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70 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27979595 73 Imidazopyridyl compounds as aldosterone synthase inhibitors.EBI Merck USA
27789139 69 Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.EBI Temple University School of Pharmacy
26938274 52 Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.EBI University of Bologna
26819663 34 Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.EBI Bristol-Myers Squibb Research and Development
26288685 59 Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
26005536 92 Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
25711516 118 Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25591066 23 Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.EBI University of Maryland
25528333 32 Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.EBI Saarland University
25462231 85 Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11-hydroxylase.EBI Universit£ degli Studi di Bari"Aldo Moro"
24775307 42 Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.EBI Viamet Pharmaceuticals, Inc.
24025069 36 Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.EBI University of Padova
23859149 76 Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
23713567 13 Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.EBI University of Maryland
23363058 68 Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.EBI University of Bologna
22861193 60 Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
22788843 46 Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
24900520 14 Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight.EBI TBA
21316976 62 17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.EBI Takeda Pharmaceutical Company, Ltd
20550118 69 Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.EBI Saarland University
20568782 16 Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.EBI University of Bologna
18061460 10 Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.EBI Saarland University
15828836 13 Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.EBI University of Maryland
12773039 37 Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.EBI Accelrys
11063622 60 Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.EBI University of the Saarland
9876107 9 The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.EBI Institute of Cancer Research
21978946 45 Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.EBI Takeda Pharmaceutical Company, Ltd.
21429754 75 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.EBI Takeda Pharmaceutical Company, Ltd
21384875 67 Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.EBI Saarland University
21341743 42 Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase.EBI Universita` degli Studi di Bari Aldo Moro
21129965 18 N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland
20684610 73 Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.EBI Saarland University
19211174 15 Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.EBI Saarland University
19049427 98 In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.EBI Saarland University
18763754 57 Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.EBI Saarland University
18674917 40 Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.EBI Saarland University
18672861 91 Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.EBI Saarland University
18024111 2 Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.EBI Saarland University
11262078 19 A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.EBI University of Bologna
11087568 55 Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).EBI University of the Saarland
9526564 21 Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.EBI University of Maryland
9379450 51 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).EBI University of Maryland
8863811 56 Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.EBI University of Maryland
8765515 37 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.EBI Cancer Research Campaign Centre for Cancer Therapeutics
8340925 18 Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.EBI Syntex Discovery Research
7608911 35 Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.EBI Institute of Cancer Research
7473546 61 Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis.EBI CRC Laboratory
2016706 29 Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.EBI CIBA-GEIGY AG.
1848629 42 gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.BDB Georgetown University
18811133 12 Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.BDB Abbott Laboratories
18665584 32 Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.BDB Bryn Mawr College
18522384 11 Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives.BDB Peking University
15355974 6 Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.BDB The Scripps Research Institute
18433114 28 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.BDB VU University Amsterdam
18419108 37 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.BDB Biovitrum AB
17660385 13 [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.BDB Abbott Laboratories