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425 articles for Abbott Laboratories

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
1433199 Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics. 16-OCT-1992 16-FEB-2019
2491891 Synthesis and activity of nonhydrolyzable pseudomonic acid analogues. XX-JAN-1989 04-JAN-2019
15006412 Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. 22-MAR-2004 26-NOV-2018
14552787 A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. 03-NOV-2003 17-NOV-2018
14592473 Heterocyclic ketones as inhibitors of histone deacetylase. 17-NOV-2003 17-NOV-2018
12951120 Alpha-keto amides as inhibitors of histone deacetylase. 06-OCT-2003 15-NOV-2018
12749893 Indole amide hydroxamic acids as potent inhibitors of histone deacetylases. 02-JUN-2003 12-NOV-2018
12419380 Trifluoromethyl ketones as inhibitors of histone deacetylase. 02-DEC-2002 09-NOV-2018
12270175 Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC). 21-OCT-2002 07-NOV-2018
12372505 Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands. 04-NOV-2002 07-NOV-2018
12113835 Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1. 05-AUG-2002 02-NOV-2018
14698167 Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder. 19-JAN-2004 16-SEP-2018
15784656 Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. XX-XXX-2005 14-DEC-2017
9873625 Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. 02-FEB-1999 10-DEC-2014
17482819 Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists. 22-JUN-2007 23-SEP-2013
10978192 Privileged molecules for protein binding identified from NMR-based screening. 05-OCT-2000 22-SEP-2013
21536435 Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists. 20-MAY-2011 22-MAY-2013
18438986 Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists. 16-MAY-2008 21-MAY-2013
19397270 Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain. 22-MAY-2009 21-MAY-2013
19385614 Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes. 22-MAY-2009 21-MAY-2013
20171098 Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. 08-MAR-2010 21-MAY-2013
18272366 Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists. 17-MAR-2008 21-MAY-2013
17181167 Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists. 21-DEC-2006 20-MAY-2013
17585748 Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors. 19-JUL-2007 20-MAY-2013
16759108 Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. 08-JUN-2006 20-MAY-2013
14971889 Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues. 19-FEB-2004 20-MAY-2013
12113836 Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs. 12-JUL-2002 19-MAY-2013
12657274 Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists. 26-MAR-2003 19-MAY-2013
23103095 Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors. 26-NOV-2012 17-MAY-2013
22263872 Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. 23-FEB-2012 17-MAY-2013
22695126 Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases. 03-JUL-2012 08-FEB-2013
22766219 Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. 20-JUL-2012 08-FEB-2013
22727637 Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors. 03-JUL-2012 08-FEB-2013
22738639 Contribution of indazolinone tautomers to kinase activity. 03-JUL-2012 08-FEB-2013
22465635 Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families. 20-APR-2012 07-FEB-2013
22626552 Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²¿ channel blockers with analgesic activity. 15-JUN-2012 07-FEB-2013
22370265 Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management. 19-MAR-2012 07-FEB-2013
20570528 Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists. 25-MAR-2011 31-DEC-2012
19919896 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. 03-FEB-2010 27-DEC-2012
19954975 Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. 03-FEB-2010 27-DEC-2012
19402666 Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors. 22-MAY-2009 23-DEC-2012
19552432 Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. 16-JUL-2009 23-DEC-2012
18023347 Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. 09-JAN-2008 15-DEC-2012
18272364 Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R). 17-MAR-2008 15-DEC-2012
18198823 Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. 21-FEB-2008 15-DEC-2012
18362070 Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. 15-APR-2008 15-DEC-2012
17483457 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. 22-MAY-2007 15-DEC-2012
18358720 Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors. 03-APR-2008 15-DEC-2012
18077160 In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. 09-JAN-2008 15-DEC-2012
18176998 Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. 08-FEB-2008 14-DEC-2012
18242993 Synthesis of potent pyrrolidine influenza neuraminidase inhibitors. 10-MAR-2008 14-DEC-2012
17827013 Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors. 01-OCT-2007 13-DEC-2012
17935989 Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. 06-NOV-2007 13-DEC-2012
17070047 Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists. 25-DEC-2006 10-DEC-2012
17434733 Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors. 04-JUN-2007 10-DEC-2012
17530838 Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. 21-JUN-2007 10-DEC-2012
16987661 Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists. 10-NOV-2006 09-DEC-2012
