 5 Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsiEBI J Nat Prod 61: 248-50 (1998) Aoyama Gakuin University 2D 3D TSV
9548816 54 Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.EBI J Med Chem 41: 1263-71 (1998) Duquesne University 2D 3D TSV
9548815 10 Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.EBI J Med Chem 41: 1252-62 (1998) University of Michigan 2D 3D TSV
9548813 53 The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.EBI J Med Chem 41: 1218-35 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9548812 67 Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.EBI J Med Chem 41: 1209-17 (1998) Kanebo Ltd. 2D 3D TSV
9548811 55 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.EBI J Med Chem 41: 1205-8 (1998) Merck & Co. 2D 3D TSV
9545432 26 Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.BDB Chem Biol 5: 185-96 (1998) Merck Research Laboratories 2D 3D TSV
9544566 1 DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.EBI J Nat Prod 61: 362-6 (1998) Ohio State University 2D 3D TSV
9544564 16 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.EBI J Nat Prod 61: 347-50 (1998) Heinrich-Heine-Universität Düsseldorf 2D 3D TSV
9544219 12 Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.EBI J Med Chem 41: 1195-200 (1998) National Hellenic Research Foundation 2D 3D TSV
9544217 2 (3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol.EBI J Med Chem 41: 1172-84 (1998) Pfizer Inc. 2D 3D TSV
9544214 197 Potent antagonists of somatostatin: synthesis and biology.EBI J Med Chem 41: 1146-54 (1998) Tulane University School of Medicine 2D 3D TSV
9544213 9 Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.EBI J Med Chem 41: 1138-45 (1998) University of Louvain 2D 3D TSV
9544212 37 New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.EBI J Med Chem 41: 1124-37 (1998) Procter & Gamble Pharmaceuticals 2D 3D TSV
9544211 39 New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.EBI J Med Chem 41: 1112-23 (1998) Procter & Gamble Pharmaceuticals 2D 3D TSV
9544210 46 Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).EBI J Med Chem 41: 1099-111 (1998) Texas Biotechnology Corporation 2D 3D TSV
9544206 94 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease.EBI J Med Chem 41: 1060-7 (1998) Warner-Lambert Company 2D 3D TSV
9544204 100 Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists.EBI J Med Chem 41: 1042-9 (1998) Parke-Davis Pharmaceutical Research 2D 3D TSV
9544200 24 Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.EBI J Med Chem 41: 1011-3 (1998) Merck Research Laboratories 2D 3D TSV
9537821 119 Pharmacological profile of antidepressants and related compounds at human monoamine transporters.BDB Eur J Pharmacol 340: 249-58 (1997) Mayo Clinic Jacksonville 2D 3D TSV
9536034 35 Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain.BDB J Pharmacol Exp Ther 285: 377-86 (1998) University of Colorado 2D 3D TSV
9536032 50 Pharmacological characterization of the human ionotropic glutamate receptor subtype GluR3 stably expressed in mammalian cells.BDB J Pharmacol Exp Ther 285: 358-70 (1998) SIBIA Neurosciences, Inc. 2D 3D TSV
9536007 23 Characterization of I2 imidazoline and sigma binding sites in the rat and human stomach.BDB J Pharmacol Exp Ther 285: 170-7 (1998) University of Bonn 2D 3D TSV
9526575 14 Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).EBI J Med Chem 41: 1001-5 (1998) Purdue University 2D 3D TSV
9526574 5 Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase.EBI J Med Chem 41: 996-1000 (1998) G. D. Searle and Company 2D 3D TSV
9526565 21 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.EBI J Med Chem 41: 913-8 (1998) Harvard Medical School 2D 3D TSV
9526564 21 Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.EBI J Med Chem 41: 902-12 (1998) University of Maryland 2D 3D TSV
9526562 257 Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.EBI J Med Chem 41: 877-93 (1998) Schering-Plough Research Institute 2D 3D TSV
9526561 22 (-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake.EBI J Med Chem 41: 864-76 (1998) University of Maryland 2D 3D TSV
9526559 49 Comparative binding energy analysis of HIV-1 protease inhibitors: incorporation of solvent effects and validation as a powerful tool in receptor-based drug design.EBI J Med Chem 41: 836-52 (1998) Universidad de Alcal£ 2D 3D TSV
9526557 6 (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.EBI J Med Chem 41: 808-20 (1998) Università degli Studi di Urbino 2D 3D TSV
9526556 18 Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.EBI J Med Chem 41: 798-807 (1998) Glaxo Wellcome Research and Development Limited 2D 3D TSV
9526555 105 Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.BDB J Med Chem 41: 787-97 (1998) Glaxo Wellcome Research and Development Limited 2D 3D TSV
9526553 6 Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.EBI J Med Chem 41: 775-7 (1998) Searle 2D 3D TSV
9517418 7 A novel kainate receptor ligand [3H]-(2S,4R)-4-methylglutamate: pharmacological characterization in rabbit brain membranes.BDB Neuropharmacology 36: 1483-8 University of Bristol 2D 3D TSV
9514878 7 Discovery of nonsteroidal androgens.BDB Biochem Biophys Res Commun 244: 1-4 (1998) University of Tennessee at Memphis 2D 3D TSV
9514015 6 Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.EBI J Nat Prod 61: 301-5 (1998) Institut für Biowissenschaften 2D 3D TSV
9513604 76 Aminopyrimidines with high affinity for both serotonin and dopamine receptors.EBI J Med Chem 41: 760-71 (1998) Warner-Lambert Company 2D 3D TSV
9513602 36 Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors.BDB J Med Chem 41: 742-51 (1998) University of Auckland 2D 3D TSV
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI J Med Chem 41: 728-41 (1998) Universit£ di Siena 2D 3D TSV
9513598 20 Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.EBI J Med Chem 41: 699-705 (1998) Organix Inc. 2D 3D TSV
9513596 28 alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity.EBI J Med Chem 41: 682-90 (1998) Warner-Lambert Company 2D 3D TSV
9513595 2 Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.EBI J Med Chem 41: 674-81 (1998) Universit£ Degli Studi di Milano 2D 3D TSV
9513594 41 Novel 3-aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with high affinity toward A1 adenosine receptors.EBI J Med Chem 41: 668-73 (1998) Università di Pisa 2D 3D TSV
9513592 13 (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.BDB J Med Chem 41: 655-7 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9495864 2 Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.EBI J Pharmacol Exp Ther 284: 1033-9 (1998) University of Tokyo 2D 3D TSV
9484512 130 Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.EBI J Med Chem 41: 640-9 (1998) Shionogi & Co., Ltd. 2D 3D TSV
9484511 111 Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.EBI J Med Chem 41: 623-39 (1998) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9484510 3 Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.EBI J Med Chem 41: 618-22 (1998) Codon Pharmaceuticals, Inc. 2D 3D TSV
9484509 12 Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.EBI J Med Chem 41: 602-17 (1998) Abbott Laboratory 2D 3D TSV
9484506 49 A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework.EBI J Med Chem 41: 564-78 (1998) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
9484505 12 A1 adenosine receptor antagonists as ligands for positron emission tomography (PET) and single-photon emission tomography (SPET).EBI J Med Chem 41: 555-63 (1998) Forschungszentrum Jülich GmbH 2D 3D TSV
9484504 14 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase.EBI J Med Chem 41: 540-54 (1998) Università di Torino 2D 3D TSV
9484500 12 Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues.EBI J Med Chem 41: 503-8 (1998) Nagoya City University 2D 3D TSV
9484499 94 Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.EBI J Med Chem 41: 489-502 (1998) Takeda Chemical Industries, Ltd. 2D 3D TSV
9484497 17 Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors.EBI J Med Chem 41: 468-77 (1998) University of Illinois at Chicago 60607-7061 2D 3D TSV
9484495 74 Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa.EBI J Med Chem 41: 437-50 (1998) Collegeville 2D 3D TSV
9484494 2 Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging agents.EBI J Med Chem 41: 428-36 (1998) University of Pennsylvania 2D 3D TSV
