PMID

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Article Title

Organization

Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.

Universidad Nacional Del Sur

Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp.

Mahidol University

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Universit£

First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.

University Of Bonn

Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.

University Of Hamburg

Aminopyridazines as acetylcholinesterase inhibitors.

Universit£

Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.

University Of North Carolina

The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.

Eisai

Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.

The Chinese Academy Of Sciences

 

m-Alkyl, α,α,α-trifluoroacetophenones: A new class of potent transition state analog inhibitors of acetylcholinesterase

TBA

Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.

Sun Yat-Sen University

Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.

Syros Pharmaceuticals

Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.

Instituto PolitéCnico Nacional

Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.

Istituto Di Strutturistica Chimica G. Giacomello

Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.

The University Of Kansas Medical Center

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Vanderbilt University

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases.

University Of Oxford

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.

Harvard Medical School

Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.

University Of California San Francisco

Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.

Cancer Research Uk Centre For Cancer Therapeutics

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

Wyeth Research

Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

A* Star

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.

Sunesis Pharmaceuticals