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434 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28613859 43 Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a"Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.EBI VFP Therapies
28279845 54 Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Nanyang Normal University
28279561 26 Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.EBI Persian Gulf University
27744187 42 Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.EBI South China University of Technology
28064079 5 Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.EBI University of Bologna
27876467 9 A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease.EBI Tehran University of Medical Sciences
27951490 72 2,4-Disubstituted quinazolines as amyloid-▀ aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.EBI University of Waterloo
27951485 59 Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-▀-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.EBI Sichuan University
27936444 93 Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.EBI Martin-Luther-University Halle-Wittenberg
27918993 29 Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.EBI University of Sfax
27951489 78 Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group.EBI Hu'nan University
27721153 18 Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.EBI Jagiellonian University Medical College
27688184 29 New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effectsáagainst NMDA-induced neurotoxicity.EBI University of Bari"A. Moro"
27597727 1 Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review.EBI Aligarh Muslim University
27560283 58 Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEBI Jagiellonian University Collegium Medicum
27914796 14 Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.EBI University of Nebraska Medical Center
27484514 107 Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
27856236 19 Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors.EBI South China University of Technology
27780618 7 Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI University of Gujrat
27598521 22 Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.EBI Ume£ University
26471320 50 Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.EBI Okayama University
27267007 58 New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.EBI Instituto de Qu£mica M£dica
27377327 22 Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.EBI Kazan (Volga region) Federal University
27309570 102 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.EBI Alma Mater Studiorum-University of Bologna
27450532 18 Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).EBI Defence Research & Development Establishment
27460699 76 Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.EBI China Pharmaceutical University
27236720 18 Natural cholinesterase inhibitors from Myristica cinnamomea King.EBI University of Malaya
27190595 70 Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.EBI Universit£ degli Studi della Magna Gr£cia Viale Europa
27046190 10 Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design.EBI TU Dortmund University
27096037 8 Stacking with No Planarity?EBI Merck & Co.
26841168 9 Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.EBI Peking University
27068142 79 Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.EBI Erzurum Technical University
26886849 72 Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.EBI Universit£t W£rzburg
26945113 9 Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.EBI University of Waterloo
26879857 50 Application of PEG-400 as a green biodegradable polymeric medium for the catalyst-free synthesis of spiro-dihydropyridines and their use as acetyl and butyrylcholinesterase inhibitors.EBI Persian Gulf University
26917219 63 Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
26618211 2 Avertoxins A-D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata.EBI Fujian Normal University
26735910 23 Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.EBI University of Bras£lia
26632651 70 Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.EBI China Pharmaceutical University
26503905 51 Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.EBI University Hospital Hradec Kralove
26159481 15 A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.EBI Alchemical Research, LLC
26363866 39 New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI 1st Affiliated Hospital of Guangxi Medical University
26386602 97 Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.EBI Virginia Tech
26242241 29 Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Jagiellonian University Medical College
26222445 5 Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.EBI GlaxoSmithKline
26189031 52 Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors.EBI University of the Punjab
25678015 6 Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.EBI Universitat de Barcelona
26105711 50 In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores.EBI Visva-Bharati (a Central University)
26043948 44 Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).EBI Defence Research & Development Establishment (DRDE)
26003339 12 From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.EBI University of Bologna
25282654 56 Design, synthesis and evaluation of novel tacrine-(▀-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
25260958 46 Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.EBI Hu'nan University
25921269 45 Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.EBI AgriIbrahim£e£en University
26107513 172 Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.EBI Universit£ degli Studi di Bari"Aldo Moro"
26003344 48 Isolation of cholinesterase and▀-secretase 1 inhibiting compounds from Lycopodiella cernua.EBI Catholic University of Daegu
25988399 126 Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.EBI Argenta Discovery Ltd
25871261 4 Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.EBI Chinese Academy of Sciences
25778991 116 Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25812965 80 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.EBI China Pharmaceutical University
25793650 47 Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.EBI CERMN
25743215 1 Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.EBI Mazandaran University of Medical Sciences
25621991 62 Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and▀-amyloid aggregation inhibitors with neuroprotective properties.EBI Jagiellonian University Medical College
25656088 32 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.EBI China Pharmaceutical University
25418133 51 N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.EBI Laboratorio de Quimica Medica (IQOG, CSIC)
25865131 40 Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity.EBI Hebei University of Science & Technology
25724825 27 Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Wenzhou Medical University