9484493 11 Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.EBI J Med Chem 41: 420-7 (1998) OXIS International, Inc. 2D 3D TSV
9484492 62 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry.EBI J Med Chem 41: 413-9 (1998) Signal Pharmaceuticals, Inc. 2D 3D TSV
9484491 23 Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.EBI J Med Chem 41: 407-12 (1998) Abbott Laboratory 2D 3D TSV
9479479 4 Ethylene biosynthesis: processing of a substrate analog supports a radical mechanism for the ethylene-forming enzyme.BDB Chem Biol 5: 49-57 (1998) Duke University 2D 3D TSV
9479476 10 Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.BDB Chem Biol 5: 13-21 (1998) University of Texas Southwestern Medical Center 2D 3D TSV
9468142 60 Design of potent selective zinc-mediated serine protease inhibitors.BDB Nature 391: 608-12 (1998) Arris 2D 3D TSV
9464370 28 Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.EBI J Med Chem 41: 401-6 (1998) Merck Research Laboratories 2D 3D TSV
9464368 78 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.EBI J Med Chem 41: 379-92 (1998) Lilly Research Laboratories 2D 3D TSV
9464367 24 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.EBI J Med Chem 41: 358-78 (1998) Lilly Research Laboratories 2D 3D TSV
9464366 30 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.EBI J Med Chem 41: 346-57 (1998) Lilly Research Laboratories 2D 3D TSV
9464365 30 Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8).EBI J Med Chem 41: 339-45 (1998) Institut für Biochemie 2D 3D TSV
9464362 19 5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.EBI J Med Chem 41: 311-7 (1998) Universit£ Louis Pasteur 2D 3D TSV
9464361 48 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.EBI J Med Chem 41: 303-10 (1998) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9464360 145 5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.EBI J Med Chem 41: 291-302 (1998) Ligand Pharmaceuticals, Inc. 2D 3D TSV
9464357 16 Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.EBI J Med Chem 41: 271-5 (1998) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9464356 24 Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.EBI J Med Chem 41: 266-70 (1998) Pfizer Inc. 2D 3D TSV
9463480 11 In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain.BDB Mol Pharmacol 53: 228-33 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9463476 21 DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.BDB Mol Pharmacol 53: 195-201 (1998) Suntory Institute for Bioorganic Research 2D 3D TSV
9461660 4 Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.EBI J Nat Prod 61: 119-21 (1998) Universit£t Bayreuth 2D 3D TSV
9461655 33 Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.EBI J Nat Prod 61: 71-6 (1998) University of Antwerp 2D 3D TSV
9461651 14 Litebamine N-homologues: preparation and anti-acetylcholinesterase activity.EBI J Nat Prod 61: 46-50 (1998) National Taiwan University 2D 3D TSV
9461647 7 Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis.EBI J Nat Prod 61: 8-12 (1998) Uppsala University 2D 3D TSV
9461646 20 Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.EBI J Nat Prod 61: 2-7 (1998) Uppsala University 2D 3D TSV
9459568 32 [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.BDB Naunyn Schmiedebergs Arch Pharmacol 357: 17-24 (1998) Lilly Research Laboratories 2D 3D TSV
9459566 23 Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.BDB Naunyn Schmiedebergs Arch Pharmacol 357: 1-9 (1998) Universität Würzburg 2D 3D TSV
9459024 9 Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA.BDB Bioorg Med Chem 5: 2267-75 (1997) Università di Camerino 2D 3D TSV
9458785 10 Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.EBI Am J Physiol 274: 157-69 (1998) Wake Forest University 2D 3D TSV
9457247 39 Synthesis and ligand binding of tropane ring analogues of paroxetine.EBI J Med Chem 41: 247-57 (1998) Research Triangle Institute 2D 3D TSV
9457244 189 Matrix metalloproteinase inhibitors: a structure-activity study.EBI J Med Chem 41: 199-223 (1998) Glycomed, Inc. 2D 3D TSV
9457242 28 Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.EBI J Med Chem 41: 183-90 (1998) National Institute of Diabetes 2D 3D TSV
9457239 18 Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands.EBI J Med Chem 41: 157-66 (1998) University of Pennsylvania 2D 3D TSV
9457238 59 Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.EBI J Med Chem 41: 148-56 (1998) University of Manchester 2D 3D TSV
9457237 14 A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase.EBI J Med Chem 41: 143-7 (1998) Tsukuba Research Institute 2D 3D TSV
9454827 23 Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.BDB J Pharmacol Exp Ther 284: 777-89 (1998) SIBIA Neurosciences, Inc. 2D 3D TSV
9454810 72 SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.BDB J Pharmacol Exp Ther 284: 644-50 (1998) Sanofi Recherche 2D 3D TSV
9454790 32 Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.BDB J Pharmacol Exp Ther 284: 500-7 (1998) University of Arizona 2D 3D TSV
9448744 42 Characterization of central- and peripheral-type benzodiazepine receptors in rat salivary glands.BDB Biochem Pharmacol 55: 209-14 (1998) Tokyo Dental College 2D 3D TSV
9438028 63 From micromolar to nanomolar affinity: a systematic approach to identify the binding site of CGRP at the human calcitonin gene-related peptide 1 receptor.EBI J Med Chem 41: 117-23 (1998) ETH Zürich 2D 3D TSV
9438027 30 Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.EBI J Med Chem 41: 109-16 (1998) Novo Nordisk A/S 2D 3D TSV
9438026 41 5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor.EBI J Med Chem 41: 102-8 (1998) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
9438025 54 Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.EBI J Med Chem 41: 96-101 (1998) G. D. Searle Research and Development 2D 3D TSV
9438024 94 Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists.EBI J Med Chem 41: 74-95 (1998) Abbott Laboratories 2D 3D TSV
9438022 55 Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors.EBI J Med Chem 41: 53-62 (1998) DuPont Merck Pharmaceutical Company 2D 3D TSV
9438021 97 Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.EBI J Med Chem 41: 46-52 (1998) National Institute of Diabetes 2D 3D TSV
9438020 67 Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile.EBI J Med Chem 41: 38-45 (1998) Warner-Lambert Company 2D 3D TSV
9438017 12 (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.EBI J Med Chem 41: 10-23 (1998) Wayne State University School of Medicine 2D 3D TSV
9435911 36 2-(1-Naphthyloxy)ethylamines with enhanced affinity for human 5-HT1D beta (h5-HT1B) serotonin receptors.EBI J Med Chem 40: 4415-9 (1998) Medical College of Virginia/Virginia Commonwealth University 2D 3D TSV
9435910 23 Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives.EBI J Med Chem 40: 4406-14 (1998) University of New Orleans 2D 3D TSV
9435909 90 Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.EBI J Med Chem 40: 4396-405 (1998) Julius-Maximilians-Universität Würzburg 2D 3D TSV
9435907 23 Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.EBI J Med Chem 40: 4378-85 (1998) F. Hoffmann-La Roche Ltd. 2D 3D TSV
9435906 26 Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.EBI J Med Chem 40: 4372-7 (1998) Schering-Plough Research Institute 2D 3D TSV
9435905 180 Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.EBI J Med Chem 40: 4360-71 (1998) Harvard University 2D 3D TSV
9435903 14 Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.EBI J Med Chem 40: 4340-46 (1998) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
9435902 60 Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.EBI J Med Chem 40: 4329-39 (1998) National Institute on Drug Abuse 2D 3D TSV
9435900 89 Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.EBI J Med Chem 40: 4308-18 (1998) COR Therapeutics, Inc. 2D 3D TSV
9435899 18 Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents.EBI J Med Chem 40: 4302-7 (1998) Rochester 2D 3D TSV
9435898 32 Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.EBI J Med Chem 40: 4290-301 (1998) Schering-Plough Research Institute 2D 3D TSV
9435897 70 Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.EBI J Med Chem 40: 4281-9 (1998) Cambridge NeuroScience, Inc. 2D 3D TSV
9435896 36 Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.EBI J Med Chem 40: 4265-80 (1998) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9435895 90 A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition.EBI J Med Chem 40: 4257-64 (1998) Université d'Orléans 2D 3D TSV
