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9 articles for Astex

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
19143567 Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. 22-JAN-2009 23-FEB-2009
18656911 Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. 28-AUG-2008 29-SEP-2008
17451234 Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery. 17-MAY-2007 04-JUN-2007
17451235 Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design. 17-MAY-2007 01-JUN-2007
17315856 Application of fragment screening by X-ray crystallography to beta-secretase. 22-MAR-2007 15-MAY-2007
17315857 Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. 22-MAR-2007 14-MAY-2007
17275837 A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. 30-MAR-2007 30-APR-2007
15658855 Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. 27-JAN-2005 22-JAN-2007
16480269 Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors. 23-FEB-2006 19-DEC-2006