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48 articles for Boehringer Ingelheim Pharmaceuticals


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
2491889 Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols. XX-JAN-1989 04-JAN-2019
27692854 N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. 01-NOV-2016 20-JUL-2018
26687487 Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. 08-JAN-2016 28-MAY-2017
25671290 Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). 26-FEB-2015 26-APR-2016
25840886 Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators. 23-APR-2015 13-APR-2016
25556098 Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches. 16-JAN-2015 08-APR-2016
25575658 Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model. 16-JAN-2015 19-MAR-2016
25516791 Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate. 17-DEC-2014 18-MAR-2016
25241927 Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists. 08-OCT-2014 08-MAR-2016
24656565 Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore. 07-APR-2014 06-FEB-2015
24506830 Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects. 27-FEB-2014 26-JUL-2014
23453841 Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists. 18-MAR-2013 24-SEP-2013
22803959 Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. 23-AUG-2012 17-MAY-2013
20000469 Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. 21-JAN-2010 28-DEC-2012
19716697 The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II. 14-SEP-2009 26-DEC-2012
18221871 Pyrazinoindolone inhibitors of MAPKAP-K2. 05-FEB-2008 15-DEC-2012
17118655 Alpha-methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands. 15-JAN-2007 11-DEC-2012
17181172 Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists. 21-DEC-2006 09-DEC-2012
1542092 Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. 03-APR-1992 24-OCT-2012
21963986 Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores. 21-OCT-2011 20-JUL-2012
21689933 Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters. 01-JUL-2011 23-MAR-2012
21354795 1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability. 14-MAR-2011 03-DEC-2011
20678931 Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. 16-AUG-2010 20-MAR-2011
20675133 SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability. 16-AUG-2010 20-MAR-2011
20462760 Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. 21-MAY-2010 20-NOV-2010
20472432 Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method. 04-JUN-2010 20-NOV-2010
19969453 Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. 03-FEB-2010 01-SEP-2010
19758802 Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. 28-SEP-2009 30-AUG-2010
19746975 Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. 01-OCT-2009 27-AUG-2010
19243942 Morpholine containing CB2 selective agonists. 09-MAR-2009 11-JAN-2010
17055721 Discovery of potent and selective PKC-theta inhibitors. 25-DEC-2006 10-NOV-2009
17010605 Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase. 19-NOV-2006 10-NOV-2009
17658737 Discovery and optimization of p38 inhibitors via computer-assisted drug design. 16-AUG-2007 10-NOV-2009
12459015 Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors. 02-DEC-2002 10-NOV-2009
12668002 Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK). 01-APR-2003 10-NOV-2009
12086485 Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate. 27-JUN-2002 10-NOV-2009
12941343 The kinetics of binding to p38MAP kinase by analogues of BIRB 796. 27-AUG-2003 10-NOV-2009
12672234 Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. 03-APR-2003 10-NOV-2009
15481974 Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives. 14-OCT-2004 10-NOV-2009
16686533 Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. 11-MAY-2006 10-NOV-2009
9873507 A dipyrido [2,3-b:3',2'-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine. 28-JAN-1999 10-NOV-2009
9871731 Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2. 25-JAN-1999 10-NOV-2009
9083488 Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. 01-MAY-1997 10-NOV-2009
7752198 Time-resolved ligand exchange reactions: kinetic models for competitive inhibitors with recombinant human renin. 21-JUN-1995 10-NOV-2009
2113949 Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors. 06-AUG-1990 10-NOV-2009
1479581 Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1. 08-FEB-1993 10-NOV-2009
7537334 Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones. 31-MAY-1995 10-NOV-2009
19692239 Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors. 15-SEP-2009 11-OCT-2009