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125 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26820555 87 Synthesis and evaluation of colletoic acid core derivatives.EBI St. Jude Children's Research Hospital
26306982 4 Novel 11-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.EBI Universitat de Barcelona
26187704 63 Discovery of 11-hydroxysteroid dehydrogenase type 1 inhibitor.EBI Incheon National University
25590374 23 Hupehenols A-E, selective 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors from Viburnum hupehense.EBI Chinese Academy of Sciences
25800116 62 Synthesis and optimization of picolinamide derivatives as a novel class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors.EBI Seoul National University
25529735 27 Synthesis and biological evaluation of picolinamides as potent inhibitors of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1).EBI Republic of Korea; Research Institute of Pharmaceutical Science and College of Pharmacy
25050169 52 Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11-Hydroxysteroid Dehydrogenase Type 1 (11-HSD-1).EBI Bristol-Myers Squibb
24960438 24 Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17-hydroxysteroid dehydrogenase 2 inhibitors.EBI University of Innsbruck
25453795 6 Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.EBI TBA
25266782 41 Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors for the treatment of metabolic disorders.EBI Bristol-Myers Squibb
24840014 25 Ingol-type diterpenes from Euphorbia antiquorum with mouse 11-hydroxysteroid dehydrogenase type 1 inhibition activity.EBI Lanzhou University
24815509 51 Discovery of camphor-derived pyrazolones as 11-hydroxysteroid dehydrogenase type 1 inhibitors.EBI Hoffmann-La Roche Inc.
24294985 42 Medicinal chemistry of inhibitors of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1).EBI AstraZeneca
24422550 107 Optimization of brain penetrant 11-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.EBI AstraZeneca
24507919 45 3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11-hydroxysteroid dehydrogenase 1 inhibitor.EBI Yonsei University
24360604 60 Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11-hydroxysteroid dehydrogenase type 1 (11-HSD1).EBI Bristol-Myers Squibb
24074876 17 Synthesis of sterically encumbered 11-aminoprogesterone derivatives and evaluation as 11-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.EBI University of Alberta
23981897 6 Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11-hydroxysteroid dehydrogenase 1 inhibitors.EBI Leopold-Franzens-Universit£t
23845218 86 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes.EBI Sanofi Deutschland GmbH
23795939 5 11-HSD1 inhibitors from Walsura cochinchinensis.EBI Chinese Academy of Sciences
23800686 45 Mono-carbonyl curcumin analogues as 11-hydroxysteroid dehydrogenase 1 inhibitors.EBI Wenzhou Medical College
23747808 51 Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11-HSD1 inhibitors: potential impact in diabetes.EBI Chinese Academy of Sciences
23659858 17 Evaluation of selective inhibitors of 11-HSD1 for the treatment of hypertension.EBI Merck& Co.
23478147 42 Discovery of SAR184841, a potent and long-lasting inhibitor of 11-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.EBI Sanofi R&D
23489629 19 N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.EBI Pfizer Inc.
23414800 47 Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.EBI Toray Industries, Inc.
23353742 29 Design, synthesis and SAR of piperidyl-oxadiazoles as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.EBI Chinese Academy of Sciences
23145773 45 Structural optimization of 2,5-thiophene amides as highly potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.EBI Saarland University
18314331 70 Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors.EBI Korea Research Institute of Chemical Technology
23153367 92 Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.EBI AstraZeneca
23088558 36 Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).EBI AstraZeneca
23040895 37 Adamantyl carboxamides and acetamides as potent human 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.EBI University of Bath
23013933 59 Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors.EBI AstraZeneca
24900382 41 Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.EBI TBA
22691057 32 Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).EBI AstraZeneca
22901389 28 Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.EBI Merck-Serono S.A.
22542009 102 Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11ß-HSD1 inhibitors.EBI Amgen Inc.
