PMID

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Article Title

Organization

Discovery of [1,2,3]Triazolo[4,5-

Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

Nagoya City University

Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design.

Tu Dortmund University

Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach.

Zhengzhou University

Recent Progress in Histone Demethylase Inhibitors.

University Of Oxford

Cyclopropanamine Compounds and Use Thereof.

Temple University

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.

Kyoto Prefectural University Of Medicine

Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide.

Waseda University

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.

Baylor College Of Medicine

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.

Shandong University

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

Sapienza University Of Rome

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.

Sapienza University Of Rome

Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents.

Zhengzhou University

Histone H3 peptide based LSD1-selective inhibitors.

Waseda University

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

John Hopkins University

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

European Institute Of Oncology

Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.

Medical University Of South Carolina

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

University Of Utah

Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.

Zhengzhou University

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.

University Of Freiburg

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Wayne State University

Oncoepigenomics: making histone lysine methylation count.

TBA

(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.

Wayne State University

Lysine demethylases inhibitors.

Kyoto Prefectural University Of Medicine

Inhibitors of histone demethylases.

University Of Copenhagen

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

University Of Southampton

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor.

Nagoya City University

Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents.

Nanjing University

Heme Proximal Hydrogen Bonding between His170 and Asp132 Plays an Essential Role in the Heme Degradation Reaction of HutZ from Vibrio cholerae.

Hokkaido University

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

Oncology Innovative Medicines Unit

Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors.

Japan Tobacco

A Structure-Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are delta/mu Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists.

University Of Arizona Tucson

Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.

Gnf

Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity.

Karo Bio

Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs.

Crefsip

Acylguanidines as small-molecule beta-secretase inhibitors.

Wyeth Research

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE).

Universite De Montreal At Succursale Centre-Ville

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

Astex

Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.

Tohoku College Of Pharmacy

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.

Merck Research Laboratories

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Glaxosmithkline

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.

University Of Newcastle

Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.

Sugen

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.

University Of Auckland

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

Hebrew University Of Jerusalem

Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.

Novartis Pharma

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.

University Of Otago

Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.

Eli Lilly