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180 articles for Chinese Academy of Sciences

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
27709945 Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selectivea 27-OCT-2016 09-JUL-2018
27142786 Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta. 27-MAY-2016 24-JUN-2018
27131066 An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core. 04-JUN-2016 09-OCT-2017
27460668 The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. 22-AUG-2016 07-OCT-2017
27353889 The design strategy of selective PTP1B inhibitors over TCPTP. 19-JUL-2016 29-SEP-2017
27077705 Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). 28-APR-2016 10-SEP-2017
26927682 Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema. 24-MAR-2016 07-AUG-2017
26698536 Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase. 21-JAN-2016 10-JUN-2017
26776360 Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors. 25-JAN-2016 05-JUN-2017
26630553 Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. 24-DEC-2015 26-MAY-2017
26479945 Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors. 12-NOV-2015 21-DEC-2016
26222905 Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein anda-Glucosidase. 28-8 -2015 20-NOV-2016
26287401 Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase anda-Glucosidase. 28-8 -2015 06-NOV-2016
26005541 Design, Synthesis, and Pharmacological Evaluation of Fused▀-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors. 25-5 -2015 21-OCT-2016
25871261 Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi. 24-APR-2015 10-OCT-2016
27082499 Discovery of a Highly Selective STK16 Kinase Inhibitor. 17-JUN-2016 30-JUN-2016
22822035 Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. 18-SEP-2012 08-MAY-2016
25980909 Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities. 25-MAY-2015 04-MAY-2016
25710631 Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes. 23-APR-2015 30-APR-2016
25569119 Small molecule discoidin domain receptor kinase inhibitors and potential medical applications. 23-APR-2015 29-APR-2016
25827399 Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis. 20-APR-2015 28-APR-2016
25594223 Glycosylated enfuvirtide: a long-lasting glycopeptide with potent anti-HIV activity. 12-FEB-2015 21-APR-2016
25891102 PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). 30-APR-2015 15-APR-2016
25872983 Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors. 30-APR-2015 13-APR-2016
25461324 Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. 12-JAN-2015 08-APR-2016
25064350 Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1. 16-AUG-2014 30-MAR-2016
24880902 Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole. 16-JUN-2014 22-MAR-2016
24906513 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B. 16-JUN-2014 22-MAR-2016
24785465 Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases. 09-JAN-2015 20-MAR-2016
25457126 (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling. 03-DEC-2014 16-MAR-2016
25442305 Bioactive compounds from the insect Aspongopus chinensis. 02-DEC-2014 14-MAR-2016
25383915 Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90. 16-DEC-2014 12-MAR-2016
25369470 Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2. 26-NOV-2014 12-MAR-2016
25333769 Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. 13-NOV-2014 11-MAR-2016
25308766 Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles. 02-DEC-2014 11-MAR-2016
25313505 Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. 02-DEC-2014 11-MAR-2016
25218912 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors. 06-OCT-2014 07-MAR-2016
25179681 Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor. 13-NOV-2014 06-MAR-2016
25626527 Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi. XX-OCT-2015 16-FEB-2016
24863981 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists. 28-JUN-2014 11-FEB-2015
24900886 Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors. 06-JUN-2014 11-FEB-2015
24815508 Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. 19-MAY-2014 11-FEB-2015
24874438 Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. 12-JUN-2014 11-FEB-2015
24751441 Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization. 09-MAY-2014 09-FEB-2015
24564525 Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility. 08-MAY-2014 08-FEB-2015
24613627 Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity. 31-MAR-2014 08-FEB-2015
24704616 Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new ROR┐ inhibitors using virtual screening, synthesis and biological evaluation. 14-APR-2014 07-FEB-2015
24593120 Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera. 25-APR-2014 07-FEB-2015
24565969 Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors. 31-MAR-2014 07-FEB-2015
24588073 Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib. 27-MAR-2014 07-FEB-2015
24153396 Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. 01-NOV-2013 25-JUL-2014
24183742 Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor. 03-DEC-2013 25-JUL-2014
23942421 The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors. 23-AUG-2013 13-APR-2014
23859780 Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors. 09-AUG-2013 13-APR-2014
23507151 Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. 15-APR-2013 13-APR-2014
23795939 11▀-HSD1 inhibitors from Walsura cochinchinensis. 26-JUL-2013 13-APR-2014
23993328 Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors. 07-OCT-2013 13-APR-2014
