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104 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28324649 99 Sulfonamides as Selective NaEBI Amgen Inc.
28287723 73 Sulfonamides as Selective NaEBI Amgen Inc.
28234467 108 Development of New Benzenesulfonamides As Potent and Selective NaEBI Bristol-Myers Squibb
28337315 22 Sodium Channel Blockers.EBI Temple University
28337316 16 Bicyclic Ketone Sulfonamide Compounds.EBI Temple University
27994738 50 Sulfonamides as Selective NaEBI Amgen, Inc.
26985315 49 Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.EBI Xenon Pharmaceuticals, Inc.
26890998 572 Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.EBI Amgen Inc.
26713098 14 Sulfonamide Compounds as Voltage Gated Sodium Channel Modulators.EBI Temple University
26396679 6 Nav1.7 Inhibitors: Potential Effective Therapy for the Treatment of Chronic Pain.EBI Therachem Research Medilab (India) Pvt. Ltd.
26358159 114 Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.EBI Daiichi Sankyo Co., Ltd
25927480 36 Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.EBI Merck Research Laboratories
25288187 45 Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.EBI Merck Research Laboratory
26101568 51 Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.EBI Pfizer Inc.
25466191 17 Dibenzazepines and dibenzoxazepines as sodium channel blockers.EBI Purdue Pharma LP
25435147 24 N-Aryl azacycles as novel sodium channel blockers.EBI Purdue Pharma L.P.
21300721 90 Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.EBI University of Oxford
25658507 218 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.EBI Amgen Inc.
25113934 65 Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.EBI Merck Research Laboratory
25026046 42 Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.EBI Purdue Pharma L.P.
25176194 69 The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.EBI Xenon Pharmaceuticals Inc.
24601592 48 Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.EBI University College London
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc.
21641215 55 Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.EBI AstraZeneca
22770500 219 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.EBI AstraZeneca
24900534 6 Cyclopropyl-spiro-piperidines Useful as Sodium Channel Blockers: Patent Highlight.EBI TBA
24900533 22 Substituted pyridines as sodium channel blockers: patent highlight.EBI TBA
22939696 85 Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship.EBI AstraZeneca
22832315 85 Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.EBI AstraZeneca
22318156 128 Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.EBI Amgen Inc.
22306122 90 The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.EBI Amgen Inc.
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18243692 85 Imidazopyridines: a novel class of hNav1.7 channel blockers.EBI Merck Research Laboratories
22364743 8 Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.EBI University of Virginia
22209205 38 Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.EBI Amgen Inc.
21634377 73 Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.EBI Amgen Inc.
21570288 57 Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain.EBI Xenon Pharmaceuticals Inc.
21106456 35 Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.EBI Merck Research Laboratories
20709552 36 Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.EBI Merck Research Laboratories
20709545 31 Substituted biaryl pyrazoles as sodium channel blockers.EBI Merck Research Laboratories
20394379 2 Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.EBI University of North Carolina
19683443 26 Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.EBI Merck Research Laboratories
19674896 12 Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.EBI Merck Research Laboratories
18289851 24 3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.EBI Merck Research Laboratories
17889534 24 Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.EBI Merck Research Laboratories
17588748 46 Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.EBI Merck Research Laboratories
17489575 7 Sodium channel blockers.EBI Purdue Pharma L.P.
16337121 22 Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.EBI Merck Research Laboratories
15878274 33 Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.EBI Merck Research Laboratories
15780630 74 Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.EBI Merck Research Laboratories
28465103 22 Benzoxazolinone aryl sulfonamides as potent, selective NaEBI Merck& Co.
28389149 56 Discovery of selective, orally bioavailable, N-linked arylsulfonamide NaEBI Department of Discovery Chemistry Merck& Co.
28385504 52 The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia.EBI WuXi AppTec (Shanghai) Co., Ltd.
19396178 6 Impact of linker strain and flexibility in the design of a fragment-based inhibitor.BDB Johns Hopkins University
19338333 37 Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.BDB Kochi Medical School
19138845 44 Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.BDB Merck Research Laboratories
19093884 36 Non-peptide macrocyclic histone deacetylase inhibitors.BDB Georgia Institute of Technology
18374572 100 Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.BDB Universita degli Studi di Firenze
15743201 58 Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.BDB Quorex Pharmaceuticals Inc.
17556356 4 Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.BDB Novartis
16509583 114 Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.BDB University of Alberta
17034120 4 Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.BDB Lilly Research Laboratories
15664855 19 Non-peptidic small molecule inhibitors of XIAP.BDB Abbott Laboratories
16884309 5 Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.BDB TaiGen Biotechnology Co.
8360874 19 Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.BDB Merck Research Laboratories
12039591 63 Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck - a selectivity insight.BDB Abbott Bioresearch Center
16298527 10 Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.BDB University of Pennsylvania
15993068 101 2-Aminoquinazoline inhibitors of cyclin-dependent kinases.BDB NAEJA Pharmaceutical Inc.
8423600 13 3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.BDB Merck Research Laboratories
11112523 7 Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface.BDB University of Maryland Biotechnology Institute