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158 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27836196 26 Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.EBI Second University of Naples
28041801 1 A one-pot laccase-catalysed synthesis of coumestan derivatives and their anticancer activity.EBI CSIR Biosciences
27597418 16 Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.EBI Bhupat and Jyoti Mehta School of Biosciences
26918635 11 Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv."Cascade").EBI University of Naples Federico II
26922224 23 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).EBI Gazi University
26899595 32 A potent and selective inhibitor targeting human and murine 12/15-LOX.EBI University of California
26708113 33 Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.EBI Second University of Naples
26753816 8 Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents.EBI Lomonosov Moscow State University
26197161 40 Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.EBI University of Ferrara
26123643 90 Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.EBI University of Jena
26088337 43 Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.EBI University of Innsbruck
25686392 3 Myxochelins target human 5-lipoxygenase.EBI Leibniz Institute for Natural Product Research and Infection Biology
25765759 195 Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.EBI University of Naples
25599836 14 Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.EBI Boehringer Ingelheim (Canada) Ltd
25553540 6 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.EBI University of Mississippi
25575659 124 SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI Goethe-University Frankfurt
25037914 76 Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.EBI Goethe-University Frankfurt
25036790 60 Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.EBI Goethe University Frankfurt
24924423 21 Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.EBI University of California
25462262 98 Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.EBI Goethe-University Frankfurt
24920381 77 SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.EBI University Jena
24794107 32 Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.EBI Peking University
24871899 31 Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.EBI University of Naples
24697244 23 Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.EBI Friedrich-Schiller-University
24684213 56 Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.EBI Harvard Medical School
24685113 44 Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.EBI Peking University
24568174 3 One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.EBI University of Athens
24393039 97 Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.EBI National Institutes of Health
24508141 30 Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.EBI Guru Nanak Dev University
23871907 64 Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.EBI University of Salerno
24368208 13 Inhibition of LOX by flavonoids: a structure-activity relationship study.EBI Universidade do Porto
24295787 5 Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.EBI Medical University of South Carolina
24900624 18 Exploring the chemical space of multitarget ligands using aligned self-organizing maps.EBI Goethe University
24231650 2 Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.EBI University of Groningen
24171493 95 Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.EBI Goethe-University Frankfurt
24074025 3 Investigating the selectivity of metalloenzyme inhibitors.EBI University of California at San Diego
23260349 51 Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.EBI Pfizer Inc.
23356879 50 Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.EBI Goethe-University Frankfurt
23337599 7 N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.EBI Guru Nanak Dev University
1848292 116 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.EBI ICI Pharma
22789707 8 Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.EBI Groningen Research Institute of Pharmacy
22992107 34 Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.EBI Eberhard Karls University
21591611 107 Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.EBI ZAFES/LiFF/Goethe-University Frankfurt
22380511 73 Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.EBI Peking University
22537178 5 Charting, navigating, and populating natural product chemical space for drug discovery.EBI Max Planck Institute of Molecular Physiology
21800856 50 Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI University of Innsbruck
22819942 2 Synthesis of benzo-annulated tryptanthrins and their biological properties.EBI Yeungnam University
22683242 47 Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.EBI University of Salerno
24900445 10 Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.EBI TBA
22551629 72 Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.EBI ZAFES/LiFF/OSF Goethe-University Frankfurt
21341744 141 A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors.EBI Goethe University Frankfurt
20451397 55 Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.EBI Universit£ Lille-Nord de France
19848434 27 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.EBI University of California Santa Cruz
19053751 89 Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.EBI Eberhard-Karls-University Tuebingen
18077363 314 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.EBI University of Oxford
18276139 44 Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.EBI Merck Frosst Centre for Therapeutic Research
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
16134928 34 Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI The Scripps Research Institute
10691695 85 Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.EBI Abbott Laboratories
9288168 12 Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.EBI Merck Frosst Centre for Therapeutic Research
9207936 198 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8831761 53 Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.EBI Merck Frosst Centre for Therapeutic Research
7490726 10 (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.EBI Abbott Laboratories
1324317 21 Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.EBI R.W. Johnson Pharmaceutical Research Institute
1321908 44 Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.EBI ICI Pharmaceuticals
1635053 47 5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.EBI Wyeth-Ayerst Research
9990449 7 A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.EBI Tokushima Bunri University
9871729 7 Synthesis and anti-inflammatory activity of chalcone derivatives.EBI Universidad de Valencia
22326163 63 SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.EBI ZAFES/LiFF/OSF Goethe-University Frankfurt
22118829 13 Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors.EBI University of Hyderabad
22059882 206 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.EBI Amira Pharmaceuticals
21958738 6 Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.EBI Universiti Putra Malaysia
21958737 24 Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.EBI National Taiwan University
21868137 69 Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.EBI Gazi University
21739938 72 Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.EBI National Human Genome Research Institute
21696952 41 Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.EBI Bristol-Myers Squibb Research and Development
21570310 74 Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1.EBI Eberhard Karls University Tuebingen
21466167 47 Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1).EBI University of Innsbruck
