PMID

Data

Article Title

Organization

Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent.

Sungkyunkwan University

 

Quaternised renzapride as a potent and selective 5-HT4 receptor agonist

TBA

Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease.

Pfizer

Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.

Pfizer

Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.

Pfizer

5-HT4 receptor ligands: applications and new prospects.

Paris-Sud University

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.

Universidad Complutense

New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.

Cnrs-Biocis

Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.

Universit£

 

Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives

TBA

 

Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands

TBA

 

Synthesis and pharmacological activity of a macrocyclic benzamide

TBA

 

New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor

TBA

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

Universidad Complutense De Madrid

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.

TBA

 

Serotonin 5-HT₄ agonist activity of a series of meso-azanoradamantane benzamides

TBA

 

Design of a potent 5-HT₄ receptor agonist with nanomolar affinity

TBA

Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

Merck

Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.

Pfizer

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

Universidad Complutense

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.

Universidad Complutense

3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor.

Universidad Complutense

Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors.

Cnrs-Biocis

Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.

Solvay Duphar

Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers.

Panjab University