PMID

Data

Article Title

Organization

Carbamazepine derivatives with P2X4 receptor-blocking activity.

University of Bonn

Design and synthesis of potent and selective P2X3 receptor antagonists derived from PPADS as potential pain modulators.

Gwangju Institute of Science and Technology (Gist)

Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists.

Gwangju Institute of Science and Technology

Ion channels as therapeutic targets: a drug discovery perspective.

Pfizer

Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.

University of Bonn

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.

Roche Palo Alto

N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.

University of Bonn

Discovery of P2X3 selective antagonists for the treatment of chronic pain.

Astrazeneca

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

Abbott Laboratories

Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.

Institute of Science and Technology

Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques.

Universit£

Purine and pyrimidine (P2) receptors as drug targets.

National Institute of Diabetes

Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist.

Roche Palo Alto

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.

Hoffmann-La Roche

Identification of second-generation P2X3 antagonists for treatment of pain.

Merck

Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells.

Gwangju Institute of Science and Technology (Gist)

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.

Shionogi

Inactivation of acetylcholinesterase by various fluorophores.

The University of Montana

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

The University of Queensland

Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.

University of Florence

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

Wyeth Research

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Merck Frosst Canada

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

Saarland University

New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.

Novartis Pharmaceuticals

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.

University of Pennsylvania