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189 articles for Bristol-Myers Squibb Company


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
US9714234 Carbazole carboxamide compounds 25-JUL-2017 15-NOV-2018
US9708337 Aryl amide-based kinase inhibitors 18-JUL-2017 05-NOV-2018
US9708253 Cyclohexyl sulfone RORγ modulators 18-JUL-2017 30-OCT-2018
US9701672 Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders 11-JUL-2017 30-OCT-2018
US10053454 Carbazole compounds useful as bromodomain inhibitors 21-AUG-2018 18-OCT-2018
US9546153 Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators 17-JAN-2017 18-SEP-2018
US9540323 7-hydroxy-indolinyl antagonists of P2Y1 receptor 10-JAN-2017 16-AUG-2018
US9688669 Oxazolidinones as modulators of mGluR5 27-JUN-2017 19-MAR-2018
US9675571 Inhibitors of indoleamine 2,3-dioxygenase (IDO) 13-JUN-2017 16-MAR-2018
US9688629 Indole carboxamide compounds 27-JUN-2017 10-MAR-2018
US9682980 Positive allosteric modulators of mGluR2 20-JUN-2017 14-FEB-2018
US9695176 Substituted imidazo[1,5-a]pyrazines as CGRP receptor antagonists 04-JUL-2017 26-JAN-2018
US9540323 7-hydroxy-indolinyl antagonists of P2Y1 receptor 10-JAN-2017 04-DEC-2017
US9499482 Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists 22-NOV-2016 20-NOV-2017
US9522888 Substituted bicyclic compounds 20-DEC-2016 13-NOV-2017
US9475817 Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors 25-OCT-2016 23-OCT-2017
US9493412 Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors 15-NOV-2016 16-OCT-2017
27326332 Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist. 21-JUN-2016 13-OCT-2017
US9458171 Pyrrolidinyl sulfone RORγ modulators 04-OCT-2016 09-OCT-2017
US9458110 Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors 04-OCT-2016 02-OCT-2017
US9453048 IAP antagonists 27-SEP-2016 11-SEP-2017
US9453018 Pyrimidinones as factor XIa inhibitors 27-SEP-2016 05-SEP-2017
26985316 Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. 17-MAR-2016 30-AUG-2017
26985314 Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A▀ Reduction in Rodents. 17-MAR-2016 30-AUG-2017
US9428511 Imidazopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 30-AUG-2016 28-AUG-2017
US9428504 7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor 30-AUG-2016 21-AUG-2017
US9427442 Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds 30-AUG-2016 14-AUG-2017
US9409908 Dihydropyridone p1 as factor XIa inhibitors 09-AUG-2016 07-AUG-2017
US9403774 Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors 02-AUG-2016 17-JUL-2017
US9394276 Substituted 1,2,3,4-tetrahydro-2,6-naphthyridines as factor XIa inhibitors 19-JUL-2016 10-JUL-2017
27073051 Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group. 23-APR-2016 03-JUL-2017
26898338 Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based┐-secretase modulators. 01-MAR-2016 30-JUN-2017
US9365558 Dihydropyridinone MGAT2 inhibitors 14-JUN-2016 26-JUN-2017
21171894 Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma. XX-AUG-2011 23-JUN-2017
US9346795 Substituted sulfonamides useful as antiapoptotic Bcl inhibitors 24-MAY-2016 12-JUN-2017
US9334290 Substituted tetrahydrocarbazole and carbazole carboxamide compounds 10-MAY-2016 31-MAY-2017
26631321 Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity. 08-JAN-2016 31-MAY-2017
26704266 Novel phenylalanine derived diamides as Factor XIa inhibitors. 08-JAN-2016 28-MAY-2017
US9334279 Hepatitis C virus inhibitors 10-MAY-2016 22-MAY-2017
US9345740 IAP antagonists 24-MAY-2016 22-MAY-2017
US9315519 Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors 19-APR-2016 24-APR-2017
US9273014 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof 01-MAR-2016 24-JAN-2017
US9266880 Substituted azaindazole compounds 23-FEB-2016 17-JAN-2017
26497283 Macrocyclic prolinyl acyl guanidines as inhibitors of▀-secretase (BACE). 31-OCT-2015 16-DEC-2016
US9249096 Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors 02-FEB-2016 12-DEC-2016
US9242975 Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors 26-JAN-2016 28-NOV-2016
US9187424 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors 17-NOV-2015 15-NOV-2016
US9221796 Selective NR2B antagonists 29-DEC-2015 31-OCT-2016
US9221767 Substituted phthalazinones as rock inhibitors 29-DEC-2015 24-OCT-2016
US9216972 Tricyclic heterocyclic compounds 22-DEC-2015 24-OCT-2016
25893046 Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5. 20-APR-2015 08-OCT-2016
US9174974 Macrocyclic factor VIIa inhibitors 03-NOV-2015 08-AUG-2016
US9174965 Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators 03-NOV-2015 02-AUG-2016
US9173879 Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a ]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof 03-NOV-2015 01-AUG-2016
US9169240 Ketone linked benzothiazole inhibitors of endothelial lipase 27-OCT-2015 25-JUL-2016
US9169252 Heteroaryl substituted nicotinamide compounds 27-OCT-2015 25-JUL-2016
US9145419 Imidazopyridazinyl compounds 29-SEP-2015 13-JUN-2016
US9139578 Amide or urea containing benzothiazole inhibitors of endothelial lipase 22-SEP-2015 06-JUN-2016
25901762 Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of thed-opioid receptor. 28-MAY-2015 07-MAY-2016
US9120798 Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor 01-SEP-2015 25-APR-2016
25728130 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. 24-MAR-2015 08-APR-2016
US9102599 N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases 11-AUG-2015 04-APR-2016
