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37 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Identification of the first potent, selective and bioavailable PPARa antagonist.EBI
Inception Sciences
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptorß agonist in clinical trials for the treatment of dyslipidemia.EBI
Madrigal Pharmaceuticals
Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptorß agonists.EBI
Sanwa Kagaku Kenkyusho
Development of novel Vitamin D Receptor-Coactivator Inhibitors.EBI
University Of Wisconsin-Milwaukee
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.EBI
St. Jude Children'S Research Hospital
Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors.EBI
New York University School Of Medicine
Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptorß (TRß) selective agonists.EBI
Kissei Pharmaceutical
2D QSAR studies on thyroid hormone receptor ligands.EBI
Universidade De S£O Paulo
QSAR study of selective ligands for the thyroid hormone receptor beta.EBI
University Of Insubria
Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.EBI
Zydus Research Centre
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.EBI
Institut Pasteur Korea
Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia.EBI
Kissei Pharmaceutical
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.EBI
University Of California San Francisco
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.EBI
Abbott Laboratories
Thyroid receptor agonists for the treatment of androgenetic alopecia.EBI
Pfizer
Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.EBI
St. Jude Children'S Hospital
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.EBI
Metabasis Therapeutics
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands.EBI
Zydus Research Centre
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.EBI
Metabasis Therapeutics
Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.EBI
Karo Bio
A new class of high affinity thyromimetics containing a phenyl-naphthylene core.EBI
Pharmaceutical Research Institute
Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines.EBI
Eli Lilly
Structural determinants of selective thyromimetics.EBI
University Of California
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.EBI
Pfizer
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.EBI
University Of California
Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.EBI
Karo Bio
A designed antagonist of the thyroid hormone receptor.EBI
University Of California
DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties.BDB
Purdue Pharma Discovery Research
WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake.BDB
Wyeth Research
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.BDB
Brigham And Women'S Hospital
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation.BDB
Tohoku University