9435894 206 New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.EBI J Med Chem 40: 4235-56 (1998) Wyeth-Ayerst Research Laboratories 2D 3D TSV
9435893 46 Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.EBI J Med Chem 40: 4222-34 (1998) University of Tokyo 2D 3D TSV
9435891 62 Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.EBI J Med Chem 40: 4199-207 (1998) National Cancer Institute-Frederick Cancer Research and Development Center 2D 3D TSV
9435890 7 Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors.EBI J Med Chem 40: 4195-8 (1998) Duquesne University 2D 3D TSV
9435889 70 Neuronal nicotinic acetylcholine receptors as targets for drug discovery.EBI J Med Chem 40: 4169-94 (1998) Abbott Laboratories 2D 3D TSV
9430133 176 Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence.BDB Neuropsychopharmacology 18: 63-101 (1998) H. Lundbeck A/S 2D 3D TSV
9417028 7 Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.BDB Science 279: 77-81 (1998) Abbott Laboratories 2D 3D TSV
9406603 49 Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.EBI J Med Chem 40: 4146-53 (1998) University of Groningen 2D 3D TSV
9406602 7 Assessment of solvation effects on calculated binding affinity differences: trypsin inhibition by flavonoids as a model system for congeneric series.EBI J Med Chem 40: 4136-45 (1998) Universidad de Alcalá 2D 3D TSV
9406601 109 Peptidomimetic inhibitors of the human cytomegalovirus protease.EBI J Med Chem 40: 4113-35 (1998) Boehringer Ingelheim Ltd. 2D 3D TSV
9406600 102 Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.EBI J Med Chem 40: 4103-12 (1998) Schering-Plough Research Institute 2D 3D TSV
9406599 51 A strategy for the incorporation of water molecules present in a ligand binding site into a three-dimensional quantitative structure--activity relationship analysis.EBI J Med Chem 40: 4089-102 (1998) University of Alcala 2D 3D TSV
9406598 24 Nonsymmetrically substituted cyclic urea HIV protease inhibitors.EBI J Med Chem 40: 4079-88 (1998) DuPont Merck Pharmaceutical Company 2D 3D TSV
9406595 18 Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.BDB J Med Chem 40: 4030-52 (1997) BioCryst Pharmaceuticals, Inc. 2D 3D TSV
9406594 82 (Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.EBI J Med Chem 40: 4026-9 (1998) Warner-Lambert Company 2D 3D TSV
9406593 5 1-[1-2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter.EBI J Med Chem 40: 4019-25 (1998) INSERM 2D 3D TSV
9406590 13 Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.EBI J Med Chem 40: 3997-4005 (1998) University of Kansas 2D 3D TSV
9405385 26 Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.BDB J Biol Chem 272: 31949-52 (1997) Schering-Plough Research Institute 2D 3D TSV
9405047 2 Energetics of heme binding to native and denatured states of cytochrome b562.BDB Biochemistry 36: 16141-6 (1997) University of Illinois 2D 3D TSV
9400006 184 Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.BDB J Pharmacol Exp Ther 283: 1305-22 (1997) Emory University 2D 3D TSV
9399974 2 Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1.EBI J Pharmacol Exp Ther 283: 1039-42 (1998) Kyoto University Hospital 2D 3D TSV
9397180 4 Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.EBI J Med Chem 40: 3979-85 (1998) Agouron Pharmaceuticals, Inc. 2D 3D TSV
9397179 40 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.EBI J Med Chem 40: 3974-8 (1998) Centre de Recherche Pierre FABRE 2D 3D TSV
9397178 1 Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.EBI J Med Chem 40: 3969-73 (1998) Universit£ Montpellier-2 des Sciences et Techniques du Languedoc 2D 3D TSV
9397176 28 Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.EBI J Med Chem 40: 3957-62 (1998) University of Arizona 2D 3D TSV
9397175 48 Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.EBI J Med Chem 40: 3947-56 (1998) INSERM 2D 3D TSV
9397172 37 Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.BDB J Med Chem 40: 3915-25 (1997) University of Auckland 2D 3D TSV
9397171 81 N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.EBI J Med Chem 40: 3905-14 (1998) University of Minnesota 2D 3D TSV
9397167 15 Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.EBI J Med Chem 40: 3869-70 (1998) Northwestern University 2D 3D TSV
9397166 25 Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.EBI J Med Chem 40: 3865-8 (1998) Merck Research Laboratories 2D 3D TSV
9397165 27 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.EBI J Med Chem 40: 3861-4 (1998) Research Triangle Institute 2D 3D TSV
9396785 65 Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.BDB Mol Pharmacol 52: 1150-6 (1997) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9395253 17 Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.BDB Life Sci 61: 2117-26 (1997) Eli Lilly and Co. 2D 3D TSV
9392883 4 Zanhasaponins A and B, antiphospholipase A2 saponins from an antiinflammatory extract of Zanha africana root bark.EBI J Nat Prod 60: 1158-60 (1998) Universitat de Val£ncia 2D 3D TSV
9383464 20 Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.BDB Chem Biol 2: 601-8 (1995) University of California, San Diego 2D 3D TSV
9383449 21 Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface.BDB Chem Biol 2: 471-81 (1995) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9379452 8 Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.EBI J Med Chem 40: 3312-8 (1997) Kennesaw State University 2D 3D TSV
9379450 51 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).EBI J Med Chem 40: 3297-304 (1997) University of Maryland 2D 3D TSV
9379447 20 Angiotensin analogues palmitoylated in positions 1 and 4.EBI J Med Chem 40: 3271-9 (1997) Universit£ de Sherbrooke 2D 3D TSV
9379446 10 6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase.EBI J Med Chem 40: 3263-70 (1997) University of Minnesota 2D 3D TSV
9379443 17 Sulfated galactocerebrosides as potential antiinflammatory agents.EBI J Med Chem 40: 3234-47 (1997) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9379442 61 Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.EBI J Med Chem 40: 3228-33 (1997) Institute of Science 2D 3D TSV
9379441 100 Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.EBI J Med Chem 40: 3217-27 (1997) Abbott Laboratories 2D 3D TSV
9379439 16 A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.EBI J Med Chem 40: 3199-206 (1997) University of California 2D 3D TSV
9379438 31 Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.EBI J Med Chem 40: 3192-8 (1997) SmithKline Beecham S.p.A. 2D 3D TSV
9379436 46 Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.EBI J Med Chem 40: 3173-81 (1997) ZENECA Pharmaceuticals 2D 3D TSV
9379435 30 Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.EBI J Med Chem 40: 3161-72 (1997) University of Michigan 2D 3D TSV
9379433 37 NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.EBI J Med Chem 40: 3144-50 (1997) Abbott Laboratories 2D 3D TSV
9379432 36 Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prEBI J Med Chem 40: 3141-3 (1997) Abbott Laboratories 2D 3D TSV
9371250 3 Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli.EBI J Med Chem 40: 3842-50 (1997) University of Michigan 2D 3D TSV
9371249 13 Synthesis and structure-activity profiles of A-homoestranes, the estratropones.EBI J Med Chem 40: 3836-41 (1997) University of Virginia 2D 3D TSV
9371244 59 4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.BDB J Med Chem 40: 3781-92 (1997) Parke-Davis Pharmaceutical Research 2D 3D TSV
9371243 57 Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.EBI J Med Chem 40: 3773-80 (1997) Westfälische Wilhelms-Universität Münster 2D 3D TSV
9371242 54 N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.EBI J Med Chem 40: 3765-72 (1997) University of Ghent 2D 3D TSV
9371239 43 Betidamino acid scan of the GnRH antagonist acyline.EBI J Med Chem 40: 3739-48 (1997) Salk Institute 2D 3D TSV
9371237 69 Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.EBI J Med Chem 40: 3726-33 (1997) Merck Research Laboratories 2D 3D TSV
9371236 7 Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.EBI J Med Chem 40: 3719-25 (1997) Warner-Lambert Company 2D 3D TSV
9371234 49 Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists.EBI J Med Chem 40: 3712-4 (1997) Lilly Research Laboratories 2D 3D TSV