US9096580 Benzofuran derivatives for the treatment of hepatitis C 04-AUG-2015 28-MAR-2016
24980053 Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists. 11-JUL-2014 25-MAR-2016
24951330 Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties. 11-JUL-2014 23-MAR-2016
US9079929 Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors 14-JUL-2015 14-MAR-2016
25453808 Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. 03-DEC-2014 14-MAR-2016
US9108951 Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors 18-AUG-2015 11-JAN-2016
US8993557 Pyridinedione carboxamide inhibitors of endothelial lipase 31-MAR-2015 03-SEP-2015
US8987268 Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 24-MAR-2015 25-AUG-2015
US8987314 Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase 24-MAR-2015 25-AUG-2015
US8975276 Inhibitors of PDE10 10-MAR-2015 03-AUG-2015
US8962651 Compounds for the treatment of hepatitis C 24-FEB-2015 22-JUL-2015
US8969586 Substituted bicyclic heteroaryl compounds 03-MAR-2015 22-JUN-2015
US8940720 Macrocycles as factor XIa inhibitors 27-JAN-2015 16-JUN-2015
US8940736 Imidazotriazinecarbonitriles useful as kinase inhibitors 27-JAN-2015 08-JUN-2015
US8921368 Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 30-DEC-2014 18-MAY-2015
US8916553 Sulfonamide compounds useful as CYP17 inhibitors 23-DEC-2014 11-MAY-2015
US8901115 Cyclic P1 linkers as factor XIa inhibitors 02-DEC-2014 04-MAY-2015
US8846673 Azaindazoles as kinase inhibitors and use thereof 30-SEP-2014 03-MAR-2015
US8828983 Macrocycles as factor XIa inhibitors 09-SEP-2014 16-FEB-2015
US8835470 Mandelamide heterocyclic compounds 16-SEP-2014 16-FEB-2015
24794104 Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. 19-MAY-2014 10-FEB-2015
24613378 Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists. 31-MAR-2014 08-FEB-2015
US8822510 Substituted 3-phenyl-1,2,4-Oxadiazole compounds 02-SEP-2014 02-FEB-2015
US8815840 Carbazole and carboline kinase inhibitors 26-AUG-2014 26-JAN-2015
US8791257 Substituted pyrrolotriazines as protein kinase inhibitors 29-JUL-2014 16-DEC-2014
US8633226 Piperidinyl derivative as a modulator of chemokine receptor activity 21-JAN-2014 06-AUG-2014
US8629282 Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases 14-JAN-2014 28-JUL-2014
24405333 Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors. 13-FEB-2014 26-JUL-2014
24507922 Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor. 10-MAR-2014 26-JUL-2014
24269480 Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds. 02-DEC-2013 25-JUL-2014
24164581 Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. 27-NOV-2013 25-JUL-2014
US8592423 Inhibitors of PDE10 26-NOV-2013 14-APR-2014
23707259 The discovery of BMS-457, a potent and selective CCR1 antagonist. 10-JUN-2013 13-APR-2014
23916594 Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists. 06-SEP-2013 13-APR-2014
24011644 Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core. 18-SEP-2013 13-APR-2014
24070783 Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain. 18-OCT-2013 13-APR-2014
23668989 New azole antagonists with high affinity for the P2Y(1) receptor. 20-MAY-2013 13-APR-2014
US8592579 Pyrrolotriazine kinase inhibitors 26-NOV-2013 17-MAR-2014
US8563583 Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists 22-OCT-2013 20-JAN-2014
US8536198 Piperidine derivatives as modulators of chemokine receptor activity 17-SEP-2013 11-NOV-2013
US8507683 Compounds for the treatment of hepatitis C 13-AUG-2013 07-OCT-2013
23477943 Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression. 25-MAR-2013 24-SEP-2013
22650305 Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors. 12-JUL-2012 17-MAY-2013
23075267 Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. 26-NOV-2012 17-MAY-2013
22939233 Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. 17-SEP-2012 08-FEB-2013
22475558 Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone. 20-APR-2012 07-FEB-2013
21073190 Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists. 15-NOV-2010 08-JAN-2013
20503967 Factor Xa inhibitors: next-generation antithrombotic agents. 02-SEP-2010 02-JAN-2013
20584610 Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists. 16-JUL-2010 31-DEC-2012
20047280 Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators. 04-FEB-2010 27-DEC-2012
19552436 In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. 16-JUL-2009 23-DEC-2012
18096386 From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. 21-JAN-2008 15-DEC-2012
18329876 Sulfonamidolactam inhibitors of coagulation factor Xa. 03-APR-2008 15-DEC-2012
18032037 Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors. 09-JAN-2008 14-DEC-2012
17588746 SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa. 30-JUL-2007 11-DEC-2012
2231596 Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. 06-DEC-1990 19-OCT-2012
22225639 Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2). 27-JAN-2012 22-JUL-2012
22041058 Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. 21-NOV-2011 21-JUL-2012
21899328 Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791 20-OCT-2011 20-JUL-2012
20399649 Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one. 04-MAY-2010 19-NOV-2010
20346664 gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. 05-APR-2010 19-NOV-2010
20176478 Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. 08-MAR-2010 18-NOV-2010
19954247 A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist. 03-DEC-2009 29-AUG-2010
19552437 Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists. 16-JUL-2009 26-AUG-2010
