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183 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27774132 20 Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.EBI Takeda Pharmaceutical Company Limited
27720325 5 Novel approach of fragment-based lead discovery applied to renin inhibitors.EBI Takeda Pharmaceutical Company, Ltd
27687967 17 Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.EBI Takeda Pharmaceutical Company Ltd
26363506 44 Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin.EBI China Pharmaceutical University
25782742 76 trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.EBI Novartis Pharma AG
25754490 44 trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.EBI Novartis Pharma AG
25728416 25 Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.EBI Merck Research Laboratories
25086681 57 Structure-based optimization of non-peptidic Cathepsin D inhibitors.EBI Merck KGaA
25050166 58 Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.EBI Novartis Institutes for BioMedical Research
25363711 62 Inhibitors of฿-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).EBI Amgen, Inc.
23993670 2 Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.EBI Kyoto Pharmaceutical University
24054120 5 The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations.EBI Novartis Institutes for Biomedical Research
23886807 39 Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.EBI Daiichi Sankyo Co., Ltd
23598247 92 Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.EBI Daiichi Sankyo Co., Ltd
23590342 105 ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.EBI F. Hoffmann-La Roche Ltd
23425156 24 The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.EBI Novartis Pharma AG
23360239 19 A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.EBI Novartis Pharma AG
3316655 34 Renin inhibitors. Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogues on plasma renin.EBI SANOFI Recherche
22200345 7 An integrated computational workflow for efficient and quantitative modeling of renin inhibitors.EBI Sanofi US
8355245 18 Activated ketone based inhibitors of human renin.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
 4 Retro-Inverso Tripeptide Renin InhibitorsEBI TBA
23122821 26 Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.EBI Daiichi Sankyo Co., Ltd
21381769 56 Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI Universite£ de Sherbrooke
24900544 8 Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.EBI TBA
22621689 1 Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.EBI National Hellenic Research Foundation
22726934 58 Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.EBI Daiichi Sankyo Co., Ltd
24900262 31 Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.EBI TBA
22450130 87 Design and synthesis of potent, isoxazole-containing renin inhibitors.EBI Merck Frosst Centre for Therapeutic Research
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
19358611 103 Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.EBI Actelion Pharmaceuticals Ltd.
10669559 180 Protease inhibitors: current status and future prospects.EBI University of Queensland
8120867 70 Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.EBI E. Merck Darmstadt
8474103 123 Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung.EBI Abbott Laboratories
8340909 14 Excursions in drug discovery.EBI Merck Research Laboratories
1433190 43 Highly potent, orally active diester macrocyclic human renin inhibitors.EBI Merck Research Laboratories
1635057 48 Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.EBI Parke-Davis Pharmaceutical Research Division of Warner-Lambert Co.
1732531 88 Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.EBI Warner-Lambert Company
2066983 10 Determination of dissociation constants of high affinity (pM) human renin inhibitors: application to analogues of ditekiren (U-71,038).EBI Upjohn Laboratories
2066966 32 Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.EBI Warner-Lambert Company
2002469 80 Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.EBI Merck Sharp and Dohme Research Laboratories
1956045 88 Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.EBI E. Merck Darmstadt
2202828 28 Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp.EBI ICI Pharmaceuticals
2194033 33 Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.EBI Abbott Laboratories
2184238 14 Renin inhibitory peptides. A beta-aspartyl residue as a replacement for the histidyl residue at the P-2 site.EBI Upjohn Company
2120440 23 Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.EBI Kissei Pharmaceutical Company, Ltd.
2566685 47 Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.EBI University of Wisconsin-Madison
2657067 23 Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue.EBI Abbott Laboratories
3045320 37 Design of rat renin inhibitory peptides.EBI Massachusetts General Hospital
3290486 7 Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site.EBI Upjohn Company
3290485 7 Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction.EBI Upjohn Company
3275777 34 Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.EBI Upjohn Company
3298652 19 Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.EBI TBA
3546690 7 alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.EBI TBA
3118024 35 Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.EBI Abbott Laboratories
3543358 96 Pepstatin analogues as novel renin inhibitors.EBI TBA
3531518 17 Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.EBI TBA
3531517 17 Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.EBI TBA
3906131 61 Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.EBI TBA
3906126 10 Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.EBI TBA
6352942 10 Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy amino acid residue 5-amino-3-hydroxy-7-methyloctanoic acid.EBI TBA
7045370 8 Renin inhibitors. Substitution of the leucyl residues of Leu-Leu-Val-Phe-OCH3 with 3-amino-2-hydroxy-5-methylhexanoic acid.EBI TBA
6267277 15 Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension.EBI TBA
 37 Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability propertiesEBI TBA
22325946 36 3,4-Diarylpiperidines as potent renin inhibitors.EBI Merck Frosst Center for Therapeutic Research
22130130 19 Discovery of pyrrolidine-basedß-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.EBI Merck Research Laboratories
22071301 115 Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.EBI Merck Frosst Centre for Therapeutic Research
21641209 120 Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.EBI Merck Frosst Centre for Therapeutic Research
21840218 62 Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.EBI Deutschland GmbH
21840215 51 Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.EBI Sanofi-Aventis Deutschland GmbH
21741239 35 Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.EBI USA.
