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18 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26041577 13 Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.EBI Istituto Giannina Gaslini
25019478 13 Flavones: an important scaffold for medicinal chemistry.EBI Punjabi University
25452003 4 F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.EBI Wuhan University of Science and Technology
25441013 49 Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.EBI Vertex Pharmaceuticals Inc
25384240 4 Discovery heralds new approach to the treatment of cystic fibrosis.EBI JL3Pharma LLC
24992073 2 A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.EBI Universit£ Grenoble Alpes
18077363 314 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.EBI University of Oxford
21707078 31 Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.EBI University of California
21397997 5 An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.EBI University Joseph Fourier-Grenoble 1/CNRS
19785436 29 Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.EBI University of California
18691893 43 Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.EBI University of California
18180157 10 Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.EBI St. Jude Children's Research Hospital
15808474 43 Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.EBI Genzyme Corp.
14761197 16 Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.EBI Université de Poitiers