24007860 Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold. 04-NOV-2013 13-APR-2014
24090912 Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy. 04-NOV-2013 13-APR-2014
23656512 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptora. 13-JUN-2013 13-APR-2014
23575276 Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors. 23-APR-2013 13-APR-2014
23644196 Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice. 14-JUN-2013 13-APR-2014
23747808 Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11▀-HSD1 inhibitors: potential impact in diabetes. 22-JUL-2013 13-APR-2014
23474386 Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors. 26-MAR-2013 12-APR-2014
23301703 Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. 15-FEB-2013 24-SEP-2013
23318905 Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action. 26-FEB-2013 24-SEP-2013
23428155 Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. 28-MAR-2013 24-SEP-2013
23316803 Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. 15-FEB-2013 24-SEP-2013
23332346 Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. 04-FEB-2013 24-SEP-2013
23473053 Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors. 11-APR-2013 24-SEP-2013
23521020 Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. 26-APR-2013 24-SEP-2013
23353742 Design, synthesis and SAR of piperidyl-oxadiazoles as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. 09-APR-2013 24-SEP-2013
22867529 Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors. 11-MAR-2013 24-SEP-2013
23357636 Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault. 15-FEB-2013 24-SEP-2013
17602798 3D-QSAR and docking studies of aminopyridine carboxamide inhibitors of c-Jun N-terminal kinase-1. 10-MAR-2008 21-MAY-2013
19962796 3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods. 01-FEB-2010 21-MAY-2013
12383007 Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses. 17-OCT-2002 20-MAY-2013
23137303 Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. 13-DEC-2012 17-MAY-2013
23148522 Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. 13-DEC-2012 17-MAY-2013
23088644 Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)¿isoleucine(315) mutant. 26-NOV-2012 17-MAY-2013
22934600 Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity. 28-SEP-2012 17-MAY-2013
22650618 Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C. 22-JUN-2012 17-MAY-2013
22863529 Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors. 15-AUG-2012 08-FEB-2013
22738629 CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design. 03-JUL-2012 08-FEB-2013
22459213 Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators. 23-APR-2012 07-FEB-2013
22464133 Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. 20-APR-2012 07-FEB-2013
22475866 Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization. 30-APR-2012 07-FEB-2013
22444684 Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties. 06-APR-2012 07-FEB-2013
22448770 Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. 12-APR-2012 07-FEB-2013
22360639 Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases. 27-APR-2012 07-FEB-2013
22578460 Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. 29-MAY-2012 07-FEB-2013
22440625 Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. 06-APR-2012 07-FEB-2013
22339342 Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine7¿°¿ methionine7¿° mutant. 22-MAR-2012 07-FEB-2013
21106276 The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes. 21-DEC-2010 04-JAN-2013
20561788 Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents. 08-JUL-2010 31-DEC-2012
20510622 Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. 23-JUN-2010 31-DEC-2012
20570525 Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase. 25-MAR-2011 31-DEC-2012
20153651 Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. 11-MAR-2010 28-DEC-2012
20041669 Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. 04-FEB-2010 28-DEC-2012
19559623 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. 15-JUL-2009 25-DEC-2012
19564108 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. 14-JUL-2009 24-DEC-2012
19595591 Synthesis and opioid receptor activity of indolopropellanes. 29-JUL-2009 24-DEC-2012
19348465 Cucurbitane-type triterpenoids from the stems of Cucumis melo. 21-JUN-2010 24-DEC-2012
19574056 Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. 21-JUL-2009 24-DEC-2012
19362470 Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. 04-MAY-2009 23-DEC-2012
18821748 Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine. 17-OCT-2008 19-DEC-2012
18571405 Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning. 21-JUL-2008 16-DEC-2012
17513302 Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. 23-JUL-2007 16-DEC-2012
18163592 Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. 25-JAN-2008 15-DEC-2012
17822295 Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase. 01-OCT-2007 14-DEC-2012
17228858 Advances in development of dopaminergic aporphinoids. 18-JAN-2007 14-DEC-2012
17098431 Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling. 15-DEC-2006 10-DEC-2012
16821765 Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. 06-JUL-2006 07-DEC-2012
15878277 Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives. 24-MAY-2005 02-DEC-2012
12801227 Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae. 12-JUN-2003 27-NOV-2012
12467625 N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. 06-DEC-2002 07-OCT-2012