16789734 Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors. 22-JUN-2006 07-DEC-2012
15634000 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention. 06-JAN-2005 03-DEC-2012
15293993 Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes. 05-AUG-2004 02-DEC-2012
15239663 Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. 08-JUL-2004 30-NOV-2012
15084133 Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. 15-APR-2004 30-NOV-2012
15261265 Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator-statin hybrids. 20-JUL-2004 30-NOV-2012
15261266 Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator. 20-JUL-2004 30-NOV-2012
10691695 Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors. 16-MAR-2000 25-NOV-2012
11356099 Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. 17-MAY-2001 25-NOV-2012
10229619 Emerging molecular approaches to pain therapy. 03-JUN-1999 14-NOV-2012
9784104 Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase. 23-NOV-1998 08-NOV-2012
9435889 Neuronal nicotinic acetylcholine receptors as targets for drug discovery. 13-FEB-1998 05-NOV-2012
9171869 Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. 27-JUN-1997 04-NOV-2012
9207936 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. 07-AUG-1997 04-NOV-2012
8709092 Modulators of leukotriene biosynthesis and receptor activation. 10-SEP-1996 01-NOV-2012
7490726 (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. 02-JAN-1996 31-OCT-2012
7658429 (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431). 04-OCT-1995 30-OCT-2012
8164249 Application of the three-dimensional structures of protein target molecules in structure-based drug design. 24-MAY-1994 29-OCT-2012
8295219 Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus. 28-FEB-1994 28-OCT-2012
8126703 Tetrapeptide CCK-A agonists: effect of backbone N-methylations on in vitro and in vivo CCK activity. 12-APR-1994 28-OCT-2012
8027984 3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists. 09-AUG-1994 27-OCT-2012
8201591 CCK-A-selective tetrapeptides containing lys(N epsilon)-amide residues: favorable in vivo and in vitro effects of N-methylation at the aspartyl residue. 07-JUL-1994 27-OCT-2012
8289183 Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes. 22-FEB-1994 26-OCT-2012
8474103 Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. 19-MAY-1993 26-OCT-2012
8410980 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. 29-OCT-1993 25-OCT-2012
1375964 Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues. 08-JUL-1992 22-OCT-2012
1833546 Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. 18-NOV-1991 21-OCT-2012
2194033 Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action. 06-AUG-1990 20-OCT-2012
2657067 Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue. 11-JUL-1989 19-OCT-2012
1700123 Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. 06-DEC-1990 19-OCT-2012
2231595 Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. 06-DEC-1990 19-OCT-2012
1977907 (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. 06-DEC-1990 19-OCT-2012
3118024 Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement. 09-DEC-1987 15-OCT-2012
15080982 Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists. 14-APR-2004 12-OCT-2012
12824023 An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist. 25-JUN-2003 07-OCT-2012
11814821 Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. 29-JAN-2002 06-OCT-2012
11354357 Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. 16-MAY-2001 05-OCT-2012
22281189 SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. 07-FEB-2012 23-JUL-2012
22326396 Aminopyrimidinone cdc7 kinase inhibitors. 21-FEB-2012 23-JUL-2012
15608078 Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties. XX-XXX-2005 07-JUN-2012
15302680 In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892. XX-XXX-2004 31-MAY-2012
15024037 [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. XX-XXX-2004 30-MAY-2012
15033391 Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. 08-XXX-2004 30-MAY-2012
12815170 [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding. XX-XXX-2003 26-MAY-2012
12606603 Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. XX-XXX-2003 13-MAY-2012
11805207 Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties. XX-XXX-2002 02-MAY-2012
11082453 ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. XX-XXX-2000 24-APR-2012
21899332 P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses. 20-OCT-2011 24-MAR-2012
21840712 Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay. 22-AUG-2011 24-MAR-2012
21106457 N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. 25-NOV-2010 23-MAR-2012
9417028 Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. 02-XXX-1998 02-MAR-2012
8887981 A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand. XX-XXX-1996 24-FEB-2012
8558445 Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor. XX-XXX-1996 21-FEB-2012
8381183 Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists. 05-XXX-1993 09-FEB-2012
7518514 (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. XX-XXX-1994 20-DEC-2011
2547939 Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor. XX-XXX-1989 22-NOV-2011
1706470 Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. XX-XXX-1991 15-NOV-2011
