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131 articles for China Pharmaceutical University


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
27688180 Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2. 05-JAN-2017 09-SEP-2018
27662032 Design, synthesis and evaluation of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives as potent inhibitors of platelet aggregation. 05-JAN-2017 09-SEP-2018
27598236 High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity. 29-NOV-2016 01-SEP-2018
27884512 Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors. 15-JAN-2017 24-AUG-2018
27484514 Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. 10-NOV-2016 17-AUG-2018
27448913 New palbociclib analogues modified at the terminal piperazine ring and their anticancer activities. 21-OCT-2016 04-AUG-2018
27690435 Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions. 22-DEC-2016 27-JUL-2018
27692996 Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease. 15-NOV-2016 21-JUL-2018
27720555 Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction. 15-NOV-2016 09-JUL-2018
27720557 Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification. 15-NOV-2016 09-JUL-2018
27712939 Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. 01-NOV-2016 09-JUL-2018
27187856 Design, synthesis and biological evaluation of novel EGFR/HER2 dual inhibitors bearing a oxazolo[4,5-g]quinazolin-2(1H)-one scaffold. 14-SEP-2016 24-JUN-2018
27176944 Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERa and VEGFR-2 as anti-breast cancer agents. 04-JUN-2016 10-OCT-2017
27460699 Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. 22-AUG-2016 06-OCT-2017
27116709 Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5. 04-JUN-2016 02-OCT-2017
27142751 Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. 31-MAY-2016 23-SEP-2017
27068889 Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2. 19-JUL-2016 15-SEP-2017
27210433 Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton's tyrosine kinase inhibitors. 09-JUN-2016 13-SEP-2017
27185012 Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral┐-opioid receptor agonists. 09-JUN-2016 12-SEP-2017
27130359 Design, synthesis and evaluation of pyrrolo[2,3-d]pyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors. 31-MAY-2016 22-AUG-2017
27054485 Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole. 14-MAY-2016 18-AUG-2017
26965867 Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed fromaa- anda▀-amino acids. 26-MAR-2016 27-JUL-2017
27020683 Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. 15-APR-2016 21-JUL-2017
21827363 Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-a converting enzyme (TACE/ADAM-17). XX-AUG-2012 10-JUL-2017
26945112 Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. 29-MAR-2016 02-JUL-2017
26713111 Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors. 29-DEC-2015 23-JUN-2017
26917219 Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease. 13-MAR-2016 19-JUN-2017
26840363 Design, synthesis and biological evaluation of 3'-benzylated analogs of 3'-epi-neoponkoranol as potenta-glucosidase inhibitors. 15-FEB-2016 18-JUN-2017
19968566 3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors. XX-APR-2010 15-JUN-2017
26826581 Design and discovery of 4-anilinoquinazoline-acylamino derivatives as EGFR and VEGFR-2 dual TK inhibitors. 02-FEB-2016 12-JUN-2017
26741358 Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. 02-FEB-2016 08-JUN-2017
26632651 Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography. 14-JAN-2016 31-MAY-2017
26638042 Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy. 21-JAN-2016 26-MAY-2017
28460360 Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors. 13-APR-2017 09-MAY-2017
28411406 Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors 08-APR-2017 21-APR-2017
28043720 Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. XX-FEB-2017 12-APR-2017
26491978 Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline. 02-NOV-2015 22-DEC-2016
26475519 Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase. 31-OCT-2015 21-DEC-2016
26363506 Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin. 09-OCT-2015 18-DEC-2016
26537784 Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors. 21-NOV-2015 17-DEC-2016
26482570 Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists. 07-NOV-2015 16-DEC-2016
26454504 Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors. 31-OCT-2015 15-DEC-2016
26420383 Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. 05-OCT-2015 04-DEC-2016
26342868 Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation. 03-OCT-2015 03-DEC-2016
26188620 Design, synthesis and biological activities of novel oxazolo[4,5-g]quinazolin-2(1H)-one derivatives as EGFR inhibitors. 18-8 -2015 26-NOV-2016
26277759 Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors. 31-8 -2015 18-NOV-2016
26258437 Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor. 28-8 -2015 16-NOV-2016
25082515 Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2. 29-8 -2014 29-OCT-2016
25282654 Design, synthesis and evaluation of novel tacrine-(▀-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease. 02-DEC-2014 27-OCT-2016
26145818 Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. 27-7 -2015 26-OCT-2016
25992974 Synthesis and Biological Evaluation of Novel Olean-28,13▀-lactams as Potential Antiprostate Cancer Agents. 11-JUN-2015 10-OCT-2016
27580186 Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. XX-OCT-2016 26-SEP-2016
25812965 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. 20-APR-2015 28-APR-2016
25839438 Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation. 20-APR-2015 23-APR-2016
25656088 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. 13-MAR-2015 22-APR-2016
25596757 Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold. 04-FEB-2015 08-APR-2016
25556101 Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. 16-JAN-2015 03-APR-2016
25461318 Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents. 12-JAN-2015 03-APR-2016
25537530 Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold. 20-JAN-2015 03-APR-2016
25542589 Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-▀-amyloid (A▀) aggregation and metal chelation properties against Alzheimer's disease. 16-JAN-2015 03-APR-2016
25064347 Discovery of N-(2-phenyl-1H-benzo[d]imidazol-5-yl)quinolin-4-amine derivatives as novel VEGFR-2 kinase inhibitors. 16-AUG-2014 30-MAR-2016
25515957 Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors. 06-JAN-2015 18-MAR-2016
