PMID

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Article Title

Organization

Magnetic Microbead Affinity Selection Screening (MagMASS) of Botanical Extracts for Inhibitors of 15-Lipoxygenase.

University Of Illinois At Chicago

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.

University Of Groningen

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution.

University Of California San Diego

A potent and selective inhibitor targeting human and murine 12/15-LOX.

University Of California

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.

University Of Groningen

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1.

Uppsala University

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase.

Uppsala University

Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.

University Of California

Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.

Goethe-University Frankfurt

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

University Jena

Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.

University Of Naples

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Harvard Medical School

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.

National Institutes Of Health

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.

University Of Salerno

Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors.

Mashhad University Of Medical Sciences

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

University Of California Santa Cruz

Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

University Of California Santa Cruz

Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.

San Francisco State University

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

University Of California

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Atherogenics

Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

University Of California

Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.

Gazi University

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

National Human Genome Research Institute

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Bristol-Myers Squibb Research And Development

Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.

Merck Frosst Centre For Therapeutic Research

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

National Human Genome Research Institute

Enzyme Inhibitors: New and Known Polybrominated Phenols and Diphenyl Ethers from Four Indo-Pacific Dysidea Sponges

TBA

 

Catechol based inhibitors of 15-lipoxygenase

TBA

 

1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor

TBA

An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.

University Of California

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Universidad De Santiago De Chile

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

University Of California

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

University Of California

A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor.

Tamkang University

Effect of catechol derivatives on cell growth and lipoxygenase activity.

Aston University

5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.

Abbott Laboratories

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.

Merck Frosst Canada