9371233 24 Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.BDB J Med Chem 40: 3707-11 (1997) Parke-Davis Pharmaceutical Research 2D 3D TSV
9357538 38 (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.EBI J Med Chem 40: 3700-5 (1997) Royal Danish School of Pharmacy 2D 3D TSV
9357537 27 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.EBI J Med Chem 40: 3694-9 (1997) Harvard Medical School 2D 3D TSV
9357536 47 Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.EBI J Med Chem 40: 3687-93 (1997) Merck Research Laboratories 2D 3D TSV
9357535 5 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.EBI J Med Chem 40: 3679-86 (1997) CoCensys Inc. 2D 3D TSV
9357534 49 Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.EBI J Med Chem 40: 3670-8 (1997) Universit£ di Siena 2D 3D TSV
9357531 58 Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.EBI J Med Chem 40: 3645-50 (1997) University of Bristol 2D 3D TSV
9357528 26 Potent anandamide analogs: the effect of changing the length and branching of the end pentyl chain.EBI J Med Chem 40: 3617-25 (1997) Organix, Inc. 2D 3D TSV
9357527 141 Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.BDB J Med Chem 40: 3601-16 (1997) Novartis Pharmaceuticals 2D 3D TSV
9357526 30 Design, synthesis, and dopamine receptor modulating activity of diketopiperazine peptidomimetics of L-prolyl-L-leucylglycinamide.EBI J Med Chem 40: 3594-600 (1997) University of Minnesota 2D 3D TSV
9357522 6 Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain.EBI J Med Chem 40: 3551-6 (1997) Novartis Pharma Inc. 2D 3D TSV
9357521 20 Differentiation between partial agonists and neutral 5-HT1B antagonists by chemical modulation of 3-[3-(N,N-dimethylamino)propyl]-4-hydroxy- N-[4-(pyridin-4-yl)phenyl]benzamide (GR-55562).EBI J Med Chem 40: 3542-50 (1997) Centre de Recherche Pierre FABRE 2D 3D TSV
9357520 18 Studies on selection blockers. 5. Design, synthesis, and biological profile of sialyl Lewis x mimetics based on modified serine-glutamic acid dipeptides.EBI J Med Chem 40: 3534-41 (1997) Kanebo 2D 3D TSV
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI J Med Chem 40: 3516-23 (1997) University of Strathclyde 2D 3D TSV
9357516 94 Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists.EBI J Med Chem 40: 3504-7 (1997) Shionogi & Co., Ltd. 2D 3D TSV
9357515 55 Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.EBI J Med Chem 40: 3501-3 (1997) Merck, Sharp and Dohme Research Laboratories 2D 3D TSV
9357514 55 3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.EBI J Med Chem 40: 3497-500 (1997) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9357513 15 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.EBI J Med Chem 40: 3494-6 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9355767 6 ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.EBI Biochem J 327: 305-10 (1997) Deutsches Krebsforschungszentrum 2D 3D TSV
9353393 5 Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.BDB J Pharmacol Exp Ther 283: 735-41 (1997) Torrey Pines Institute for Molecular Studies 2D 3D TSV
9353361 3 [3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits.BDB J Pharmacol Exp Ther 283: 488-93 (1997) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9351641 31 Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.BDB Neuroreport 8: 3189-96 (1997) CNRS UPR 9023 2D 3D TSV
9349523 22 Cloning and expression of a human serotonin 5-HT4 receptor cDNA.BDB J Neurochem 69: 1810-9 (1997) Janssen Research Foundation 2D 3D TSV
9341924 11 Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.EBI J Med Chem 40: 3484-8 (1997) Prassis Istituto di Ricerche Sigma-Tau 2D 3D TSV
9341921 7 Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.EBI J Med Chem 40: 3456-65 (1997) Université Blaise Pascal 2D 3D TSV
9341919 29 Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.EBI J Med Chem 40: 3442-52 (1997) Pfizer Central Research 2D 3D TSV
9341917 69 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.EBI J Med Chem 40: 3423-33 (1997) Southern Methodist University 2D 3D TSV
9341916 30 Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase.EBI J Med Chem 40: 3408-22 (1997) Rhône-Poulenc Rorer 2D 3D TSV
9341915 24 Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.EBI J Med Chem 40: 3402-7 (1997) Instituto de Química Médica (CSIC) 2D 3D TSV
9341914 15 New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent.EBI J Med Chem 40: 3393-401 (1997) Sanofi Recherche 2D 3D TSV
9341913 28 Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5.EBI J Med Chem 40: 3381-92 (1997) Ludwig-Maximilians-University 2D 3D TSV
9341912 43 Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.EBI J Med Chem 40: 3369-80 (1997) Pharmacia& Upjohn 2D 3D TSV
9341911 133 Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.EBI J Med Chem 40: 3359-68 (1997) Genentech Inc. 2D 3D TSV
9341908 2 Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase.EBI J Med Chem 40: 3336-45 (1997) Southern Illinois University 2D 3D TSV
9341905 33 C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.EBI J Med Chem 40: 3319-22 (1997) Warner-Lambert Company 2D 3D TSV
9336327 37 The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299.BDB J Pharmacol Exp Ther 283: 216-25 (1997) Preclinical R & D, Astra Arcus AB 2D 3D TSV
9322361 1 Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1.EBI J Nat Prod 60: 894-9 (1997) Searle Research and Development 2D 3D TSV
9321514 1 Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.EBI Drug Metab Dispos 25: 1123-9 (1997) Toho University School of Pharmaceutical Sciences 2D 3D TSV
9313928 89 Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.BDB Br J Pharmacol 122: 217-24 (1997) Kyoto University 2D 3D TSV
9305929 19 Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.BDB J Biol Chem 272: 24612-6 (1997) Synaptic Pharmaceutical Corporation 2D 3D TSV
9303569 35 Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.BDB Naunyn Schmiedebergs Arch Pharmacol 356: 328-34 (1997) Rhône-Poulenc Rorer 2D 3D TSV
9303567 37 SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 356: 312-20 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9303561 3 Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants.BDB FEBS Lett 413: 489-94 (1997) Organon N.V. 2D 3D TSV
9301676 14 Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.EBI J Med Chem 40: 3119-29 (1997) Université René Descartes-Paris V 2D 3D TSV
9301675 53 Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.EBI J Med Chem 40: 3109-18 (1997) Universit£ degli Studi di Bari 2D 3D TSV
9301674 60 Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.EBI J Med Chem 40: 3100-8 (1997) University of Ferrara 2D 3D TSV
9301673 234 Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.EBI J Med Chem 40: 3091-9 (1997) Klinikum der Friedrich-Schiller-Universit£t Jena 2D 3D TSV
9301672 18 Molecular modeling and 3D-QSAR studies on the interaction mechanism of tripeptidyl thrombin inhibitors with human alpha-thrombin.EBI J Med Chem 40: 3085-90 (1997) Chinese Academy of Sciences 2D 3D TSV
9301669 24 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.EBI J Med Chem 40: 3064-70 (1997) University of Minnesota 2D 3D TSV
9301668 18 Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.EBI J Med Chem 40: 3057-63 (1997) National Cancer Institute 2D 3D TSV
9301666 65 Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.EBI J Med Chem 40: 3040-8 (1997) University 2D 3D TSV
9301665 75 Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.EBI J Med Chem 40: 3032-9 (1997) Duquesne University 2D 3D TSV
9301662 50 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.EBI J Med Chem 40: 3009-13 (1997) University of North Texas 2D 3D TSV
9301661 32 Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.EBI J Med Chem 40: 2997-3008 (1997) Purdue University 2D 3D TSV
9301658 53 Ras farnesyltransferase: a new therapeutic target.EBI J Med Chem 40: 2971-90 (1997) Warner-Lambert Company 2D 3D TSV
9298538 16 Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).BDB Br J Pharmacol 122: 126-32 (1997) Roche Bioscience 2D 3D TSV
9290757 14 The somatostatin analog octreotide as potential treatment for re-stenosis and chronic rejection.BDB Transplant Proc 29: 2599-600 (1997) Novartis Pharma Research 2D 3D TSV
9288177 20 Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.EBI J Med Chem 40: 2948-52 (1997) University of Ferrara 2D 3D TSV