25481394 Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists. 22-DEC-2014 18-MAR-2016
25462267 Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors. 08-DEC-2014 17-MAR-2016
25438757 Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease. 02-DEC-2014 14-MAR-2016
25787859 Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. XX-OCT-2015 29-FEB-2016
25346381 Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking. XX-JUN-2015 01-OCT-2015
24824064 Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I). 19-JUN-2014 10-FEB-2015
24726809 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. 30-APR-2014 09-FEB-2015
24607591 Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors. 08-APR-2014 08-FEB-2015
24512214 Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. 27-MAR-2014 07-FEB-2015
24763261 Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening. 05-MAY-2014 07-FEB-2015
23792318 Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors. 05-AUG-2013 26-DEC-2014
24674599 Identification of dipeptidyl peptidase IV inhibitors: virtual screening, synthesis and biological evaluation. XX-SEP-2014 05-NOV-2014
24095756 Multifunctional tacrine-flavonoid hybrids with cholinergic,▀-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. 04-NOV-2013 13-APR-2014
24099996 Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton. 04-NOV-2013 13-APR-2014
23685572 Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. 14-JUN-2013 13-APR-2014
23511019 Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. 15-APR-2013 13-APR-2014
23639542 NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity. 10-MAY-2013 13-APR-2014
23501112 Novel IKK▀ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method. 04-JUN-2013 12-APR-2014
23541836 Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents. 15-APR-2013 12-APR-2014
23199480 Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. 18-DEC-2012 24-SEP-2013
23481647 Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors. 18-MAR-2013 24-SEP-2013
23466230 Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate. 18-MAR-2013 24-SEP-2013
20158205 Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. 04-MAR-2010 21-MAY-2013
22512543 Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors. 10-MAY-2012 17-MAY-2013
22663155 Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain. 22-JUN-2012 17-MAY-2013
22985853 Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors. 01-OCT-2012 17-MAY-2013
22750010 Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. 20-JUL-2012 08-FEB-2013
22704238 Design, synthesis and biological evaluation ofß-carboline derivatives as novel inhibitors targeting B-Raf kinase. 03-JUL-2012 08-FEB-2013
23043765 Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity. 26-NOV-2012 08-FEB-2013
22818848 Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases. 03-SEP-2012 08-FEB-2013
22516281 Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor. 07-MAY-2012 07-FEB-2013
22472693 Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques. 20-APR-2012 07-FEB-2013
19889536 Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase. 16-NOV-2009 27-DEC-2012
18847277 Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. 23-MAY-2011 25-DEC-2012
19482383 Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. 20-JUL-2009 24-DEC-2012
18485715 Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase. 05-JUN-2008 16-DEC-2012
18346893 Pharmacophore identification of Raf-1 kinase inhibitors. 03-APR-2008 15-DEC-2012
17095225 Pharmacophore identification of KSP inhibitors. 22-JAN-2007 13-DEC-2012
16546381 Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase. 24-APR-2006 07-DEC-2012
16169219 Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. 05-OCT-2005 04-DEC-2012
15324906 The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. 24-AUG-2004 01-DEC-2012
22472167 Studies on gambogic acid (IV): Exploring structure-activity relationship with I¿B kinase-beta (IKKß). 30-APR-2012 23-JUL-2012
22204907 Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. 13-JAN-2012 22-JUL-2012
21708416 Combination of pharmacophore model development and binding mode analyses: identification of ligand features essential for I¿B kinase-beta (IKKß) inhibitors and virtual screening based on it. 31-AUG-2011 24-MAR-2012
21724305 Synthesis and Na+/H+ exchanger inhibitory activity of benzoylguanidine derivatives. 31-AUG-2011 24-MAR-2012
21856161 De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. 12-SEP-2011 23-MAR-2012
21708467 Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin. 04-JUL-2011 23-MAR-2012
19433354 Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors. 29-MAY-2009 05-DEC-2011
21396745 Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors. 28-MAR-2011 03-DEC-2011
21123066 Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. 24-DEC-2010 22-AUG-2011
20934346 Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. 02-NOV-2010 14-JUN-2011
21055929 Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. 24-NOV-2010 14-JUN-2011
20537544 Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. 23-JUN-2010 20-NOV-2010
19642687 Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. 28-AUG-2009 17-NOV-2010
19822426 Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group. 26-OCT-2009 30-AUG-2010
19428156 Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. 20-JUL-2009 27-AUG-2010
19136179 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. 04-MAY-2009 26-AUG-2010
10691728 Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua. 25-APR-2000 11-JAN-2010
18701301 Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents. 04-SEP-2008 11-JAN-2010
18701305 Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. 04-SEP-2008 11-JAN-2010
18930653 The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS. 13-NOV-2008 11-JAN-2010
19185489 Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers. 23-FEB-2009 11-JAN-2010
18947905 Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas. 02-MAR-2009 11-JAN-2010
16246555 Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. 26-DEC-2005 10-NOV-2009
17587576 Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. 30-JUL-2007 10-NOV-2009
15664832 Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. 24-JAN-2005 10-NOV-2009
17412584 Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists. 30-APR-2007 10-NOV-2009
17346962 Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury. 06-APR-2007 10-NOV-2009
18517260 Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships, and X-ray Crystallographic Studies. 26-JUN-2008 29-JUN-2008