22360639 12 Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.EBI Chinese Academy of Sciences
24900439 34 Synthesis and biological evaluation of cyclic sulfamide derivatives as 11-hydroxysteroid dehydrogenase 1 inhibitors.EBI TBA
22440625 44 Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.EBI Chinese Academy of Sciences
24900270 22 Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.EBI TBA
21138273 11 Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 1.EBI University of Ljubljana
19564108 48 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.EBI Chinese Academy of Sciences
19574056 25 Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.EBI Chinese Academy of Sciences
19185488 56 Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.EBI Amgen, Inc.
18553955 43 Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.EBI Amgen, Inc.
18533708 25 Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.EBI University of Innsbruck
18440812 113 Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.EBI Merck Research Laboratories
18434143 96 Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.EBI Merck& Co.
18242087 18 Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.EBI Shanghai Institute of Materia Medica
17490884 39 beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.EBI Wyeth Research
12190302 9 Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.EBI Biovitrum
22148241 3 Cyclopeptide Alkaloids from Ziziphus apetala.EBI Kunming Institute of Botany
21983444 78 Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).EBI Bristol-Myers Squibb Research& Development
21983439 65 Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).EBI Bristol-Myers Squibb
21873057 13 Potent and novel 11ß-HSD1 inhibitors identified from shape and docking based virtual screening.EBI Shanghai Pharmaceutical Holding Co. Ltd
21786805 130 Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.EBI Vitae Pharmaceuticals
21689935 55 Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).EBI Bristol-Myers Squibb
21334894 218 Substituted phenyl triazoles as selective inhibitors of 11 β-Hydroxysteroid Dehydrogenase Type 1.EBI Merck& Co
21439819 49 Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.EBI Sanofi-aventis R&D,
21421311 135 Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.EBI Merck Research Laboratories
21376605 26 Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.EBI University of Technology
21093259 38 Synthesis and 11ß hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.EBI Korea University
21093258 66 Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.EBI Amgen Inc
20971000 76 The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors.EBI Amgen Inc.
20864344 110 Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.EBI Vitae Pharmaceuticals
20851614 22 Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.EBI University of Natural Resources and Applied Life Sciences
20510621 44 A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series.EBI AstraZeneca PLC
20465278 27 Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).EBI Amgen Inc.
20452767 65 Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.EBI University of Edinburgh
20363126 50 The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.EBI Pfizer Global Research& Development
20149650 65 Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.EBI Merck Research Laboratories
20045318 18 Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors.EBI Korea University
19914836 2 Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.EBI Vienna University of Technology
20100662 6 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.EBI University of Innsbruck
20064717 64 Spirocyclic ureas: orally bioavailable 11beta-HSD1 inhibitors identified by computer-aided drug design.EBI Vitae Pharmaceuticals
19625185 44 The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.EBI Schering-Plough Research Institute
19673466 101 Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.EBI Wyeth Research
19395260 29 Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.EBI Merck-Serono
19181519 71 Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).EBI TBA
19053753 67 Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.EBI Amgen, Inc.
18789704 4 Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.EBI Amgen Inc.
18653260 24 Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors.EBI Institute of Materia Medica
18578516 83 Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.EBI Wyeth Research
18440811 207 4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.EBI Merck Research Laboratories
17919905 56 The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.EBI Amgen Inc.
17600707 48 Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.EBI Biovitrum AB
17442567 27 Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.EBI Biovitrum AB
17350260 56 Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.EBI University of Edinburgh
17201418 105 Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.EBI Abbott Laboratories
17070044 102 Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.EBI Abbott Laboratories
17000111 127 Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.EBI Abbott Laboratories
16996734 93 Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.EBI Abbott Laboratories
16931002 73 Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.EBI Abbott Laboratories
16899366 85 Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.EBI Abbott Laboratories
16890427 81 Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.EBI Abbott Laboratories
16759088 38 The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.EBI University of Innsbruck
16185866 53 Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.EBI Merck & Co.
15911270 19 Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.EBI Wyeth Research
18511278 87 Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).BDB Amgen Inc.
18485702 31 Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.BDB Bristol-Myers Squibb Company
19473839 26 N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.BDB Pfizer
19450980 21 Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.BDB Merck-Serono
19217779 15 Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.BDB Amgen
18419108 37 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.BDB Biovitrum AB
17110106 78 Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.BDB Abbott Laboratories
17266194 16 2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.BDB Amgen