25707322 47 Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.EBI Jagiellonian University Medical College
25684426 45 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.EBI Virginia Tech
25597004 18 Iminosugars as a new class of cholinesterase inhibitors.EBI University of Strasburg
25089370 40 Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.EBI P. J. Safarik University
25088549 47 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A▀ aggregation, and▀-secretase.EBI Central China Normal University
25047936 183 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.EBI Universit£t Regensburg
25019478 13 Flavones: an important scaffold for medicinal chemistry.EBI Punjabi University
25016233 14 Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting▀-amyloid, tau, and cholinesterase pathologies.EBI Universitat de Barcelona
24934993 6 Coumarin hybrids as novel therapeutic agents.EBI Punjabi University
24909082 9 Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.EBI N.D. Zelinsky Institute of Organic Chemistry
24811300 20 Biased and unbiased strategies to identify biologically active small molecules.EBI Institut de Chimie des Substances Naturelles
25537270 6 Sulfonamides as multifunctional agents for Alzheimer's disease.EBI University of Massachusetts Boston
25455147 4 Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.EBI Seoul National University
25454267 5 Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.EBI TBA
25453793 1 Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells.EBI TBA
25453812 21 New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.EBI Institute of Pharmacology and Toxicology
25259726 44 Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-▀ aggregation and to exert anticholinesterase and antioxidant effects.EBI Alma Mater Studiorum-University of Bologna
25226236 19 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.EBI University of Ljubljana
25222040 6 Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.EBI Zhejiang University
25190468 15 Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties.EBI Pt. Ravishankar Shukla University
25189690 94 Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.EBI Eastern Mediterranean University
25156301 8 Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with▀-amyloid and tau anti-aggregating properties.EBI Universitat de Barcelona
24980117 62 Synthesis ofa,▀-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid▀-induced cytotoxicity.EBI Universiti Kebangsaan Malaysia
24738476 15 New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI Instituto de Qu£mica M£dica
24726809 72 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI China Pharmaceutical University
24721830 33 Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).EBI Defence Research & Development Establishment (DRDE)
24630558 31 Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.EBI Southwest Research Institute
24606395 8 Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.EBI University of Wollongong
24568372 40 Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.EBI Universitat de Barcelona
24131448 7 Oxidative stress in Alzheimer's disease: are we connecting the dots?EBI University of Bologna
24704618 27 Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.EBI University of Strasburg
24704612 23 Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever.EBI Universidad Industrial de Santander
24681980 3 Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.EBI University of Bologna
24657052 42 Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.EBI Universit£ de Franche Comt£
24900626 15 Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.EBI University of Siena
24220173 37 Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.EBI Charles University in Prague
24220172 25 Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.EBI Sun Yat-sen University
23454132 68 Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.EBI Universiti Sains Malaysia
23395652 1 Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.EBI University of Illinois at Chicago
23286284 50 Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
23273608 20 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.EBI The Hong Kong University of Science and Technology
23273219 17 Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.EBI Baskent University
23276831 11 Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives.EBI Birla Institute of Technology
23199476 36 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
17276075 4 Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.EBI Universit£ di Bologna
15317459 46 Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.EBI Universitat de Barcelona
12109912 9 Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.EBI University of Bologna
11141093 20 Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.EBI University of Bologna
14643329 30 3D-QSAR studies on natural acetylcholinesterase inhibitors of Sarcococca saligna by comparative molecular field analysis (CoMFA).EBI University of Innsbruck
21074294 60 Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE).EBI Universidade Federal do Rio de Janeiro (UFRJ)
9435905 180 Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.EBI Harvard University
8558505 77 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.EBI University of Missouri St. Louis
22795665 24 Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.EBI Universit£ de Sfax
23148598 8 Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.EBI Universit£ de Rouen
23062825 37 Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.EBI Abo Akademi University
22817559 4 Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors.EBI Institute for Medical Research and Occupational Health
23164658 78 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.EBI University of Bologna
23041347 33 Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.EBI Central China Normal University
22944335 43 O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.EBI Sun Yat-sen University
23078965 19 Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.EBI Instituto de Qu£mica Org£nica General (CSIC)
22775474 9 Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.EBI Kieler Wirkstoff-Zentrum (KiWiZ) at the Helmholtz-Zenrum f�r Ozeanforschung GEOMAR
22818849 36 Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.EBI P. J. Safarik University
22704921 34 Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.EBI University of Waterloo
24900454 43 The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?EBI TBA
22503231 66 Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
22425563 16 Prospective acetylcholinesterase inhibitory activity of indole and its analogs.EBI Naresuan University
22243648 112 New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.EBI Instituto de Qu£mica M£dica
22445674 43 Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.EBI Graduate School of Gyeongsang National University
