PMID

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Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents.

University Of Messina

Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase.

TBA

Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.

Xiangtan University

Identification of new non-carboxylic acid containing inhibitors of aldose reductase.

University Of Messina

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

Universit£

Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.

Universit£

Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.

Sankyo

1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.

Universit£

Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.

TBA

Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.

Wyeth-Ayerst Research

Spiro hydantoin aldose reductase inhibitors.

Pfizer

Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.

Universit£

In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.

University Of Messina

Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.

Central South University

 

Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase

TBA

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors.

Dipartimento Di Scienze Farmaceutiche

Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.

Ep811-Cnrs

N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3-diones. 2.

Wyeth-Ayerst Research

Spiro oxazolidinedione aldose reductase inhibitors.

TBA

N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

TBA

Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.

TBA

Computer-assisted design and synthesis of novel aldose reductase inhibitors.

Wyeth-Ayerst Research

(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.

Wyeth-Ayerst Research

Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.

Wyeth-Ayerst Research

Quinazolineacetic acids and related analogues as aldose reductase inhibitors.

Wyeth-Ayerst Research