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24 articles for Amgen


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
22019296 Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. 07-NOV-2011 21-JUL-2012
8643460 Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. 14-XXX-1996 21-FEB-2012
19764794 Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. 22-OCT-2009 06-DEC-2009
17869515 Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. 01-OCT-2007 10-NOV-2009
10882355 Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease. 24-JUL-2000 10-NOV-2009
19464171 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. 01-JUL-2009 01-JUL-2009
19217779 Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors. 15-MAR-2009 20-APR-2009
18321037 Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. 27-MAR-2008 06-JAN-2009
16951187 AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. 01-SEP-2006 13-OCT-2008
18763753 Design, synthesis, and biological evaluation of potent c-Met inhibitors. 25-SEP-2008 10-OCT-2008
18553959 Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458). 10-JUL-2008 16-SEP-2008
18426196 Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. 22-MAY-2008 16-SEP-2008
17920884 New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation. 01-DEC-2007 29-APR-2008
17697781 Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors. 15-OCT-2007 28-MAR-2008
17709247 Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. 01-OCT-2007 28-MAR-2008
17585749 Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides. 26-JUL-2007 28-FEB-2008
17585751 Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. 26-JUL-2007 28-FEB-2008
17585750 Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. 26-JUL-2007 28-FEB-2008
17696416 Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors. 06-SEP-2007 11-SEP-2007
17276681 Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties. 15-APR-2007 09-SEP-2007
16884310 Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. 10-AUG-2006 06-SEP-2007
17253678 Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. 22-FEB-2007 17-APR-2007
17253679 Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase. 22-FEB-2007 17-APR-2007
17266194 2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1. 08-FEB-2007 12-FEB-2007