22185619 50 Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.EBI Universitat de Barcelona
21189039 3 Biotransformation of turmerones by Aspergillus niger.EBI Kinki University
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc
21144749 55 Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.EBI University of Defence
21215642 10 Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.EBI University of Defence
20951037 25 Substituted spiro [2.3'] oxindolespiro [3.2¿]-5,6-dimethoxy-indane-1¿-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.EBI Universiti Sains Malaysia
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20627738 32 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.EBI National Institute on Aging
20575555 45 Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.EBI Universidad Autonoma de Madrid
20025280 3 Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.EBI Istituto di Cristallografia
19879672 16 Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.EBI Institute for Medical Research and Occupational Health
19473849 33 Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.EBI COBRA
18954037 40 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI University of Bologna
18640842 45 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.EBI Laboratorio de Radicales Libres (IQOG, CSIC)
16989531 10 Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.EBI Leopold-Franzens-Universit£t
11374978 12 Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.EBI Seoul National University
18517184 47 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
18479118 114 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
18249544 12 Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
18333606 29 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.EBI Fudan University
18232655 32 Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.EBI TBA
17998161 19 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.EBI University of Bologna
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
18023348 16 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.EBI Sapienza University of Rome
17822295 13 Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.EBI Chinese Academy of Sciences
17944454 34 First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.EBI University of Bonn
17888667 33 Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.EBI University of Mysore
17850125 66 Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.EBI University of Bologna
17154513 56 Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.EBI Universitat de Barcelona
16483771 5 Isoquinoline derivatives as potential acetylcholinesterase inhibitors.EBI Naresuan University
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15715468 44 Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.EBI National Institute on Aging
15887964 47 Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.EBI Universit£ di Siena
15633997 18 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.EBI University of Bologna
15481986 69 A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition.EBI University of Kansas
12502352 28 Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.EBI Universit£ di Siena
11741490 18 Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.EBI Universitat de Barcelona
11495583 62 Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
11101357 84 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
10052979 45 Aminopyridazines as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
10508425 68 Mixture-based synthetic combinatorial libraries.EBI Torrey Pines Institute for Molecular Studies
9784091 25 Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.EBI University of Bologna
8978837 60 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.EBI University of North Carolina
7707311 18 Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.EBI Pfizer Inc
8496937 30 Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.EBI Kyowa Hakko Kogyo Co., Ltd
1573636 28 Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.EBI Pfizer Inc
1552502 74 Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.EBI University of South Carolina
2016711 5 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.EBI SRI International
2913310 68 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.EBI SRI International
3746817 21 Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.EBI TBA
11858995 1 Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation.EBI Organon Laboratories Ltd
12182862 56 Novel piperidinium and pyridinium agents as water-soluble acetylcholinesterase inhibitors for the reversal of neuromuscular blockade.EBI Organon Laboratories Ltd
12182861 37 Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Organon Laboratories Ltd
 32 Acetylcholinesterase inhibition by fused dihydroquinazoline compoundsEBI TBA
 4 Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine AEBI TBA
21438612 4 Amidine-oximes: reactivators for organophosphate exposure.EBI Human BioMolecular Research Institute
22206546 42 Nonquaternary reactivators for organophosphate-inhibited cholinesterases.EBI Human BioMolecular Research Institute
22257528 5 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.EBI Punjabi University
22054058 22 Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.EBI University of Bologna
22023459 42 Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Universitat Aut£noma de Barcelona
22019465 28 Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.EBI Zhejiang University
22001085 22 Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases.EBI Moscow State University
22000936 33 Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.EBI University of Lisbon
21955943 47 Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.EBI Pfizer Inc
21924611 38 Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.EBI Chungnam National University
21920739 14 Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.EBI Charles University in Prague
21924801 20 Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.EBI University of Bologna
21939219 16 Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies.EBI Guangzhou University of Chinese Medicine
21873056 50 Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aß-aggregation inhibitors: Synthesis and biological evaluation.EBI University of Waterloo
21798635 32 Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.EBI Institut f£r Molekulare Physiologie
21733699 121 Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.EBI St. Jude Children's Research Hospital
21570751 8 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.EBI Medical University
21459491 96 Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.EBI Universit£ degli Studi di Genova
21435752 76 New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.EBI CNRS
19443217 60 Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.EBI Chemical Diversity Research Institute
19423342 10 Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.EBI Sention Inc.