9288176 95 Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.EBI J Med Chem 40: 2936-47 (1997) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9288174 24 Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex.EBI J Med Chem 40: 2922-30 (1997) TBA 2D 3D TSV
9288173 56 Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK11195).EBI J Med Chem 40: 2910-21 (1997) Universit£ di Siena 2D 3D TSV
9288171 28 Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.EBI J Med Chem 40: 2895-901 (1997) National Institute on Aging 2D 3D TSV
9288168 12 Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.EBI J Med Chem 40: 2866-75 (1997) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
9288166 74 Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.EBI J Med Chem 40: 2843-57 (1997) Lilly Research Laboratories 2D 3D TSV
9288162 40 Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.EBI J Med Chem 40: 2813-7 (1997) Northwestern University 2D 3D TSV
9287420 4 Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B.EBI J Nat Prod 60: 842-3 (1997) National Taiwan University 2D 3D TSV
9281594 12 Molecular cloning and pharmacological characterization of a new galanin receptor subtype.BDB Mol Pharmacol 52: 337-43 (1997) The Schering-Plough Research Institute 2D 3D TSV
9276024 42 Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids.EBI J Med Chem 40: 2780-7 (1997) Westfälische Wilhelms-Universität Münster 2D 3D TSV
9276019 11 beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity.EBI J Med Chem 40: 2740-9 (1997) University of Arizona 2D 3D TSV
9276018 47 Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.EBI J Med Chem 40: 2733-9 (1997) Oregon State University 2D 3D TSV
9276017 27 Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease.EBI J Med Chem 40: 2726-32 (1997) Universidad Central de Venezuela 2D 3D TSV
9276016 50 Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.BDB J Med Chem 40: 2706-25 (1997) Glaxo Wellcome Research and Development 2D 3D TSV
9276015 41 Synthesis, biological evaluation, and structure-activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2.EBI J Med Chem 40: 2694-705 (1997) Ludwig-Maximilians-University 2D 3D TSV
9276014 62 Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.EBI J Med Chem 40: 2688-93 (1997) Warner-Lambert Company 2D 3D TSV
9276013 38 N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.EBI J Med Chem 40: 2674-87 (1997) Roche Bioscience 2D 3D TSV
9276012 53 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.EBI J Med Chem 40: 2661-73 (1997) Organix Inc. 2D 3D TSV
9270020 3 Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.EBI Cancer Res 57: 3506-10 (1997) Toho University School of Pharmaceutical Sciences 2D 3D TSV
9262370 33 I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.BDB J Pharmacol Exp Ther 282: 1011-9 (1997) Neurogen Corporation 2D 3D TSV
9258372 40 Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment on 5-HT1A affinity/selectivity.EBI J Med Chem 40: 2653-6 (1997) Universidad Complutense 2D 3D TSV
9258367 99 Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.EBI J Med Chem 40: 2596-608 (1997) National Institute of Diabetes 2D 3D TSV
9258366 41 Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.EBI J Med Chem 40: 2588-95 (1997) NIDDK 2D 3D TSV
9258365 28 Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.EBI J Med Chem 40: 2579-87 (1997) National Institute of Environmental Health Sciences 2D 3D TSV
9258364 10 H3-receptor antagonists: synthesis and structure-activity relationships of para- and meta-substituted 4(5)-phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles.EBI J Med Chem 40: 2571-8 (1997) Universit£ degli Studi di Parma 2D 3D TSV
9258362 30 The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon.EBI J Med Chem 40: 2555-62 (1997) University of Arizona 2D 3D TSV
9258359 9 Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.EBI J Med Chem 40: 2533-8 (1997) Codon Pharmaceuticals, Inc. 2D 3D TSV
9258358 65 Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.BDB J Med Chem 40: 2525-32 (1997) Novartis Pharmaceuticals 2D 3D TSV
9258357 25 Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.EBI J Med Chem 40: 2502-24 (1997) Agouron Pharmaceuticals, Inc. 2D 3D TSV
9258356 34 5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.EBI J Med Chem 40: 2491-501 (1997) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
9258354 10 Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter.EBI J Med Chem 40: 2474-81 (1997) University of Oklahoma 2D 3D TSV
9258353 45 Selective inhibitors of monoamine oxidase. 4. SAR of tricyclic N-methylcarboxamides and congeners binding at the tricyclics' hydrophilic binding site.EBI J Med Chem 40: 2466-73 (1997) Wellcome Research Laboratories 2D 3D TSV
9258349 12 An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.EBI J Med Chem 40: 2440-4 (1997) University of Pennsylvania 2D 3D TSV
9254595 10 Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2.BDB Biochemistry 36: 10006-14 (1997) Schering-Plough Research Institute 2D 3D TSV
9247857 14 Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position.BDB J Enzym Inhib 12: 155-60 (1997) R&D, Zambon Group Spa 2D 3D TSV
9247853 7 Yeast hexokinase inhibitors designed from the 3-D enzyme structure rebuilding.BDB J Enzym Inhib 12: 101-21 (1997) Groupe de Chimie Organique Biologique 2D 3D TSV
9240358 40 Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones.BDB J Med Chem 40: 2430-3 (1997) Boehringer Ingelheim Pharmaceuticals Inc. 2D 3D TSV
9240357 3 Synthesis of racemic 6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones as antagonists of N-methyl-d-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.EBI J Med Chem 40: 2424-9 (1997) CoCensys, Inc. 2D 3D TSV
9240352 111 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.EBI J Med Chem 40: 2374-85 (1997) Merck Sharp and Dohme 2D 3D TSV
9240351 4 Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils.EBI J Med Chem 40: 2363-73 (1997) Life Science Research Center 2D 3D TSV
9240345 33 Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.EBI J Med Chem 40: 2296-303 (1997) Parke-Davis Pharmaceutical Research 2D 3D TSV
9240343 28 Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.EBI J Med Chem 40: 2289-92 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9226416 18 Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists.BDB Eur J Pharmacol 329: 223-9 (1997) University of Sydney 2D 3D TSV
9225298 39 Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.BDB Neuropharmacology 36: 713-20 F. Hoffmann-La Roche Ltd. 2D 3D TSV
9225293 47 [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.BDB Neuropharmacology 36: 671-9 Roche Bioscience 2D 3D TSV
9225287 174 RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist.BDB Neuropharmacology 36: 621-9 Roche Bioscience 2D 3D TSV
9225286 13 SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.BDB Neuropharmacology 36: 609-20 SmithKline Beecham Pharmaceuticals 2D 3D TSV
9224570 23 Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.BDB Chem Biol 4: 461-71 (1997) Massachusetts Institute of Technology 2D 3D TSV
9224565 1 The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.BDB Chem Biol 4: 423-31 (1997) Vertex Pharmaceuticals 2D 3D TSV
9223589 17 N-(3-lodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichloro phenyl)nortropane (beta-CDIT), a tropane derivative: pharmacological characterization as a specific ligand for the dopamine transporter in the rodent brain.BDB J Pharmacol Exp Ther 282: 467-74 (1997) INSERM U316 2D 3D TSV
9223586 8 [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors.BDB J Pharmacol Exp Ther 282: 445-51 (1997) Georgetown University 2D 3D TSV
9223568 38 Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo.BDB J Pharmacol Exp Ther 282: 301-8 (1997) Yamanouchi Pharmaceutical Co., Ltd. 2D 3D TSV
9223553 16 [35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents.BDB J Pharmacol Exp Ther 282: 181-91 (1997) Institut de Recherches Servier 2D 3D TSV
9216846 36 Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.EBI J Med Chem 40: 2266-75 (1997) University of North Carolina at Chapel Hill 27599 2D 3D TSV
9216844 14 A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs.EBI J Med Chem 40: 2252-8 (1997) University of California at San Diego 2D 3D TSV
9216843 32 Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.EBI J Med Chem 40: 2241-51 (1997) University of California at San Diego 2D 3D TSV