21708467 19 Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin.EBI China Pharmaceutical University
21621998 110 Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.EBI Merck Frosst Centre for Therapeutic Research
21497958 12 Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches.EBI Gyeongsang National University (GNU)
21429746 88 The discovery and synthesis of potent zwitterionic inhibitors of renin.EBI Merck Frosst Centre for Therapeutic Research
21112780 30 Design and synthesis of potent macrocyclic renin inhibitors.EBI Medivir AB
20731374 65 Direct renin inhibitors as a new therapy for hypertension.EBI Novartis Pharmaceuticals Corp
20880704 200 Design and synthesis of aminohydantoins as potent and selective humanß-secretase (BACE1) inhibitors with enhanced brain permeability.EBI Pfizer Inc.
20850300 45 Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.EBI Sanofi-Aventis Deutschland GmbH
20843690 60 Piperidine-based renin inhibitors: upper chain optimization.EBI Actelion Pharmaceuticals Ltd
20843686 99 Design and optimization of new piperidines as renin inhibitors.EBI Actelion Pharmaceuticals Ltd
20728350 41 Identification of a new biaryl scaffold generating potent renin inhibitors.EBI Merck Frosst Center for Therapeutic Research
20673718 5 Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.EBI Merck Frosst Centre for Therapeutic Research
20206513 35 Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.EBI Merck Frosst Centre for Therapeutic Research
19853442 35 New classes of potent and bioavailable human renin inhibitors.EBI Actelion Pharmaceuticals Ltd
19959358 57 Optimization of orally bioavailable alkyl amine renin inhibitors.EBI Vitae Pharmaceuticals
19968289 201 Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.EBI Wyeth Research
19757823 98 Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.EBI Wyeth Research
19493591 7 Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity.EBI University of Toyama
19615901 52 The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.EBI Nagasaki International University
 18 Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human reninEBI TBA
 23 Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosetsEBI TBA
 16 Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitorsEBI TBA
 3 Synthesis of α-hydroxy statine through a facially selective osmylation of a chiral α-amido crotonateEBI TBA
 9 Rational design, synthesis, and X-ray structure of renin inhibitors with extended P1 sidechainsEBI TBA
 3 CP-71,362, an unusually potent inhibitor of rat and dog reninEBI TBA
 11 Tetrahydroisoquinoline as a phenylalanine replacement in renin inhibitorsEBI TBA
 13 Preparation of a novel series of phosphonate norstatine renin inhibitorsEBI TBA
 4 Design and synthesis of a prototypical non-peptidic inhibitor model for the enzme reninEBI TBA
 15 The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration.EBI TBA
 22 Novel pseudosymmetric inhibitors of HIV-1 proteaseEBI TBA
 24 Diol sulfonamides: A potent and novel class of inhibitors of human reninEBI TBA
 6 Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→ P3)-P1' sitesEBI TBA
 12 MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.EBI TBA
 38 Conformationally restricted peptide isosteres. 2.1 Synthesis and in vitro potency of dipeptide renin inhibitors employing a 2-alkylsulfonyl-3-phenylcyclopropane carboxamide as a P3 amino acid replacementEBI TBA
19323562 14 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.EBI Abbott Laboratories
17482814 37 Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.EBI Merck Research Laboratories
16143527 32 Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.EBI Pfizer Global Research and Development
15837327 12 Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.EBI Pfizer Global Research and Development
14741251 12 Rational design and synthesis of selective BACE-1 inhibitors.EBI Merck Research Laboratories
10360745 40 Piperidine-renin inhibitors compounds with improved physicochemical properties.EBI F. Hoffmann-La Roche Ltd.