21397996 36 Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI University of Bologna
21417225 116 Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.EBI Universidad de Granada
21236667 16 Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.EBI Department of Pharmaceutical Sciences-Alma Mater Studiorum-Bologna University
21216144 13 (+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.EBI Alchemical Research, LLC
21429752 72 Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and A β-aggregation inhibitors.EBI University of Waterloo
21397501 54 Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.EBI Charles University
21236521 58 Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.EBI University of Defence
20954721 12 Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.EBI The University of Winnipeg
21105730 30 Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.EBI St. Jude Children's Research Hospital
20801550 9 Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides.EBI Tarbiat Modares University
20817518 23 Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.EBI Charles University
20684567 38 Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.EBI Central Drug Research Institute
20655219 7 Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.EBI McMaster University
20420456 6 Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.EBI University of Bologna
20545360 38 Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.EBI Instituto de Quimica Medica
20053484 417 Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.EBI Sichuan University
20350807 7 Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.EBI Laboratorio de Radicales Libres y Química Computacional (IQOG, CSIC)
20138518 40 Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.EBI Military Health Sciences
19856923 40 Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.EBI Instituto de Quimica Medica (CSIC)
20189400 16 Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.EBI University of Missouri St. Louis
20181484 46 Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.EBI Dalhousie University
20171894 49 Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.EBI University of Bologna
19726199 30 Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.EBI The Chinese Academy of Sciences
19813747 12 Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.EBI University of Bologna
19493592 30 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.EBI University of Mysore
19422203 1 Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.EBI Chinese Academy of Sciences
19505825 12 Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.EBI Alma Mater Studiorum-Bologna University
19215141 8 Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.EBI Istanbul University
 18 Acetylcholinesterase inhibition by tacrine analoguesEBI TBA
 52 Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidaseEBI TBA
 13 Synthesis and structure-activity relationships of new acetylcholinesterase inhibitors: Morpholinoalkylcarbamoyloxyeseroline derivativesEBI TBA
 39 The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivatiesEBI TBA
 20 Physical parameters for brian uptake: optimizing log P, log D and pKa of T H AEBI TBA
 3 Total synthesis of an optically active 8-carba-physostigmine analog: a potent acetylcholinesterase inhibitorEBI TBA
18817366 43 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.EBI Trinity College
18786825 30 Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.EBI European Research Centre for Drug Discovery and Development (NatSynDrugs)
18701300 55 Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI University of Leipzig
18681480 14 Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.EBI Bielefeld University
18650096 17 Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.EBI Quaid-i-Azam University
18605718 17 Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.EBI University of Bologna
18524585 20 Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Sun Yat-sen University
18419109 18 Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.EBI University of Bologna
18396354 29 Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.EBI University of Bologna
10869205 2 The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'.EBI Leiden University
18047264 10 Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.EBI Bologna University
17918819 114 Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects.EBI Novo Nordisk A/S
17655212 56 Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.EBI University of Bologna
17503851 2 Fawcettimine-related alkaloids from Lycopodium serratum.EBI Chiba University
17399985 136 Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.EBI St. Jude Children's Research Hospital
17181144 30 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.EBI Laboratorio de Radicales Libres (IQOG, CSIC)
17008100 54 Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.EBI University of Bologna
16945529 42 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.EBI Friedrich-Schiller-Universität Jena
16821800 96 Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.EBI Pfizer Inc
16735118 23 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.EBI University of Mysore
16107154 41 Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.EBI St. Jude Children's Research Hospital
15878275 11 Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors.EBI Universidad Nacional de Rosario
15801859 40 Anchor-GRIND: filling the gap between standard 3D QSAR and the GRid-INdependent descriptors.EBI IMIM/Universitat Pompeu Fabra
15686892 14 A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates.EBI National Chung-Hsing University
15603953 13 Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.EBI Korea Research Institute of Bioscience and Biotechnology
15588084 4 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.EBI University of Bologna
15566295 2 Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products.EBI Leopold-Franzens University of Innsbruck
14711311 104 Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.EBI Novo Nordisk A/S
14521407 87 Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.EBI GlaxoSmithKline
12620072 3 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.EBI University of Bologna
