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15 articles for Chugai Pharmaceutical Co., Ltd

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
27189888 Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents. 09-JUN-2016 13-SEP-2017
24157370 The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. 01-NOV-2013 25-JUL-2014
23265889 Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation. 14-JAN-2013 24-SEP-2013
23122816 Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors. 26-NOV-2012 17-MAY-2013
21050768 Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer. 12-NOV-2010 03-JAN-2013
20381361 Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists. 30-APR-2010 30-DEC-2012
17064916 Discovery of 7alpha-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships. 20-NOV-2006 10-DEC-2012
22192591 Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. 13-JAN-2012 22-JUL-2012
22225917 Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). 26-JAN-2012 22-JUL-2012
21875802 Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design. 12-SEP-2011 24-MAR-2012
21873071 5a-Carba-ß-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. 12-SEP-2011 23-MAR-2012
21316229 Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799. 07-MAR-2011 24-AUG-2011
21316218 Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. 07-MAR-2011 24-AUG-2011
18674905 Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination. 11-AUG-2008 11-JAN-2010
19254843 Synthesis of new camptothecin analogs with improved antitumor activities. 16-MAR-2009 11-JAN-2010