9871752 A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis. 11-MAR-1999 28-SEP-2012
9873409 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A. 29-JAN-1999 28-SEP-2012
22130133 Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors. 30-DEC-2011 22-JUL-2012
21665484 Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold. 24-JUN-2011 23-MAR-2012
21439694 Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. 02-MAY-2011 23-MAR-2012
21733683 Structure-activity study on a series ofa-glutamic acid scaffold based compounds as new ADAMTS inhibitors. 18-JUL-2011 23-MAR-2012
21737266 C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. 18-JUL-2011 23-MAR-2012
21481589 New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. 02-MAY-2011 06-DEC-2011
21561768 Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase. 03-JUN-2011 04-DEC-2011
21405128 Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent. 07-APR-2011 03-DEC-2011
21376587 Hybrid compounds as new Bcr/Abl inhibitors. 14-MAR-2011 03-DEC-2011
21334902 Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands. 14-MAR-2011 24-AUG-2011
21247762 Synthesis, modification, and evaluation of (R)-de-O-methyllasiodiplodin and analogs as nonsteroidal antagonists of mineralocorticoid receptor. 07-FEB-2011 23-AUG-2011
20817450 Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. 20-SEP-2010 12-JUN-2011
20674358 Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents. 16-AUG-2010 20-MAR-2011
20576578 ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. 25-JUN-2010 21-NOV-2010
20471252 Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. 04-JUN-2010 20-NOV-2010
20472439 Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B. 31-MAY-2010 20-NOV-2010
20472448 Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators. 31-MAY-2010 20-NOV-2010
20353152 A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. 15-APR-2010 19-NOV-2010
20405848 Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. 06-MAY-2010 19-NOV-2010
20363629 Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. 20-APR-2010 19-NOV-2010
19476336 Chemical constituents from the aerial parts of Artemisia minor. 26-JUN-2009 17-NOV-2010
20047779 Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. 17-FEB-2010 17-NOV-2010
20178321 Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. 18-MAR-2010 02-SEP-2010
19896374 Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. 16-NOV-2009 31-AUG-2010
19700318 O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. 14-SEP-2009 30-AUG-2010
19422203 Pyrrolidinoindoline alkaloids from Selaginella moellendorfii. 26-JUN-2009 27-AUG-2010
19041163 Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors. 27-MAR-2009 25-AUG-2010
18707891 Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities. 17-SEP-2008 11-JAN-2010
19358610 Halogen bonding--a novel interaction for rational drug design? 07-MAY-2009 11-JAN-2010
18835172 Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities. 22-OCT-2008 11-JAN-2010
18562201 Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. 25-JUL-2008 11-JAN-2010
19162488 Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. 23-FEB-2009 11-JAN-2010
18976926 Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring. 25-NOV-2008 11-JAN-2010
16252917 Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. 28-OCT-2005 11-JAN-2010
18783955 N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. 17-SEP-2008 11-JAN-2010
19138149 Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. 05-FEB-2009 11-JAN-2010
18579388 Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. 11-AUG-2008 11-JAN-2010
19091557 A novel sesquiterpene quinone from Hainan sponge Dysidea villosa. 26-DEC-2008 11-JAN-2010
12141863 Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. 26-JUL-2002 11-JAN-2010
16499324 Bioactive compounds from Peperomia pellucida. 27-FEB-2006 11-JAN-2010
16420030 Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. 19-JAN-2006 10-NOV-2009
16563751 Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. 24-APR-2006 10-NOV-2009
17336065 Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling. 06-APR-2007 10-NOV-2009
17574424 Aza analogues of equol: novel ligands for estrogen receptor beta. 16-JUL-2007 10-NOV-2009
17126020 Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. 08-JAN-2007 10-NOV-2009
17303416 Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors. 02-APR-2007 10-NOV-2009
17488103 Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol. 24-MAY-2007 10-NOV-2009
17883259 Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. 29-OCT-2007 10-NOV-2009
15664828 Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold. 24-JAN-2005 10-NOV-2009
12431052 Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A. 14-NOV-2002 10-NOV-2009
12419367 Natural PTP1B inhibitors from Broussonetia papyrifera. 06-NOV-2002 10-NOV-2009
11784138 Elucidating the inhibiting mode of AHPBA derivatives against HIV-1 protease and building predictive 3D-QSAR models. 10-JAN-2002 10-NOV-2009
12161117 3-Pyrroline containing arylacetamides: a novel series of remarkably selective kappa-agonists. 05-AUG-2002 10-NOV-2009
14684295 Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. 19-DEC-2003 10-NOV-2009
16143526 Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases. 26-SEP-2005 10-NOV-2009
15911274 Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators. 24-MAY-2005 10-NOV-2009
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