PMID

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Article Title

Organization

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.

University Of California Davis

Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.

Sumitomo Dainippon Pharma

Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.

Dainippon Sumitomo Pharma

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.

Toray Industries

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.

Toray Industries

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

Glaxosmithkline

The many faces of the adamantyl group in drug design.

University Of Sydney

A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors.

Dainippon Sumitomo Pharma

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

Merck Research Laboratories

Orally bioavailable potent soluble epoxide hydrolase inhibitors.

University Of California Davis

Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method.

Boehringer Ingelheim Pharmaceuticals

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

Merck Research Laboratories

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.

Boehringer Ingelheim Pharmaceuticals

Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.

Boehringer Ingelheim Pharmaceuticals

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.

Merck Research Laboratories

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.

Boehringer Ingelheim Pharmaceuticals

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.

Merck Research Laboratories

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

University Of California Davis

Adamantyl thioureas as soluble epoxide hydrolase inhibitors.

University Of California Davis

Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.

University Of California Davis