10360744 26 Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.EBI F. Hoffmann-La Roche Ltd
8474102 29 Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-725EBI Abbott Laboratories
8474101 30 Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.EBI Abbott Laboratories
8410992 35 Renin inhibitors containing a pyridyl amino diol derived C-terminus.EBI Hoechst AG
8410973 75 Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.EBI University of Florida
8254610 14 Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.EBI Warner-Lambert Company
7932521 81 Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog.EBI Abbott Laboratories
7752198 8 Time-resolved ligand exchange reactions: kinetic models for competitive inhibitors with recombinant human renin.EBI Boehringer Ingelheim Pharmaceuticals
7473584 16 alpha-Hydroxy phosphinyl-based inhibitors of human renin.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
6993683 8 N-(alpha-Hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin.EBI TBA
6767029 14 Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.EBI TBA
6384520 9 Inhibition of renin by substrate analogue inhibitors containing the olefinic amino acid 5(S)-amino-7-methyl-3(E)-octenoic acid.EBI TBA
3906130 5 A uniquely potent renin inhibitor and its unanticipated plasma binding component.EBI TBA
3882966 28 Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.EBI TBA
3312604 33 Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond.EBI Abbott Laboratories
3309316 50 Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.EBI Merck Sharp & Dohme Research Laboratories
3309315 8 alpha,alpha-Difluoro-beta-aminodeoxystatine-containing renin inhibitory peptides.EBI Upjohn Company
3309313 48 Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.EBI Abbott Laboratories
3305947 7 Fluoro ketone containing peptides as inhibitors of human renin.EBI TBA
3305946 31 New inhibitors of human renin that contain novel Leu-Val replacements.EBI TBA
3302256 45 Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides.EBI TBA
3295239 9 Renin inhibitors. Design of angiotensinogen transition-state analogues containing novel. (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid.EBI TBA
3279210 19 Renin inhibitors containing psi[CH2O] pseudopeptide inserts.EBI Upjohn Company
3279206 16 New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.EBI Abbott Laboratories
3276890 28 Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.EBI Abbott Laboratories
3143010 28 Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.EBI Abbott Laboratories
3143009 50 Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency.EBI Abbott Laboratories
3137345 19 Synthesis and biological activity of some transition-state inhibitors of human renin.EBI Ciba-Geigy Limited
3127587 33 New human renin inhibitors containing an unnatural amino acid, norstatine.EBI Kissei Pharmaceutical Co., Ltd.
3126296 43 Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.EBI University of Wisconsin
3050088 47 Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.EBI Merck Sharp & Dohme Research Laboratories
2661820 18 Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond.EBI Ciba-Geigy Pharmaceuticals Division
2405159 49 Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites.EBI Warner-Lambert Company
2404121 20 Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites.EBI Abbott Laboratories
2202829 18 Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence.EBI ICI Pharmaceuticals
2197411 13 Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin.EBI Upjohn Company
2187994 40 Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.EBI Abbott Laboratories
2118184 14 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 2. Synthesis, biological properties and molecular modeling of hydroxyethylene isostere derivatives.EBI ICI Pharmaceuticals
2118183 18 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 1. Synthesis and biological properties of alkyl alcohol and statine derivatives.EBI ICI Pharmaceuticals
2105396 14 New inhibitors of renin that contain novel phosphostatine Leu-Val replacements.EBI Abbott Laboratories
1995887 14 Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys.EBI Upjohn Company
1992151 10 Design of a well-absorbed renin inhibitor.EBI Abbott Laboratories
1992113 12 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives.EBI ICI Pharmaceuticals
1901910 87 New inhibitors of human renin that contain novel replacements at the P2 site.EBI Warner-Lambert Company
1895289 8 Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.EBI Merck Sharp and Dohme Research Laboratories
1738148 16 Renin inhibitory pentols showing improved enteral bioavailability.EBI Hoechst AG
1597860 24 Renin inhibitors containing C-termini derived from mercaptoheterocycles.EBI Merck Sharp & Dohme Research Laboratories
1588555 83 C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.EBI Abbott Laboratories
1588554 66 Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement.EBI Abbott Laboratories
1588553 32 1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors.EBI University of Texas
1552498 55 Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.EBI Warner-Lambert Company
1548675 10 Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.EBI Merck Sharp and Dohme Research Laboratories
1548674 13 New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin.EBI Wyeth-Ayerst Research
1495010 19 Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.EBI Merck Research Laboratories
1404233 68 Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'.EBI E. Merck Darmstadt
24072703 64 Structural determinants of Tau aggregation inhibitor potency.BDB The Ohio State University
10580501 2 Kainate receptors are involved in synaptic plasticity.BDB University of Bristol
9262370 33 I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.BDB Neurogen Corporation
12498885 9 Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition.BDB Massachusetts Institute of Technology
17296300 14 Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.BDB University of San Francisco