21319773 8 Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.EBI University of Veterinary and Pharmaceutical Sciences Brno
21323313 45 Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.EBI University of Salerno
21310608 55 A novel class of dual mPGES-1/5-LO inhibitors based on thea-naphthyl pirinixic acid scaffold.EBI Goethe-University Frankfurt
21189019 22 Identifying chelators for metalloprotein inhibitors using a fragment-based approach.EBI University of California
21044840 47 Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.EBI Merck Frosst Centre for Therapeutic Research
20866075 87 Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.EBI National Human Genome Research Institute
20667741 11 Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.EBI University of Hyderabad
19561619 5 Bioactivity-guided mapping and navigation of chemical space.EBI Institut für Molekulare Physiologie
20236826 6 Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.EBI University of Graz
20056549 12 Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.EBI National Taiwan University
19481465 31 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.EBI Karl-Franzens-Universit£t Graz
 76 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesisEBI TBA
 14 Benzoxepin and benzothiepin derivatives as potent, orally active inhibitors of 5-lipoxygenaseEBI TBA
 13 Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic propertiesEBI TBA
 4 Synthesis and Biological Evaluation of New Leukotriene Analogs.EBI TBA
 8 Synthesis and biological evaluation of new arachidonic acid analogsEBI TBA
 4 Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl groupEBI TBA
 25 Justicidin E: A new leukotriene biosynthesis inhibitor.EBI TBA
 32 Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitorsEBI TBA
 21 1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitorEBI TBA
 6 Phenothiazine and phenoxazine derivatives of nafazatrom. In vitro evaluation as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors.EBI TBA
 12 Enzymic and nonenzymic lipid peroxidation: inhibition by substituted phenoxazinesEBI TBA
19152786 5 Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.EBI Université de Moncton
18976930 10 Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.EBI National Institute of Advanced Industrial Science and Technology (AIST)
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18541424 4 Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.EBI University of Alberta
11678654 3 Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.EBI Universidad de Murcia
10978197 3 Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.EBI Institute of Pharmaceutical Sciences
9544564 16 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.EBI Heinrich-Heine-Universität Düsseldorf
17461565 39 Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.EBI Johann Wolfgang Goethe-Universität
17378609 29 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.EBI Tahitian Noni International
16464579 36 Substituted coumarins as potent 5-lipoxygenase inhibitors.EBI Merck Frosst Centre for Therapeutic Research
15863327 9 5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.EBI Pfizer Global Research & Development
15686917 21 5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.EBI UCB Research
15566290 60 New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.EBI Université de Lille 2
15482930 22 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.EBI UCB Research
15081022 20 5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.EBI UCB Research
14736252 12 4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics.EBI Pfizer Global Research and Development
11859001 30 Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.EBI Laboratoires Innothera
11212092 1 Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation.EBI Universidade Federal do Rio de Janeiro
9871745 8 Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.EBI Merck Frosst Centre For Therapeutic Research
9719605 62 New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.EBI Procter & Gamble Pharmaceuticals
9544211 39 New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.EBI Procter & Gamble Pharmaceuticals
9111294 1 Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.EBI Université H. Poincaré
9057869 25 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8831760 108 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.EBI Abbott Laboratories
8410991 88 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.EBI Merck Frosst Centre for Therapeutic Research
8289184 45 Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.EBI Centre de Recherches
8246226 89 Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.EBI Ciba-Geigy Corporation
8201600 41 Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.EBI Universität Regensburg
8164257 18 Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.EBI Merck Frosst Centre for Therapeutic Research
8120869 10 Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.EBI Merck Frosst Centre for Therapeutic Research
8021931 19 (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI Merckle GmbH
7861415 3 Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma.EBI Solvay Pharma
7837242 24 Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors.EBI CIBA-GEIGY Corporation
7562928 35 Chiral dioxolane inhibitors of leukotriene biosynthesis: structure-activity relationships and syntheses using asymmetric dihydroxylation.EBI Zeneca Pharmaceuticals
7473582 29 Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.EBI Merck Frosst Centre for Therapeutic Research
6298421 10 Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.EBI TBA
3669017 8 Phenylephrine derivatives as leukotriene D4 antagonists.EBI Wyeth Laboratories
3346867 6 Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.EBI Wellcome Research Laboratories
2542553 31 Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.EBI Merck Frosst Canada Inc.
2502629 90 Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.EBI Rorer Central Research
2465410 3 Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.EBI Dainippon Pharmaceutical Co., Ltd.
2329571 12 Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.EBI Sankyo Company Ltd.
2319562 12 Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.EBI Molecular Therapeutics Inc.
2157009 49 Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.EBI Rorer Central Research
2113949 126 Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.EBI Boehringer Ingelheim Pharmaceuticals
2066991 40 Syntheses of 5,7,8- and 5,6,7-trioxygenated 3-alkyl-3',4'-dihydroxyflavones and their inhibitory activities against arachidonate 5-lipoxygenase.EBI University of Tokushima
2066989 89 4-hydroxythiazole inhibitors of 5-lipoxygenase.EBI Abbott Laboratories
1648621 55 (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.EBI ICI Pharmaceuticals
28390993 46 New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.BDB Alexandria University
26416255 15 Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors.BDB Hans Knöll Institute
25359714 55 Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.BDB Universidad de Santiago
24889744 4 Identification of 1, 4-Dihydrothieno [3', 2':5, 6]thiopyrano[4, 3-c] pyrazole derivatives as human 5-Lipo-oxygenase inhibitors.BDB Peking University
22404847 24 Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors.BDB Korea Research Institute of Chemical Technology
15798001 56 Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.BDB Kyowa Hakko Kogyo Co., Ltd.
19492852 44 Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.BDB Friedrich Alexander University Erlangen
18710209 14 Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.BDB Eberhard-Karls-University Tuebingen
16821792 16 Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.BDB Friedrich Alexander University Erlangen