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63 articles for Bristol-Myers Squibb Research and Development


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
28105289 Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists. 12-JAN-2017 21-AUG-2018
27836399 [2.2.1]-Bicyclic sultams as potent androgen receptor antagonists. 01-DEC-2016 13-AUG-2018
27564532 Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing. 08-SEP-2016 18-JUL-2018
27583770 Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locke 13-OCT-2016 06-JUL-2018
26924461 Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. 24-MAR-2016 15-AUG-2017
27055941 Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). 16-JUN-2016 14-JUL-2017
26819663 Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. 28-JAN-2016 12-JUL-2017
26848108 Design and optimization of tricyclic gamma-secretase modulators. 16-FEB-2016 26-JUN-2017
26200936 Applications of Fluorine in Medicinal Chemistry. 12-NOV-2015 17-DEC-2016
25801931 Pseudosaccharin amines as potent and selective KV1.5 blockers. 14-OCT-2015 04-DEC-2016
26386604 Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. 03-OCT-2015 03-DEC-2016
26022839 Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup. 08-JUN-2015 16-OCT-2016
25857941 BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent. 23-APR-2015 23-APR-2016
25845281 Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. 23-APR-2015 23-APR-2016
25529736 Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. 16-JAN-2015 19-MAR-2016
24881565 Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors. 16-JUN-2014 12-FEB-2015
24685542 Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases. 21-APR-2014 08-FEB-2015
24397558 Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. 13-MAR-2014 26-JUL-2014
23747226 Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex. 24-JUN-2013 13-APR-2014
23726344 Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. 10-JUN-2013 13-APR-2014
23416006 Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors. 04-MAR-2013 24-SEP-2013
23368907 Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. 11-JUL-2013 24-SEP-2013
23465610 Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones. 18-MAR-2013 24-SEP-2013
23177783 Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists. 18-DEC-2012 24-SEP-2013
23253443 Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression. 31-DEC-2012 24-SEP-2013
22340081 Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor. 12-MAR-2012 17-JUN-2013
22902653 Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. 31-AUG-2012 08-FEB-2013
19821562 Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases. 05-NOV-2009 26-DEC-2012
18424044 Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties. 05-MAY-2008 16-DEC-2012
18288793 Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215 20-MAR-2008 15-DEC-2012
18291645 Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists. 17-MAR-2008 15-DEC-2012
18359226 Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. 15-APR-2008 15-DEC-2012
18378446 Tetrazole based amides as growth hormone secretagogues. 15-APR-2008 15-DEC-2012
18221875 Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors. 18-FEB-2008 15-DEC-2012
18061445 Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE). 21-JAN-2008 14-DEC-2012
18054227 Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. 21-JAN-2008 14-DEC-2012
21974952 Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. 21-OCT-2011 21-JUL-2012
22018461 Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066). 07-NOV-2011 21-JUL-2012
21882820 Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. 06-OCT-2011 20-JUL-2012
21996520 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. 21-OCT-2011 20-JUL-2012
21696952 Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase. 01-JUL-2011 23-MAR-2012
21411322 Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines. 04-APR-2011 02-DEC-2011
21177105 Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases. 11-JAN-2011 21-AUG-2011
21035336 5-amino-pyrazoles as potent and selective p38a inhibitors. 08-NOV-2010 14-JUN-2011
20833042 Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors. 11-OCT-2010 13-JUN-2011
20804198 Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38a MAP kinase inhibitor for the treatment of inflammatory diseases. 16-SEP-2010 12-JUN-2011
20675137 Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase. 16-AUG-2010 20-MAR-2011
20483614 5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists. 04-JUN-2010 20-NOV-2010
20382527 Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. 20-APR-2010 19-NOV-2010
20405922 Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). 06-MAY-2010 19-NOV-2010
19769332 Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity 03-DEC-2009 30-AUG-2010
19740659 Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase. 28-SEP-2009 30-AUG-2010
19376699 Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase. 04-MAY-2009 26-AUG-2010
19375914 Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE. 04-MAY-2009 26-AUG-2010
18479916 Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors. 30-MAY-2008 11-JAN-2010
19467597 Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability. 09-JUN-2009 11-JAN-2010
19201606 Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. 23-FEB-2009 11-JAN-2010
18644722 Synthesis and evaluation of acylguanidine FXa inhibitors. 11-AUG-2008 11-JAN-2010
18289854 Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase. 17-MAR-2008 11-NOV-2009
17937986 Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors. 06-NOV-2007 11-NOV-2009
18296051 Benzothiazole based inhibitors of p38alpha MAP kinase. 17-MAR-2008 11-NOV-2009
18055203 Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA. 21-JAN-2008 11-NOV-2009
17574413 Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators. 30-JUL-2007 10-NOV-2009