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220 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI
Wayne State University
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.EBI
National University Of Singapore
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI
Georgia Institute Of Technology
Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.EBI
Tsinghua University
2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.EBI
Taipei Medical University
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.EBI
Integral Biosciences
Synthesis of a selective HDAC6 inhibitor active in neuroblasts.EBI
University Of Geneva
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI
University Of Navarra
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI
Broad Institute Of Mit And Harvard
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI
West China Hospital Of Sichuan University
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.EBI
China Pharmaceutical University
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.EBI
Martin-Luther University Of Halle-Wittenberg
Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.EBI
Sungkyunkwan University
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI
University Of Milan
Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI
Sungkyunkwan University
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI
Sichuan University
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.EBI
Shanghai Institute Of Materia Medica
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.EBI
Washington University
Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.EBI
Albert-Ludwigs-University Of Freiburg
Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.EBI
Universidade Federal De Alfenas
Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI
Shenyang Pharmaceutical University
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.EBI
Massachusetts General Hospital
Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI
Shenyang Pharmaceutical University
Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI
Orchid Chemicals & Pharmaceuticals
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.EBI
China Pharmaceutical University
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.EBI
European Institute Of Oncology
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI
University Of Minnesota
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.EBI
Wroclaw University Of Technology
Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.EBI
China Pharmaceutical University
Triazine as a promising scaffold for its versatile biological behavior.EBI
Thapar University
New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.EBI
Ronzoni Institute For Chemical And Biochem. Research
Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.EBI
University Of Milan
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI
Guangzhou Institute Of Biomedicine And Health
Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.EBI
Shandong University
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI
University Of Minnesota
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI
University College London
Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.EBI
The Walter And Eliza Hall Institute Of Medical Research
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI
St. Jude Children'S Research Hospital
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI
Novartis Institutes For Biomedical Research
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI
University Of Florida
Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.EBI
The Walter And Eliza Hall Institute Of Medical Research
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.EBI
Colorado State University
Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.EBI
Shandong University
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.EBI
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University)
Natural Product Primary Sulfonamides and Primary Sulfamates.EBI
Griffith University
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.EBI
University Of California
Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.EBI
Fujian University Of Traditional Chinese Medicine
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.EBI
Methylgene
Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI
Shandong University
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI
Istituto Ortopedico Rizzoli (Ior)
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.EBI
Yonsei University
Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.EBI
Georgia Institute Of Technology
Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.EBI
Central South University
Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.EBI
Roche Innovation Center Shanghai
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.EBI
Taipei Medical University
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI
H�Pital Kirchberg
A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.EBI
University Of Oklahoma
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.EBI
Sapienza University Of Rome
Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI
Nippon Pharmaceutical Chemicals
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI
Shandong University
Aurones as histone deacetylase inhibitors: identification of key features.EBI
University Of Geneva
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI
TBA
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI
Technical University Of Denmark
The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.EBI
Georgia Institute Of Technology
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI
Roche Pharmaceutical Research And Early Development
ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.EBI
University Of Bologna
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI
Chinese Academy Of Sciences
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.EBI
Csir-Indian Institute Of Integrative Medicine
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.EBI
Chinese National Center For Drug Screening
Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.EBI
Nagoya University
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.EBI
Merck Research Laboratories
Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI
Taipei Medical University
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI
Universit£
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI
Universit£
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI
Universit£
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI
Shandong University
Development of a chimeric c-Src kinase and HDAC inhibitor.EBI
University Of Michigan
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.EBI
National Taiwan University
3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.EBI
Georgia Institute Of Technology
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI
Broad Institute Of Mit And Harvard
Development ofEBI
Shandong University
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.EBI
Heinrich Heine Universit£T
The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.EBI
Wayne State University
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.EBI
Kyoto Prefectural University Of Medicine
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI
Roche R & D Center China
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI
University Of Illinois At Chicago
Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.EBI
TBA
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.EBI
Graduate School Of Life Science And Systems Engineering
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI
Kyoto Prefectural University Of Medicine
Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.EBI
TBA
CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.EBI
Chinese Academy Of Sciences
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.EBI