19541481 Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. 14-JUL-2009 26-AUG-2010
18550370 Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa. 21-JUL-2008 11-JAN-2010
19481449 Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists. 09-JUN-2009 11-JAN-2010
18722120 Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists. 15-SEP-2008 11-JAN-2010
19010676 Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer. 26-DEC-2008 11-JAN-2010
19046881 Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties. 26-DEC-2008 11-JAN-2010
19131247 Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists. 27-JAN-2009 11-JAN-2010
19896847 Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. 15-DEC-2009 06-DEC-2009
18160284 From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists. 21-JAN-2008 11-NOV-2009
12408705 Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. 31-OCT-2002 10-NOV-2009
12639540 Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors. 17-MAR-2003 10-NOV-2009
12639577 Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics. 17-MAR-2003 10-NOV-2009
17643988 Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications. 22-AUG-2007 10-NOV-2009
12067561 CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships. 17-JUN-2002 10-NOV-2009
17720492 Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2). 18-SEP-2007 10-NOV-2009
12166951 Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists. 08-AUG-2002 10-NOV-2009
12361393 Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. 03-OCT-2002 10-NOV-2009
18485702 Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. 01-JUN-2008 12-OCT-2009
19351168 N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation. 14-MAY-2009 08-JUN-2009
19361210 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. 14-MAY-2009 08-JUN-2009
19361209 Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists. 14-MAY-2009 08-JUN-2009
18178084 Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase. 15-JAN-2008 10-MAY-2009
18799592 Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. 00-DEC-2008 09-MAY-2009
19267461 Novel tricyclic inhibitors of IkappaB kinase. 09-APR-2009 02-MAY-2009
18763755 Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor acti 09-OCT-2008 06-APR-2009
19260711 Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily. 12-MAR-2009 05-APR-2009
19143533 Discovery and Structure-Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists. 14-JAN-2009 05-APR-2009
18242982 Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. 01-MAR-2008 09-FEB-2009
18234496 Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). 15-FEB-2008 09-FEB-2009
17459705 Novel inhibitors of fatty acid amide hydrolase. 15-JUN-2007 08-FEB-2009
18282708 Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents. 15-MAR-2008 26-JAN-2009
18998662 Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors. 11-NOV-2008 05-JAN-2009
17197177 Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors. 01-MAR-2007 06-DEC-2008
17540562 Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors. 01-AUG-2007 04-DEC-2008
18690676 Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities. 11-SEP-2008 16-SEP-2008
16458511 Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series. 15-APR-2006 04-AUG-2008
17656086 Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. 15-SEP-2007 28-MAY-2008
15713402 Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase. 01-MAR-2005 28-MAY-2008
18412317 (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential. 08-MAY-2008 10-MAY-2008
18260618 Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes. 13-MAR-2008 28-MAR-2008
17402721 Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling. 03-MAY-2007 28-MAR-2008
16610787 Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. 20-APR-2006 05-JAN-2008
17585753 Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). 26-JUL-2007 09-DEC-2007
14521405 Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants. 09-OCT-2003 10-NOV-2007
17914785 Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa. 01-NOV-2007 10-NOV-2007
17174550 Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues. 01-MAR-2007 08-NOV-2007
17181141 Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. 28-DEC-2006 07-OCT-2007
16190753 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. 06-OCT-2005 02-JUL-2007
17154512 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase i 16-NOV-2006 22-JAN-2007
15454208 SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. 01-NOV-2004 02-JAN-2007
15454209 5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa. 01-NOV-2004 01-JAN-2007
16682200 Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa. 15-JUL-2006 19-DEC-2006
15163180 Sultam hydroxamates as novel matrix metalloproteinase inhibitors. 03-JUN-2004 17-OCT-2006
14698155 Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3. 19-JAN-2004 27-SEP-2005
15027863 N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. 25-MAR-2004 14-SEP-2005
15537345 Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases. 18-NOV-2004 12-SEP-2005
12643928 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases. 24-MAR-2003 07-SEP-2005
12431050 Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern. 21-NOV-2002 06-SEP-2005
12824044 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. 21-JUL-2003 05-SEP-2005
15125971 Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. 07-JUN-2004 30-AUG-2005
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