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48 articles for DuPont Pharmaceuticals Company


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
9888839 Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors. 11-FEB-1999 20-MAY-2013
11170646 Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. 22-FEB-2001 26-NOV-2012
11472217 Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. 26-JUL-2001 25-NOV-2012
10794681 Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents. 29-JUN-2000 25-NOV-2012
10669572 4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist. 13-MAR-2000 25-NOV-2012
10072680 Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies. 13-APR-1999 13-NOV-2012
10425086 Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1. 31-AUG-1999 12-NOV-2012
11212098 Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. 09-FEB-2001 04-OCT-2012
11266155 Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz. 26-MAR-2001 04-OCT-2012
11206461 3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors. 05-FEB-2001 04-OCT-2012
10698459 The de novo design and synthesis of cyclic urea inhibitors of factor Xa: optimization of the S4 ligand. 28-MAR-2000 02-OCT-2012
10673109 Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors. 07-MAR-2000 01-OCT-2012
9873633 MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. 02-FEB-1999 29-SEP-2012
11266160 Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. 26-MAR-2001 10-NOV-2009
10465557 Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents. 24-NOV-1999 10-NOV-2009
10743945 Ring constrained analogues of beta-alanine-containing GPIIb/IIIa receptor antagonists. 26-JUN-2000 10-NOV-2009
10230612 Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors. 24-JUN-1999 10-NOV-2009
10576691 Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents. 20-DEC-1999 10-NOV-2009
10230641 Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists. 24-JUN-1999 10-NOV-2009
11585440 Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release. 04-OCT-2001 10-NOV-2009
10782670 Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors. 20-JUN-2000 10-NOV-2009
10866393 Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors. 07-NOV-2000 10-NOV-2009
10360755 P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors. 22-JUL-1999 10-NOV-2009
11549469 Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase. 10-SEP-2001 10-NOV-2009
10072679 Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. 13-APR-1999 10-NOV-2009
9934481 Tricyclic ureas: a new class of HIV-1 protease inhibitors. 05-APR-1999 10-NOV-2009
10072681 Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. 13-APR-1999 10-NOV-2009
10230640 4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists. 24-JUN-1999 10-NOV-2009
10328310 Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. 03-AUG-1999 10-NOV-2009
10633036 Isoxazolines as potent antagonists of the integrin alpha(v)beta(3). 14-FEB-2000 10-NOV-2009
9873607 The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies. 02-FEB-1999 10-NOV-2009
9873692 Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa. 26-JAN-1999 10-NOV-2009
11087565 Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. 04-DEC-2000 10-NOV-2009
10230622 Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. 24-JUN-1999 10-NOV-2009
10021912 Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate. 11-MAY-1999 10-NOV-2009
10328312 Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa. 03-AUG-1999 10-NOV-2009
10425087 Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. 31-AUG-1999 10-NOV-2009
10633037 Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3). 14-FEB-2000 10-NOV-2009
17466326 Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials. 08-JUN-2007 23-JUL-2008
11514172 Identification of selective inhibitors of cyclin dependent kinase 4. 20-AUG-2001 23-DEC-2005
15482910 Parallel synthesis of acylsemicarbazide libraries: preparation of potent cyclin dependent kinase (cdk) inhibitors. 15-NOV-2004 23-DEC-2005
10522695 Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors. 04-OCT-1999 04-JAN-2005
10937734 Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors. 07-AUG-2000 04-JAN-2005
11459666 Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors. 23-JUL-2001 04-JAN-2005
10821714 Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors. 18-MAY-2000 04-JAN-2005
11378361 4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors. 04-JUN-2001 28-OCT-2004
10576692 Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA). 15-NOV-1999 28-OCT-2004
9888839 Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors. 14-JAN-1999 21-SEP-2004