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10 articles for Boehringer Ingelheim (Canada) Ltd

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
25599836 Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity. 18-FEB-2015 21-APR-2016
23768906 Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype. 24-JUN-2013 13-APR-2014
23545108 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. 15-APR-2013 12-APR-2014
21550240 From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons. 03-JUN-2011 04-DEC-2011
20185309 Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series. 08-MAR-2010 18-NOV-2010
19945870 Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization. 03-FEB-2010 31-AUG-2010
15013003 Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency. 11-MAR-2004 10-NOV-2009
14684311 Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. 19-DEC-2003 10-NOV-2009
9871780 Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams. 11-MAR-1999 10-NOV-2009
9873610 Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. 02-FEB-1999 10-NOV-2009