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23 articles for Arena Pharmaceuticals


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
27864071 Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 15-DEC-2016 23-AUG-2018
26048791 Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. 13-6 -2015 11-NOV-2016
25666818 Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat. 18-2 -2015 02-NOV-2016
25488844 Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists. 26-DEC-2014 18-MAR-2016
22435740 (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. 14-JUN-2012 08-FEB-2013
22633692 Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. 15-JUN-2012 07-FEB-2013
18194865 A new family of H3 receptor antagonists based on the natural product Conessine. 18-FEB-2008 15-DEC-2012
22264481 Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. 07-FEB-2012 23-JUL-2012
22172695 Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916). 30-DEC-2011 22-JUL-2012
21852130 Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists. 12-SEP-2011 21-JUL-2012
21444206 Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. 02-MAY-2011 04-DEC-2011
20363624 Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). 20-APR-2010 20-NOV-2010
20455563 Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. 03-JUN-2010 20-NOV-2010
19773162 Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. 12-OCT-2009 30-AUG-2010
19722526 Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity. 17-SEP-2009 27-AUG-2010
19524438 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. 14-JUL-2009 26-AUG-2010
18554904 Novel H3 receptor antagonists with improved pharmacokinetic profiles. 21-JUL-2008 11-JAN-2010
18698756 Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. 05-SEP-2008 11-JAN-2010
18665582 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice. 22-AUG-2008 11-JAN-2010
17931863 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b. 06-NOV-2007 11-NOV-2009
17358052 Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. 29-MAR-2007 10-NOV-2009
17588745 Agonist lead identification for the high affinity niacin receptor GPR109a. 07-AUG-2007 10-NOV-2009
17804224 Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. 18-SEP-2007 10-NOV-2009