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41 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28246042 2 Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.EBI University of Ljubljana
27541007 45 Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.EBI University of Ljubljana
27100032 4 New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase.EBI University of Ljubljana
27096044 30 Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.EBI Cubist Pharmaceuticals Inc
26786695 12 Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.EBI Cubist Pharmaceuticals
26949507 4 The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership.EBI University College London
26487916 8 Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.EBI Cubist Pharmaceuticals Inc
26483137 2 Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.EBI Inter American University of Puerto Rico
26191374 4 Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.EBI Vertex Pharmaceuticals Inc
26098163 66 Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.EBI University of Ljubljana
25137573 7 Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity.EBI University of Leeds
24959892 152 Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).EBI AstraZeneca
24629449 2 Computer-aided identification of novel 3,5-substituted rhodanine derivatives with activity against Staphylococcus aureus DNA gyrase.EBI University of the Sciences
24098982 39 Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents.EBI AstraZeneca R&D Boston
23968485 67 Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.EBI Actelion Pharmaceuticals Ltd
24900376 5 Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight.EBI TBA
22814212 10 Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.EBI AstraZeneca
22041057 14 Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.EBI AstraZeneca R&D Boston
26460684 39 Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.EBI Cubist Pharmaceuticals Inc
25317480 4 Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.EBI Vertex Pharmaceuticals Inc
25288496 106 Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus.EBI Birla Institute of Technology & Science-Pilani
24239017 15 Design, synthesis and biological evaluation of ?-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.EBI Biota Holdings Ltd
23566517 69 Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.EBI Pfizer Inc.
23084277 3 Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.EBI Merck Research Laboratories
21425851 14 Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).EBI Achillion Pharmaceuticals, Inc.
20404126 20 Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.EBI University of Minnesota Medical School
19736016 12 Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.EBI Daiichi Sankyo Co., Ltd
19147367 9 Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.EBI Anhui University of Technology
17502409 10 Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.EBI Achillion Pharmaceuticals
18262793 9 Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.EBI Anhui University of Technology
18457383 6 Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.EBI Kyorin Pharmaceutical Co Ltd
17228862 7 Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.EBI Achillion Pharmaceuticals, Inc.
29871847 26 Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.EBI The Ohio State University
30031974 3 Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies.EBI Medical University of Warsaw
29778894 30 New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.EBI University of Ljubljana
29751233 2 New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV.EBI Islamia College University
29803359 13 Drug efficacy of novel 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans; evaluated via DNA gyrase inhibition, bacterial cell wall lesion and antibacterial prospective.EBI Bharathiar University
28406299 46 Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.EBI Actelion Pharmaceuticals Ltd
27689732 30 Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B.EBI University of Ljubljana
18690678 66 Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.BDB Vertex Pharmaceuticals Inc