Taipei Medical University
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.EBI
Imperial College
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI
Guru Ghasidas University
Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.EBI
Georgia Institute Of Technology
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.EBI
University Of Illinois At Chicago
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR.EBI
TBA
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI
Broad Institute Of Harvard And Mit
Diversity-oriented synthesis: exploring the intersections between chemistry and biology.EBI
Memorial Sloan-Kettering Cancer Center
On the inhibition of histone deacetylase 8.EBI
University Of Notre Dame
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.EBI
Mcgill University
Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.EBI
Takeda California
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.EBI
The Scripps Research Institute
Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide.EBI
Georgia Institute Of Technology
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI
Irbm/Merck Research Laboratories
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.EBI
The Broad Institute Of Harvard And Mit
Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.EBI
Waseda University
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).EBI
University Of Freiburg
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI
Merck Research Laboratories
Histone deacetylase inhibitors: from bench to clinic.EBI
Menarini Ricerche
A series of novel, potent, and selective histone deacetylase inhibitors.EBI
Irbm/Merck Research Laboratories
Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.EBI
Crest Research Project
Histone deacetylase inhibitors.EBI
Aton Pharma
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.EBI
Sapienza University Of Rome
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.EBI
Merck Research Laboratories
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.EBI
Merck Research Laboratories
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.EBI
Dac
Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.EBI
University Of Applied Sciences
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).EBI
Harvard Medical School
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI
University Of Illinois At Chicago
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.EBI
Wayne State University
Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.EBI
University Of Wisconsin-Milwaukee
Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities.EBI
Shandong University
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI
S*Bio
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.EBI
Taipei Medical University
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.EBI
Novartis Institutes For Biomedical Research
Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.EBI
East China Normal University
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI
Broad Institute Of Harvard And Mit
Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.EBI
Chroma Therapeutics
Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.EBI
Shandong University
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI
Universita` Degli Studi Di Siena
Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI
Yonsei University
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and ActivityEBI
TBA
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.EBI
University Of Regensburg
Inhibitors selective for HDAC6 in enzymes and cells.EBI
The University Of Queensland
An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist.EBI
Mcgill University
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI
The Scripps Research Institute
Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI
Università
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.EBI
Georgia Institute Of Technology
Inside HDAC with HDAC inhibitors.EBI
Universit£
Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI
S*Bio
Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI
Universit£
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI
Novartis Institutes For Biomedical Research
Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI
University Of Illinois At Chicago
Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.EBI
Graduate School Of Life Science And Systems Engineering
Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI
Curis
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI
Ortho-Biotech Oncology Research & Development
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.EBI
Methylgene
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.EBI
Istituto Di Ricerche Di Biologia Molecolare
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI
Sigma-Tau Research And Development
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.EBI
Irbm/Merck Research Laboratories
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI
University Of Illinois At Chicago
Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.EBI
Nagoya City University
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI
Irbm/Merck Research Laboratories
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.EBI
University Of Regensburg
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI
R&D Sigma-Tau
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.EBI
Methylgene
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI
Merck Research Laboratories
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI
S*Bio
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).EBI
Methylgene
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.EBI
Methylgene
Sulfamides as novel histone deacetylase inhibitors.EBI
Methylgene
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.EBI
Irbm-Merck Research Laboratories Rome
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI
Merck Research Laboratories
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.EBI
Irbm-Merck Research Laboratories Rome
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI
Institute Of Organic Synthesis
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI
University Of Illinois At Chicago
Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.EBI
Nycomed
Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI
Merck Research Laboratories
Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.EBI
Graduate School Of Life Science And Systems Engineering
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI
Merck Research Laboratories
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.EBI
The University Of Tokyo
Design of novel histone deacetylase inhibitors.EBI
Merck Research Laboratories
Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.EBI
University Of Illinois At Chicago
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.EBI
Ithaca College
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.EBI
Nagoya City University
Design and synthesis of phthalimide-type histone deacetylase inhibitors.EBI
The University Of Tokyo Yayoi
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.EBI
The Scripps Research Institute
Potent and Selective EphA4 Agonists for the Treatment of ALS.BDB
Sanford Burnham Prebys Medical Discovery Institute
Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.BDB
Shandong University
Localization and function of the D3 dopamine receptor.BDB
U. 109
Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB
National Institutes Of Diabetes And Digestive And Kidney Diseases
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.BDB
Sanofi Recherche
Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.BDB
TBA
Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.BDB
TBA
Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.BDB
University Of Amsterdam
Quinolone-based HDAC inhibitors.BDB
Orchid Chemicals & Pharmaceuticals
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.BDB
Sapienza University Of Rome