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20 articles for Actelion Pharmaceuticals Ltd


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
26231163 Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers. 17-8 -2015 27-NOV-2016
26045032 Recent trends in orexin research--2010 to 2015. 13-6 -2015 14-NOV-2016
25838147 Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2. 23-APR-2015 23-APR-2016
25113932 Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y(12) antagonists for inhibition of platelet aggregation. 26-AUG-2014 01-APR-2016
US9096595 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators 04-AUG-2015 28-MAR-2016
24447850 Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1. 10-FEB-2014 25-JUL-2014
23719231 Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2. 10-JUN-2013 13-APR-2014
23968485 Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. 26-SEP-2013 13-APR-2014
23324405 Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold. 28-JAN-2013 13-APR-2014
23434414 Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1. 18-MAR-2013 24-SEP-2013
23006603 Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. 15-OCT-2012 17-MAY-2013
22726929 Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype. 03-JUL-2012 08-FEB-2013
20843686 Design and optimization of new piperidines as renin inhibitors. 11-OCT-2010 13-JUN-2011
20843690 Piperidine-based renin inhibitors: upper chain optimization. 11-OCT-2010 13-JUN-2011
20144866 Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists. 22-FEB-2010 18-NOV-2010
19853442 New classes of potent and bioavailable human renin inhibitors. 05-NOV-2009 17-NOV-2010
18845436 N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists. 30-OCT-2009 25-AUG-2010
12617929 The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. 05-MAR-2003 10-NOV-2009
17000102 Inhibitors of Plasmepsin II-potential antimalarial agents. 19-NOV-2006 10-NOV-2009
12617928 Bis-sulfonamides as endothelin receptor antagonists. 05-MAR-2003 10-NOV-2009