17630989 Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. XX-JUL-2007 07-NOV-2011
16492149 Structure-based optimization of MurF inhibitors. XX-JAN-2006 17-OCT-2011
21315587 Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists. 21-FEB-2011 24-AUG-2011
21316222 Thienopyrrole acetic acids as antagonists of the CRTH2 receptor. 07-MAR-2011 24-AUG-2011
21288717 Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. 21-FEB-2011 23-AUG-2011
21282054 Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions. 21-FEB-2011 23-AUG-2011
20945906 Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. 04-NOV-2010 14-JUN-2011
20965738 Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain. 02-NOV-2010 14-JUN-2011
20855211 Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. 19-OCT-2010 13-JUN-2011
20870405 Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. 19-OCT-2010 13-JUN-2011
20471255 Biochemical and biophysical characterization of unique switch pocket inhibitors of p38a. 13-SEP-2010 12-JUN-2011
20817523 Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. 20-SEP-2010 12-JUN-2011
20457525 In vitro studies on a class of quinoline containing histamine H3 antagonists. 21-MAY-2010 20-NOV-2010
20457518 Discovery of TRPV1 antagonist ABT-116. 21-MAY-2010 20-NOV-2010
20346655 Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. 05-APR-2010 19-NOV-2010
20337371 Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. 15-APR-2010 18-NOV-2010
19679477 Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs. 26-AUG-2009 17-NOV-2010
20045315 Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. 03-FEB-2010 02-SEP-2010
19921781 Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity. 08-JAN-2010 31-AUG-2010
19926477 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization. 03-FEB-2010 31-AUG-2010
19888760 Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. 05-NOV-2009 29-AUG-2010
19553114 Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). 14-JUL-2009 27-AUG-2010
19588934 Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships. 01-SEP-2009 26-AUG-2010
18632269 Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. 29-JUL-2008 11-JAN-2010
18501613 Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. 13-JUN-2008 11-JAN-2010
18586490 Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent. 21-JUL-2008 11-JAN-2010
18557606 7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors. 03-JUL-2008 11-JAN-2010
19323562 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects. 16-APR-2009 11-JAN-2010
18479921 Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase. 30-MAY-2008 11-JAN-2010
19232492 Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. 09-MAR-2009 11-JAN-2010
19419141 Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. 22-MAY-2009 11-JAN-2010
18722778 Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. 17-SEP-2008 11-JAN-2010
18841882 Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. 06-NOV-2008 11-JAN-2010
19842661 Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. 12-NOV-2009 23-NOV-2009
18183945 Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. 08-FEB-2008 11-NOV-2009
17931867 Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors. 06-NOV-2007 11-NOV-2009
12729655 Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. 05-MAY-2003 10-NOV-2009
11378352 Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). 29-MAY-2001 10-NOV-2009
17055723 Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases. 15-JAN-2007 10-NOV-2009
17532216 Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. 10-JUL-2007 10-NOV-2009
1652023 Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. 25-SEP-1991 10-NOV-2009
12238918 N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. 19-SEP-2002 10-NOV-2009
10780916 Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH). 11-MAY-2000 10-NOV-2009
11052791 Identification of novel inhibitors of urokinase via NMR-based screening. 07-NOV-2000 10-NOV-2009
16451081 Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. 02-FEB-2006 10-NOV-2009
8676339 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. 15-AUG-1996 10-NOV-2009
3172130 Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis. 18-NOV-1988 10-NOV-2009
3309313 Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. 06-NOV-1987 10-NOV-2009
17918921 Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists. 25-OCT-2007 10-NOV-2009
15380232 Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists. 21-SEP-2004 10-NOV-2009
11728194 Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. 30-NOV-2001 10-NOV-2009
3312604 Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond. 09-DEC-1987 10-NOV-2009
11312920 Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. 23-APR-2001 10-NOV-2009
16750628 Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors. 17-JUL-2006 10-NOV-2009
1732540 Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a. 25-FEB-1992 10-NOV-2009
11300880 Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. 13-APR-2001 10-NOV-2009
2066989 4-hydroxythiazole inhibitors of 5-lipoxygenase. 14-AUG-1991 10-NOV-2009
1588555 C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties. 23-JUN-1992 10-NOV-2009
2308149 Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. 06-APR-1990 10-NOV-2009
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