11755352 40 Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Organon Laboratories Ltd
11754575 51 Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.EBI GlaxoSmithKline
11689088 22 Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.EBI Università di Bologna
10890154 14 Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.EBI Kitasato University
10346939 30 Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.EBI National Institute on Aging Intramural Research Program
9871686 23 Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.EBI Glaxo Wellcome Research and Development
9871563 31 Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.EBI Istituto di Strutturistica Chimica G. Giacomello
9301662 50 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.EBI University of North Texas
9288171 28 Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.EBI National Institute on Aging
8709135 20 Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.EBI Warner-Lambert Company
26583263 3 1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum.EBI Chinese Academy of Sciences
26827140 83 Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.EBI Institute of Physiologically Active Compounds Russian Academy of Sciences
26795115 34 Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.EBI Southeast University
26585276 17 Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin.EBI University of Missouri-St. Louis
25282266 40 Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.EBI Sun Yat-sen University
24900610 5 Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.EBI New York Structural Biology Center
24140444 30 Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.EBI Alma Mater Studiorum University of Bologna
24076173 64 Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.EBI The University of Iowa
8064800 32 Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.EBI Pfizer Inc
8027982 19 Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.EBI Pfizer Inc
23838422 22 Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.EBI Instituto de Qu£mica Org£nica General (CSIC)
23791077 12 Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.EBI University of Waterloo
23746477 7 New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.EBI University of Monastir
23719283 32 Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.EBI Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
23540646 14 Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.EBI University of Massachusetts Boston
23466605 36 Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.EBI Chinese Academy of Sciences
23453838 18 Synthesis and anti-acetylcholinesterase properties of novel ?- and ?-substituted alkoxy organophosphonates.EBI The University of Montana
7636841 16 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.EBI Pfizer Inc
16989529 3 Oculatol, oculatolide, and A-nor sterols from the sponge Haliclona oculata.EBI Peking University
6492073 1 Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.EBI TBA
30096650 102 Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.EBI China Pharmaceutical University
30096649 22 Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase.EBI TNO
30031971 30 Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.EBI University of Ljubljana
30025348 149 Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.EBI Consejo Superior de Investigaciones Cient�ficas (IQM-CSIC)
30351923 12 Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
30339371 76 Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency.EBI Umea University
30245401 61 Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.EBI University of Porto
30243151 23 Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.EBI China Pharmaceutical University
3783578 37 Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.EBI TBA
30383374 20 Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.EBI Institute for Medical Research and Occupational Health
29676580 3 Identification of Lycopodium Alkaloids Produced by an Ultraviolet-Irradiated Strain of Paraboeremia, an Endophytic Fungus from Lycopodium serratum var. longipetiolatum.EBI Nagoya City University
29541355 35 Dual GSK-3?/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.EBI China Pharmaceutical University
29335209 16 Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.EBI University of S£o Paulo
3669008 1 Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.EBI Astra Alab AB
30104121 55 Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.EBI Institute of Physiologically Active Compounds Russian Academy of Sciences
30017317 18 Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.EBI Mansoura University
29605809 19 Success stories of natural product-based hybrid molecules for multi-factorial diseases.EBI Punjabi University
29429576 9 In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.EBI Prin. K. M. Kundnani College of Pharmacy
30183289 3 Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis.EBI Xinjiang Technical Institute of Physics and Chemistry
30125110 20 Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.EBI Universit£ Grenoble Alpes
29533874 76 The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.EBI University of Defence
29466774 78 Synthesis and activity towards Alzheimer's disease inávitro: Tacrine, phenolic acid and ligustrazine hybrids.EBI Chinese Academy of Medical Sciences & Peking Union Medical College
28923380 44 Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.EBI Xinyang Normal University
28800459 68 Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI China Pharmaceutical University
28797883 56 Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI Shanghai University of Traditional Chinese Medicine
28728108 61 New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.EBI Universidad de Sevilla
28728106 21 Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.EBI Central South University
2913311 25 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication.EBI SRI International
29958119 28 Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.EBI Laboratory of Medicinal Chemistry (IQOG, CSIC)
29886321 20 Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, inávitro evaluation and docking studies.EBI CNRS
29857276 53 Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and ?-secretase inhibition activities.EBI Tehran University of Medical Sciences
