PMID

Data

Article Title

Organization

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

University Of Arizona

Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.

Uppsala University

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

University Of Arizona

Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.

Uppsala University

Design and synthesis of side-chain conformationally restricted phenylalanines and their use for structure-activity studies on tachykinin NK-1 receptor.

Universit£

Tetrapeptide tachykinin antagonists: synthesis and modulation of the physicochemical and pharmacological properties of a new series of partially cyclic analogs.

Institut De Recherches Servier

Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles.

Rochester

Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.

Rochester

Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.

TBA

Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.

Novartis Institute For Medical Sciences

 

An SAR study for the non-peptide substance P receptor (NK1) antagonist, CP-96,345.

TBA

Discovery of a potent and efficacious peptide derivative ford/µ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

University Of Arizona

Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

Uppsala University

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

University Of Arizona

 

3-Benzyloxy-2-phenylpiperidine NK₁ antagonists: the influence of alpha methyl substitution

TBA

 

4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists

TBA

 

Perhydrothiopyranopyrroles derivatives : A novel series of potent and selective nonpeptide NK1 antagonists.

TBA

 

Application of the multipin peptide synthesis technique for peptide receptor binding studies: Substance P as A model system

TBA

 

A facile synthesis of the novel Neurokinin A antagonist SR 48968

TBA

 

Synthesis of RP-67,580, a new potent nonpeptide substance P antagonist

TBA

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

University Of Arizona

Conformational comparisons of a series of tachykinin peptide analogs.

Mississippi State University

3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.

Eli Lilly

Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.

Merck Sharp And Dohme Research Laboratories

Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists.

Merck Sharp And Dohme Research Laboratories

Antagonists of substance P. Further modifications of substance P antagonists obtained by replacing either positions 7, 9 or 7, 8 and 11 of SP with D-amino acid residues.

TBA

Synthesis and substance P antagonist activity of naphthimidazolium derivatives.

Rochester