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51 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28171725 20 Fluorinated Chaperone-▀-Cyclodextrin Formulations for▀-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.EBI University of Sevilla
26361824 20 Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.EBI University of Seville
27598312 51 Design and Synthesis of Potent Quinazolines as Selective▀-Glucocerebrosidase Modulators.EBI Northwestern University Feinberg School of Medicine
25461326 20 Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.EBI Universitat Rovira i Virgili
25250725 295 Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.EBI Leiden University
24803362 12 Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy.EBI Technical University Graz
24657053 8 Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.EBI University of Toyama
23880081 8 Rapid modifications of N-substitution in iminosugars: development of new▀-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.EBI Genomics Research Center
19397268 21 Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.EBI Peking University
23106358 96 a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.EBI University of Toyama
22646221 11 Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.EBI National Center for Advancing Translation Sciences
22762530 2 Conformationally-locked N-glycosides with selectiveß-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.EBI Universitat Rovira i Virgili
22512696 61 Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.EBI Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC)
22360565 20 Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.EBI University of British Columbia
24900357 16 The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.EBI TBA
20557054 56 Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.EBI Universitat de Barcelona
18595718 51 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.EBI Hokuriku University
10843222 17 Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.EBI University of Tokyo
10098675 6 Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.EBI Technische Universit£t Berlin
9871687 6 A new strong inhibitor of beta-mannosidase.EBI S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle.
 63 Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraolsEBI TBA
 15 The Interaction of Anhydroalditols with Sweet-Almond -glucosidase and Escherichia coli -galactosidase: implications for the design of potent glycosidase inhibitorsEBI TBA
21862336 9 Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.EBI University of Reading
21546253 41 Docking and SAR studies of D- and L-isofagomine isomers as humanß-glucocerebrosidase inhibitors.EBI University of Toyama
21370884 80 New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.EBI Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
21292481 4 Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.EBI Aarhus University
24900289 155 Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated IminosugarsEBI TBA
17187079 1 Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.EBI Harvard Medical School
20231099 9 Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors.EBI Universit£ d'Orl£ans& CNRS
19931460 6 Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.EBI Utrecht University
 37 Synthesis of a new inhibitor of α-fucosidaseEBI TBA
 5 Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitors of glycosidasesEBI TBA
 6 β-Glucosidase inhibitors incorporating pyridinium as a glucosyl mimicEBI TBA
 25 Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.EBI TBA
15165148 13 Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.EBI Hokuriku University
11392550 5 Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.EBI Institut für Biochemie der Technischen Universität Graz
11327590 7 Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.EBI Technische Universität Graz
25359714 55 Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.BDB Universidad de Santiago
14534366 25 Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at mu, delta, and kappa opioid receptors.BDB Cornell University
18778048 11 Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.BDB Yale University
16634628 42 Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.BDB Johnson & Johnson Pharmaceutical