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21 articles for Elan Pharmaceuticals


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDArticle TitlePublishedDeposition
23777782 Orally available and efficaciousa41/a47 integrin inhibitors. 02-JUL-2013 13-APR-2014
23522834 Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. 15-APR-2013 13-APR-2014
23570791 Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors. 23-APR-2013 13-APR-2014
23856050 Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. 24-JUL-2013 13-APR-2014
23454015 Triazolopyridazine LRRK2 kinase inhibitors. 18-MAR-2013 24-SEP-2013
23465612 Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. 18-MAR-2013 24-SEP-2013
23219325 Novel cinnoline-based inhibitors of LRRK2 kinase activity. 18-DEC-2012 24-SEP-2013
23453068 Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors. 18-MAR-2013 24-SEP-2013
20634069 Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. 27-JUL-2010 01-JAN-2013
19811916 Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. 26-OCT-2009 25-DEC-2012
21813278 Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. 22-AUG-2011 23-MAR-2012
21570836 Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. 03-JUN-2011 05-DEC-2011
21112785 Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. 24-DEC-2010 22-AUG-2011
21071223 Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. 24-NOV-2010 14-JUN-2011
20833041 Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model. 11-OCT-2010 13-JUN-2011
20822903 Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. 20-SEP-2010 12-JUN-2011
12723942 Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase. 01-MAY-2003 10-NOV-2009
14561080 Human beta-secretase (BACE) and BACE inhibitors. 16-OCT-2003 10-NOV-2009
14695829 Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase. 01-JAN-2004 25-JUL-2007
17300163 Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase. 22-FEB-2007 14-MAY-2007
9753439 Thermodynamic analysis of the binding of the polyglutamate chain of 5-formyltetrahydropteroylpolyglutamates to serine hydroxymethyltransferase. 29-SEP-1998 31-MAR-2003