30040425 3 A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera.EBI University of Colombo
29795757 100 Discovery of EBI Emory University
29421570 28 Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.EBI Federal University of Alfenas
29407958 15 Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI Jiangxi University of Traditional Chinese Medicine
29324339 115 Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.EBI VFP Therapies
29400966 23 Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera.EBI Peking University
29150331 1 Anti-amyloidogenic and anti-apoptotic effect of ?-bisabolol against A? induced neurotoxicity in PC12 cells.EBI Alagappa University
28505534 28 Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.EBI University of Maribor
29969030 24 Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.EBI IQOG, CSIC
29031067 30 New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.EBI Sapienza University of Rome
28898076 26 Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.EBI Huazhong University of Science and Technology
28863358 21 From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.EBI University of S£o Paulo
28759875 30 An overview of benzo[b]thiophene-based medicinal chemistry.EBI Jain University
30017112 36 Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.EBI Abbottabad University of Science and Technology
2202827 55 Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.EBI NIDDK
28445039 15 Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.EBI Chinese Academy of Sciences
28751142 27 Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease.EBI Central South University
28587871 34 Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.EBI Tehran University of Medical Sciences
28578994 28 Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.EBI Urals Branch of Russian Academy of Sciences
28458136 57 Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
28242552 30 Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.EBI Instituto de Qu£mica M£dica
28242549 86 Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.EBI Sun Yat-sen University
29033232 164 Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.EBI Nanyang Normal University
28986116 87 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.EBI Institute of Physiologically Active Compounds Russian Academy of Sciences
28684009 45 Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase.EBI Fourth Military Medical University
1738152 21 Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI University of Illinois
1738151 69 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI University of Illinois
28850227 85 Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI St. John's University
28433681 44 N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.EBI Ume£ University
28388521 28 Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.EBI Shanghai University of Traditional Chinese Medicine
1507203 96 Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.EBI University of South Carolina
29227101 30 The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.EBI University of Ljubljana
28371641 32 Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.EBI China Pharmaceutical University
29400965 83 Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.EBI Julius Maximilian University of W£rzburg
28552337 15 One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.EBI Madurai Kamaraj University
29091431 48 Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.EBI TNO
28404526 23 Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.EBI University of Missouri St. Louis
28400237 19 Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.EBI University of Waterloo
20846091 3 A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides.BDB Gyeongsang National University
14500740 13 Differential activation of formyl peptide receptor signaling by peptide ligands.BDB Pohang University of Science and Technology
10411562 36 Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.BDB Merck Frosst Centre for Therapeutic Research
8996189 24 Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.BDB Pfizer Inc
21168763 9 Natural product-guided discovery of a fungal chitinase inhibitor.BDB University of Dundee
18849971 56 Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.BDB University of California San Francisco
19167885 24 Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.BDB GSK
18541433 45 Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.BDB Abbott Laboratories
19143567 49 Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.BDB Astex
19022670 8 Potent inhibitors of HCV-NS3 protease derived from boronic acids.BDB Schering-Plough Research Institute
19193158 77 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.BDB University of Tampere
17373783 62 Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.BDB AstraZeneca
18973287 87 Structural Requirements for Eszopiclone and Zolpidem Binding to the gamma-Aminobutyric Acid Type-A (GABAA) Receptor Are Different.BDB University of Wisconsin at Madison
18947224 54 Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease.BDB Neurocrine Bioscience
18983139 12 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia.BDB Abbott Laboratories
18227510 8 The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.BDB Harvard Medical School
18973288 34 Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride SynthesisBDB Wyeth Research
18922779 15 Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.BDB Burnham Institute for Medical Research
18942827 66 Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors.BDB Novartis
18855374 55 Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).BDB Saarland University
18834108 22 Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.BDB University of Connecticut at Storrs
10639181 68 Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.BDB Vanderbilt University School of Medicine
17154493 13 4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.BDB IRBM-MRL
18217703 51 Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.BDB IRBM-MRL
17567119 7 Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.BDB NCI-FCRDC
16750629 28 p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.BDB Merck Research Laboratories