9216842 28 Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.EBI J Med Chem 40: 2228-40 (1997) Warner-Lambert Company 2D 3D TSV
9216839 113 Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.EBI J Med Chem 40: 2196-210 (1997) Schering-Plough Research Institute 2D 3D TSV
9216838 1 Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity.EBI J Med Chem 40: 2191-5 (1997) Wayne State University School of Medicine 2D 3D TSV
9216835 30 Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.BDB J Med Chem 40: 2164-76 (1997) Boehringer Ingelheim (Canada) Ltd. 2D 3D TSV
9216834 153 Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.EBI J Med Chem 40: 2156-63 (1997) Suntory Ltd. 2D 3D TSV
9216831 60 Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.EBI J Med Chem 40: 2133-9 (1997) University of Michigan Medical Center 2D 3D TSV
9216829 14 (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.EBI J Med Chem 40: 2123-5 (1997) Abbott Laboratories 2D 3D TSV
9216827 1 Inhibition of human telomerase by a G-quadruplex-interactive compound.EBI J Med Chem 40: 2113-6 (1997) Institute for Drug Development 2D 3D TSV
9214741 4 Activity of Parthenolide at 5HT2A receptors.EBI J Nat Prod 60: 651-3 (1997) University of Montana 2D 3D TSV
9214739 1 Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.EBI J Nat Prod 60: 638-41 (1997) University of Antwerp 2D 3D TSV
9207949 26 Non-peptide RGD surrogates which mimic a Gly-Asp beta-turn: potent antagonists of platelet glycoprotein IIb-IIIa.EBI J Med Chem 40: 2085-101 (1997) Lilly Research Laboratories 2D 3D TSV
9207948 65 Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists.EBI J Med Chem 40: 2064-84 (1997) DuPont Merck Pharmaceutical Company 2D 3D TSV
9207944 6 Synthesis and in vitro evaluation of two progressive series of bifunctional polyhydroxybenzamide catechol-O-methyltransferase inhibitors.EBI J Med Chem 40: 2035-9 (1997) University of Otago 2D 3D TSV
9207938 15 Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.EBI J Med Chem 40: 1977-81 (1997) University of Minnesota 2D 3D TSV
9207936 198 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.EBI J Med Chem 40: 1955-68 (1997) Abbott Laboratories 2D 3D TSV
9207934 6 Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor.EBI J Med Chem 40: 1941-6 (1997) Sanofi Winthrop Inc. 2D 3D TSV
9203642 14 Binding of a thrombin receptor tethered ligand analogue to human platelet thrombin receptor.BDB Mol Pharmacol 51: 350-6 (1997) Schering-Plough Research Institute 2D 3D TSV
9195869 28 Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.BDB Chem Biol 4: 287-95 (1997) Laboratorium für Organische Chemie 2D 3D TSV
9195867 15 Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.BDB Chem Biol 4: 297-307 (1997) University of California Berkeley 2D 3D TSV
9191971 28 Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.EBI J Med Chem 40: 1930-6 (1997) Duquesne University 2D 3D TSV
9191969 31 Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives.EBI J Med Chem 40: 1906-18 (1997) Institut de Recherche Servier 2D 3D TSV
9191968 88 Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.EBI J Med Chem 40: 1901-5 (1997) Glaxo Wellcome Research and Development 2D 3D TSV
9191966 79 Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase.EBI J Med Chem 40: 1886-93 (1997) University of Nottingham 2D 3D TSV
9191965 58 Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase.EBI J Med Chem 40: 1876-85 (1997) ZENECA Pharmaceuticals 2D 3D TSV
9191963 12 Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives.EBI J Med Chem 40: 1863-9 (1997) Kyowa Hakko Kogyo Co., Ltd. 2D 3D TSV
9191960 21 A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.EBI J Med Chem 40: 1835-44 (1997) Organix Inc. 2D 3D TSV
9191958 18 Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.BDB J Med Chem 40: 1820-6 (1997) University of Auckland 2D 3D TSV
9191957 210 Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.EBI J Med Chem 40: 1808-19 (1997) Universit£ de Caen 2D 3D TSV
9191956 51 Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.EBI J Med Chem 40: 1794-807 (1997) SmithKline Beecham S.p.A. Milano 2D 3D TSV
9191954 9 Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.EBI J Med Chem 40: 1779-88 (1997) Merck Research Laboratories 2D 3D TSV
9191953 11 Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.EBI J Med Chem 40: 1773-8 (1997) CV Therapeutics 2D 3D TSV
9191952 63 Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.EBI J Med Chem 40: 1771-2 (1997) Warner-Lambert Company 2D 3D TSV
9191951 8 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.EBI J Med Chem 40: 1768-70 (1997) UPR 421 du CNRS 2D 3D TSV
9191950 20 Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.EBI J Med Chem 40: 1763-7 (1997) Centre de Recherches de Vitry-Alfortville 2D 3D TSV
9190866 26 Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.BDB J Pharmacol Exp Ther 281: 1303-11 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9188796 1 Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.EBI Biochim Biophys Acta 1326: 12-22 (1997) Academic Hospital Vrije Universiteit 2D 3D TSV
9185324 7 Rabbit cerebral cortex 5HT1a receptors.BDB Comp Biochem Physiol C, Pharmacol Toxicol Endocrinol 117: 19-24 (1997) University of Montana 2D 3D TSV
9182127 9 Perhydrogenation of tabersonine, ans Aspidiosperma indole alkaloid.EBI J Nat Prod 60: 419-20 (1997) Université de Caen Basse-Normandle 2D 3D TSV
9177352 5 A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.BDB Nature 387: 620-4 (1997) The University of Tokyo 2D 3D TSV
9171886 39 Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors.EBI J Med Chem 40: 1755-61 (1997) CNRS-BIOCIS 2D 3D TSV
9171885 7 Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist.EBI J Med Chem 40: 1749-54 (1997) Pfizer Inc. 2D 3D TSV
9171884 52 Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.EBI J Med Chem 40: 1738-48 (1997) University of Michigan Medical Center 2D 3D TSV
9171882 7 Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.EBI J Med Chem 40: 1726-30 (1997) University of Kansas 2D 3D TSV
9171881 17 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.EBI J Med Chem 40: 1720-5 (1997) University of Minnesota 2D 3D TSV
9171880 21 Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.BDB J Med Chem 40: 1707-9 (1997) DuPont Merck Pharmaceutical Company 2D 3D TSV
9171878 69 Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.EBI J Med Chem 40: 1690-7 (1997) ImmunoPharmaceutics Inc. 2D 3D TSV
9171877 92 Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists.EBI J Med Chem 40: 1682-9 (1997) ImmunoPharmaceutics Inc. 2D 3D TSV
9171875 32 Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dine.EBI J Med Chem 40: 1657-67 (1997) ANSTO 2D 3D TSV
9171874 50 Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.EBI J Med Chem 40: 1648-56 (1997) Universidad Complutense 2D 3D TSV
9171873 192 1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.EBI J Med Chem 40: 1634-47 (1997) Searle Research and Development 2D 3D TSV
9171872 85 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.EBI J Med Chem 40: 1619-33 (1997) Searle Research and Development 2D 3D TSV
9171871 7 Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.EBI J Med Chem 40: 1608-18 (1997) Brigham Young University 2D 3D TSV
9171870 4 Synthesis and pharmacological properties of a close analogue of an antithrombotic pentasaccharide (SR 90107A/ORG 31540).EBI J Med Chem 40: 1600-7 (1997) Sanofi Recherche 2D 3D TSV
9171869 114 Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.EBI J Med Chem 40: 1585-99 (1997) Abbott Laboratories 2D 3D TSV
9171867 16 Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.EBI J Med Chem 40: 1570-7 (1997) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9171866 12 Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.EBI J Med Chem 40: 1565-9 (1997) Merck Research Laboratories 2D 3D TSV
9166718 19 Differential expression of multiple somatostatin receptors in the rat cerebellum during development.BDB J Neurochem 68: 2263-72 (1997) INSERM U159 2D 3D TSV
9163561 56 The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.BDB Eur J Pharmacol 325: 145-53 (1997) CNS-Pharmacology 2D 3D TSV
9157194 2 Fagomine isomers and glycosides from Xanthocercis zambesiaca.EBI J Nat Prod 60: 312-4 (1997) Hokuriku University 2D 3D TSV
9154976 18 Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs.EBI J Med Chem 40: 1550-8 (1997) Institut de Chimie des Substances Naturelles CNRS 2D 3D TSV
