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17 articles for AstraZeneca Pharmaceuticals


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
21728345 Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency. 16-AUG-2011 05-FEB-2013
22197139 Multiparameter exploration of piperazine derivatives asd-opioid receptor agonists for CNS indications. 13-JAN-2012 22-JUL-2012
22197137 4-Piperidin-4-ylidenemethyl-benzamides asd-opioid receptor agonists for CNS indications: identifying clinical candidates. 13-JAN-2012 22-JUL-2012
11408556 Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. XX-XXX-2001 01-MAY-2012
21524576 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity. 20-MAY-2011 04-DEC-2011
21320776 Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists. 07-MAR-2011 24-AUG-2011
21295468 Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). 21-FEB-2011 23-AUG-2011
20980155 Developing dual functional allosteric modulators of GABA(A) receptors. 12-NOV-2010 20-AUG-2011
21067920 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators. 24-NOV-2010 14-JUN-2011
20727752 Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. 13-SEP-2010 12-JUN-2011
20719509 SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. 30-AUG-2010 20-MAR-2011
20088516 De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist. 19-FEB-2010 01-SEP-2010
18996007 The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. 25-NOV-2008 11-JAN-2010
18986805 Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. 25-NOV-2008 11-JAN-2010
18617397 Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode. 29-JUL-2008 11-JAN-2010
10987424 The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. 04-JAN-2001 10-NOV-2009
11356112 Potent reversible inhibitors of the protein tyrosine phosphatase CD45. 17-MAY-2001 10-NOV-2009