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34 articles for Daiichi Sankyo Co., Ltd


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
26358159 Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors. 31-OCT-2015 17-DEC-2016
26234904 Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558. 31-8 -2015 23-NOV-2016
25497965 Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach. 22-DEC-2014 18-MAR-2016
24412111 Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration. 27-JAN-2014 25-JUL-2014
23598247 Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor. 10-MAY-2013 13-APR-2014
23886807 Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors. 20-AUG-2013 13-APR-2014
23528296 Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. 15-APR-2013 12-APR-2014
23218775 A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid. 18-DEC-2012 24-SEP-2013
22261021 Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist. 26-JAN-2012 24-SEP-2013
22995624 Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships. 01-OCT-2012 17-MAY-2013
23084275 Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1). 05-NOV-2012 17-MAY-2013
23122821 Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors. 26-NOV-2012 17-MAY-2013
22749869 Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors. 20-JUL-2012 08-FEB-2013
22726934 Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors. 03-JUL-2012 08-FEB-2013
22487179 Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists. 20-APR-2012 07-FEB-2013
20542703 Discovery of potent and orally active tricyclic-based FBPase inhibitors. 13-JUL-2010 31-DEC-2012
20219371 Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives. 22-MAR-2010 30-DEC-2012
18039572 Design, synthesis, and biological activity of piperidine diamine derivatives as factor Xa inhibitor. 21-JAN-2008 15-DEC-2012
22264485 Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. 07-FEB-2012 23-JUL-2012
22225641 Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists. 27-JAN-2012 22-JUL-2012
22044620 Orally active zwitterionic factor Xa inhibitors with long duration of action. 21-NOV-2011 21-JUL-2012
21802309 Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors. 22-AUG-2011 23-MAR-2012
21316975 2-aminomethylphenylamine as a novel scaffold for factor Xa inhibitor. 01-MAR-2011 24-AUG-2011
21353782 Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors. 14-MAR-2011 24-AUG-2011
21232950 Discovery of imidazo[1,2-b]pyridazines as IKKß inhibitors. Part 2: improvement of potency in vitro and in vivo. 24-JAN-2011 23-AUG-2011
20675134 Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship. 16-AUG-2010 20-MAR-2011
20637613 Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3. 27-JUL-2010 19-MAR-2011
20359891 A prodrug approach towards the development of tricyclic-based FBPase inhibitors. 20-APR-2010 19-NOV-2010
19762234 Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors. 28-SEP-2009 30-AUG-2010
19540759 Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide. 14-JUL-2009 27-AUG-2010
19541482 Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation. 14-JUL-2009 26-AUG-2010
19124247 A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid. 03-FEB-2009 11-JAN-2010
18952443 Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist. 17-NOV-2008 11-JAN-2010
19109017 (-)-Cercosporamide derivatives as novel antihyperglycemic agents. 27-JAN-2009 11-JAN-2010