9154975 5 Binding affinities for sulfonamide inhibitors with human thrombin using Monte Carlo simulations with a linear response method.EBI J Med Chem 40: 1539-49 (1997) Yale University 2D 3D TSV
9154973 20 Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding.BDB J Med Chem 40: 1519-29 (1997) University of Auckland 2D 3D TSV
9154971 15 Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).EBI J Med Chem 40: 1495-510 (1997) The Institute of Cancer Research 2D 3D TSV
9154969 20 Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.BDB J Med Chem 40: 1465-74 (1997) DuPont Merck Pharmaceutical Company 2D 3D TSV
9154968 47 Smart region definition: a new way to improve the predictive ability and interpretability of three-dimensional quantitative structure-activity relationships.EBI J Med Chem 40: 1455-64 (1997) University of Perugia 2D 3D TSV
9154967 10 Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.BDB J Med Chem 40: 1447-54 (1997) Universita di Roma La Sapienza 2D 3D TSV
9154966 11 Synthesis and structure-activity relationships of 17beta-substituted 14beta-hydroxysteroid 3-(alpha-L-rhamnopyranoside)s: steroids that bind to the digitalis receptor.EBI J Med Chem 40: 1439-46 (1997) University of Manitoba 2D 3D TSV
9154965 36 Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.EBI J Med Chem 40: 1422-38 (1997) G. D. Searle Research and Development 2D 3D TSV
9152366 4 Novel cyclic peptide agonist of high potency and selectivity for the type II vasoactive intestinal peptide receptor.BDB J Pharmacol Exp Ther 281: 629-33 (1997) University of California, San Francisco 2D 3D TSV
9149537 75 The 5-HT7 receptor: orphan found.BDB Trends Pharmacol Sci 18: 104-7 (1997) Roche Bioscience 2D 3D TSV
9144661 24 BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.BDB Neuropharmacology 36: 233-9 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9139660 4 Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.EBI Science 276: 955-60 (1997) New York University Medical Center 2D 3D TSV
9135033 36 Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter.EBI J Med Chem 40: 1366-72 (1997) INSERM 2D 3D TSV
9135032 217 Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).EBI J Med Chem 40: 1347-65 (1997) Searle Research and Development 2D 3D TSV
9135029 29 Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.EBI J Med Chem 40: 1316-26 (1997) Georgetown University Medical Center 2D 3D TSV
9135028 114 Pharmacological options in the treatment of benign prostatic hyperplasia.EBI J Med Chem 40: 1293-315 (1997) Pfizer Central Research 2D 3D TSV
9134746 2 Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.EBI J Nat Prod 60: 387-9 (1997) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
9131252 80 Pharmacology and functions of metabotropic glutamate receptors.BDB Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Emory University 2D 3D TSV
9125406 23 Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release.BDB Brain Res 753: 219-24 (1997) State University of New York at Old Westbury 2D 3D TSV
9111301 17 Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.EBI J Med Chem 40: 1270-5 (1997) Institute of Cancer Research 2D 3D TSV
9111299 25 N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor.EBI J Med Chem 40: 1252-7 (1997) Yamanouchi Pharmaceutical Company, Ltd. 2D 3D TSV
9111298 18 Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.EBI J Med Chem 40: 1247-51 (1997) Research Triangle Institute 2D 3D TSV
9111297 55 Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.EBI J Med Chem 40: 1230-46 (1997) The University of Toledo 2D 3D TSV
9111295 48 Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the"address" sequence.EBI J Med Chem 40: 1211-8 (1997) Oregon State University 2D 3D TSV
9111294 1 Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.EBI J Med Chem 40: 1201-10 (1997) Université H. Poincaré 2D 3D TSV
9111292 38 Arylamide inhibitors of HIV-1 integrase.EBI J Med Chem 40: 1186-94 (1997) National Cancer Institute 2D 3D TSV
9108306 17 Molecular cloning and characterization of a new receptor for galanin.BDB FEBS Lett 405: 285-90 (1997) Merck Research Laboratories 2D 3D TSV
9103528 17 PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.BDB J Pharmacol Exp Ther 281: 440-7 (1997) Pharmacia & Upjohn, Inc. 2D 3D TSV
9090873 2 Rigidone, a sesquiterpene o-quinone from the gorgonian Pseudopterogorgia rigida.EBI J Nat Prod 60: 309-11 (1997) SmithKline Beecham Pharmaceuticals 2D 3D TSV
9089668 95 Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.BDB Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Northwestern University 2D 3D TSV
9089339 48 Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.EBI J Med Chem 40: 1173-7 (1997) Duquesne University 2D 3D TSV
9089338 29 Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors.EBI J Med Chem 40: 1169-72 (1997) Abbott Laboratories 2D 3D TSV
9089337 3 4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators.EBI J Med Chem 40: 1165-8 (1997) Northwestern University 2D 3D TSV
9089336 77 Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.BDB J Med Chem 40: 1149-64 (1997) Upjohn 2D 3D TSV
9089334 3 Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases.EBI J Med Chem 40: 1130-5 (1997) Warner-Lambert Company 2D 3D TSV
9089333 37 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2.EBI J Med Chem 40: 1112-29 (1997) Universit£ di Firenze 2D 3D TSV
9089328 170 Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.EBI J Med Chem 40: 1063-74 (1997) Warner-Lambert Company 2D 3D TSV
9089327 58 Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities.EBI J Med Chem 40: 1049-62 (1997) Abbott Park 2D 3D TSV
9083493 95 Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.EBI J Med Chem 40: 1026-40 (1997) Merck Research Laboratories 2D 3D TSV
9083491 8 Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).EBI J Med Chem 40: 1005-17 (1997) MediChem Research, Inc. 2D 3D TSV
9083490 37 New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides.EBI J Med Chem 40: 996-1004 (1997) ZENECA Pharmaceuticals 2D 3D TSV
9083489 30 Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.EBI J Med Chem 40: 990-5 (1997) Hungarian Academy of Sciences 2D 3D TSV
9083488 29 Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.EBI J Med Chem 40: 980-9 (1997) Boehringer Ingelheim Pharmaceuticals 2D 3D TSV
9083484 84 New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.EBI J Med Chem 40: 952-60 (1997) Cooperation Pharmaceutique Fran�aise 2D 3D TSV
9083483 172 Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.EBI J Med Chem 40: 942-51 (1997) National Cancer Institute 2D 3D TSV
9083482 40 Hydrazide-containing inhibitors of HIV-1 integrase.EBI J Med Chem 40: 937-41 (1997) National Cancer Institute 2D 3D TSV
9083481 38 Discovery of HIV-1 integrase inhibitors by pharmacophore searching.EBI J Med Chem 40: 930-6 (1997) National Cancer Institute 2D 3D TSV
9083480 125 HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.EBI J Med Chem 40: 920-9 (1997) National Cancer Institute 2D 3D TSV
9083477 11 Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.BDB J Med Chem 40: 885-97 (1997) Uppsala University 2D 3D TSV
9083475 4 Synthesis and pharmacology of novel analogues of oxytocin and deaminooxytocin: directed methods for the construction of disulfide and trisulfide bridges in peptides.EBI J Med Chem 40: 864-76 (1997) University of Minnesota 2D 3D TSV
9083474 12 Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives.EBI J Med Chem 40: 858-63 (1997) University of New Orleans 2D 3D TSV
9083473 33 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.EBI J Med Chem 40: 851-7 (1997) National Institutes of Health 2D 3D TSV
9083471 30 GRID/GOLPE 3D quantitative structure-activity relationship study on a set of benzamides and naphthamides, with affinity for the dopamine D3 receptor subtype.EBI J Med Chem 40: 833-40 (1997) University Centre for Pharmacy 2D 3D TSV
9083470 9 Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.EBI J Med Chem 40: 830-2 (1997) Merck Research Laboratories 2D 3D TSV
9081563 67 Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.BDB J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) TBA 2D 3D TSV
9067317 2 Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).EBI J Pharmacol Exp Ther 280: 1304-11 (1997) Sankyo Co., Ltd. 2D 3D TSV
