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51 articles for Bristol-Myers Squibb


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
27958732 Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. 22-DEC-2016 11-SEP-2018
27914948 Triazolopyridine ethers as potent, orally active mGlu 15-JAN-2017 04-SEP-2018
28105277 Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. 12-JAN-2017 20-AUG-2018
27994765 Discovery of Highly Potent Liver X Receptor▀ Agonists. 08-DEC-2016 12-AUG-2018
27816517 Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors. 01-DEC-2016 10-AUG-2018
27994742 Development of 1 08-DEC-2016 01-AUG-2018
26005539 Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety. 25-5 -2015 21-OCT-2016
21289073 Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans. 19-APR-2011 08-MAY-2016
22587986 The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery. 18-JUL-2012 08-MAY-2016
22983304 Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology. 15-NOV-2012 08-MAY-2016
25690789 Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88. 24-MAR-2015 09-APR-2016
25050169 Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11▀-Hydroxysteroid Dehydrogenase Type 1 (11▀-HSD-1). 22-JUL-2014 29-MAR-2016
25435151 Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXR▀. 26-DEC-2014 14-MAR-2016
25405503 Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity. 16-DEC-2014 13-MAR-2016
25266782 Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11▀-HSD1) inhibitors for the treatment of metabolic disorders. 02-DEC-2014 10-MAR-2016
24513044 Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent. 24-FEB-2014 10-FEB-2015
24767843 2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists. 09-MAY-2014 09-FEB-2015
24182233 Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties. 03-JAN-2014 08-FEB-2015
24424134 Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors. 27-JAN-2014 25-JUL-2014
24360604 Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11▀-hydroxysteroid dehydrogenase type 1 (11▀-HSD1). 13-JAN-2014 25-JUL-2014
23993336 Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists. 18-SEP-2013 13-APR-2014
23743287 2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents. 24-JUN-2013 13-APR-2014
23964740 Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). 26-SEP-2013 13-APR-2014
23602442 Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility. 10-MAY-2013 13-APR-2014
23414837 Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists. 04-MAR-2013 24-SEP-2013
19902958 Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors. XX-XXX-0 10-JUN-2013
22995620 Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors. 01-OCT-2012 17-MAY-2013
22409629 Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor. 12-APR-2012 07-FEB-2013
19321341 Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. 03-APR-2009 23-DEC-2012
17062777 Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling. 28-DEC-2006 15-DEC-2012
18364256 Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors. 15-APR-2008 15-DEC-2012
18395443 Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor. 05-MAY-2008 15-DEC-2012
16546383 Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore. 24-APR-2006 07-DEC-2012
12747783 Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties. 15-MAY-2003 27-NOV-2012
21782431 Monosubstituted¿-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors ofß-secretase (BACE). 21-OCT-2011 21-JUL-2012
21983439 Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). 21-OCT-2011 20-JUL-2012
21689935 Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). 01-JUL-2011 23-MAR-2012
21705217 Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38a MAP kinase inhibitors. 18-JUL-2011 23-MAR-2012
21087862 Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. 24-DEC-2010 22-AUG-2011
20684603 Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. 05-AUG-2010 20-MAR-2011
20598534 Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes. 16-JUL-2010 19-MAR-2011
20218621 Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). 01-APR-2010 18-NOV-2010
20034793 Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles. 03-FEB-2010 02-SEP-2010
20100660 Phenyltriazolinones as potent factor Xa inhibitors. 15-FEB-2010 01-SEP-2010
19665893 Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists. 26-AUG-2009 30-AUG-2010
19004630 Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)). 25-NOV-2008 11-JAN-2010
18313298 The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor. 17-MAR-2008 11-NOV-2009
12643933 Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease. 19-MAR-2003 10-NOV-2009
12161142 C-3 Amido-indole cannabinoid receptor modulators. 05-AUG-2002 10-NOV-2009
15566298 The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase. 29-NOV-2004 10-NOV-2009
15177471 Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta. 05-JUL-2004 11-NOV-2007