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36 articles for Academy of Sciences of the Czech Republic


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
28004945 Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIß (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. 12-JAN-2017 25-JUL-2018
28004946 Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIß (PI4KB). 12-JAN-2017 25-JUL-2018
27064517 Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene. 26-MAY-2016 23-SEP-2017
27074627 Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. 26-MAY-2016 23-SEP-2017
20578976 Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine. XX-APR-2011 19-JUN-2017
22292590 Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro. 31-JAN-2012 03-MAY-2017
26275679 Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases. 31-8 -2015 18-NOV-2016
25923815 Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II. 28-MAY-2015 09-OCT-2016
24954515 Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. 28-JUL-2014 23-MAR-2016
25462239 Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study. 08-DEC-2014 17-MAR-2016
25435471 Norbornane-based nucleoside and nucleotide analogues locked in North conformation. 22-DEC-2014 14-MAR-2016
25259627 Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides. 23-OCT-2014 09-MAR-2016
23727536 The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase. 22-JUL-2013 13-APR-2014
23850568 The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. 09-SEP-2013 13-APR-2014
20542427 Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles. 08-JUL-2010 22-MAY-2013
22775318 Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2. 09-AUG-2012 17-MAY-2013
22725979 Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. 12-JUL-2012 17-MAY-2013
22169265 Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates. 30-DEC-2011 08-FEB-2013
22264015 N-phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase. 23-FEB-2012 07-FEB-2013
20053558 Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. 03-FEB-2010 28-DEC-2012
15056001 A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution. 01-APR-2004 30-NOV-2012
12941319 2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors. 27-AUG-2003 08-OCT-2012
22249123 Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. 26-JAN-2012 22-JUL-2012
21711054 Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. 04-AUG-2011 23-MAR-2012
21395315 Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides. 07-APR-2011 03-DEC-2011
21195612 8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase. 11-JAN-2011 21-AUG-2011
20408532 Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta. 20-MAY-2010 19-NOV-2010
19666228 Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. 21-AUG-2009 31-AUG-2010
19534555 Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. 18-JUN-2009 11-JAN-2010
12941318 Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors. 27-AUG-2003 10-NOV-2009
16970402 HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site. 14-SEP-2006 10-NOV-2009
16789752 Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates. 22-JUN-2006 10-NOV-2009
16789755 S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. 22-JUN-2006 10-NOV-2009
16337119 Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. 01-MAR-2006 04-JAN-2008
12699382 An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study. 24-APR-2003 22-JUN-2004