Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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18 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.

Aurigene Discovery Technologies

Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.

Aurigene Discovery Technologies

Factor Xa inhibitors: next-generation antithrombotic agents.

Bristol-Myers Squibb

GRID/CPCA: a new computational tool to design selective ligands.

Boehringer Ingelheim Pharma

Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.

Klinikum Der Friedrich-Schiller-Universit£T Jena

Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.

Rh£Ne-Poulenc Rorer

Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.

Endotis Pharma

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors

TBA

Characterization of LY806303 as a potent and selective inhibitor of thrombin

TBA

Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position.

University Of Antwerp

Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.

Pfizer

Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the (D)-Arg-Gly-Arg tripeptide sequence.

Cor Therapeutics

3-Amidinophenylalanine-based inhibitors of urokinase.

UniversitäT Jena

Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

Institut FüR Biochemie

Design of benzamidine-type inhibitors of factor Xa.

Institut FüR Biochemie

Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions.

Eli Lilly