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Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.

Tohoku Medical And Pharmaceutical University

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

Indiana University School Of Medicine

Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.

Sanford-Burnham Medical Research Institute

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

Indiana University

Therapeutic potential of targeting the oncogenic SHP2 phosphatase.

Indiana University School Of Medicine

Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.

Shandong University

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.

Japan Science And Technology Agency

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

Indiana University School Of Medicine

Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.

Chinese Academy Of Medical Sciences And Peking Union Medical College

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Indiana University School Of Medicine

Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.

University Of Paris

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.

TBA

Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.

Imperial College

Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

Indiana University School Of Medicine

Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.

Sanford-Burnham Medical Research Institute

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Indiana University School Of Medicine

Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors.

New York University

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.

Xiamen University

Using small molecules to target protein phosphatases.

Max Planck Institute Of Molecular Physiology

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

University Of California

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Indiana University School Of Medicine

Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.

Institute For Medical Research

 

Synthesis and phosphatase inhibitory activity of analogs of sulfircin

TBA

Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.

Institute For Medical Research

Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.

University Of Bonn

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.

Eli Lilly

Protein tyrosine phosphatase 1B inhibitors from Morus root bark.

Korea Research Institute Of Bioscience And Biotechnology (Kribb)

PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.

Korea Research Institute Of Chemical Technology

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.

Technische UniversitäT MüNchen

Rhodanine derivatives as inhibitors of JSP-1.

Ceptyr

Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.

The Ohio State University

Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets.

Shandong University

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.

Purdue University

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

University Of Pittsburgh

Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition.

Tohoku University

Highly Potent and Selective

Purdue University

Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.

University Of Pittsburgh

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.

Wyeth-Ayerst Research

Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.

University Of Utah

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.

Wyeth-Ayerst Research

Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

Indiana University School Of Medicine

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.

University Of Manchester

A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.

Tohoku Medical And Pharmaceutical University

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.

Chinese Academy Of Sciences

The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors.

Max-Planck-Institut FÜR Kohlenforschung

Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

University Of California Berkeley