PMID

Data

Article Title

Organization

Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties.

Pennwalt

Carbostyril derivatives having potent beta-adrenergic agonist properties.

TBA

Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without beta-adrenoceptor antagonism.

TBA

Affinity labels for beta-adrenoceptors: preparation and properties of alkylating beta-blockers derived from indole.

TBA

Alkylating beta-blockers: activity of isomeric bromoacetyl alprenolol menthanes.

TBA

Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.

TBA

Synthesis and adrenoceptor affinity of some highly polar beta-substituted catecholamines.

TBA

beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.

TBA

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.

TBA

Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.

Kissei Pharmaceutical

Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.

Universit£

Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.

Kissei Pharmaceutical

Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.

National Institute Of Diabetes And Digestive And Kidney Diseases

SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.

Searle Research And Development

Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.

Bristol-Myers Squibb

Design and synthesis of propranolol analogues as serotonergic agents.

Virginia Commonwealth University

Syntheses and adrenergic activities of ring-fluorinated epinephrines.

National Institute Of Diabetes

Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.

TBA

Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.

Medical University Of Lublin

Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.

National Institute Of Mental Health

 

SYNTHESIS AND BIOLOGICAL EVALUATION OF A FLUORINATED ANALOG OF THE β-ADRENERGIC BLOCKING AGENT, METOPROLOL

TBA

(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.

Wyeth Research (Uk)

Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.

Mayo Foundation

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.

Eli Lilly

Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.

Solvay Duphar

In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.

TBA

Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.

Warner-Lambert

(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.

TBA

Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.

National Institute Of Diabetes

Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.

Virginia Commonwealth University

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

American Cyanamid

Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.

University Of North Carolina At Chapel Hill

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

University Of North Carolina At Chapel Hill