9067310 20 Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats.BDB J Pharmacol Exp Ther 280: 1241-9 (1997) Institut de Recherches Servier 2D 3D TSV
9057869 25 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.EBI J Med Chem 40: 819-24 (1997) Abbott Laboratories 2D 3D TSV
9057862 41 4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.EBI J Med Chem 40: 754-65 (1997) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
9057861 33 (E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.EBI J Med Chem 40: 749-53 (1997) University of Washington 2D 3D TSV
9057859 37 Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.EBI J Med Chem 40: 730-8 (1997) CoCensys Inc. 2D 3D TSV
9057858 23 From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus.EBI J Med Chem 40: 717-29 (1997) Genentech 2D 3D TSV
9057857 169 Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.EBI J Med Chem 40: 705-16 (1997) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9057856 53 Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid rEBI J Med Chem 40: 695-704 (1997) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
9057855 33 Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.EBI J Med Chem 40: 684-94 (1997) Nippon Zoki Pharmaceutical Company Ltd. 2D 3D TSV
9057854 41 Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.EBI J Med Chem 40: 677-83 (1997) Agouron Pharmaceuticals, Inc. 2D 3D TSV
9057852 74 Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.EBI J Med Chem 40: 659-67 (1997) Hebrew University 2D 3D TSV
9057851 30 Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.EBI J Med Chem 40: 647-58 (1997) INSERM 2D 3D TSV
9057850 27 Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.EBI J Med Chem 40: 639-46 (1997) Pharmacia & Upjohn 2D 3D TSV
9046353 2 (+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent.EBI J Med Chem 40: 622-4 (1997) Auburn University 2D 3D TSV
9046352 86 New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.EBI J Med Chem 40: 608-21 (1997) CNRS-BIOCIS 2D 3D TSV
9046350 8 Conformational analysis of three NK1 tripeptide antagonists: a proton nuclear magnetic resonance study.EBI J Med Chem 40: 594-601 (1997) Universit£ degli Studi di Napoli Federico II 2D 3D TSV
9046348 45 [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.EBI J Med Chem 40: 574-85 (1997) Università di Catania 2D 3D TSV
9046346 1 Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles.EBI J Med Chem 40: 547-58 (1997) J. Uriach & Cía, S.A. 2D 3D TSV
9046341 44 Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI J Med Chem 40: 506-14 (1997) CIBA-GEIGY Corporation 2D 3D TSV
9046340 23 Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI J Med Chem 40: 495-505 (1997) Novartis Pharmaceuticals Corporation 2D 3D TSV
9046338 42 Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.EBI J Med Chem 40: 479-85 (1997) Duquesne University 2D 3D TSV
9046337 48 Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.EBI J Med Chem 40: 470-8 (1997) Duquesne University 2D 3D TSV
9046332 26 Antiulcer agents. 6. Analysis of the in vitro biochemical and in vivo gastric antisecretory activity of substituted imidazo[1,2-a]pyridines and related analogues using comparative molecular field analysis and hypothetical active site lattice methodologies.EBI J Med Chem 40: 427-36 (1997) Schering-Plough Research Institute 2D 3D TSV
9046331 38 Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.BDB J Med Chem 40: 413-26 (1997) Parke-Davis Pharmaceutical Research 2D 3D TSV
9046330 32 Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.EBI J Med Chem 40: 408-12 (1997) Charles University 2D 3D TSV
9045884 44 Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.BDB J Clin Invest 99: 789-98 (1997) Cedars-Sinai Research Institute 2D 3D TSV
9023329 6 Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors.BDB J Pharmacol Exp Ther 280: 1102-8 (1997) University of Cambridge 2D 3D TSV
9023294 3 Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist.BDB J Pharmacol Exp Ther 280: 802-12 (1997) Sanofi Recherche 2D 3D TSV
9022806 7 Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.EBI J Med Chem 40: 385-90 (1997) Abbott Laboratories 2D 3D TSV
9022803 9 Selectin-ligand interactions revealed by molecular dynamics simulation in solution.EBI J Med Chem 40: 362-9 (1997) Kanebo Ltd. 2D 3D TSV
9022799 38 (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.EBI J Med Chem 40: 331-41 (1997) Ferring Research Institute 2D 3D TSV
9022798 58 Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.EBI J Med Chem 40: 322-30 (1997) Abbott Laboratories 2D 3D TSV
9022797 24 Nicotinamide derivatives as a new class of gastric H+/K(+)-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N-substituted 2-(benzhydryl- and benzylsulfinyl)nicotinamides.EBI J Med Chem 40: 313-21 (1997) Dainippon Pharmaceutical Company, Ltd. 2D 3D TSV
9022796 57 5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.EBI J Med Chem 40: 300-12 (1997) Solvay Pharma 2D 3D TSV
9021894 65 Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline.BDB Synapse 25: 137-46 (1997) University of Toronto 2D 3D TSV
9016352 9 Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.BDB Mol Pharmacol 51: 109-18 (1997) Max-Planck Institute for Experimental Medicine 2D 3D TSV
9016337 39 Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model.EBI J Med Chem 40: 125-31 (1997) Universita' degli Studi di Siena 2D 3D TSV
9016336 15 Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.EBI J Med Chem 40: 117-24 (1997) Groningen University Hospital 2D 3D TSV
9016331 6 Synthesis and evaluation of trimetoquinol derivatives: novel thromboxane A2/prostaglandin H2 antagonists with diminished beta-adrenergic agonist activity.EBI J Med Chem 40: 85-91 (1997) Ohio State University 2D 3D TSV
9016330 9 3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors.EBI J Med Chem 40: 73-84 (1997) CoCensys, Inc. 2D 3D TSV
9016329 5 Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.EBI J Med Chem 40: 61-72 (1997) CoCensys, Inc. 2D 3D TSV
9016328 19 Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.EBI J Med Chem 40: 50-60 (1997) DuPont Merck Pharmaceutical Company 2D 3D TSV
9016326 38 Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.EBI J Med Chem 40: 35-43 (1997) Organix Inc. 2D 3D TSV
9016324 54 Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.EBI J Med Chem 40: 18-23 (1997) Allergan Pharmaceuticals 2D 3D TSV
9016323 2 Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.EBI J Med Chem 40: 9-17 (1997) University of Pennsylvania 2D 3D TSV
9016322 10 Rationally designed inhibitors of inosine monophosphate dehydrogenase.EBI J Med Chem 40: 4-8 (1997) University of Chicago 2D 3D TSV
9016321 30 2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.EBI J Med Chem 40: 1-3 (1997) Neurogen Corporation 2D 3D TSV
9015795 50 Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.BDB Neuropsychopharmacology 16: 93 (1997) University of Toronto 2D 3D TSV
9014347 1 Cochliobolic acid, a novel metabolite produced by Cochliobolus lunatus, inhibits binding of TGF-alpha to the EGF receptor in a SPA assay.EBI J Nat Prod 60: 6-8 (1997) Xenova Ltd. 2D 3D TSV
9014146 35 Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors.BDB Neuropharmacology 35: 1307-14 (1996) National Institute of Diabetes, Digestive, and Kidney Diseases 2D 3D TSV
9005255 74 Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides.EBI J Med Chem 39: 5119-36 (1997) Lilly Research Laboratories 2D 3D TSV
9003524 23 3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists.EBI J Med Chem 40: 250-9 (1997) Division of Warner Lambert Company 2D 3D TSV
9003523 71 Coumarin-based inhibitors of HIV integrase.EBI J Med Chem 40: 242-9 (1997) National Cancer Institute 2D 3D TSV
9003521 249 Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety.EBI J Med Chem 40: 226-35 (1997) A Division of Eli Lilly & Company 2D 3D TSV
9003520 15 Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.EBI J Med Chem 40: 216-25 (1997) University of Alberta 2D 3D TSV
9003518 23 Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.EBI J Med Chem 40: 201-9 (1997) Simon Fraser University 2D 3D TSV
9003517 63 Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.EBI J Med Chem 40: 192-200 (1997) Warner-Lambert Company 2D 3D TSV
9003516 17 Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.EBI J Med Chem 40: 181-91 (1997) DuPont Merck Research Laboratories 2D 3D TSV

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EBI Curated by ChEMBL