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117 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.EBI
Harvard Medical School
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI
Jagiellonian University Medical College
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.EBI
University Of Kansas
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.EBI
Vanderbilt University
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI
Jagiellonian University Medical College
Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.EBI
Universit Degli Studi Di Milano
Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding.EBI
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Molecular determinants of biased agonism at the dopamine D2 receptor.EBI
Friedrich-Alexander University
Further evaluation of the tropane analogs of haloperidol.EBI
Florida A&M University
Identification of a new selective dopamine D4 receptor ligand.EBI
Florida A&M University
Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.EBI
State Key Laboratory Of Drug Research
Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand.EBI
Goethe University
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI
The University Of Sydney
Synopsis of some recent tactical application of bioisosteres in drug design.EBI
Bristol-Myers Squibb Pharmaceutical Research And Development
Bis-spirolabdane diterpenoids from Leonotis nepetaefolia.EBI
University Of Mississippi
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.EBI
The University Of Sydney
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI
National Institute Of Mental Health
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.EBI
Gedeon Richter
N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors.EBI
National Institute Of Mental Health
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI
National Institute Of Mental Health
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI
Hunter College And The Graduate Center Of The City University Of New York
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?EBI
Friedrich-Schiller-Universit£T Jena
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics.EBI
Johann Wolfgang Goethe Universit£T
High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.EBI
Purdue University
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI
Abbott Laboratories
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.EBI
Purdue University
Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.EBI
University Of Bonn
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists.EBI
Universit£
Selective optimization of side activities: another way for drug discovery.EBI
Prestwick Chemical
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).EBI
Purdue University
From hit to lead. Analyzing structure-profile relationships.EBI
Universities Of Lille
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI
Virginia Commonwealth University
Chiral indolo[3,2-f][3]benzazecine-type dopamine receptor antagonists: synthesis and activity of racemic and enantiopure derivatives.EBI
Martin-Luther-Universit£T Halle-Wittenberg
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.EBI
University Of South Florida
Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity.EBI
The University Of Sydney
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.EBI
The University Of Sydney
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.EBI
National Institute Of Mental Health
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.EBI
Purdue University
Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.EBI
Friedrich-Schiller-Universit£T Jena
Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.EBI
Merck Research Laboratories
Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.EBI
Merck Research Laboratories
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI
University Of Medicine And Dentistry Of New Jersey-Robert Wood Johnson Medical School And The Informatics Institute Of Umdnj
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI
Institute Of Nuclear Chemistry Johannes Gutenberg-University Mainz
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.EBI
Pfizer
Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.EBI
Friedrich-Schiller-UniversitäT Jena
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.EBI
Cairo University
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI
National Institute Of Mental Health
Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.EBI
Friedrich-Schiller-UniversitäT Jena
Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors.EBI
Friedrich-Schiller-UniversitäT Jena
Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.EBI
Schering-Plough Research Institute
Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1.EBI
University Of Nebraska Medical Center
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.EBI
Lundbeck Research Usa
Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.EBI
Friedrich-Schiller-UniversitäT Jena
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI
Columbia University College Of Physicians And Surgeons
Abolishing Dopamine DEBI
University Of Regensburg
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI
Columbia University College Of Physicians And Surgeons
Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.EBI
University Of Nebraska Medical Center
Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com.EBI
Abbott
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.EBI
Columbia University College Of Physicians And Surgeons
2-(Fluoromethoxy)-4'-(EBI
Universidad Complutense De Madrid
Distal kinetic deuterium isotope effect: Phenyl ring deuteration attenuates N-demethylation of Lu AF35700.EBI
H. Lundbeck
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2YEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.EBI
Friedrich-Schiller-UniversitäT Jena
Adenosine AEBI
Heinrich Heine University Duesseldorf
New tetrahydroisoquinoline-based DEBI
City University Of New York
Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.EBI
Cracow University Of Technology
1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.EBI
Neurogen
Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2YEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Isolation and Pharmacological Characterization of Six Opioidergic EBI
University Of Illinois At Chicago
Structure-Activity Relationship of Heterocyclic P2YEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Development of pyrimidone D1 dopamine receptor positive allosteric modulators.EBI
National Institutes Of Health
Identification of C10 nitrogen-containing aporphines with dopamine DEBI
City University Of New York
Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines.EBI
City University Of New York
Exploration of Alternative Scaffolds for P2YEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge EBI
University Of Mississippi
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.EBI
University Of Texas Medical Branch
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective DEBI
National Institute Of Neurological Disorders And Stroke
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.EBI
Shanghaitech University
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI
Knoll Pharmaceuticals
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine DEBI
University Of Pennsylvania
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine DEBI
University Of North Carolina At Chapel Hill
NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.EBI
Neurogen
Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine DEBI
Temple University School Of Pharmacy
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1EBI
Amri
Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine DEBI
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HTEBI
University Of Minnesota Twin Cities
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.EBI
Yamanouchi Pharmaceutical
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.EBI
Drug Discovery Laboratory
Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.EBI
Pfizer
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.EBI
Texas Tech University Health Sciences Center
Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine DEBI
Southern Illinois University Edwardsville
Structure-Guided Modification of Heterocyclic Antagonists of the P2YEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Development of molecular tools based on the dopamine DEBI
Friedrich-Alexander University
?-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.EBI
Friedrich-Alexander University Erlangen-N£Rnberg
Return of DEBI
University Of Nebraska Medical Center
Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for?-Arrestin-Biased DEBI
Friedrich-Alexander University Erlangen-Nuernberg
Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.BDB
Case Western Reserve University
Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.BDB
Columbia University
WAY-100635 is a potent dopamine D4 receptor agonist.BDB
Purdue University
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.BDB
Mcgill University
Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex.BDB
Case Western Reserve University
SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization.BDB
Sanofi-Synthelabo Recherche
Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.BDB
Harvard University
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.BDB
Case Western Reserve University
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.BDB
Case Western Reserve University
L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.BDB
Case Western Reserve University
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.BDB
Institut De Recherches Servier
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.BDB
Case Western Reserve University
In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.BDB
WestfÄLische Wilhelms-UniversitÄ
The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor.BDB
Case Western Reserve University
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.BDB
Centre De Recherches De Croissy
Iloperidone binding to human and rat dopamine and 5-HT receptors.BDB
Hoechst Marion Roussel
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.BDB
Hoechst Marion Roussel
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.BDB
University Of Toronto