PMID

Data

Article Title

Organization

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

Boehringer Ingelheim Pharmaceuticals

Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors.

Palatin Technologies

 

A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastase

TBA

 

Synthesis and porcine pancreatic elastase inhibitory evaluation of 6α-(sulfonyl)oxy-and 6α-chloropenicillanate sulfone esters and 3α-(acyloxy)methyl-6α-chloropenam sulfones

TBA

 

1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhi...

TBA

 

Enantioselective synthesis and antielastase activity of 1,3,4-trisubstituted and 3,4-disubstituted β-lactam antibiotics

TBA

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

The Oxford Centre For Molecular Sciences And The Dyson Perrins Laboratory

Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.

The Oxford Centre For Molecular Sciences

Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.

Kyoto Pharmaceutical University

Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.

Nippon Steel

N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.

Nippon Steel

Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.

Boehringer Ingelheim (Canada)

Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.

Boehringer Ingelheim (Canada)

Peptidomimetic inhibitors of the human cytomegalovirus protease.

Boehringer Ingelheim

Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.

Zeneca Pharmaceuticals

7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.

Southern Methodist University

Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives.

Institut De Recherche Servier

Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.

Zeneca Pharmaceuticals Group

Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.

Thrombosis Research Institute

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.

Zeneca Pharmaceuticals